Synthesis of amide warhead containing coumarin derivatives as potential pancreatic lipase inhibitors: in silico and in vitro evaluation for obesity treatment

[1]  N. Yadav,et al.  Molecular modelling, synthesis and in vitro evaluation of quinazolinone hybrid analogues as potential pancreatic lipase inhibitors. , 2022, Journal of biomolecular structure & dynamics.

[2]  O. Tsivileva,et al.  Coumarins as Fungal Metabolites with Potential Medicinal Properties , 2022, Antibiotics.

[3]  Ginson George,et al.  Synthesis, molecular modelling, in vitro and in vivo evaluation of conophylline inspired novel benzyloxy substituted indole glyoxylamides as potent pancreatic lipase inhibitors , 2021, Journal of biomolecular structure & dynamics.

[4]  S. Mohankumar,et al.  Targeting Obesity with plant-derived pancreatic lipase inhibitors: A comprehensive review. , 2020, Pharmacological research.

[5]  A. Saeed,et al.  Functionalized furo[3,2-c]coumarins as anti-proliferative, anti-lipolytic, and anti-inflammatory compounds: Synthesis and molecular docking studies , 2019, Journal of Molecular Structure.

[6]  F. Leonetti,et al.  Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds , 2018, Molecules.

[7]  H. Oku,et al.  In vivo and in vitro anti-obesity activities of dihydropyranocoumarins derivatives from Peucedanum japonicum Thunb , 2017 .

[8]  S. Sridhar,et al.  Synthesis, evaluation and molecular modelling studies of 2-(carbazol-3-yl)-2-oxoacetamide analogues as a new class of potential pancreatic lipase inhibitors. , 2017, Bioorganic & medicinal chemistry.

[9]  G. Brahmachari.  Room Temperature One-Pot Green Synthesis of Coumarin-3-carboxylic Acids in Water: A Practical Method for the Large-Scale Synthesis , 2015 .

[10]  N. Nwobodo.  Toxicity and Safety Concerns in Orlistat Therapy for Obesity: A Critical Evaluation , 2015 .

[11]  H. Oku,et al.  Pteryxin: a coumarin in Peucedanum japonicum Thunb leaves exerts antiobesity activity through modulation of adipogenic gene network. , 2014, Nutrition.

[12]  H. Oku,et al.  Partially purified Peucedanum japonicum Thunb extracts exert anti-obesity effects in vitro. , 2014, Nutrition.

[13]  Hiroki Sato,et al.  Anti-hyperlipidemic constituents from the bark of Shorea roxburghii , 2012, Journal of Natural Medicines.

[14]  Z. Gu,et al.  Inhibitory effect of osthole on alcohol-induced fatty liver in mice. , 2009, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[15]  B. Cox,et al.  Kinetics of amide formation through carbodiimide/N-hydroxybenzotriazole (HOBt) couplings. , 2007, The Journal of organic chemistry.

[16]  T. Widlanski,et al.  An Intuitive Look at the Relationship of Ki and IC50: A More General Use for the Dixon Plot , 2003 .

[17]  H. van Tilbeurgh,et al.  The 2.46 A resolution structure of the pancreatic lipase-colipase complex inhibited by a C11 alkyl phosphonate. , 1994, Biochemistry.

[18]  H. Tilbeurgh,et al.  Interfacial activation of the lipase–procolipase complex by mixed micelles revealed by X-ray crystallography , 1993, Nature.

[19]  F. Winkler,et al.  Structure of human pancreatic lipase , 1990, Nature.

[20]  P. Hadváry,et al.  Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin. , 1988, The Biochemical journal.

[21]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[22]  D. Burk,et al.  The Determination of Enzyme Dissociation Constants , 1934 .

[23]  Junsoo Lee,et al.  Esculetin, a coumarin derivative, suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes , 2015 .

[24]  D. Mikhailidis,et al.  Orlistat-Associated Adverse Effects and Drug Interactions , 2008, Drug safety.