Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD
暂无分享,去创建一个
H C Clevers | A F Baas | J Boudeau | G P Sapkota | L Smit | R Medema | N A Morrice | D R Alessi | H. Clevers | R. Medema | G. Sapkota | D. Alessi | N. Morrice | J. Boudeau | A. Baas | A. Baas | L. Smit | Gopal P. Sapkota | L. Smit
[1] T. Mäkelä,et al. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[2] M. Uhler,et al. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. , 2000, The Biochemical journal.
[3] A. M. Johnston,et al. SPAK, a STE20/SPS1-related kinase that activates the p38 pathway , 2000, Oncogene.
[4] J. Johnston,et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID) , 1995, Nature.
[5] Norinobu M. Watanabe,et al. The Ste20 group kinases as regulators of MAP kinase cascades. , 2001, Trends in cell biology.
[6] D. Campbell,et al. Identification of protein phosphorylation sites by a combination of mass spectrometry and solid phase Edman sequencing. , 2002, Journal of biomolecular techniques : JBT.
[7] A. Ashworth,et al. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. , 2001, Human molecular genetics.
[8] Ronald A. DePinho,et al. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation , 2002, Nature.
[9] J. Nezu,et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase , 1998, Nature Genetics.
[10] S. Goodman,et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. , 2000, Gastroenterology.
[11] Norinobu M. Watanabe,et al. Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up‐regulated during postnatal mouse cerebral development , 2000, FEBS letters.
[12] A. Wilks,et al. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase , 1991, Molecular and cellular biology.
[13] G. Sapkota,et al. Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth* , 2001, The Journal of Biological Chemistry.
[14] F. Kanai,et al. LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest* , 2001, The Journal of Biological Chemistry.
[15] Jiahuai Han,et al. NIK is a new Ste20‐related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain , 1997, The EMBO journal.
[16] C. Hanson,et al. Identification and Characterization of a Novel Ste20/Germinal Center Kinase-related Kinase, Polyploidy-associated Protein Kinase* , 2003, The Journal of Biological Chemistry.
[17] R. Bernards,et al. A System for Stable Expression of Short Interfering RNAs in Mammalian Cells , 2002, Science.
[18] Q. Deveraux,et al. ILPIP, a Novel Anti-apoptotic Protein That Enhances XIAP-mediated Activation of JNK1 and Protection against Apoptosis* , 2002, The Journal of Biological Chemistry.
[19] L. Notarangelo,et al. Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains , 2000, Molecular and Cellular Biology.
[20] L. Cantley,et al. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. , 2001, Molecular cell.
[21] Hiroyuki Miyoshi,et al. Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. , 2002, Cancer research.
[22] G. Sapkota,et al. Identification and characterization of four novel phosphorylation sites (Ser 31 , Ser 325 , Thr 336 and Thr 366 ) on LKB1/STK11, the protein kinase mutated in Peutz–Jeghers cancer syndrome , 2022 .
[23] O. Silvennoinen,et al. The Pseudokinase Domain Is Required for Suppression of Basal Activity of Jak2 and Jak3 Tyrosine Kinases and for Cytokine-inducible Activation of Signal Transduction* , 2002, The Journal of Biological Chemistry.
[24] S. Pellegrini,et al. A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[25] T. Mäkelä,et al. Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). , 2002, Human molecular genetics.
[26] M. Stratton,et al. A serine/threonine kinase gene defective in Peutz–Jeghers syndrome , 1998, Nature.
[27] J. Nezu,et al. Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients. , 1999, Biochemical and biophysical research communications.
[28] Daniel St Johnston,et al. A role for Drosophila LKB1 in anterior–posterior axis formation and epithelial polarity , 2003, Nature.
[29] O. Silvennoinen,et al. Regulation of the Jak2 Tyrosine Kinase by Its Pseudokinase Domain , 2000, Molecular and Cellular Biology.
[30] D. Morton,et al. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. , 2000, Development.
[31] D. Payan,et al. TNIK, a Novel Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Regulates the Cytoskeleton* , 1999, The Journal of Biological Chemistry.
[32] J. Nezu,et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. , 1998, Nature genetics.
[33] K. Alitalo,et al. Vascular Abnormalities and Deregulation of VEGF in Lkb1-Deficient Mice , 2001, Science.
[34] T. Roberts,et al. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways , 1997, Molecular and cellular biology.
[35] A. Villa,et al. Structural and functional basis for JAK3-deficient severe combined immunodeficiency. , 1997, Blood.
[36] K. Jishage,et al. Role of Lkb1, the causative gene of Peutz–Jegher's syndrome, in embryogenesis and polyposis , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[37] M. Seldin,et al. Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. , 2002, Cancer research.
[38] J. Kuriyan,et al. The Conformational Plasticity of Protein Kinases , 2002, Cell.
[39] L. Aaltonen,et al. Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[40] H Clevers,et al. The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes. , 1995, Blood.