The Structural Design of a Magnetic Driven Wireless Capsule Robot for Drug Delivery

The development of the millimeter-level wireless magnetic actuated robot has provided the possibility for the development of endoscope. In the modern medical system, drugs enter the human body by oral administration and reach the intestinal tract through the esophagus and stomach. If the lesion is located in the gastrointestinal tract, most of the drugs have been absorbed by other parts, and the efficacy is not maximized. In this paper, a structure design of multi-capsule robotic group fixed-point drug release based on Ferro fluid is proposed. The robots group is composed of a front robot and a rear robot, each of which is composed of the robotic body, permanent magnet and Ferro fluid. Permanent magnets are fixed inside of the robot and the rotating electromagnetic field generated by the Helmholtz coils actuates the robots to move forward. Each robot is injected with Ferro fluid, and a clamping force can be generated between the two robots by applying an external magnetic field. The experimental results show that the capsule robots group can reach the designated location for drug release by rotating magnetic field and external permanent magnet.

[1]  S. Konishi,et al.  Capsule microrobot for targeting in medical diagnostic treatment , 2011, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference.

[2]  Metin Sitti,et al.  Design and Rolling Locomotion of a Magnetically Actuated Soft Capsule Endoscope , 2012, IEEE Transactions on Robotics.

[3]  Shuxiang Guo,et al.  Design of A Novel Drug-delivery Module for Active Locomotive Intestinal Capsule Endoscopy , 2018, 2018 IEEE International Conference on Mechatronics and Automation (ICMA).

[4]  M. Sitti,et al.  Magnetically Actuated Soft Capsule With the Multimodal Drug Release Function , 2013, IEEE/ASME Transactions on Mechatronics.

[5]  Tsuyoshi Murata,et al.  {m , 1934, ACML.

[6]  Shuxiang Guo,et al.  Development and Evaluation of Novel Magnetic Actuated Microrobot with Spiral Motion Using Electromagnetic Actuation System , 2016 .

[7]  Yan Zhao,et al.  Development of Multiple Capsule Robots in Pipe , 2018, Micromachines.

[8]  Metin Sitti,et al.  Six-degree-of-freedom magnetic actuation for wireless microrobotics , 2016, Int. J. Robotics Res..

[9]  R. Eliakim,et al.  Wireless capsule video endoscopy: three years of experience. , 2004, World journal of gastroenterology.

[10]  Metin Sitti,et al.  Shape-Programmable Soft Capsule Robots for Semi-Implantable Drug Delivery , 2012, IEEE Transactions on Robotics.

[12]  P. Dario,et al.  Capsule endoscopy: progress update and challenges ahead , 2009, Nature Reviews Gastroenterology &Hepatology.

[13]  Shuxiang Guo,et al.  A Wireless Multiple Modular Capsule Robot , 2018, 2018 13th World Congress on Intelligent Control and Automation (WCICA).

[14]  Jean-François Rey,et al.  Olympus Capsule Endoscope for Small and Large Bowel Exploration , 2006 .

[15]  Timothy G. Constandinou,et al.  Wireless Capsule Endoscope for Targeted Drug Delivery: Mechanics and Design Considerations , 2013, IEEE Transactions on Biomedical Engineering.

[16]  Shuxiang Guo,et al.  Magnetic Driven Wireless Multiple Capsule Robots with Different Structures , 2018, 2018 IEEE International Conference on Mechatronics and Automation (ICMA).

[17]  J. Koenderink Q… , 2014, Les noms officiels des communes de Wallonie, de Bruxelles-Capitale et de la communaute germanophone.

[18]  P. Cochat,et al.  Et al , 2008, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[19]  Shuxiang Guo,et al.  A novel hybrid microrobot using rotational magnetic field for medical applications , 2015, Biomedical Microdevices.

[20]  Shuxiang Guo,et al.  Characteristic evaluation of a wireless capsule microrobotic system , 2013, 2013 IEEE International Conference on Mechatronics and Automation.

[21]  Sung Hoon Kim,et al.  Magnetic Robot and Manipulation for Active-Locomotion With Targeted Drug Release , 2014, IEEE/ASME Transactions on Mechatronics.