The role of DNA methylation in the central nervous system and neuropsychiatric disorders.

[1]  Guoping Fan,et al.  DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. , 2009, Human molecular genetics.

[2]  S. Haggarty,et al.  HDAC2 negatively regulates memory formation and synaptic plasticity , 2009, Nature.

[3]  G. Ming,et al.  Neuronal Activity–Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis , 2009, Science.

[4]  B. Cairns,et al.  DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45 , 2008, Cell.

[5]  C. Sandi,et al.  KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress , 2008, Neuron.

[6]  Miklós Palkovits,et al.  GABAA Receptor Promoter Hypermethylation in Suicide Brain: Implications for the Involvement of Epigenetic Processes , 2008, Biological Psychiatry.

[7]  T. Bestor,et al.  The Colorful History of Active DNA Demethylation , 2008, Cell.

[8]  Jian‐Kang Zhu.  Epigenome Sequencing Comes of Age , 2008, Cell.

[9]  Qian Tao,et al.  DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. , 2008, Human molecular genetics.

[10]  E. Kavalali,et al.  Activity-Dependent Suppression of Miniature Neurotransmission through the Regulation of DNA Methylation , 2008, The Journal of Neuroscience.

[11]  J. Sweatt,et al.  Covalent Modification of DNA Regulates Memory Formation , 2008, Neuron.

[12]  R. Jaenisch,et al.  Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

[13]  Adrian Bird,et al.  Perceptions of epigenetics , 2007, Nature.

[14]  Li-Huei Tsai,et al.  Recovery of learning and memory is associated with chromatin remodelling , 2007, Nature.

[15]  Eric J. Nestler,et al.  Epigenetic regulation in psychiatric disorders , 2007, Nature Reviews Neuroscience.

[16]  G. Fan,et al.  Epigenetic Regulation of Neural Gene Expression and Neuronal Function , 2007, Pediatric Research.

[17]  A. Chess,et al.  Gene Body-Specific Methylation on the Active X Chromosome , 2007, Science.

[18]  T. Kouzarides.  Chromatin Modifications and Their Function , 2007, Cell.

[19]  Christof Niehrs,et al.  Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation , 2007, Nature.

[20]  D. Watanabe,et al.  Transition of mouse de novo methyltransferases expression from Dnmt3b to Dnmt3a during neural progenitor cell development , 2006, Neuroscience.

[21]  Yi Zhang,et al.  JmjC-domain-containing proteins and histone demethylation , 2006, Nature Reviews Genetics.

[22]  J. David Sweatt,et al.  Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus* , 2006, Journal of Biological Chemistry.

[23]  A. Bird,et al.  Genomic DNA methylation: the mark and its mediators. , 2006, Trends in biochemical sciences.

[24]  J. MacDonald,et al.  Stage-specific induction of DNA methyltransferases in olfactory receptor neuron development. , 2005, Developmental biology.

[25]  F. Gage,et al.  Chromatin remodeling in neural development and plasticity. , 2005, Current opinion in cell biology.

[26]  I. Weaver,et al.  Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life , 2005, The Journal of Neuroscience.

[27]  M. Mayford,et al.  Epigenetic Mechanisms and Gene Networks in the Nervous System , 2005, The Journal of Neuroscience.

[28]  Frank Lyko,et al.  DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. , 2005, Journal of the National Cancer Institute.

[29]  P. Golshani,et al.  Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation. , 2005, Thalamus & related systems.

[30]  Guoping Fan,et al.  DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling , 2005, Development.

[31]  T. Bestor,et al.  Eukaryotic cytosine methyltransferases. , 2005, Annual review of biochemistry.

[32]  G. Fan,et al.  Methyl-CpG binding proteins in the nervous system , 2005, Cell Research.

[33]  E. Li,et al.  Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system , 2005, Journal of neuroscience research.

[34]  A. Guidotti,et al.  DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[35]  T. Kouzarides,et al.  Myc represses transcription through recruitment of DNA methyltransferase corepressor , 2005, The EMBO journal.

[36]  Yang Shi,et al.  Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1 , 2004, Cell.

[37]  Albert Jeltsch,et al.  The Dnmt1 DNA-(cytosine-C5)-methyltransferase Methylates DNA Processively with High Preference for Hemimethylated Target Sites* , 2004, Journal of Biological Chemistry.

[38]  Mark Groudine,et al.  Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells , 2004, Nature Structural &Molecular Biology.

[39]  F. Gage,et al.  Epigenetic control of neural stem cell fate. , 2004, Current opinion in genetics & development.

[40]  K. Morris,et al.  Small Interfering RNA-Induced Transcriptional Gene Silencing in Human Cells , 2004, Science.

[41]  Michael J Meaney,et al.  Epigenetic programming by maternal behavior , 2004, Nature Neuroscience.

[42]  I. Suetake,et al.  DNMT3L Stimulates the DNA Methylation Activity of Dnmt3a and Dnmt3b through a Direct Interaction* , 2004, Journal of Biological Chemistry.

[43]  M. Mayford,et al.  CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation , 2004, Neuron.

[44]  A. Jeltsch,et al.  Chromatin Targeting of de Novo DNA Methyltransferases by the PWWP Domain* , 2004, Journal of Biological Chemistry.

[45]  K. Robertson,et al.  DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. , 2004, Biochemical and biophysical research communications.

[46]  A. Guidotti,et al.  DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[47]  A. Bird,et al.  DNA methylation and Rett syndrome. , 2003, Human molecular genetics.

[48]  S. Pradhan,et al.  Mammalian DNA (cytosine-5) methyltransferases and their expression. , 2003, Clinical immunology.

[49]  A. Bird,et al.  Deficiency of Mbd2 suppresses intestinal tumorigenesis , 2003, Nature Genetics.

[50]  E. Lein,et al.  Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[51]  J. Eubanks,et al.  The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells. , 2003, Journal of neurobiology.

[52]  A. Bird,et al.  Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals , 2003, Nature Genetics.

[53]  Dimitris Thanos,et al.  Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure , 2002, Cell.

[54]  R. Jaenisch,et al.  Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[55]  S. Minucci,et al.  Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor , 2002, Science.

[56]  H. Zoghbi,et al.  Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. , 2002, Human molecular genetics.

[57]  A. Bird.  DNA methylation patterns and epigenetic memory. , 2002, Genes & development.

[58]  M. Nakao,et al.  DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. , 2001, Developmental cell.

[59]  T. Bestor,et al.  Dnmt3L and the Establishment of Maternal Genomic Imprints , 2001, Science.

[60]  C. Allis,et al.  Translating the Histone Code , 2001, Science.

[61]  A. Bird,et al.  The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. , 2001, Genes & development.

[62]  R. Roberts,et al.  Recombinant Human DNA (Cytosine-5) Methyltransferase , 2001, The Journal of Biological Chemistry.

[63]  R. Jaenisch,et al.  Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice , 2001, Nature Genetics.

[64]  R. Jaenisch,et al.  DNA Hypomethylation Perturbs the Function and Survival of CNS Neurons in Postnatal Animals , 2001, The Journal of Neuroscience.

[65]  A. Bird,et al.  A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome , 2001, Nature Genetics.

[66]  K. Inano,et al.  Maintenance-type DNA methyltransferase is highly expressed in post-mitotic neurons and localized in the cytoplasmic compartment. , 2000, Journal of biochemistry.

[67]  S. Baylin,et al.  DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci , 2000, Nature Genetics.

[68]  Peter L. Jones,et al.  DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters , 2000, Nature Genetics.

[69]  Luke Hughes-Davies,et al.  DNA methyltransferase Dnmt1 associates with histone deacetylase activity , 2000, Nature Genetics.

[70]  C. Wijmenga,et al.  The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[71]  C. Hsieh.  In Vivo Activity of Murine De Novo Methyltransferases, Dnmt3a and Dnmt3b , 1999, Molecular and Cellular Biology.

[72]  N. Tommerup,et al.  Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene , 1999, Nature.

[73]  M. Meaney,et al.  Nongenomic transmission across generations of maternal behavior and stress responses in the rat. , 1999, Science.

[74]  C. Papadopoulos,et al.  Nanoelectronics: Growing Y-junction carbon nanotubes , 1999, Nature.

[75]  D. Haber,et al.  DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development , 1999, Cell.

[76]  R. Holliday.  Is there an epigenetic component in long-term memory? , 1999, Journal of theoretical biology.

[77]  H. Zoghbi,et al.  Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 , 1999, Nature Genetics.

[78]  A. Bird,et al.  The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites , 1999, Nature.

[79]  E. Li,et al.  Cloning, expression and chromosome locations of the human DNMT3 gene family. , 1999, Gene.

[80]  M. Szyf,et al.  A mammalian protein with specific demethylase activity for mCpG DNA , 1999, Nature.

[81]  R. Roberts,et al.  I. EXPRESSION, PURIFICATION, AND COMPARISON OF DE NOVO AND MAINTENANCE METHYLATION* , 1999 .

[82]  J. Herman,et al.  Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer , 1999, Nature Genetics.

[83]  E. Li,et al.  Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. , 1998, Nucleic acids research.

[84]  Colin A. Johnson,et al.  Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex , 1998, Nature.

[85]  Shakti Sharma,et al.  Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. , 1997, Science.

[86]  A. Bird,et al.  MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin , 1997, Cell.

[87]  D. Goldman,et al.  DNA mismatch repair and DNA methylation in adult brain neurons , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[88]  Raoul C. M. Hennekam,et al.  Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP , 1995, Nature.

[89]  C. Finch,et al.  Methylation of the rat glial fibrillary acidic protein gene shows tissue‐specific domains , 1994, Journal of neuroscience research.

[90]  R. Jaenisch,et al.  Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[91]  T. Ono,et al.  Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice. , 1994, Differentiation; research in biological diversity.

[92]  Rudolf Jaenisch,et al.  Targeted mutation of the DNA methyltransferase gene results in embryonic lethality , 1992, Cell.

[93]  V. Ingram,et al.  Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. , 1988, Journal of molecular biology.

[94]  F. Watt,et al.  Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter. , 1988, Genes & development.

[95]  T. Mohandas,et al.  Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[96]  P. Jones,et al.  Phenotypic conversion of cultured mouse embryo cells by aza pyrimidine nucleosides. , 1978, Developmental biology.