Growth arrest‐specific 6 modulates adiponectin expression and insulin resistance in adipose tissue

Obesity is characterized by disturbed adipocytokine expression and insulin resistance in adipocytes. Growth arrest‐specific 6 (GAS6) is a gene encoding the Gas6 protein, which is expressed in fibroblasts, and its related signaling might be associated with adipose tissue inflammation, glucose intolerance and insulin resistance. The aim of this study was to investigate the associations among Gas6, adipocytokines and insulin resistance in adipocytes.

[1]  C. Knibbe,et al.  Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial , 2016, Nutrition & Diabetes.

[2]  L. Sun,et al.  Relationship of Serum Adiponectin Levels and Metformin Therapy in Patients with Type 2 Diabetes , 2016, Hormone and Metabolic Research.

[3]  Y. Saisho.  Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect. , 2015, Endocrine, metabolic & immune disorders drug targets.

[4]  Y. Hung,et al.  The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation , 2015, International journal of endocrinology.

[5]  K. Moore,et al.  Netrin-1 promotes adipose tissue macrophage accumulation and insulin resistance in obesity , 2014, Nature Medicine.

[6]  Y. Hung,et al.  The levels of plasma growth arrest-specific protein 6 is associated with insulin sensitivity and inflammation in women. , 2014, Diabetes Research and Clinical Practice.

[7]  Y. Hung,et al.  Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. , 2013, The Journal of clinical endocrinology and metabolism.

[8]  I. Scroyen,et al.  Axl Deficiency Does Not Affect Adipogenesis or Adipose Tissue Development , 2012, Obesity.

[9]  Y. Hung,et al.  The growth arrest-specific 6 (Gas6) gene polymorphism c.834+7G>A is associated with type 2 diabetes. , 2012, Diabetes research and clinical practice.

[10]  V. Christiaens,et al.  Growth Arrest-Specific Protein 6 Receptor Antagonism Impairs Adipocyte Differentiation and Adipose Tissue Development in Mice , 2011, Journal of Pharmacology and Experimental Therapeutics.

[11]  L. Gilardini,et al.  In vitro and in vivo Effects of Metformin on Human Adipose Tissue Adiponectin , 2011, Obesity Facts.

[12]  K. Walsh,et al.  Adipokines in inflammation and metabolic disease , 2011, Nature Reviews Immunology.

[13]  Y. Hung,et al.  Plasma Protein Growth Arrest–Specific 6 Levels Are Associated With Altered Glucose Tolerance, Inflammation, and Endothelial Dysfunction , 2010, Diabetes Care.

[14]  C. Fernandes‐Santos,et al.  A Mouse Model of Metabolic Syndrome: Insulin Resistance, Fatty Liver and Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 Mice Fed a High Fat Diet , 2010, Journal of clinical biochemistry and nutrition.

[15]  J. Olefsky,et al.  Insulin sensitivity: modulation by nutrients and inflammation. , 2008, The Journal of clinical investigation.

[16]  F. Newell,et al.  Human SGBS Cells – a Unique Tool for Studies of Human Fat Cell Biology , 2008, Obesity Facts.

[17]  Y. Ouchi,et al.  Adiponectin antagonizes stimulatory effect of tumor necrosis factor-alpha on vascular smooth muscle cell calcification: regulation of growth arrest-specific gene 6-mediated survival pathway by adenosine 5'-monophosphate-activated protein kinase. , 2008, Endocrinology.

[18]  P. D. de Frutos,et al.  Vitamin K-dependent actions of Gas6. , 2008, Vitamins and hormones.

[19]  S. Kihara,et al.  Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. , 2007, The Journal of clinical investigation.

[20]  H. Waki,et al.  Endocrine functions of adipose tissue. , 2007, Annual review of pathology.

[21]  P. Carmeliet,et al.  Role of Gas-6 in Adipogenesis and Nutritionally Induced Adipose Tissue Development in Mice , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[22]  S. Kihara,et al.  Obesity, adiponectin and vascular inflammatory disease , 2003, Current opinion in lipidology.

[23]  Z. Bloomgarden,et al.  Inflammation and insulin resistance. , 2003, Diabetes care.

[24]  C. Schneider,et al.  The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade , 1993, Molecular and cellular biology.

[25]  Lennart Philipson,et al.  Genes specifically expressed at growth arrest of mammalian cells , 1988, Cell.