Tumorigenicity study of sodium erythorbate administered orally to mice.

Sodium erythorbate (SE) was administered at concentrations of 0, 1.25, or 2.5% (maximum tolerated dose, MTD) in the drinking-water to groups of 50 male B6C3F1 mice respectively. Female groups, each consisting of 50 mice, received SE in the drinking-water at concentrations of 0, 2.5 or 5% (MTD). Treatment continued for 96 wks and the experiment was terminated during wk 110. Tumors were observed at various sites including the liver, hematopoietic system, lung and soft tissue. However, at any of the sites, the tumor incidence, the time to death with tumors or the histological distribution of tumors did not differ significantly from those in the untreated control group. Thus, the present study did not demonstrate a tumorigenic effect of SE on B6C3F1 mice by means of oral administration.

[1]  K. Inai,et al.  Hepatocellular Tumorigenicity of Butylated Hydroxytoluene Administered Orally to B6C3F1 Mice , 1988, Japanese journal of cancer research : Gann.

[2]  K. Inai,et al.  Tumorigenicity study of disodium glycyrrhizinate administered orally to mice. , 1985, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[3]  K. Inai,et al.  Tumorigenicity study of butyl and isobutyl p-hydroxybenzoates administered orally to mice. , 1985, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[4]  S. Fukushima,et al.  Promoting activities of butylated hydroxyanisole, butylated hydroxytoluene and sodium L-ascorbate on forestomach and urinary bladder carcinogenesis initiated with methylnitrosourea in F344 male rats. , 1984, Gan.

[5]  K. Hori,et al.  Sodium erythorbate is not carcinogenic in F344 rats. , 1984, Experimental and molecular pathology.

[6]  Joseph K. Haseman,et al.  Use of Historical Control Data in Carcinogenicity Studies in Rodents , 1984, Toxicologic pathology.

[7]  K. Hori,et al.  Effect of erythorbate on N-methyl-N'-nitro-N-nitrosoguanidine-induced stomach carcinogenesis in F344 rats. , 1983, The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku.

[8]  J Wahrendorf,et al.  Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments. , 1980, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Supplement.

[9]  J M Ward,et al.  Neoplastic and nonneoplastic lesions in aging (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice. , 1979, Journal of the National Cancer Institute.

[10]  井内 康輝,et al.  Chronic Toxicity of Sodium Nitrite in Mice,with Reference to Its Tumorigenicity , 1979 .

[11]  J. Guttenplan.  Mechanisms of inhibition by ascorbate of microbial mutagenesis induced by N-nitroso compounds. , 1978, Cancer research.

[12]  A. A. Nelson,et al.  Subacute and Chronic Toxicities of Ascorbyl Palmitates , 1946, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.