Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular cloning. Its primary sequence is very similar to that of the human epidermal growth factor receptor and the v-erbB oncogene product; the chromosomal location of the gene for this protein is coincident with the neu oncogene, which suggests that the two genes may be identical.

[1]  R. Weinberg,et al.  The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. , 1985, Science.

[2]  C R King,et al.  Amplification of a novel v-erbB-related gene in a human mammary carcinoma. , 1985, Science.

[3]  Charles J. Sherr,et al.  The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1 , 1985, Cell.

[4]  W. Möller,et al.  Phosphate‐binding sequences in nucleotide‐binding proteins , 1985, FEBS letters.

[5]  A. Look,et al.  Transmembrane orientation of glycoproteins encoded by the v-fms oncogene , 1985, Cell.

[6]  P. H. Seeburg,et al.  Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes , 1985, Nature.

[7]  A. Ullrich,et al.  Epidermal growth factor: Is the precursor a receptor? , 1985, Nature.

[8]  R. Weinberg,et al.  The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen , 1984, Nature.

[9]  S. Hakomori,et al.  Cell surface expression of the mcdonough strain of feline sarcoma virus fms gene product (gp140fms) , 1984, Cell.

[10]  D. Russell,et al.  The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA , 1984, Cell.

[11]  J. Downward,et al.  Autophosphorylation sites on the epidermal growth factor receptor , 1984, Nature.

[12]  Jonathan A. Cooper,et al.  Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane , 1984, Nature.

[13]  M. Sternberg,et al.  Modelling the ATP‐binding site of oncogene products, the epidermal growth factor receptor and related proteins , 1984, FEBS letters.

[14]  P. Seeburg,et al.  Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells , 1984, Nature.

[15]  Y H Xu,et al.  Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. , 1984, Science.

[16]  J. Spiess,et al.  Production of an epidermal growth factor receptor-related protein. , 1984, Science.

[17]  A. Ullrich,et al.  Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences , 1984, Nature.

[18]  J. Bishop,et al.  The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[19]  U. Francke Random X inactivation resulting in mosaic nullisomy of region Xp21.1----p21.3 associated with heterozygosity for ornithine transcarbamylase deficiency and for chronic granulomatous disease. , 1984, Cytogenetics and cell genetics.

[20]  T. Ooi,et al.  The erbB gene of avian erythroblastosis virus is a member of the src gene family , 1983, Cell.

[21]  P. Cuatrecasas,et al.  Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor. , 1983, The Journal of biological chemistry.

[22]  R F Doolittle,et al.  Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. , 1983, Science.

[23]  W. Rutter,et al.  Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins. , 1983, Science.

[24]  Paul Stroobant,et al.  Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus , 1983, Nature.

[25]  A. Ullrich,et al.  Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor , 1983, Nature.

[26]  P. Pilch,et al.  The beta subunit of the insulin receptor is an insulin-activated protein kinase. , 1983, Biochemistry.

[27]  E. Van Obberghen,et al.  Receptor-mediated phosphorylation of the hepatic insulin receptor: evidence that the Mr 95,000 receptor subunit is its own kinase. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[28]  R. Roth,et al.  Insulin receptor: evidence that it is a protein kinase. , 1983, Science.

[29]  C. Kahn,et al.  Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system. , 1983, The Journal of biological chemistry.

[30]  P. Pilch,et al.  Stimulation of tyrosine-specific phosphorylation in vitro by insulin-like growth factor I , 1983, Nature.

[31]  S. Anderson,et al.  Monoclonal antibodies to the transformation-specific glycoprotein encoded by the feline retroviral oncogene v-fms , 1982, Journal of virology.

[32]  M. Cobb,et al.  Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[33]  J. Vieira,et al.  A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. , 1982, Gene.

[34]  C. Kahn,et al.  Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. , 1982, The Journal of biological chemistry.

[35]  C. Kahn,et al.  Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system , 1982, Nature.

[36]  R. Doolittle,et al.  A simple method for displaying the hydropathic character of a protein. , 1982, Journal of molecular biology.

[37]  M. O. Dayhoff,et al.  Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[38]  C. Heldin,et al.  Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor , 1982, Nature.

[39]  C. Kahn,et al.  Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. , 1982, Science.

[40]  U. Francke,et al.  Requirement of the human chromosome 11 long arm for replication of herpes simplex virus type 1 in nonpermissive Chinese hamster x human diploid fibroblast hybrids , 1982, Somatic cell genetics.

[41]  M. Kozak Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. , 1981, Nucleic acids research.

[42]  R. Weinberg,et al.  Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts , 1981, Nature.

[43]  J Messing,et al.  A system for shotgun DNA sequencing. , 1981, Nucleic acids research.

[44]  J. Bishop,et al.  Molecular cloning of the avian erythroblastosis virus genome and recovery of oncogenic virus by transfection of chicken cells , 1980, Journal of virology.

[45]  R. Crea,et al.  Synthesis of oligonucleotides on cellulose by a phosphotriester method. , 1980, Nucleic acids research.

[46]  G R Stark,et al.  Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[47]  E. Southern Gel electrophoresis of restriction fragments. , 1979, Methods in enzymology.

[48]  T. Maniatis,et al.  The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA , 1978, Cell.

[49]  F. Sanger,et al.  DNA sequencing with chain-terminating inhibitors. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[50]  H. Boedtker,et al.  RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. , 1977, Biochemistry.

[51]  U. Francke,et al.  Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[52]  J. Taylor,et al.  Efficeint transcription of RNA into DNA by avian sarcoma virus polymerase. , 1976, Biochimica et biophysica acta.

[53]  J. Yunis High resolution of human chromosomes. , 1976, Science.