Lympho‐stromal interactions in the thymus: medullary thymocytes react with I‐A determinants on autochthonous thymic stimulator cells

Primary (1o) and secondary (2o) syngeneic mixed lymphocyte culture (SMLC) reactions in autochthonous murine thymus cell cultures (peanut agglutinin‐unreactive) or syngeneic mixed thymus‐spleen cell cultures were studied. The 1o thymic SMLC responder cells were Thy‐1+, Lyt‐1+, Lyt‐2−. The 1o thymic syngeneic mixed lymphocyte reaction (SMLR) could be inhibited with monoclonal antibodies directed against determinants Ia.m1 and Ia.m6, in the absence of complement.

[1]  J. Smith,et al.  Autologous mixed lymphocyte culture responder T cells are in the concanavalin A reactive subpopulation and separate from alloreactive cells. , 1981, Clinical immunology and immunopathology.

[2]  J. Smith,et al.  Autologous mixed lymphocyte reactions in NZB mice: analysis in recombinant inbred lines shows a T cell defect unrelated to autoantibody production , 1981, European journal of immunology.

[3]  C. Elson,et al.  Deficiency of the autologous mixed lymphocyte reaction in patients with primary biliary cirrhosis. , 1980, The Journal of clinical investigation.

[4]  R. Steinman,et al.  Dendritic Cells: Features and Functions , 1980, Immunological reviews.

[5]  D. Katz,et al.  Existence of T cells manifesting self-reactivity indistinguishable from alloreactivity. , 1980, Journal of immunology.

[6]  O. Stutman,et al.  Lyt 1 cells respond to la‐bearing macrophages in the murine syngeneic mixed lymphocyte reaction , 1980, European journal of immunology.

[7]  R. Thorn.  Murine T-cell-mediated cytotoxicity against syngeneic and allogeneic cell lines induced by fetal calf serum. , 1980, Cellular immunology.

[8]  E. Engleman,et al.  Autologous mixed lymphocyte reaction in patients with Hodgkin's disease. Evidence for a T cell defect. , 1980, The Journal of clinical investigation.

[9]  E. Rothenberg.  Expression of differentiation antigens in subpopulations of mouse thymocytes: Regulation at the level of de novo synthesis , 1980, Cell.

[10]  R. Steinman,et al.  Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction , 1980, The Journal of experimental medicine.

[11]  E. Shevach,et al.  The syngeneic mixed leukocyte reaction: the genetic requirements for the recognition of self resemble the requirements for the recognition of antigen in association with self. , 1980, Journal of immunology.

[12]  M. Ernst,et al.  Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization , 1980, The Journal of experimental medicine.

[13]  H. Kunkel,et al.  Helper factors derived from autologous mixed lymphocyte cultures. , 1980, Cellular immunology.

[14]  J. Smith,et al.  Surface phenotype of responder cells in the syngeneic mixed lymphocyte reaction in mice. , 1980, Cellular immunology.

[15]  N. Ponzio.  Lymphocyte responses to syngeneic antigens. I. Enhancement of the murine autologous mixed lymphocyte response by polyethylene glycol. , 1980, Cellular immunology.

[16]  D. Katz,et al.  Adaptive differentiation of lymphocytes: theoretical implications for mechanisms of cell--cell recognition and regulation of immune responses. , 1980, Advances in immunology.

[17]  F. Bach,et al.  Lyt phenotypes of responding cells in secondary alloantigen responses. , 1979, Journal of immunology.

[18]  M. Weksler,et al.  Lymphocyte transformation induced by autologous cells. VIII. Impaired autologous mixed lymphocyte reactivity in patients with acute infectious mononucleosis , 1979, The Journal of experimental medicine.

[19]  E. Clark,et al.  Production and characterization of cytotoxic Thy‐1 antibody‐secreting hybrid cell lines Detection of T cell subsets , 1979, European journal of immunology.

[20]  H. Lemke,et al.  Fine Specificity Analysis with Monoclonal Antibodies of Antigens Controlled by the Major Histocompatibility Complex and by the Qa/TL Region in Mice , 1979, Immunological Reviews.

[21]  I. Green,et al.  Specificity and suppressor function of human T cells responsive to autologous non-T cells. , 1979, Journal of immunology.

[22]  G. Hämmerling,et al.  Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies , 1979, The Journal of experimental medicine.

[23]  I. Weissman,et al.  Expression of MHC antigens by mouse thymic dendritic cells. , 1979, Journal of immunology.

[24]  S. Sharrow,et al.  An Lyt differentiated thymocyte subpopulation detected by flow microfluorometry , 1979, Nature.

[25]  G. Roelants,et al.  Peanut agglutinin. II. Characterization of the Thy‐1, Tla and Ig phenotype of peanut agglutinin‐positive cells in adult, embryonic and nude mice using double immunofluorescence , 1979, European journal of immunology.

[26]  P. Golstein,et al.  Mouse T cell-mediated cytolysis specifically triggered by cytophilic xenogeneic serum determinants: a caveat for the interpretation of experiments done under "syngeneic" conditions. , 1978, Journal of immunology.

[27]  J. Smith,et al.  Syngeneic mixed lymphocyte reaction in mice: strain distribution, kinetics, participating cells, and absence in NZB mice. , 1978, Journal of immunology.

[28]  B. Benacerraf,et al.  Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[29]  F. Bach,et al.  T-cell-specific murine Ia antigens: serology of I-J and I-E subregion specificities , 1978, The Journal of experimental medicine.

[30]  A. Steinberg,et al.  Failure of autologous mixed lymphocyte reactions between T and non-T cells in patients with systemic lupus erythematosus. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[31]  H. Wekerle.  Immunological T-cell memory in the in vitro-induced experimental autoimmune orchitis: specificity of the reaction and tissue distribution of the autoantigens , 1978, The Journal of experimental medicine.

[32]  E. Thorsby,et al.  Stimulation of T lymphocytes by autologous non-T lymphoid cells. Participation of HLA-D? , 2008, Tissue antigens.

[33]  R. Kozak,et al.  Lymphocyte transformation induced by autologous cells. V. generation of immunologic memory and specificity during the autologous mixed lymphocyte reaction , 1977, The Journal of experimental medicine.

[34]  H. Wekerle.  In vitro induction of immunological memory against testicular autoantigens , 1977, Nature.

[35]  L. Andersson,et al.  Secondary in vitro responses of T lymphocytes to non-H-2 alloantigens self-H-2-restricted responses induced in heterologous serum are not dependent on primary-stimulating non-H-2 alloantigens , 1977, The Journal of experimental medicine.

[36]  M. Linker-Israeli,et al.  Separation of mouse thymocytes into two subpopulations by the use of peanut agglutinin. , 1976, Cellular immunology.

[37]  M. Howe.  Isogeneic Lymphocyte Interaction: Responsiveness of Murine Thymocytes to Self Antigens , 1973, The Journal of Immunology.

[38]  I. Cohen,et al.  Regulation of autosensitization. The immune activation and specific inhibition of self-recognizing thymus-derived lymphocytes. , 1973 .

[39]  H. von Boehmer,et al.  Syngeneic mixed lymphocyte reaction between thymocytes and peripheral lymphoid cells in mice: strain specificity and nature of the target cell. , 1973, Journal of immunology.

[40]  I. Cohen,et al.  The induction of a cellular immune reaction against self-antigens present in the thymus. , 1973, Advances in experimental medicine and biology.

[41]  E. Raviola,et al.  EVIDENCE FOR A BLOOD-THYMUS BARRIER USING ELECTRON-OPAQUE TRACERS , 1972, The Journal of experimental medicine.

[42]  W. Byrd,et al.  Responsiveness of thymus cells to syngeneic and allogeneic lymphoid cells. , 1972, Nature: New biology.

[43]  A. Goldstein,et al.  Isogeneic lymphocyte interaction: recognition of self antigens by cells of the neonatal thymus. , 1970, Proceedings of the National Academy of Sciences of the United States of America.

[44]  R. A. Phillips,et al.  Separation of cells by velocity sedimentation , 1969, Journal of cellular physiology.