Biomolecular characterisation of leucocytes by infrared spectroscopy

Over the last 15 years, infrared (IR) spectroscopy has developed into a novel and powerful biomedical tool that has multiple applications in the field of haematology. By revealing subtle alterations in both the conformation and concentration of key macromolecules, such as DNA, protein and lipids, IR spectroscopy has been employed to investigate multiple aspects of leucocyte physiology. IR spectroscopy has been used, for example, to diagnose and prognose leukaemia; to characterise differentiation and apoptotic processes; to predict drug sensitivity and resistance in leukaemic patients undergoing chemotherapy; to monitor the response of leucocytes to chemotherapy and to perform human leucocyte antigen matching for bone marrow transplant patients. Such studies have provided insight into pathogenic mechanisms underlying specific leucocyte disorders, especially leukaemia. While it is likely to be some considerable time before IR spectroscopy is sufficiently developed to displace the established technologies, IR spectroscopy has the potential to become a valuable analytic tool in basic and clinical haematology.

[1]  V. Ling,et al.  Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies , 1985, Nature.

[2]  J. Ramesh,et al.  Preliminary results of evaluation of progress in chemotherapy for childhood leukemia patients employing Fourier-transform infrared microspectroscopy and cluster analysis. , 2003, The Journal of laboratory and clinical medicine.

[3]  J. Bausch,et al.  Lipid analysis. , 1993, Current opinion in biotechnology.

[4]  James P Freyer,et al.  Methods for measuring the infrared spectra of biological cells , 2003 .

[5]  F. Gasparri,et al.  Monitoring of apoptosis of HL60 cells by Fourier-transform infrared spectroscopy. , 2003, The Biochemical journal.

[6]  M. Manfait,et al.  Ultrastructural appraisal of the multidrug resistance in K562 and LR73 cell lines from Fourier transform infrared spectroscopy. , 1993, Cancer research.

[7]  H. Mantsch,et al.  Apoptosis-induced structural changes in leukemia cells identified by IR spectroscopy , 2001 .

[8]  S. Collins,et al.  Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[9]  H P Koeffler,et al.  Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. , 1983, Blood.

[10]  Wolfgang Petrich.  MID-INFRARED AND RAMAN SPECTROSCOPY FOR MEDICAL DIAGNOSTICS? , 2006 .

[11]  Hugo Guterman,et al.  Studies on acute human infections using FTIR microspectroscopy and cluster analysis. , 2004, Biopolymers.

[12]  H. Mantsch,et al.  Study of chronic lymphocytic leukemia cells by FT-IR spectroscopy and cluster analysis. , 1996, Leukemia research.

[13]  John Calvin Reed,et al.  Apoptosis-based therapies for hematologic malignancies. , 2005, Blood.

[14]  E. Goormaghtigh,et al.  Infrared spectroscopy as a tool for discrimination between sensitive and multiresistant K562 cells. , 2002, European journal of biochemistry.

[15]  S. Mordechai,et al.  Fourier transform infrared spectroscopy in cancer detection. , 2005, Future oncology.

[16]  M. Diem,et al.  Infrared spectroscopy of human tissue. V. Infrared spectroscopic studies of myeloid leukemia (ML-1) cells at different phases of the cell cycle. , 1999, Biospectroscopy.

[17]  Stephen French,et al.  Essential haematology , 2004, BMJ.

[18]  B. Wood,et al.  Fourier Transform Infrared Spectroscopy as a Method for Monitoring the Molecular Dynamics of Lymphocyte Activation , 2000 .

[19]  Li Jia,et al.  Quantitative determination of apoptosis on leukemia cells by infrared spectroscopy , 2001, Apoptosis.

[20]  R. Mohammad,et al.  Bryostatin 1-induced hairy cell features on chronic lymphocytic leukemia cells in vitro. , 1993, Experimental hematology.

[21]  J. Ramesh,et al.  Novel methodology for the follow-up of acute lymphoblastic leukemia using FTIR microspectroscopy. , 2002, Journal of biochemical and biophysical methods.

[22]  Y. Okubo,et al.  Lipid Analysis of Peripheral Blood Monocytes in Psoriatic Patients Using Fourier‐Transform Infrared Microspectroscopy , 2001, The Journal of dermatology.

[23]  S. Mordechai,et al.  Continuous monitoring of WBC (biochemistry) in an adult leukemia patient using advanced FTIR-spectroscopy. , 2006, Leukemia research.

[24]  Paul Dumas,et al.  Chemical heterogeneity in cell death: combined synchrotron IR and fluorescence microscopy studies of single apoptotic and necrotic cells. , 2003, Biopolymers.

[25]  J. Dufer,et al.  Analysis of DNA content in multidrug‐resistant cells by image and flow cytometry , 1996, Cell proliferation.

[26]  H. Mantsch,et al.  Infrared spectroscopic study of bryostatin 1-induced membrane alterations in a B-CLL cell line , 1999, Leukemia.

[27]  P. Schlag,et al.  Industrial Forum · Industrieforum , 2001, Oncology Research and Treatment.

[28]  Z. Wang,et al.  Monitoring all-trans-retinoic acid-induced differentiation of human acute promyelocytic leukemia NB4 cells by Fourier-transform infrared spectroscopy , 2003, Leukemia.

[29]  A. Zwinderman,et al.  EFFECTOR MECHANISMS IN GRAFT‐VERSUS-HOST DISEASE IN RESPONSE TO MINOR HISTOCOMPATIBILITY ANTIGENS: I. ABSENCE OF CORRELATION WITH CYTOTOXIC EFFECTOR CELLS , 1990, Transplantation.

[30]  S. Sun,et al.  A rapid method for detecting conformational changes during differentiation and apoptosis of HL60 cells by Fourier‐transform infrared spectroscopy , 2001, Biotechnology and applied biochemistry.

[31]  T. Wheldon,et al.  The radiobiological basis of total body irradiation. , 1997, The British journal of radiology.

[32]  O. Fardel,et al.  Conformational changes in membrane proteins of multidrug-resistant K562 and primary rat hepatocyte cultures as studied by Fourier transform infrared spectroscopy. , 1994, Anticancer research.

[33]  C. Raffoux,et al.  Evaluation of HLA-class II identity between unrelated individuals by serological typing, DNA-RFLP method, and mixed lymphocyte reaction. , 1990, Human immunology.

[34]  P. Macchia,et al.  An investigation of acute lymphoblastic leukemia (ALL) in children by means of infrared spectroscopy. Part IV. , 1988, Haematologica.

[35]  H. Mantsch,et al.  Molecular and chemical characterization of blood cells by infrared spectroscopy: a new optical tool in hematology. , 2005, Blood cells, molecules & diseases.

[36]  R. Mohammad,et al.  Similarities between the sensitivity to 2-chlorodeoxyadenosine of lymphocytes from CLL patients and bryostatin 1-treated WSU-CLL cells: an infrared spectroscopic study. , 1998, Cancer letters.

[37]  P. Vergamini,et al.  New possibilities of research in chronic lymphatic leukemia by means of Fourier transform-infrared spectroscopy--II. , 1985, Leukemia research.

[38]  Henry H. Mantsch,et al.  Prognosis of chronic lymphocytic leukemia from infrared spectra of lymphocytes , 1997 .

[39]  R. Salzer,et al.  Identification of B and T cells in human spleen sections by infrared microspectroscopic imaging , 2005, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[40]  E. Taillandier,et al.  Infrared spectroscopy of DNA. , 1992, Methods in enzymology.

[41]  J. Lefaix,et al.  Infrared Microspectroscopic Characteristics of Radiation-Induced Apoptosis in Human Lymphocytes , 2003, Radiation research.

[42]  B. Wood,et al.  Fourier-transform infrared spectroscopy as a tool for detecting early lymphocyte activation: a new approach to histocompatibility matching. , 2000, Human immunology.

[43]  N. Sharon,et al.  Lectins: cell-agglutinating and sugar-specific proteins. , 1972, Science.

[44]  R. Consolini,et al.  Analytical infrared spectral differences between human normal and leukaemic cells (CLL)--I. , 1984, Leukemia research.

[45]  H. Mantsch,et al.  Comparison of infrared spectra of CLL cells with their ex vivo sensitivity (MTT assay) to chlorambucil and cladribine. , 1997, Leukemia research.