Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut

[1]  H. Jasper.  Intestinal Stem Cell Aging: Origins and Interventions. , 2020, Annual review of physiology.

[2]  B. Edgar,et al.  Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut , 2019, Nature Communications.

[3]  R. Havekes,et al.  A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota , 2019, Journal of sleep research.

[4]  Zhengquan Yu,et al.  Role of melatonin in sleep deprivation‐induced intestinal barrier dysfunction in mice , 2019, Journal of pineal research.

[5]  M. Irwin.  Sleep and inflammation: partners in sickness and in health , 2019, Nature Reviews Immunology.

[6]  Larry N. Singh,et al.  Host mitochondria influence gut microbiome diversity: A role for ROS , 2019, Science Signaling.

[7]  Mingmei Zhou,et al.  Chronic paradoxical sleep deprivation‐induced depression‐like behavior, energy metabolism and microbial changes in rats , 2019, Life sciences.

[8]  Wenxia Zhang,et al.  D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep , 2019, Nature Communications.

[9]  E. Tobaldini,et al.  Short sleep duration and cardiometabolic risk: from pathophysiology to clinical evidence , 2019, Nature Reviews Cardiology.

[10]  Gero Miesenböck,et al.  A potassium channel β-subunit couples mitochondrial electron transport to sleep , 2019, Nature.

[11]  I. Bronshtein,et al.  Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons , 2019, Nature Communications.

[12]  H. Bringmann.  Genetic sleep deprivation: using sleep mutants to study sleep functions , 2019, EMBO reports.

[13]  D. Holtzman,et al.  The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans , 2019, Science.

[14]  Jeffrey M. Donlea.  Roles for sleep in memory: insights from the fly , 2019, Current Opinion in Neurobiology.

[15]  P. Libby,et al.  Sleep modulates hematopoiesis and protects against atherosclerosis , 2019, Nature.

[16]  Vijay Kumar Chattu,et al.  The Global Problem of Insufficient Sleep and Its Serious Public Health Implications , 2018, Healthcare.

[17]  B. Lemaître,et al.  Microbiota‐Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan , 2018, Immunity.

[18]  E. Campbell,et al.  Control and dysregulation of redox signalling in the gastrointestinal tract , 2018, Nature Reviews Gastroenterology & Hepatology.

[19]  B. Lemaître,et al.  Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster , 2018, Genetics.

[20]  M. Zwart,et al.  Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila , 2018, eLife.

[21]  A. Dillin,et al.  The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling , 2018, Cell.

[22]  J. F. Young,et al.  NADPH oxidase-generated reactive oxygen species in mature follicles are essential for Drosophila ovulation , 2018, Proceedings of the National Academy of Sciences.

[23]  N. Stavropoulos,et al.  A bidirectional relationship between sleep and oxidative stress in Drosophila , 2018, PLoS biology.

[24]  S. Kar,et al.  Rapid Eye Movement sleep deprivation of rat generates ROS in the hepatocytes and makes them more susceptible to oxidative stress , 2018, Sleep Science.

[25]  E. Taveras,et al.  Association of sleep disturbances with obesity, insulin resistance and the metabolic syndrome. , 2018, Metabolism: clinical and experimental.

[26]  U. Knaus,et al.  NADPH oxidases and ROS signaling in the gastrointestinal tract , 2018, Mucosal Immunology.

[27]  D. Gibson,et al.  Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines , 2018, Front. Immunol..

[28]  A. Bogers,et al.  Reactive Oxygen Species: Radical Factors in the Evolution of Animal Life: A molecular timescale from Earth's earliest history to the rise of complex life. , 2018, BioEssays : news and reviews in molecular, cellular and developmental biology.

[29]  B. Kalyanaraman,et al.  Detection and Characterization of Reactive Oxygen and Nitrogen Species in Biological Systems by Monitoring Species-Specific Products. , 2017, Antioxidants & redox signaling.

[30]  D. Johnson,et al.  Wake-up Call to Clinicians: The Impact of Sleep Dysfunction on Gastrointestinal Health and Disease , 2017, Journal of clinical gastroenterology.

[31]  D. Tuveson,et al.  Transcriptional Regulation by Nrf2 , 2017, Antioxidants & redox signaling.

[32]  A. Bergmann,et al.  Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila , 2017, eLife.

[33]  A. Keene,et al.  Sleep-dependent modulation of metabolic rate in Drosophila , 2017, bioRxiv.

[34]  C. Cirelli,et al.  Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals. , 2017, Cold Spring Harbor perspectives in biology.

[35]  N. Naidoo,et al.  Reduced Sleep During Social Isolation Leads to Cellular Stress and Induction of the Unfolded Protein Response , 2017, Sleep.

[36]  U. Knaus,et al.  ROS in gastrointestinal inflammation: Rescue Or Sabotage? , 2017, British journal of pharmacology.

[37]  M. Pfeffer,et al.  Synchronizing effects of melatonin on diurnal and circadian rhythms. , 2017, General and comparative endocrinology.

[38]  Goran Medic,et al.  Short- and long-term health consequences of sleep disruption , 2017, Nature and science of sleep.

[39]  M. Walker,et al.  The sleep-deprived human brain , 2017, Nature Reviews Neuroscience.

[40]  N. Buchon,et al.  Drosophila as a model for homeostatic, antibacterial, and antiviral mechanisms in the gut , 2017, PLoS pathogens.

[41]  Patrick M. Smith,et al.  Regulation of life span by the gut microbiota in the short-lived African turquoise killifish , 2017, bioRxiv.

[42]  Qiang Liu,et al.  Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective , 2017, Front. Cell Dev. Biol..

[43]  A. Neish,et al.  Redox signaling mediated by the gut microbiota. , 2017, Free radical biology & medicine.

[44]  Aleksandra A. Kolodziejczyk,et al.  Dysbiosis and the immune system , 2017, Nature Reviews Immunology.

[45]  B. Kalyanaraman,et al.  Recent developments in detection of superoxide radical anion and hydrogen peroxide: Opportunities, challenges, and implications in redox signaling. , 2017, Archives of biochemistry and biophysics.

[46]  J. Sastre,et al.  Redox signaling in the gastrointestinal tract. , 2017, Free radical biology & medicine.

[47]  N. Perrimon,et al.  Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut , 2017, eLife.

[48]  F. Bushman,et al.  Human and rat gut microbiome composition is maintained following sleep restriction , 2017, Proceedings of the National Academy of Sciences.

[49]  Akhilesh Pandey,et al.  Homer1a drives homeostatic scaling-down of excitatory synapses during sleep , 2017, Science.

[50]  Giulio Tononi,et al.  Ultrastructural evidence for synaptic scaling across the wake/sleep cycle , 2017, Science.

[51]  C. A. Frank,et al.  Conserved properties of Drosophila Insomniac link sleep regulation and synaptic function , 2017, bioRxiv.

[52]  Beidong Liu,et al.  Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases , 2017, Oxidative medicine and cellular longevity.

[53]  S. Birman,et al.  Drosophila Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function , 2017, PLoS genetics.

[54]  F. Dalle,et al.  Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack. , 2016, Cell host & microbe.

[55]  D. Averill-Bates,et al.  Activation of apoptosis signalling pathways by reactive oxygen species. , 2016, Biochimica et biophysica acta.

[56]  G. Tononi,et al.  Contribution of sleep to the repair of neuronal DNA double-strand breaks: evidence from flies and mice , 2016, Scientific Reports.

[57]  H. Vogel,et al.  Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals , 2016, Molecular metabolism.

[58]  R. Farré,et al.  Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice , 2016, Scientific Reports.

[59]  E. Wendler,et al.  Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice. , 2016, Free radical biology & medicine.

[60]  A. Dillin,et al.  Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis , 2016, Cell.

[61]  C. Helfrich-Förster,et al.  Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF , 2016, PLoS genetics.

[62]  H. Schiöth,et al.  Recurrent Sleep Fragmentation Induces Insulin and Neuroprotective Mechanisms in Middle-Aged Flies , 2016, Front. Aging Neurosci..

[63]  J. Krueger,et al.  Sleep function: Toward elucidating an enigma. , 2016, Sleep medicine reviews.

[64]  M. Rosbash,et al.  Age-Related Reduction of Recovery Sleep and Arousal Threshold in Drosophila. , 2016, Sleep.

[65]  N. Zmora,et al.  The microbiome and innate immunity , 2016, Nature.

[66]  K. Westerterp,et al.  Quality Sleep Is Associated With Overnight Metabolic Rate in Healthy Older Adults , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[67]  Qili Liu,et al.  Sleep Drive Is Encoded by Neural Plastic Changes in a Dedicated Circuit , 2016, Cell.

[68]  A. Sehgal,et al.  Genetic Dissociation of Daily Sleep and Sleep Following Thermogenetic Sleep Deprivation in Drosophila. , 2016, Sleep.

[69]  R. McCarley,et al.  Functions and Mechanisms of Sleep , 2016, AIMS neuroscience.

[70]  W. Fischer,et al.  How did life survive Earth's great oxygenation? , 2016, Current opinion in chemical biology.

[71]  Hyung-Ryong Kim,et al.  Endoplasmic Reticulum Stress and Associated ROS , 2016, International journal of molecular sciences.

[72]  Y. Ben-Neriah,et al.  Inflammatory networks underlying colorectal cancer , 2016, Nature Immunology.

[73]  J. Hirsh,et al.  Caffeine promotes wakefulness via dopamine signaling in Drosophila , 2016, Scientific Reports.

[74]  D. Doman,et al.  Sleep Dysfunction and Gastrointestinal Diseases. , 2015, Gastroenterology & hepatology.

[75]  Gerald M. Rubin,et al.  Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body , 2015, Current Biology.

[76]  Pavel Masek,et al.  Identification of Neurons with a Privileged Role in Sleep Homeostasis in Drosophila melanogaster , 2015, Current Biology.

[77]  D. Dinges,et al.  Resting metabolic rate varies by race and by sleep duration , 2015, Obesity.

[78]  R. Reiter,et al.  Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism , 2015, Molecules.

[79]  M. Pellegrini,et al.  Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality. , 2015, Cell reports.

[80]  A. Sehgal,et al.  Sleep deprivation suppresses aggression in Drosophila , 2015, eLife.

[81]  T. Kietzmann,et al.  Antioxidant responses and cellular adjustments to oxidative stress , 2015, Redox biology.

[82]  J. Jepson,et al.  TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila , 2015, Current Biology.

[83]  E. Manjarrez,et al.  Sleep Deprivation and Oxidative Stress in Animal Models: A Systematic Review , 2015, Oxidative medicine and cellular longevity.

[84]  A. Dillin,et al.  Endocrine aspects of organelle stress—cell non-autonomous signaling of mitochondria and the ER. , 2015, Current opinion in cell biology.

[85]  C. Thorpe,et al.  Oxidative protein folding: from thiol-disulfide exchange reactions to the redox poise of the endoplasmic reticulum. , 2015, Free radical biology & medicine.

[86]  R. Reiter,et al.  The Keap1-Nrf2-antioxidant response element pathway: A review of its regulation by melatonin and the proteasome , 2015, Molecular and Cellular Endocrinology.

[87]  A. Szabo,et al.  Cell injury and repair resulting from sleep loss and sleep recovery in laboratory rats. , 2014, Sleep.

[88]  F. Cecconi,et al.  Oxidative stress and autophagy: the clash between damage and metabolic needs , 2014, Cell Death and Differentiation.

[89]  D. Walker,et al.  AMPK modulates tissue and organismal aging in a non-cell-autonomous manner. , 2014, Cell reports.

[90]  Atulya S R Iyengar,et al.  Flight and Seizure Motor Patterns in Drosophila Mutants: Simultaneous Acoustic and Electrophysiological Recordings of Wing Beats and Flight Muscle Activity , 2014, Journal of neurogenetics.

[91]  H. Ryoo,et al.  Integration of UPRER and Oxidative Stress Signaling in the Control of Intestinal Stem Cell Proliferation , 2014, PLoS genetics.

[92]  R. Kaufman,et al.  Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. , 2014, Antioxidants & redox signaling.

[93]  R. Franco,et al.  Oxidative stress, redox signaling, and autophagy: cell death versus survival. , 2014, Antioxidants & redox signaling.

[94]  T. Finkel,et al.  Cellular mechanisms and physiological consequences of redox-dependent signalling , 2014, Nature Reviews Molecular Cell Biology.

[95]  N. Chandel,et al.  ROS Function in Redox Signaling and Oxidative Stress , 2014, Current Biology.

[96]  A. Sehgal,et al.  A Critical Period of Sleep for Development of Courtship Circuitry and Behavior in Drosophila , 2014, Science.

[97]  S. Mitra,et al.  Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. , 2014, Physiological reviews.

[98]  K. Ocorr,et al.  ROS Regulate Cardiac Function via a Distinct Paracrine Mechanism , 2014, Cell reports.

[99]  W. Joiner,et al.  SLEEPLESS Is a Bifunctional Regulator of Excitability and Cholinergic Synaptic Transmission , 2014, Current Biology.

[100]  S. Reddy,et al.  Reactive oxygen species in inflammation and tissue injury. , 2014, Antioxidants & redox signaling.

[101]  A. Sehgal,et al.  Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount , 2014, eLife.

[102]  William B. Mair,et al.  You Are What You Host: Microbiome Modulation of the Aging Process , 2014, Cell.

[103]  G. Tononi,et al.  Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration , 2014, Neuron.

[104]  T. Wagener,et al.  Sleep, immunity and inflammation in gastrointestinal disorders. , 2013, World journal of gastroenterology.

[105]  Won-Jae Lee,et al.  Role of DUOX in gut inflammation: lessons from Drosophila model of gut-microbiota interactions , 2013, Front. Cell. Infect. Microbiol..

[106]  J. Lambeth,et al.  Symbiotic lactobacilli stimulate gut epithelial proliferation via Nox‐mediated generation of reactive oxygen species , 2013, The EMBO journal.

[107]  J. Baur,et al.  Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism , 2013, Aging cell.

[108]  E. Elinav,et al.  Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms , 2013, Nature Reviews Cancer.

[109]  Daniel J. R. Christensen,et al.  Sleep Drives Metabolite Clearance from the Adult Brain , 2013, Science.

[110]  R. Scully,et al.  Double strand break repair functions of histone H2AX. , 2013, Mutation research.

[111]  J. Sekelsky,et al.  The Development of a Monoclonal Antibody Recognizing the Drosophila melanogaster Phosphorylated Histone H2A Variant (γ-H2AV) , 2013, G3: Genes, Genomes, Genetics.

[112]  M. Walker,et al.  The impact of sleep deprivation on food desire in the human brain , 2013, Nature Communications.

[113]  Rebecca C Taylor,et al.  XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity , 2013, Cell.

[114]  Hsiao Yu Fang,et al.  Morphological and molecular characterization of adult midgut compartmentalization in Drosophila. , 2013, Cell reports.

[115]  J. Ryu,et al.  Bacterial-Derived Uracil as a Modulator of Mucosal Immunity and Gut-Microbe Homeostasis in Drosophila , 2013, Cell.

[116]  M. Miura,et al.  Homeostatic epithelial renewal in the gut is required for dampening a fatal systemic wound response in Drosophila. , 2013, Cell reports.

[117]  R. Eckel,et al.  Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain , 2013, Proceedings of the National Academy of Sciences.

[118]  Jean Cadet,et al.  DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation. , 2013, Cold Spring Harbor perspectives in biology.

[119]  P. Magistretti,et al.  Sustained sleep fragmentation affects brain temperature, food intake and glucose tolerance in mice , 2013, Journal of sleep research.

[120]  Q. Ma.  Role of nrf2 in oxidative stress and toxicity. , 2013, Annual review of pharmacology and toxicology.

[121]  D. Hines,et al.  Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling , 2013, Translational Psychiatry.

[122]  D. Walker,et al.  Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila , 2012, Proceedings of the National Academy of Sciences.

[123]  C. Billington,et al.  Partial sleep deprivation by environmental noise increases food intake and body weight in obesity resistant rats , 2012, Obesity.

[124]  Qili Liu,et al.  Two Dopaminergic Neurons Signal to the Dorsal Fan-Shaped Body to Promote Wakefulness in Drosophila , 2012, Current Biology.

[125]  Julie H. Simpson,et al.  A GAL4-driver line resource for Drosophila neurobiology. , 2012, Cell reports.

[126]  P. Meerlo,et al.  Metabolic consequences of chronic sleep restriction in rats: Changes in body weight regulation and energy expenditure , 2012, Physiology & Behavior.

[127]  Daryl M. Gohl,et al.  Layered reward signaling through octopamine and dopamine in Drosophila , 2012, Nature.

[128]  Cory Pfeiffenberger,et al.  Cul3 and the BTB Adaptor Insomniac Are Key Regulators of Sleep Homeostasis and a Dopamine Arousal Pathway in Drosophila , 2012, PLoS genetics.

[129]  S. Tufik,et al.  Effect of chronic sleep restriction and aging on calcium signaling and apoptosis in the hippocampus of young and aged animals , 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[130]  J. Juang,et al.  Infection-induced intestinal oxidative stress triggers organ-to-organ immunological communication in Drosophila. , 2012, Cell host & microbe.

[131]  M. W. Young,et al.  Control of Sleep by Cyclin A and Its Regulator , 2012, Science.

[132]  K. Alzoubi,et al.  The neuroprotective effect of vitamin E on chronic sleep deprivation-induced memory impairment: The role of oxidative stress , 2012, Behavioural Brain Research.

[133]  M. W. Young,et al.  insomniac and Cullin-3 Regulate Sleep and Wakefulness in Drosophila , 2011, Neuron.

[134]  H. Okano,et al.  Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death , 2011, Proceedings of the National Academy of Sciences.

[135]  D. Walker,et al.  Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. , 2011, Cell metabolism.

[136]  Juyoung Yoon,et al.  Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species. , 2011, Chemical Society reviews.

[137]  Giulio Tononi,et al.  Sleep and Synaptic Homeostasis: Structural Evidence in Drosophila , 2011, Science.

[138]  N. Dolu,et al.  The effects of long-term sleep deprivation on the long-term potentiation in the dentate gyrus and brain oxidation status in rats , 2011, Neuroscience Research.

[139]  S. Redline,et al.  Short duration of sleep increases risk of colorectal adenoma , 2011, Cancer.

[140]  B. Biteau,et al.  Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. , 2011, Cell stem cell.

[141]  V. Mudera,et al.  Evolution of oxygen utilization in multicellular organisms and implications for cell signalling in tissue engineering , 2011, Journal of tissue engineering.

[142]  R. Lehmann,et al.  Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila , 2010, PLoS genetics.

[143]  G. Rubin,et al.  Refinement of Tools for Targeted Gene Expression in Drosophila , 2010, Genetics.

[144]  J. Mullington,et al.  Sleep loss and inflammation. , 2010, Best practice & research. Clinical endocrinology & metabolism.

[145]  Aimee M. Caron,et al.  Energy expenditure is affected by rate of accumulation of sleep deficit in rats. , 2010, Sleep.

[146]  A. Pack,et al.  Changes in components of energy regulation in mouse cortex with increases in wakefulness. , 2010, Sleep.

[147]  Donald E. Canfield,et al.  Large colonial organisms with coordinated growth in oxygenated environments 2.1 Gyr ago , 2010, Nature.

[148]  G. Tononi,et al.  Sleep, aging, and lifespan in Drosophila , 2010, BMC Neuroscience.

[149]  N. Naidoo,et al.  The UPR and the Anti-oxidant Response: Relevance to Sleep and Sleep Loss , 2010, Molecular Neurobiology.

[150]  R. Parker,et al.  Eukaryotic stress granules: the ins and outs of translation. , 2009, Molecular cell.

[151]  M. Bertagnolli,et al.  Molecular origins of cancer: Molecular basis of colorectal cancer. , 2009, The New England journal of medicine.

[152]  A. Sehgal,et al.  SLEEPLESS, a Ly–6/Neurotoxin Family Member, Regulates Levels, Localization, and Activity of Shaker , 2009, Nature Neuroscience.

[153]  A. Guo,et al.  Sleep deprivation specifically impairs short-term olfactory memory in Drosophila. , 2009, Sleep.

[154]  Nichole A. Broderick,et al.  Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. , 2009, Genes & development.

[155]  R. Benca,et al.  Sleep deprivation in pigeons and rats using motion detection. , 2009, Sleep.

[156]  João Wosniak,et al.  Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. , 2009, Antioxidants & redox signaling.

[157]  U. Banerjee,et al.  Reactive Oxygen Species prime Drosophila haematopoietic progenitors for differentiation , 2009, Nature.

[158]  B. Oh,et al.  Coordination of multiple dual oxidase–regulatory pathways in responses to commensal and infectious microbes in drosophila gut , 2009, Nature Immunology.

[159]  L. Hendershot,et al.  Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species. , 2009, Antioxidants & redox signaling.

[160]  Na Zhang,et al.  RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis , 2009, Science.

[161]  Roger E. Summons,et al.  The Continuing Puzzle of the Great Oxidation Event , 2009, Current Biology.

[162]  B. Edgar,et al.  Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut , 2009, Cell.

[163]  Giorgio F. Gilestro,et al.  Widespread Changes in Synaptic Markers as a Function of Sleep and Wakefulness in Drosophila , 2009, Science.

[164]  Sylvain Pradervand,et al.  Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. , 2009, Cell host & microbe.

[165]  H. Clevers,et al.  Stem cells, self-renewal, and differentiation in the intestinal epithelium. , 2009, Annual review of physiology.

[166]  S. Anton,et al.  Molecular inflammation: Underpinnings of aging and age-related diseases , 2009, Ageing Research Reviews.

[167]  Y. Ip,et al.  Tissue damage-induced intestinal stem cell division in Drosophila. , 2009, Cell stem cell.

[168]  M. Affolter,et al.  Tip-Cell Migration Controls Stalk-Cell Intercalation during Drosophila Tracheal Tube Elongation , 2008, Current Biology.

[169]  Heinrich Jasper,et al.  JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. , 2008, Cell stem cell.

[170]  S. Powers,et al.  Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. , 2008, Physiological reviews.

[171]  P. Shaw,et al.  D1 Receptor Activation in the Mushroom Bodies Rescues Sleep-Loss-Induced Learning Impairments in Drosophila , 2008, Current Biology.

[172]  Jau-Shyong Hong,et al.  Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. , 2008, Trends in immunology.

[173]  A. Sehgal,et al.  Identification of SLEEPLESS, a Sleep-Promoting Factor , 2008, Science.

[174]  Stefan R. Pulver,et al.  An internal thermal sensor controlling temperature preference in Drosophila , 2008, Nature.

[175]  W. Le,et al.  Sleep deprivation of rats: the hyperphagic response is real. , 2008, Sleep.

[176]  Mi-Ae Yoo,et al.  Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor , 2008, Aging cell.

[177]  Anil Kumar,et al.  Protective effect of alprazolam against sleep deprivation-induced behavior alterations and oxidative damage in mice , 2008, Neuroscience Research.

[178]  Chiara Cirelli,et al.  Molecular correlates of sleep and wakefulness in the brain of the white‐crowned sparrow , 2008, Journal of neurochemistry.

[179]  U. Banerjee,et al.  A protocol for in vivo detection of reactive oxygen species , 2008 .

[180]  Peter Libby,et al.  Inflammatory mechanisms: the molecular basis of inflammation and disease. , 2007, Nutrition reviews.

[181]  M. Toledano,et al.  ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis , 2007, Nature Reviews Molecular Cell Biology.

[182]  James Lee,et al.  Prolonged deprivation of sleep-like rest raises metabolic rate in the Pacific beetle cockroach, Diploptera punctata (Eschscholtz) , 2007, Journal of Experimental Biology.

[183]  A. Pack,et al.  A role for the molecular chaperone protein BiP/GRP78 in Drosophila sleep homeostasis. , 2007, Sleep.

[184]  C. Peyron,et al.  Gene expression in the rat brain during sleep deprivation and recovery sleep: an Affymetrix GeneChip® study , 2006, Neuroscience.

[185]  C. Cirelli.  Cellular consequences of sleep deprivation in the brain. , 2006, Sleep medicine reviews.

[186]  Dean P. Jones.  Redefining oxidative stress. , 2006, Antioxidants & redox signaling.

[187]  G. Tononi,et al.  Changes in brain gene expression after long‐term sleep deprivation , 2006, Journal of neurochemistry.

[188]  Kevin P. Keegan,et al.  A dynamic role for the mushroom bodies in promoting sleep in Drosophila , 2006, Nature.

[189]  B. Halliwell.  Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life , 2006, Plant Physiology.

[190]  Sen-Lin Lai,et al.  Genetic mosaic with dual binary transcriptional systems in Drosophila , 2006, Nature Neuroscience.

[191]  G. Thomas,et al.  Brush border spectrin is required for early endosome recycling in Drosophila , 2006, Journal of Cell Science.

[192]  Tobias M. Rasse,et al.  Bruchpilot, a Protein with Homology to ELKS/CAST, Is Required for Structural Integrity and Function of Synaptic Active Zones in Drosophila , 2006, Neuron.

[193]  A. Spradling,et al.  The adult Drosophila posterior midgut is maintained by pluripotent stem cells , 2006, Nature.

[194]  N. Perrimon,et al.  Evidence that stem cells reside in the adult Drosophila midgut epithelium , 2006, Nature.

[195]  W. Lee,et al.  A Direct Role for Dual Oxidase in Drosophila Gut Immunity , 2005, Science.

[196]  R. Palmiter,et al.  NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates , 2005, Science.

[197]  Giulio Tononi,et al.  Sleep and wakefulness modulate gene expression in Drosophila , 2005, Journal of neurochemistry.

[198]  Sang Ki Park,et al.  Dopamine Is a Regulator of Arousal in the Fruit Fly , 2005, The Journal of Neuroscience.

[199]  Giulio Tononi,et al.  Reduced sleep in Drosophila Shaker mutants , 2005, Nature.

[200]  D. Stainier.  No Organ Left Behind: Tales of Gut Development and Evolution , 2005, Science.

[201]  A. Pack,et al.  Sleep deprivation induces the unfolded protein response in mouse cerebral cortex , 2005, Journal of neurochemistry.

[202]  Robert S. Balaban,et al.  Mitochondria, Oxidants, and Aging , 2005, Cell.

[203]  N. Hogg,et al.  Antioxidant defense responses to sleep loss and sleep recovery. , 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

[204]  M. Evans,et al.  Oxidative DNA damage and disease: induction, repair and significance. , 2004, Mutation research.

[205]  Giulio Tononi,et al.  Sleep homeostasis in Drosophila melanogaster. , 2004, Sleep.

[206]  M. Ashburner,et al.  The DrosDel Collection , 2004, Genetics.

[207]  S. Tufik,et al.  Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice , 2004, Neuropharmacology.

[208]  Scott Barolo,et al.  New Drosophila transgenic reporters: insulated P-element vectors expressing fast-maturing RFP. , 2004, BioTechniques.

[209]  C. Cirelli,et al.  Sleep deprivation and cellular responses to oxidative stress. , 2004, Sleep.

[210]  G. Tononi,et al.  Extensive and Divergent Effects of Sleep and Wakefulness on Brain Gene Expression , 2004, Neuron.

[211]  E. Stadtman,et al.  Free radical-mediated oxidation of free amino acids and amino acid residues in proteins , 2003, Amino Acids.

[212]  Francine Laden,et al.  Night-shift work and risk of colorectal cancer in the nurses' health study. , 2003, Journal of the National Cancer Institute.

[213]  R. Hardeland,et al.  Non‐vertebrate melatonin , 2003, Journal of pineal research.

[214]  H. Heller,et al.  Differential increase in the expression of heat shock protein family members during sleep deprivation and during sleep , 2003, Neuroscience.

[215]  G. Tononi,et al.  Electrophysiological Correlates of Rest and Activity in Drosophila melanogaster , 2002, Current Biology.

[216]  G. Bubenik.  REVIEW: Gastrointestinal Melatonin: Localization, Function, and Clinical Relevance , 2002, Digestive Diseases and Sciences.

[217]  R. Glaser,et al.  DNA double-strand break-induced phosphorylation of Drosophila histone variant H2Av helps prevent radiation-induced apoptosis. , 2002, Nucleic acids research.

[218]  J. Siegel,et al.  Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem , 2002, Neuroreport.

[219]  J. Siegel,et al.  Increases in amino-cupric-silver staining of the supraoptic nucleus after sleep deprivation , 2002, Brain Research.

[220]  G. Tononi,et al.  Stress response genes protect against lethal effects of sleep deprivation in Drosophila , 2002, Nature.

[221]  S. Benzer,et al.  Life extension in Drosophila by feeding a drug , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[222]  J. Nobrega,et al.  SLEEP DEPRIVATION DOES NOT AFFECT INDICES OF NECROSIS OR APOPTOSIS IN RAT BRAIN , 2002, The International journal of neuroscience.

[223]  G. Tononi,et al.  Gene expression in the brain across the sleep–waking cycle 1 1 Published on the World Wide Web on 30 October 2000. , 2000, Brain Research.

[224]  G. Tononi,et al.  Correlates of sleep and waking in Drosophila melanogaster. , 2000, Science.

[225]  Allan I Pack,et al.  Rest in Drosophila Is a Sleep-like State , 2000, Neuron.

[226]  E. Rogakou,et al.  Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo , 1999, The Journal of cell biology.

[227]  G. Tononi,et al.  No evidence of brain cell degeneration after long-term sleep deprivation in rats 1 Published on the World Wide Web on 8 July 1999. 1 , 1999, Brain Research.

[228]  Liqun Luo,et al.  Mosaic Analysis with a Repressible Cell Marker for Studies of Gene Function in Neuronal Morphogenesis , 1999, Neuron.

[229]  J. Nobrega,et al.  Sleep deprivation induces brain region‐specific decreases in glutathione levels , 1998, Neuroreport.

[230]  P. Callaerts,et al.  Molecular and biochemical characterization of the aaNAT1 (Dat) locus in Drosophila melanogaster: differential expression of two gene products. , 1998, DNA and cell biology.

[231]  E. Rogakou,et al.  DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139* , 1998, The Journal of Biological Chemistry.

[232]  S. Tufik,et al.  Absence of oxidative stress following paradoxical sleep deprivation in rats 1 These results have been presented as an oral communication during the 13th European Congress on Sleep Research, Brussels, Belgium, 1996. 1 , 1997, Neuroscience Letters.

[233]  I. Fridovich.  Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters* , 1997, The Journal of Biological Chemistry.

[234]  M. Bentivoglio,et al.  The pioneering experimental studies on sleep deprivation. , 1997, Sleep.

[235]  B. Babior.  Superoxide: a two-edged sword. , 1997, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[236]  A. Rechtschaffen,et al.  Sleep deprivation in the rat by the disk-over-water method , 1995, Behavioural Brain Research.

[237]  L. Aiello,et al.  The Expensive-Tissue Hypothesis: The Brain and the Digestive System in Human and Primate Evolution , 1995, Current Anthropology.

[238]  E. Reimund.  The free radical flux theory of sleep. , 1994, Medical hypotheses.

[239]  N. Perrimon,et al.  Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. , 1993, Development.

[240]  T. Wehr,et al.  Nutritional and metabolic adaptations to prolonged sleep deprivation in the rat. , 1993, The American journal of physiology.

[241]  M. Bonnet,et al.  Metabolism during normal, fragmented, and recovery sleep. , 1991, Journal of applied physiology.

[242]  B. Halliwell,et al.  The measurement and mechanism of lipid peroxidation in biological systems. , 1990, Trends in biochemical sciences.

[243]  Scott S. Campbell,et al.  Animal sleep: A review of sleep duration across phylogeny , 1984, Neuroscience & Biobehavioral Reviews.

[244]  B. Ames,et al.  Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. , 1983, Analytical biochemistry.

[245]  A. Rechtschaffen,et al.  Physiological correlates of prolonged sleep deprivation in rats. , 1983, Science.

[246]  R. Mittler.  ROS Are Good. , 2017, Trends in plant science.

[247]  D. Walker,et al.  Role of gut microbiota in aging-related health decline: insights from invertebrate models , 2017, Cellular and Molecular Life Sciences.

[248]  D. Gozal,et al.  Chronic sleep fragmentation during the sleep period induces hypothalamic endoplasmic reticulum stress and PTP1b-mediated leptin resistance in male mice. , 2015, Sleep.

[249]  V. Dhawan.  Reactive Oxygen and Nitrogen Species: General Considerations , 2014 .

[250]  L. Rochette,et al.  Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential. , 2013, Molecular nutrition & food research.

[251]  William D S Killgore,et al.  Effects of sleep deprivation on cognition. , 2010, Progress in brain research.

[252]  G. Sykiotis,et al.  Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. , 2008, Developmental cell.

[253]  P. Shaw,et al.  Essentials of sleep recordings in Drosophila: moving beyond sleep time. , 2005, Methods in enzymology.

[254]  A. Rechtschaffen,et al.  Sleep deprivation in the rat: III. Total sleep deprivation. , 1989, Sleep.

[255]  D A Schoeller,et al.  Sleep deprivation in the rat: V. Energy use and mediation. , 1989, Sleep.

[256]  A. Rechtschaffen,et al.  Sleep deprivation in the rat: VIII. High EEG amplitude sleep deprivation. , 1989, Sleep.