Neo-lignans in the Seed Crusts of Trewia nudiflora

Four new neo-lignans were isolated from the chloroform portion of 70% ethanol extract of the seed crusts of Trewia nudiflora L., and were determined to be 9′-methoxy-7′-en-3′,8:4′,7-diepoxyneolignan-3,4,9-triol 1, 9′-methoxy-7′-en-3′,7:4′,8-diepoxyneolignan-3,4,9-triol 2, 9′- ethoxy-7′-en-3′,8:4′,7-diepoxyneolignan-3,4,9-triol 3, 9′-butoxy-7′-en-3′,8:4′,7-diepoxy-neolignan -3,4,9-triol 4, respectively, on the basis of spectral data. The antimicrobial bioassays showed that 4 had evident inhibitory activity against Mycobacterium tuberculosis.