Active Microelectronic Neurosensor Arrays for Implantable Brain Communication Interfaces

We have built a wireless implantable microelectronic device for transmitting cortical signals transcutaneously. The device is aimed at interfacing a cortical microelectrode array to an external computer for neural control applications. Our implantable microsystem enables 16-channel broadband neural recording in a nonhuman primate brain by converting these signals to a digital stream of infrared light pulses for transmission through the skin. The implantable unit employs a flexible polymer substrate onto which we have integrated ultra-low power amplification with analog multiplexing, an analog-to-digital converter, a low power digital controller chip, and infrared telemetry. The scalable 16-channel microsystem can employ any of several modalities of power supply, including radio frequency by induction, or infrared light via photovoltaic conversion. As of the time of this report, the implant has been tested as a subchronic unit in nonhuman primates (~ 1 month), yielding robust spike and broadband neural data on all available channels.

[1]  A P Georgopoulos,et al.  On the relations between the direction of two-dimensional arm movements and cell discharge in primate motor cortex , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[2]  Andrew S. Whitford,et al.  Cortical control of a prosthetic arm for self-feeding , 2008, Nature.

[3]  Dawn M. Taylor,et al.  Direct Cortical Control of 3D Neuroprosthetic Devices , 2002, Science.

[4]  C.M. Zierhofer,et al.  High-efficiency coupling-insensitive transcutaneous power and data transmission via an inductive link , 1990, IEEE Transactions on Biomedical Engineering.

[5]  Jon A. Mukand,et al.  Neuronal ensemble control of prosthetic devices by a human with tetraplegia , 2006, Nature.

[6]  Guy M McKhann,et al.  Cortical control of a prosthetic arm for self-feeding. , 2008, Neurosurgery.

[7]  D. Borton,et al.  A Brain Implantable Microsystem with Hybrid RF/IR Telemetry for Advanced Neuroengineering Applications , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[8]  D R Humphrey,et al.  Predicting Measures of Motor Performance from Multiple Cortical Spike Trains , 1970, Science.

[9]  W.R. Patterson,et al.  Development of a chipscale integrated microelectrode/microelectronic device for brain implantable neuroengineering applications , 2005, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[10]  K. E. Jones,et al.  A glass/silicon composite intracortical electrode array , 2006, Annals of Biomedical Engineering.

[11]  L. Del Castillo,et al.  A miniaturized neuroprosthesis suitable for implantation into the brain , 2003, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[12]  Patrick D Wolf,et al.  A single-chip signal processing and telemetry engine for an implantable 96-channel neural data acquisition system , 2007, Journal of neural engineering.

[13]  Michael J. Black,et al.  Closed-loop neural control of cursor motion using a Kalman filter , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[14]  S. Meagher.  Instant neural control of a movement signal , 2002 .

[15]  David M. Santucci,et al.  Learning to Control a Brain–Machine Interface for Reaching and Grasping by Primates , 2003, PLoS biology.

[16]  Reid R. Harrison,et al.  A low-power, low-noise CMOS amplifier for neural recording applications , 2002, 2002 IEEE International Symposium on Circuits and Systems. Proceedings (Cat. No.02CH37353).

[17]  P. Mohseni,et al.  Wireless multichannel biopotential recording using an integrated FM telemetry circuit , 2005, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[18]  Yoon-Kyu Song,et al.  A microelectrode/microelectronic hybrid device for brain implantable neuroprosthesis applications , 2004, IEEE Transactions on Biomedical Engineering.

[19]  R. J. Vetter,et al.  Silicon-substrate intracortical microelectrode arrays for long-term recording of neuronal spike activity in cerebral cortex , 2003, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[20]  Yoon-Kyu Song,et al.  CMOS ICs for Brain Implantable Neural Recording Microsystems , 2007 .

[21]  Stephen I. Ryu,et al.  HermesC: RF wireless low-power neural recording system for freely behaving primates , 2008, 2008 IEEE International Symposium on Circuits and Systems.