Inhaled corticosteroids in asthma

Recent understanding of the pathogenesis of asthma has involved concepts of airway inflammation with bronchial mucosal oedema and inflammatory cell infiltration of the bronchial mucosa in addition to airway smooth muscle constriction. Although the exact mode of their action is not known, corticosteroids are potent inhibitors of general inflammatory responses by such actions as the inhibition of production of inflammatory mediators such as the leukotrienes' and modulation of lymphocyte responses and inflammatory cell infiltration."> Local application of corticosteroids should, therefore, inhibit the inflammatory responses of airways.

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