Pulmonary Scopulariopsis in a chronic tobacco smoker.

A 70-year-old male smoker, with a three-month status of post-balloon angioplasty for ischaemic heart disease, presented with a one-week history of fever, haemoptysis and chest discomfort on coughing. The patient did not report any loss of weight or appetite. On examination, he was febrile. Pulmonary function tests revealed obstructive airway disease. High resolution computed tomography of the lungs revealed fibrosis with bronchiectasis in both the upper lobes, and a spiculating subpleural mass in the posterior aspect of the right lung apex. Subsequent bronchoalveolar lavage (BAL) culture yielded the Scopulariopsis species. Our patient was treated with a four-week course of amphotericin B, followed by itraconazole. At the 24-month follow-up, the patient was asymptomatic. Subsequent BAL cultures revealed no fungal growths, and radiological studies showed a regression in the lesion.

[1]  R. Larsen,et al.  Emerging fungal pathogens in pulmonary disease , 2007, Current opinion in pulmonary medicine.

[2]  M. J. Buitrago,et al.  In Vitro Activities of 10 Combinations of Antifungal Agents against the Multiresistant Pathogen Scopulariopsis brevicaulis , 2006, Antimicrobial Agents and Chemotherapy.

[3]  E. Baron,et al.  Aspergillus, Fusarium, and other opportunistic moniliaceous fungi. , 2006 .

[4]  G. Verleden,et al.  Fatal Scopulariopsis infection in a lung transplant recipient: a case report. , 2005, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[5]  W. Kern,et al.  Breakthrough Invasive Infection Due to Debaryomyces hansenii (teleomorph Candida famata) and Scopulariopsis brevicaulis in a Stem Cell Transplant Patient Receiving Liposomal Amphotericin B and Caspofungin for Suspected Aspergillosis , 2005, Infection.

[6]  M. J. Buitrago,et al.  Scopulariopsis brevicaulis, a Fungal Pathogen Resistant to Broad-Spectrum Antifungal Agents , 2003, Antimicrobial Agents and Chemotherapy.

[7]  Y. Sohara,et al.  Scopulariopsis fungus ball. , 2002, The Annals of thoracic surgery.

[8]  M. Mahimkar,et al.  Biological monitoring of bidi industry workers occupationally exposed to tobacco. , 1999, Toxicology letters.

[9]  J. Guarro,et al.  In Vitro Antifungal Susceptibilities ofScopulariopsis Isolates , 1999, Antimicrobial Agents and Chemotherapy.

[10]  R. Wiesner,et al.  Phaeohyphomycosis due to Scopulariopsis brumptii in a liver transplant recipient. , 1994, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[11]  D. Larone Medically Important Fungi: A Guide to Identification , 1976 .