Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses

Near-infrared spectroscopy has proven to be a valuable method to monitor tissue oxygenation and haemodynamics non-invasively and in real-time. Quantification of such parameters requires measurements of the time-of-flight of light through tissue, typically achieved using picosecond pulsed lasers, with their associated cost, complexity, and size. In this work, we present an alternative approach that employs spread-spectrum excitation to enable the development of a small, low-cost, dual-wavelength system using vertical-cavity surface-emitting lasers. Since the optimal wavelengths and drive parameters for optical spectroscopy are not served by commercially available modules as used in our previous single-wavelength demonstration platform, we detail the design of a custom instrument and demonstrate its performance in resolving haemodynamic changes in human subjects during apnoea and cognitive task experiments.

[1]  Daniel J. Gauthier,et al.  An advanced active quenching circuit for ultra-fast quantum cryptography , 2017, Optics express.

[2]  Robert J Cooper,et al.  MONSTIR II: a 32-channel, multispectral, time-resolved optical tomography system for neonatal brain imaging. , 2014, The Review of scientific instruments.

[3]  Davide Contini,et al.  Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity. , 2015, Biomedical optics express.

[4]  Davide Contini,et al.  Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing. , 2013, Biomedical optics express.

[5]  Marco Ferrari,et al.  Functional Near-Infrared Spectroscopy (fNIRS) for Assessing Cerebral Cortex Function During Human Behavior in Natural/Social Situations: A Concise Review , 2019 .

[6]  T. J. Huppert,et al.  Brain activation during neurocognitive testing using functional near-infrared spectroscopy in patients following concussion compared to healthy controls , 2014, Brain Imaging and Behavior.

[7]  Hillman Emc,et al.  Experimental and theoretical investigations of near infrared tomographic imaging methods and clinical applications. , 2002 .

[8]  Yukio Yamada,et al.  Time-Domain Near-Infrared Spectroscopy and Imaging: A Review , 2019, Applied Sciences.

[9]  S R Arridge,et al.  The theoretical basis for the determination of optical pathlengths in tissue: temporal and frequency analysis. , 1992, Physics in medicine and biology.

[10]  Simon R. Arridge,et al.  A dual-wavelength spread spectrum-based spectroscopic system For time-domain near-infrared diffuse optical imaging , 2019, BiOS.

[11]  Simon R. Arridge,et al.  Dynamic image reconstruction in time-resolved diffuse optical tomography , 2015, Photonics West - Biomedical Optics.

[12]  M. Schweiger,et al.  Theoretical and experimental investigation of near-infrared light propagation in a model of the adult head. , 1997, Applied optics.

[13]  N. Motomura,et al.  Frontal Activity during the Digit Symbol Substitution Test Determined by Multichannel Near-Infrared Spectroscopy , 2008, Neuropsychobiology.

[14]  Ilias Tachtsidis,et al.  Clinical Brain Monitoring with Time Domain NIRS: A Review and Future Perspectives , 2019, Applied Sciences.

[15]  Ali Hasnain,et al.  Spread spectrum time-resolved diffuse optical measurement system for enhanced sensitivity in detecting human brain activity , 2017, Journal of biomedical optics.

[16]  T. W. L. Scheeren,et al.  Monitoring tissue oxygenation by near infrared spectroscopy (NIRS): background and current applications , 2012, Journal of Clinical Monitoring and Computing.

[17]  S R Arridge,et al.  Direct calculation of the moments of the distribution of photon time of flight in tissue with a finite-element method. , 1995, Applied optics.

[18]  A. Villringer,et al.  Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons. , 2004, Applied optics.

[19]  S. Arridge Optical tomography in medical imaging , 1999 .

[20]  Ilias Tachtsidis,et al.  MAESTROS: A Multiwavelength Time-Domain NIRS System to Monitor Changes in Oxygenation and Oxidation State of Cytochrome-C-Oxidase , 2019, IEEE Journal of Selected Topics in Quantum Electronics.

[21]  A. Finger,et al.  Pseudo Random Signal Processing: Theory and Application , 2005 .

[22]  Nanguang Chen,et al.  Laplace-domain diffuse optical measurement , 2018, Scientific Reports.

[23]  S. Arridge,et al.  Fast silicon photomultiplier improves signal harvesting and reduces complexity in time-domain diffuse optics. , 2015, Optics express.

[24]  Ileana Pirovano,et al.  Time Domain Near Infrared Spectroscopy Device for Monitoring Muscle Oxidative Metabolism: Custom Probe and In Vivo Applications , 2018, Sensors.

[25]  Davide Contini,et al.  Time domain functional NIRS imaging for human brain mapping , 2014, NeuroImage.

[26]  Simon R. Arridge,et al.  Calibration techniques and datatype extraction for time-resolved optical tomography , 2000 .

[27]  Frédéric Frederic Lange Lange,et al.  MAESTROS: A Multiwavelength Time-Domain NIRS System to Monitor Changes in Oxygenation and Oxidation State of Cytochrome-C-Oxidase , 2018, Ieee Journal of Selected Topics in Quantum Electronics.

[28]  Robert J. Cooper,et al.  Watching the brain at work , 2014, Nature Photonics.

[29]  Fumio Koyama,et al.  Monolithically integrated multi-wavelength VCSEL arrays using high-contrast gratings. , 2010, Optics express.

[30]  R. Cubeddu,et al.  Multi-channel time-resolved system for functional near infrared spectroscopy. , 2006, Optics express.

[31]  Jaakko Virtanen,et al.  Properties of end-expiratory breath hold responses measured with near-infrared spectroscopy , 2011, BiOS.

[32]  David A. Boas,et al.  Twenty years of functional near-infrared spectroscopy: introduction for the special issue , 2014, NeuroImage.

[33]  S. Arridge,et al.  A spread spectrum approach to time-domain near-infrared diffuse optical imaging using inexpensive optical transceiver modules , 2018, Biomedical optics express.

[34]  Zhongxing Zhang,et al.  Near-infrared spectroscopy (NIRS) as a useful tool to evaluate the treatment efficacy of positive airways pressure therapy in patients with obstructive sleep apnea syndrome (OSAS): A pilot study , 2014 .