Cryo-EM structure supports a role of AQP7 as a junction protein

[1]  M. McCarthy,et al.  An effector index to predict target genes at GWAS loci , 2021, Human Genetics.

[2]  Kyle J. Gaulton,et al.  Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation , 2020, Nature Genetics.

[3]  L. Groop,et al.  Islet Gene View - a tool to facilitate islet research , 2018, bioRxiv.

[4]  J. Hansen,et al.  Aquaglyceroporins and orthodox aquaporins in human adipocytes. , 2021, Biochimica et biophysica acta. Biomembranes.

[5]  Xiaoyan Liu,et al.  Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus , 2021, The Journal of biological chemistry.

[6]  M. Prentki,et al.  New Mammalian Glycerol-3-Phosphate Phosphatase: Role in β-Cell, Liver and Adipocyte Metabolism , 2021, Frontiers in Endocrinology.

[7]  J. Samra,et al.  Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes , 2021, Diabetologia.

[8]  Stephen C. J. Parker,et al.  The Trans-Ancestral Genomic Architecture of Glycemic Traits , 2020, Nature Genetics.

[9]  Trevor Hastie,et al.  Genetics of 35 blood and urine biomarkers in the UK Biobank , 2020, Nature Genetics.

[10]  G. Frühbeck,et al.  Aquaporin-7 and aquaporin-12 modulate the inflammatory phenotype of endocrine pancreatic beta-cells. , 2020, Archives of biochemistry and biophysics.

[11]  B. L. de Groot,et al.  Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7. , 2019, Structure.

[12]  Christopher J. Williams,et al.  Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix , 2019, Acta crystallographica. Section D, Structural biology.

[13]  U. Laforenza,et al.  Human adipose glycerol flux is regulated by a pH gate in AQP10 , 2018, Nature Communications.

[14]  P. Shepherd,et al.  The role of adherens junction proteins in the regulation of insulin secretion , 2018, Bioscience reports.

[15]  Peter Dahl,et al.  Quantification of the Intracellular Life Time of Water Molecules to Measure Transport Rates of Human Aquaglyceroporins , 2017, The Journal of Membrane Biology.

[16]  G. Frühbeck,et al.  Role of aquaporin-7 in ghrelin- and GLP-1-induced improvement of pancreatic β-cell function after sleeve gastrectomy in obese rats , 2017, International Journal of Obesity.

[17]  David J. Fleet,et al.  cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination , 2017, Nature Methods.

[18]  D. M. Smith,et al.  Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes , 2016, Cell metabolism.

[19]  Surajit Banerjee,et al.  X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors , 2014, Nature.

[20]  R. Neutze,et al.  X-ray structure of human aquaporin 2 and its implications for nephrogenic diabetes insipidus and trafficking , 2014, Proceedings of the National Academy of Sciences.

[21]  M. Prentki,et al.  Metabolic signaling in fuel-induced insulin secretion. , 2013, Cell metabolism.

[22]  P. Emsley,et al.  Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.

[23]  Rebecca A Robbins,et al.  Crystal structure of human aquaporin 4 at 1.8 Å and its mechanism of conductance , 2009, Proceedings of the National Academy of Sciences.

[24]  C. Delporte,et al.  Contrasting Effects of Glycerol and Urea Transport on Rat Pancreatic β-Cell Function , 2009, Cellular Physiology and Biochemistry.

[25]  Rob Horsefield,et al.  High-resolution x-ray structure of human aquaporin 5 , 2008, Proceedings of the National Academy of Sciences.

[26]  Oliver Fiehn,et al.  Quality control for plant metabolomics: reporting MSI-compliant studies. , 2008, The Plant journal : for cell and molecular biology.

[27]  Klaus Schulten,et al.  Exploring gas permeability of cellular membranes and membrane channels with molecular dynamics. , 2007, Journal of structural biology.

[28]  E. Füchtbauer,et al.  AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism. , 2007, American journal of physiology. Renal physiology.

[29]  M. Fujimiya,et al.  Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. , 2007, Molecular and cellular biology.

[30]  W. Stamer,et al.  Ion Channel Function of Aquaporin-1 Natively Expressed in Choroid Plexus , 2006, The Journal of Neuroscience.

[31]  Kazushi Kimura,et al.  Implications of the aquaporin-4 structure on array formation and cell adhesion. , 2006, Journal of molecular biology.

[32]  D. Fu,et al.  Crystal Structure of AqpZ Tetramer Reveals Two Distinct Arg-189 Conformations Associated with Water Permeation through the Narrowest Constriction of the Water-conducting Channel* , 2006, Journal of Biological Chemistry.

[33]  S. Harrison,et al.  Lipid–protein interactions in double-layered two-dimensional AQP0 crystals , 2005, Nature.

[34]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[35]  T. Gonen,et al.  Aquaporin-0 membrane junctions form upon proteolytic cleavage. , 2004, Journal of molecular biology.

[36]  Peter Agre,et al.  From structure to disease: the evolving tale of aquaporin biology , 2004, Nature Reviews Molecular Cell Biology.

[37]  M. Yasui,et al.  Aquaporin Water Channels , 2004 .

[38]  Andrea J Yool,et al.  New roles for old holes: ion channel function in aquaporin-1. , 2002, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[39]  Bong-Gyoon Han,et al.  Structural basis of water-specific transport through the AQP1 water channel , 2001, Nature.

[40]  Andreas Engel,et al.  Structural determinants of water permeation through aquaporin-1 , 2000, Nature.

[41]  J. Regan,et al.  Cloned human aquaporin-1 is a cyclic GMP-gated ion channel. , 2000, Molecular pharmacology.

[42]  B. Wallace,et al.  HOLE: a program for the analysis of the pore dimensions of ion channel structural models. , 1996, Journal of molecular graphics.

[43]  J. Regan,et al.  Forskolin Stimulation of Water and Cation Permeability in Aquaporin1 Water Channels , 1996, Science.

[44]  S. Bonner-Weir.  Morphological Evidence for Pancreatic Polarity of β-Cell Within Islets of Langerhans , 1988, Diabetes.