Structure-activity relationship and pharmacokinetic studies of 3-O-substitutedflavonols as anti-prostate cancer agents.

[1]  F. Perez-Vizcaino,et al.  Research trends in flavonoids and health. , 2018, Archives of biochemistry and biophysics.

[2]  Shilong Zheng,et al.  3-O-Substituted-3',4',5'-trimethoxyflavonols: Synthesis and cell-based evaluation as anti-prostate cancer agents. , 2017, Bioorganic & medicinal chemistry.

[3]  Shenmin Zhang,et al.  Flavonoids with Therapeutic Potential in Prostate Cancer. , 2016, Anti-cancer agents in medicinal chemistry.

[4]  Shilong Zheng,et al.  A new class of flavonol-based anti-prostate cancer agents: Design, synthesis, and evaluation in cell models. , 2016, Bioorganic & medicinal chemistry letters.

[5]  B. Karlan,et al.  Evaluation of MCF10A as a Reliable Model for Normal Human Mammary Epithelial Cells , 2015, PloS one.

[6]  L. Howells,et al.  Inhibition of prostate cancer cell growth by 3′,4′,5′-trimethoxyflavonol (TMFol) , 2015, Cancer Chemotherapy and Pharmacology.

[7]  J. Arunakaran,et al.  Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent against prostate cancer in an in vivo model by inhibiting the EGFR signaling pathway. , 2014, Food & function.

[8]  F. Greco,et al.  Flavonoids as prospective compounds for anti-cancer therapy. , 2013, The international journal of biochemistry & cell biology.

[9]  M. F. Proença,et al.  Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin. , 2013, European journal of medicinal chemistry.

[10]  R. Goldbohm,et al.  Dietary flavonoid intake, black tea consumption, and risk of overall and advanced stage prostate cancer. , 2013, American journal of epidemiology.

[11]  Y. Chao,et al.  Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: exploration of the role of tylophorine e ring on biological activity. , 2012, Journal of medicinal chemistry.

[12]  Xianglin Shi,et al.  Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways , 2012, PloS one.

[13]  P. R. Jenkins,et al.  Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents. , 2012, European journal of medicinal chemistry.

[14]  Donald J L Jones,et al.  Tissue distribution and metabolism of the putative cancer chemopreventive agent 3',4',5'-trimethoxyflavonol (TMFol) in mice. , 2012, Biomedical chromatography : BMC.

[15]  Hong Yang,et al.  Vitexicarpin induces apoptosis in human prostate carcinoma PC-3 cells through G2/M phase arrest. , 2012, Asian Pacific journal of cancer prevention : APJCP.

[16]  S. Basu,et al.  First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics. , 2011, Journal of pharmaceutical sciences.

[17]  J. Rhim,et al.  Novel human prostate epithelial cell culture models for the study of carcinogenesis and of normal stem cells and cancer stem cells. , 2011, Advances in experimental medicine and biology.

[18]  L. Klotz,et al.  Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells , 2010, Nutrition and cancer.

[19]  K. Khan,et al.  Isolation and synthesis of flavonols and comparison of their antioxidant activity , 2010, Natural product research.

[20]  Wen-bo Jiang,et al.  Flavonoids: recent advances as anticancer drugs. , 2010, Recent patents on anti-cancer drug discovery.

[21]  H. Mukhtar,et al.  A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice. , 2008, Cancer research.

[22]  C. la Vecchia,et al.  Flavonoids and Prostate Cancer Risk: A Study in Italy , 2006, Nutrition and cancer.

[23]  L. Klotz,et al.  Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines , 2006, Prostate Cancer and Prostatic Diseases.

[24]  J. Freudenheim,et al.  Intakes of Selected Nutrients, Foods, and Phytochemicals and Prostate Cancer Risk in Western New York , 2005, Nutrition and cancer.

[25]  J. Arunakaran,et al.  Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression , 2005, Journal of Cancer Research and Clinical Oncology.

[26]  S. Gomez,et al.  Soy and isoflavone consumption in relation to prostate cancer risk in China. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[27]  J. Harborne,et al.  Advances in flavonoid research since 1992. , 2000, Phytochemistry.

[28]  A. Burke,et al.  Aspects of the Algar-Flynn-Oyamada (AFO) reaction , 1996 .

[29]  J. Lechner,et al.  Establishment and characterization of a human prostatic carcinoma cell line (PC-3). , 1979, Investigative urology.

[30]  D. Paulson,et al.  Isolation of a human prostate carcinoma cell line (DU 145) , 1978, International journal of cancer.