Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock.
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[1] P. Ghezzi,et al. Urinary TNF-binding protein (TNF soluble receptor) protects mice against the lethal effect of TNF and endotoxic shock. , 1993, European cytokine network.
[2] L. Shapiro,et al. A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses. , 1995, Journal of immunology.
[3] C. Dinarello,et al. Biologic basis for interleukin-1 in disease. , 1996, Blood.
[4] R. Davis,et al. An osmosensing signal transduction pathway in mammalian cells. , 1994, Science.
[5] H. Tilg,et al. Induction of circulating soluble tumour necrosis factor receptor and interleukin 1 receptor antagonist following interleukin 1 alpha infusion in humans. , 1994, Cytokine.
[6] D. Wallach,et al. Structural requirements for inducible shedding of the p55 tumor necrosis factor receptor. , 1994, The Journal of biological chemistry.
[7] H. Holtmann,et al. Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate. , 1987, Journal of immunology.
[8] G. Wong,et al. A phase I trial of recombinant human interleukin-1 beta alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer. , 1991, Blood.
[9] S. Opal. Clinical Trials of Novel Therapeutic Agents: Why did they fail? , 1995 .
[10] W. Urba,et al. The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies. , 1992, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[11] J. Gabrilove,et al. Clinical pharmacology of recombinant human tumor necrosis factor in patients with advanced cancer. , 1987, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[12] T. van der Poll,et al. Tumor necrosis factor is involved in the appearance of interleukin-1 receptor antagonist in endotoxemia. , 1994, The Journal of infectious diseases.
[13] C. Dinarello,et al. Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits. , 1988, The American journal of physiology.
[14] S. Crooke,et al. Cloning of a phospholipase A2-activating protein. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[15] R. Ulevitch,et al. Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits. , 1988, The Journal of clinical investigation.
[16] P. Suter,et al. Imbalance between tumour necrosis factor-alpha and soluble TNF receptor concentrations in severe meningococcaemia. The J5 Study Group. , 1992, Immunology.
[17] C. Herzog,et al. [Interleukin 1 and tumor necrosis factor]. , 1987, Zeitschrift fur Rheumatologie.
[18] I. Olsson,et al. Interleukin-1 beta induces interleukin-1 receptor antagonist and tumor necrosis factor binding protein in humans. , 1993, Cancer research.
[19] B. Beutler,et al. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. , 1985, Science.
[20] D. Wallach,et al. Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors. , 1990, The Journal of biological chemistry.
[21] C. Dinarello,et al. Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[22] J. Vincent,et al. Influence of an anti‐tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis , 1993, Critical care medicine.
[23] R. Bast,et al. Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor. , 1994, Nature.
[24] D. Boraschi,et al. PRO cytokine strategies , 1991 .
[25] H. Holtmann,et al. Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity. , 1990, The Journal of biological chemistry.
[26] B. Brenner,et al. Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells. , 1991, The Journal of clinical investigation.
[27] M. Turner,et al. Modulation of cytokine production by transforming growth factor-beta. , 1989, Journal of immunology.
[28] S. Opal,et al. Initial evaluation of human recombinant interleukin‐1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open‐label, placebocontrolled multicenter trial , 1994, Critical care medicine.
[29] R. Locksley,et al. Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues , 1992, The Journal of experimental medicine.
[30] R. Bast,et al. Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor , 1994, Nature.
[31] L. Shapiro,et al. Detection of tumor necrosis factor soluble receptor p55 in blood samples from healthy and endotoxemic humans. , 1993, The Journal of infectious diseases.
[32] J. Mier,et al. Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans. , 1992, Cytokine.
[33] L Bibbs,et al. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. , 1994, Science.
[34] L. Moldawer,et al. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[35] H. Tabuchi,et al. Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide‐induced lethality , 1991, European journal of immunology.
[36] G. Slotman,et al. THE EFFECTS OF HUMAN RECOMBINANT INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL-1ra) ON PLASMA LEVELS OF PROSTAGLANDINS AND LEUKOTRIENES IN SEPTIC PATIENTS , 1994 .
[37] S. Moncada,et al. Nitric oxide: physiology, pathophysiology, and pharmacology. , 1991, Pharmacological reviews.
[38] R. Locksley,et al. The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[39] D. Wallach,et al. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors , 1992, The Journal of experimental medicine.
[40] M. Gelb,et al. Interleukin 1 alpha causes rapid activation of cytosolic phospholipase A2 by phosphorylation in rat mesangial cells. , 1994, The Journal of clinical investigation.
[41] J. Mier,et al. Hematologic and immunomodulatory effects of an interleukin-1 receptor antagonist coinfusion during low-dose endotoxemia in healthy humans. , 1993, Blood.
[42] J. Lowenthal,et al. A urine inhibitor of interleukin 1 activity that blocks ligand binding. , 1987, Journal of immunology.
[43] U. Gullberg,et al. Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy. , 1993, European cytokine network.
[44] Robert C. Thompson,et al. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor , 1990, Nature.
[45] P. Roux‐Lombard,et al. Tumour necrosis factor soluble receptors behave as acute phase reactants following surgery in patients with rheumatoid arthritis, chronic osteomyelitis and osteoarthritis , 1993, Clinical and experimental immunology.
[46] J. Vincent,et al. Administration of anti-TNF antibody improves left ventricular function in septic shock patients. Results of a pilot study. , 1992, Chest.
[47] R. Thompson,et al. Interleukin-1 (IL-1) receptor antagonist prevents Staphylococcus epidermidis-induced hypotension and reduces circulating levels of tumor necrosis factor and IL-1 beta in rabbits , 1993, Infection and immunity.
[48] A. H. Drummond,et al. Processing of tumour necrosis factor-alpha precursor by metalloproteinases. , 1994, Nature.
[49] J. Nerup,et al. Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury. , 1995, Critical care medicine.
[50] Jerry L. Adams,et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis , 1994, Nature.
[51] T. Ikejima,et al. Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. , 1988, The Journal of clinical investigation.
[52] C. Thiemermann,et al. Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo. , 1993, European journal of pharmacology.
[53] K. Tracey,et al. Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia , 1989, The Journal of experimental medicine.
[54] I. Orlow,et al. Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta. , 1993, Science.
[55] C. Dinarello,et al. Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells , 1991, Brain Research.
[56] L. Moldawer,et al. Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease. , 1992, Blood.
[57] J. Dayer,et al. Modulation of IL-1 inflammatory and immunomodulatory properties by IL-6. , 1991, European cytokine network.
[58] A. Vander,et al. In vivo evidence that the rise in plasma IL 6 following injection of a fever-inducing dose of LPS is mediated by IL 1 beta. , 1990, Cytokine.
[59] C. Dinarello,et al. Production of interleukin-1-receptor antagonist during experimental endotoxaemia , 1991, The Lancet.
[60] F. Guesdon,et al. Specific activation of beta-casein kinase by the inflammatory cytokines interleukin 1 and tumour necrosis factor. , 1994, The Biochemical journal.
[61] S. Schwaitzberg,et al. Glycosylated recombinant human tumor necrosis factor binding protein-1 reduces mortality, shock, and production of tumor necrosis factor in rabbit Escherichia coli sepsis. , 1995, Critical care medicine.
[62] G. Koch,et al. Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome: A Randomized, Controlled, Double-blind, Multicenter Clinical Trial , 1995 .
[63] J. Woody,et al. Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis , 1994, The Lancet.
[64] M. Kracht,et al. Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver , 1994, The Journal of experimental medicine.
[65] D. Dripps,et al. Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. , 1991, The Journal of biological chemistry.
[66] T. van der Poll,et al. Activation of coagulation after administration of tumor necrosis factor to normal subjects. , 1990, The New England journal of medicine.
[67] C J Fisher,et al. The clinical evaluation of new drugs for sepsis. A prospective study design based on survival analysis. , 1993, JAMA.
[68] T. J. Hayes,et al. Comparison between effects of interleukin-1 alpha administration and sublethal endotoxemia in primates. , 1991, The American journal of physiology.
[69] M. T. Brewer,et al. Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist , 1990, Nature.
[70] D. Wallach,et al. Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients. , 1991, Cancer research.
[71] H. Mühl,et al. Two distinct signaling pathways trigger the expression of inducible nitric oxide synthase in rat renal mesangial cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[72] R. F. Johnston,et al. Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome: Results From a Randomized, Double-blind, Placebo-Controlled Trial , 1994 .
[73] H. Büller,et al. Effects on leukocytes after injection of tumor necrosis factor into healthy humans , 1992 .
[74] D. Wallach,et al. A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity. , 1989, The Journal of biological chemistry.
[75] J. Hsuan,et al. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27 , 1994, Cell.
[76] Kevin J. Tracey,et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia , 1987, Nature.
[77] R. Bone,et al. Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome , 1993, Annals of Internal Medicine.
[78] C. Perez,et al. A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF , 1988, Cell.
[79] M. Gerhart,et al. Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing , 1994, Nature.
[80] T. Fahey,et al. Interleukin 1 receptor blockade attenuates the host inflammatory response. , 1990, Proceedings of the National Academy of Sciences of the United States of America.