The UniProt-GO Annotation database in 2011

The GO annotation dataset provided by the UniProt Consortium (GOA: http://www.ebi.ac.uk/GOA) is a comprehensive set of evidenced-based associations between terms from the Gene Ontology resource and UniProtKB proteins. Currently supplying over 100 million annotations to 11 million proteins in more than 360 000 taxa, this resource has increased 2-fold over the last 2 years and has benefited from a wealth of checks to improve annotation correctness and consistency as well as now supplying a greater information content enabled by GO Consortium annotation format developments. Detailed, manual GO annotations obtained from the curation of peer-reviewed papers are directly contributed by all UniProt curators and supplemented with manual and electronic annotations from 36 model organism and domain-focused scientific resources. The inclusion of high-quality, automatic annotation predictions ensures the UniProt GO annotation dataset supplies functional information to a wide range of proteins, including those from poorly characterized, non-model organism species. UniProt GO annotations are freely available in a range of formats accessible by both file downloads and web-based views. In addition, the introduction of a new, normalized file format in 2010 has made for easier handling of the complete UniProt-GOA data set.

Rachael P. Huntley | Emily Dimmer | Yasmin Alam-Faruque | Tony Sawford | Maria Jesus Martin | Claire O'Donovan | Rolf Apweiler | Marie-Claude Blatter | Elisabeth Coudert | Kristian B. Axelsen | Guillaume Keller | Alan Bridge | Lydie Bougueleret | Ioannis Xenarios | Michael Gardner | Michel Schneider | Damien Lieberherr | Ruth Y. Eberhardt | Phillippe Lemercier | Paul Browne | Michele Magrane | Maria Livia Famiglietti | Anne Estreicher | Lionel Breuza | Serenella Ferro | Sylvain Poux | Michael Tognolli | Chantal Hulo | Silvia Jimenez | Ghislaine Argoud-Puy | Benoit Bely | Emmanuel Boutet | Isabelle Cusin | Marc Feuermann | Arnaud Gos | Ursula Hinz | Ivo Pedruzzi | Klemens Pichler | Catherine Rivoire | Bernd Roechert | Andrea H. Auchincloss | Patrick Masson | Diego Poggioli | Wei Mun Chan | Kati Laiho | Shyamala Sundaram | Andre Stutz | Nadine Gruaz-Gumowski | Duncan Legge | Harminder Sehra | Silvia Braconi-Quintaje | Janet James | Florence Jungo | Madelaine Moinat | Paula Duek-Roggli | I. Xenarios | M. Magrane | R. Apweiler | Y. Alam-Faruque | R. Huntley | E. Dimmer | T. Sawford | M. Martin | C. O’Donovan | B. Roechert | S. Poux | Paul Browne | A. Bridge | L. Bougueleret | L. Breuza | M. Feuermann | U. Hinz | P. Masson | I. Pedruzzi | Serenella Ferro | H. Sehra | A. Auchincloss | K. Axelsen | B. Bely | M. Blatter | E. Boutet | E. Coudert | A. Estreicher | A. Gos | N. Gruaz-Gumowski | C. Hulo | F. Jungo | G. Keller | K. Laiho | P. Lemercier | D. Lieberherr | K. Pichler | C. Rivoire | A. Stutz | S. Sundaram | M. Tognolli | Isabelle Cusin | Ghislaine Argoud-Puy | Michel Schneider | M. Famiglietti | R. Eberhardt | D. Legge | D. Poggioli | J. James | S. Jimenez | M. Moinat | M. Gardner | Silvia Braconi-Quintaje | P. Duek-Roggli | R. Y. Eberhardt

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