Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals.

[1]  S. Waisbren,et al.  "Maternal Thyroid Deficiency During Pregnancy and Subsequent Neuropsychological Development of the Child" (1999), by James E. Haddow et al. , 2014 .

[2]  Ivonne M C M Rietjens,et al.  In vitro pituitary and thyroid cell proliferation assays and their relevance as alternatives to animal testing. , 2013, ALTEX.

[3]  Julien Nadjar,et al.  Thyroid hormone's action on progenitor/stem cell biology: new challenge for a classic hormone? , 2013, Biochimica et biophysica acta.

[4]  K. Gauthier,et al.  Thyroid hormone receptors: the challenge of elucidating isotype-specific functions and cell-specific response. , 2013, Biochimica et biophysica acta.

[5]  Á. Pascual,et al.  Thyroid hormone receptors, cell growth and differentiation. , 2013, Biochimica et biophysica acta.

[6]  L. Sachs,et al.  Mechanisms of thyroid hormone receptor action during development: lessons from amphibian studies. , 2013, Biochimica et biophysica acta.

[7]  Won Gu Kim,et al.  Thyroid hormone receptors and cancer. , 2013, Biochimica et biophysica acta.

[8]  A. Murk,et al.  Persistent toxic burdens of halogenated phenolic compounds in humans and wildlife. , 2013, Environmental science & technology.

[9]  Annemarie P van Wezel,et al.  Effect of combining in vitro estrogenicity data with kinetic characteristics of estrogenic compounds on the in vivo predictive value. , 2013, Toxicology in vitro : an international journal published in association with BIBRA.

[10]  L. Hoffmann,et al.  New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[11]  L. Kiemeney,et al.  Association between thyroid function, thyroid autoimmunity, and state and trait factors of depression , 2012, Acta psychiatrica Scandinavica.

[12]  Michael Kyba,et al.  Generation of functional thyroid from embryonic stem cells , 2012, Nature.

[13]  R. Zoeller,et al.  Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action. , 2012, Toxicology.

[14]  M. Zimmermann,et al.  Update on iodine status worldwide , 2012, Current opinion in endocrinology, diabetes, and obesity.

[15]  R. Núñez Miguel,et al.  Similarities and differences in interactions of thyroid stimulating and blocking autoantibodies with the TSH receptor. , 2012, Journal of molecular endocrinology.

[16]  David M. Reif,et al.  Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals , 2012, Environmental health perspectives.

[17]  G. Brent,et al.  Mechanisms of thyroid hormone action. , 2012, The Journal of clinical investigation.

[18]  M. de Cock,et al.  Does perinatal exposure to endocrine disruptors induce autism spectrum and attention deficit hyperactivity disorders? Review , 2012, Acta paediatrica.

[19]  Jens Mittag,et al.  Thyroid hormone and the central control of homeostasis. , 2012, Journal of molecular endocrinology.

[20]  T. Caciari,et al.  Exposure to Arsenic in urban and rural areas and effects on thyroid hormones , 2012, Inhalation toxicology.

[21]  M. Nielen,et al.  Triple bioaffinity mass spectrometry concept for thyroid transporter ligands. , 2012, Analytical chemistry.

[22]  R. H. Costa-e-Sousa,et al.  Minireview: The neural regulation of the hypothalamic-pituitary-thyroid axis. , 2012, Endocrinology.

[23]  Alena Bartonova,et al.  We’re only in it for the knowledge? A problem solving turn in environment and health expert elicitation , 2012, Environmental Health.

[24]  Suchi Smita,et al.  Nanoparticles in the environment: assessment using the causal diagram approach , 2012, Environmental Health.

[25]  Alena Bartonova,et al.  Policy relevant results from an expert elicitation on the health risks of phthalates , 2012, Environmental Health.

[26]  A. Bartoňová,et al.  Policy relevant Results from an Expert Elicitation on the Human Health Risks of Decabromodiphenyl ether (decaBDE) and Hexabromocyclododecane (HBCD) , 2012, Environmental Health.

[27]  M. Gershengorn,et al.  Persistent signaling by thyrotropin‐releasing hormone receptors correlates with G‐protein and receptor levels , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[28]  David M. Reif,et al.  Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management. , 2012, Chemical research in toxicology.

[29]  F. Wondisford,et al.  Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding. , 2012, Molecular endocrinology.

[30]  J. Lechleiter,et al.  The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolism. , 2012, Molecular endocrinology.

[31]  J. Price,et al.  Thyroid hormone signaling acts as a neurogenic switch by repressing Sox2 in the adult neural stem cell niche. , 2012, Cell stem cell.

[32]  A. Swaroop,et al.  Minireview: the role of nuclear receptors in photoreceptor differentiation and disease. , 2012, Molecular endocrinology.

[33]  Christopher Chang Neonatal autoimmune diseases: a critical review. , 2012, Journal of autoimmunity.

[34]  G. Major,et al.  Tetrabromobisphenol-A disrupts thyroid hormone receptor alpha function in vitro: use of fluorescence polarization to assay corepressor and coactivator peptide binding. , 2012, Chemosphere.

[35]  F. B. Davis,et al.  Combined QM/MM Study of Thyroid and Steroid Hormone Analogue Interactions with αvβ3 Integrin , 2012, Journal of biomedicine & biotechnology.

[36]  E. Fernandez,et al.  Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers , 2012, Proceedings of the National Academy of Sciences.

[37]  J. Bassett,et al.  Thyroid hormone metabolism in skeletal development and adult bone maintenance , 2012, Trends in Endocrinology & Metabolism.

[38]  J. Patel,et al.  Secretion and transfer of the thyroid hormone binding protein transthyretin by human placenta. , 2012, Placenta.

[39]  M. Zimmermann,et al.  Global iodine status in 2011 and trends over the past decade. , 2012, The Journal of nutrition.

[40]  M. Lopez-Espinosa,et al.  Thyroid Function and Perfluoroalkyl Acids in Children Living Near a Chemical Plant , 2012, Environmental health perspectives.

[41]  L. Schomburg,et al.  Identification of iopanoic acid as substrate of type 1 deiodinase by a novel nonradioactive iodide-release assay. , 2012, Endocrinology.

[42]  Kenneth R. Reuhl,et al.  Polychlorinated Biphenyl Congeners that Increase the Glucuronidation and Biliary Excretion of Thyroxine Are Distinct from the Congeners that Enhance the Serum Disappearance of Thyroxine , 2012, Drug Metabolism and Disposition.

[43]  F. Casas,et al.  Depletion of the p43 mitochondrial T3 receptor in mice affects skeletal muscle development and activity , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[44]  Bruno Hagenbuch,et al.  The expression and function of organic anion transporting polypeptides in normal tissues and in cancer. , 2012, Annual review of pharmacology and toxicology.

[45]  F. Casas,et al.  Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[46]  A. Halestrap The monocarboxylate transporter family—Structure and functional characterization , 2012, IUBMB life.

[47]  D. Unuane,et al.  Endocrine disorders & female infertility. , 2011, Best practice & research. Clinical endocrinology & metabolism.

[48]  H. Stapleton,et al.  Halogenated phenolic contaminants inhibit the in vitro activity of the thyroid-regulating deiodinases in human liver. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[49]  R. Uzbekov,et al.  Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes. , 2011, Current neurovascular research.

[50]  E. Dadachova,et al.  Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS) , 2011, Proceedings of the National Academy of Sciences.

[51]  M. Duffel,et al.  Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1. , 2011, Chemical research in toxicology.

[52]  A. Grüters,et al.  Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy. , 2011, European journal of endocrinology.

[53]  Catherine E Willett,et al.  Application of an integrated testing strategy to the U.S. EPA endocrine disruptor screening program. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[54]  David S. Sharlin,et al.  Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea. , 2011, Endocrinology.

[55]  Mi-Kyung Song,et al.  Identification of classifiers for increase or decrease of thyroid peroxidase activity in the FTC-238/hTPO recombinant cell line. , 2011, Environmental science & technology.

[56]  J. Dumont,et al.  Cell biology of H2O2 generation in the thyroid: Investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines , 2011, Molecular and Cellular Endocrinology.

[57]  H. Biebermann,et al.  Molecules important for thyroid hormone synthesis and action - known facts and future perspectives , 2011, Thyroid research.

[58]  K. Rhoden,et al.  Intracellular anion fluorescence assay for sodium/iodide symporter substrates. , 2011, Analytical biochemistry.

[59]  S. Chakrabarti Thyroid Functions and Bipolar Affective Disorder , 2011, Journal of thyroid research.

[60]  J. Safer Thyroid hormone action on skin , 2011, Dermato-endocrinology.

[61]  A. Bianco,et al.  Minireview: cracking the metabolic code for thyroid hormone signaling. , 2011, Endocrinology.

[62]  C. Sladek,et al.  A rexinoid antagonist increases the hypothalamic–pituitary–thyroid set point in mice and thyrotrope cells , 2011, Molecular and Cellular Endocrinology.

[63]  A. Piekiełko-Witkowska,et al.  Iodothyronine deiodinases and cancer , 2011, Journal of endocrinological investigation.

[64]  Ruili Huang,et al.  Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors , 2011, Environmental health perspectives.

[65]  R. Mortimer,et al.  Delivery of maternal thyroid hormones to the fetus , 2011, Trends in Endocrinology & Metabolism.

[66]  L. Martínez,et al.  Analysis of agonist and antagonist effects on thyroid hormone receptor conformation by hydrogen/deuterium exchange. , 2011, Molecular endocrinology.

[67]  G. Braunstein,et al.  Update on subclinical hyperthyroidism. , 2011, American family physician.

[68]  R. Paschke Molecular pathogenesis of nodular goiter , 2011, Langenbeck's Archives of Surgery.

[69]  Ruili Huang,et al.  A Quantitative High-Throughput Screen Identifies Novel Inhibitors of the Interaction of Thyroid Receptor β with a Peptide of Steroid Receptor Coactivator 2 , 2011, Journal of biomolecular screening.

[70]  R. Paschke Nodulogenesis and goitrogenesis. , 2011, Annales d'endocrinologie.

[71]  R. Mortimer,et al.  Thyroid hormones and fetal neurological development. , 2011, The Journal of endocrinology.

[72]  David M. Reif,et al.  Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. , 2011, Toxicology.

[73]  M. Dentice,et al.  Deiodinases: the balance of thyroid hormone: local impact of thyroid hormone inactivation. , 2011, The Journal of endocrinology.

[74]  R. Judson,et al.  Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment. , 2011, Chemical research in toxicology.

[75]  David M. Reif,et al.  Using Nuclear Receptor Activity to Stratify Hepatocarcinogens , 2011, PloS one.

[76]  Ruili Huang,et al.  Methylsulfonylnitrobenzoates, a New Class of Irreversible Inhibitors of the Interaction of the Thyroid Hormone Receptor and Its Obligate Coactivators That Functionally Antagonizes Thyroid Hormone* , 2011, The Journal of Biological Chemistry.

[77]  S. Costagliola,et al.  G protein-coupled receptors: mutations and endocrine diseases , 2011, Nature Reviews Endocrinology.

[78]  Catherine L. Worth,et al.  Research resource: Update and extension of a glycoprotein hormone receptors web application. , 2011, Molecular endocrinology.

[79]  Yin Wei,et al.  In vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol A. , 2011, Journal of environmental sciences.

[80]  Albertinka J Murk,et al.  Detection of thyroid hormone receptor disruptors by a novel stable in vitro reporter gene assay. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.

[81]  F. B. Davis,et al.  Membrane receptor for thyroid hormone: physiologic and pharmacologic implications. , 2011, Annual review of pharmacology and toxicology.

[82]  T. Plant,et al.  The role and potential sites of action of thyroid hormone in timing the onset of puberty in male primates , 2010, Brain Research.

[83]  Daniel E. Westholm,et al.  Evidence of evolutionary conservation of function between the thyroxine transporter Oatp1c1 and major facilitator superfamily members. , 2010, Endocrinology.

[84]  Bas J Blaauboer,et al.  The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[85]  Liang-Hong Guo,et al.  Structure-based investigation on the binding interaction of hydroxylated polybrominated diphenyl ethers with thyroxine transport proteins. , 2010, Toxicology.

[86]  P. Kosian,et al.  Inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[87]  J. Lasker,et al.  Current in vitro high throughput screening approaches to assess nuclear receptor activation. , 2010, Current drug metabolism.

[88]  V. Darras,et al.  Impact of monocarboxylate transporter-8 deficiency on the hypothalamus-pituitary-thyroid axis in mice. , 2010, Endocrinology.

[89]  K. Poppe,et al.  Thyroid function and human reproductive health. , 2010, Endocrine reviews.

[90]  F. Goglia,et al.  Thyroid hormones, mitochondrial bioenergetics and lipid handling. , 2010, Current opinion in endocrinology, diabetes, and obesity.

[91]  W. Miyazaki,et al.  Disruption of Thyroid Hormone Receptor–Mediated Transcription and Thyroid Hormone–Induced Purkinje Cell Dendrite Arborization by Polybrominated Diphenyl Ethers , 2010, Environmental health perspectives.

[92]  David M. Reif,et al.  Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data , 2010, Environmental health perspectives.

[93]  R. Weiss,et al.  Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion. , 2010, The Journal of clinical investigation.

[94]  E. Ropstad,et al.  Distribution of PCB 118 and PCB 153 and hydroxylated PCB metabolites (OH-CBs) in maternal, fetal and lamb tissues of sheep exposed during gestation and lactation. , 2010, Chemosphere.

[95]  A. Grüters,et al.  Essential Molecular Determinants for Thyroid Hormone Transport and First Structural Implications for Monocarboxylate Transporter 8* , 2010, The Journal of Biological Chemistry.

[96]  U. Schweizer,et al.  The tricyclic antidepressant desipramine inhibits T3 import into primary neurons , 2010, Neuroscience Letters.

[97]  Asa Bradman,et al.  Polybrominated Diphenyl Ether (PBDE) Flame Retardants and Thyroid Hormone during Pregnancy , 2010, Environmental health perspectives.

[98]  Bas J Blaauboer,et al.  Biokinetic Modeling and in Vitro–in Vivo Extrapolations , 2010, Journal of toxicology and environmental health. Part B, Critical reviews.

[99]  David M. Reif,et al.  Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals , 2010, Journal of toxicology and environmental health. Part B, Critical reviews.

[100]  Melvin E Andersen,et al.  Computational Systems Biology and Dose-Response Modeling in Relation to New Directions in Toxicity Testing , 2010, Journal of toxicology and environmental health. Part B, Critical reviews.

[101]  J. Bailar,et al.  Toxicity Testing in the 21st Century: A Vision and a Strategy , 2010, Journal of toxicology and environmental health. Part B, Critical reviews.

[102]  M. Zatelli,et al.  Therapeutic concentrations of mitotane (o,p'-DDD) inhibit thyrotroph cell viability and TSH expression and secretion in a mouse cell line model. , 2010, Endocrinology.

[103]  J. Dumont,et al.  Signal transduction in the human thyrocyte and its perversion in thyroid tumors , 2010, Molecular and Cellular Endocrinology.

[104]  Ruben Abagyan,et al.  Improved docking, screening and selectivity prediction for small molecule nuclear receptor modulators using conformational ensembles , 2010, J. Comput. Aided Mol. Des..

[105]  L. Jin,et al.  Species specific thyroid signal transduction: Conserved physiology, divergent mechanisms , 2010, Molecular and Cellular Endocrinology.

[106]  Laura N. Vandenberg,et al.  Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol A , 2010, Environmental health perspectives.

[107]  R. H. Bassett,et al.  Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts , 2010, Proceedings of the National Academy of Sciences.

[108]  Y. Lévi,et al.  Endocrine disruptors and thyroid hormone physiology. , 2010, Biochemical pharmacology.

[109]  M. Zatelli,et al.  Therapeutic concentrations of mitotane inhibit thyrotroph cell viability and TSH secretion in a mouse cell line model , 2010 .

[110]  E. Nillni Regulation of the hypothalamic Thyrotropin Releasing Hormone (TRH) neuron by neuronal and peripheral inputs , 2010, Frontiers in Neuroendocrinology.

[111]  J. Franklyn,et al.  Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction. , 2010, Placenta.

[112]  P. Davis,et al.  Molecular aspects of thyroid hormone actions. , 2010, Endocrine reviews.

[113]  G. Gabrielsen,et al.  In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus). , 2010, Environmental science & technology.

[114]  T. Reinehr Obesity and thyroid function , 2010, Molecular and Cellular Endocrinology.

[115]  H. Krause,et al.  A Live Zebrafish-Based Screening System for Human Nuclear Receptor Ligand and Cofactor Discovery , 2010, PloS one.

[116]  S. Cianchetta,et al.  Perchlorate transport and inhibition of the sodium iodide symporter measured with the yellow fluorescent protein variant YFP-H148Q/I152L. , 2010, Toxicology and applied pharmacology.

[117]  F. B. Davis,et al.  Thyroid hormone and angiogenesis. , 2010, Vascular pharmacology.

[118]  M. Kawanishi,et al.  Establishment of yeast reporter assay systems to detect ligands of thyroid hormone receptors alpha and beta. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.

[119]  G. Brent,et al.  Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation , 2010, Trends in Endocrinology & Metabolism.

[120]  I. Aamir,et al.  Frequency of autoimmune thyroid disease in chronic urticaria. , 2010, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.

[121]  T. Visser,et al.  Study of the transport of thyroid hormone by transporters of the SLC10 family , 2010, Molecular and Cellular Endocrinology.

[122]  H. Heuer,et al.  Thyroid hormone action during brain development: More questions than answers , 2010, Molecular and Cellular Endocrinology.

[123]  K. Blomgren,et al.  Stimulatory Effects of Thyroid Hormone on Brain Angiogenesis in vivo and in vitro , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[124]  K. Crofton,et al.  Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[125]  Asa Bradman,et al.  PBDE Concentrations in Women’s Serum and Fecundability , 2010, Environmental health perspectives.

[126]  Na Li,et al.  Hormone Activity of Hydroxylated Polybrominated Diphenyl Ethers on Human Thyroid Receptor-β: In Vitro and In Silico Investigations , 2009, Environmental health perspectives.

[127]  David M. Reif,et al.  In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project , 2009, Environmental health perspectives.

[128]  A. Grüters,et al.  Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent. , 2009, Journal of molecular endocrinology.

[129]  B. Haugen Drugs that suppress TSH or cause central hypothyroidism. , 2009, Best practice & research. Clinical endocrinology & metabolism.

[130]  E. Pearce,et al.  Environmental pollutants and the thyroid. , 2009, Best practice & research. Clinical endocrinology & metabolism.

[131]  Min Zhou,et al.  Translational implications of nongenomic actions of thyroid hormone initiated at its integrin receptor. , 2009, American journal of physiology. Endocrinology and metabolism.

[132]  E. Park,et al.  Regulation of Pyruvate Dehydrogenase Kinase 4 (PDK4) by Thyroid Hormone , 2009, The Journal of Biological Chemistry.

[133]  M. Rossi,et al.  Presence of a putative steroidal allosteric site on glycoprotein hormone receptors. , 2009, European journal of pharmacology.

[134]  Y. Ambroise,et al.  Synthesis and Evaluation of Imidazo[2,1‐b]thiazoles as Iodide Efflux Inhibitors in Thyrocytes , 2009, ChemMedChem.

[135]  Yunbo Shi Dual functions of thyroid hormone receptors in vertebrate development: the roles of histone-modifying cofactor complexes. , 2009, Thyroid : official journal of the American Thyroid Association.

[136]  Eva Cecilie Bonefeld-Jorgensen,et al.  Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions. , 2009, Toxicology letters.

[137]  J. Buxbaum,et al.  Transthyretin: the servant of many masters , 2009, Cellular and Molecular Life Sciences.

[138]  B. Raaka,et al.  Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice , 2009, Proceedings of the National Academy of Sciences.

[139]  J J Strain,et al.  Preliminary evidence of immune function modulation by thyroid hormones in healthy men and women aged 55-70 years. , 2009, The Journal of endocrinology.

[140]  P. J. Hofmann,et al.  Interference of endocrine disrupters with thyroid hormone receptor-dependent transactivation. , 2009, Toxicological sciences : an official journal of the Society of Toxicology.

[141]  P. Larsen Type 2 iodothyronine deiodinase in human skeletal muscle: new insights into its physiological role and regulation. , 2009, The Journal of clinical endocrinology and metabolism.

[142]  I. Colin,et al.  Iodide deficiency-induced angiogenic stimulus in the thyroid occurs via HIF- and ROS-dependent VEGF-A secretion from thyrocytes. , 2009, American journal of physiology. Endocrinology and metabolism.

[143]  M. Lamoree,et al.  Competitive binding of poly- and perfluorinated compounds to the thyroid hormone transport protein transthyretin. , 2009, Toxicological sciences : an official journal of the Society of Toxicology.

[144]  Y. Lévi,et al.  In vitro assessment of thyroid and estrogenic endocrine disruptors in wastewater treatment plants, rivers and drinking water supplies in the greater Paris area (France). , 2009, The Science of the total environment.

[145]  K. Yamamoto,et al.  DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity , 2009, Science.

[146]  J. Baxter,et al.  Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes , 2009, Nature Reviews Drug Discovery.

[147]  Melvin E Andersen,et al.  Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment , 2009, Risk analysis : an official publication of the Society for Risk Analysis.

[148]  C. Klaassen,et al.  Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism. , 2009, Toxicological sciences : an official journal of the Society of Toxicology.

[149]  M. Breteler,et al.  Thyroid function, the risk of dementia and neuropathologic changes: The Honolulu–Asia Aging Study , 2009, Neurobiology of Aging.

[150]  Fredric E. Wondisford,et al.  Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism. , 2009, Endocrinology.

[151]  T. Scanlan 3-Iodothyronamine (T1AM): A New Player on the Thyroid Endocrine Team? , 2009 .

[152]  P. Kopp,et al.  Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. , 2009, Endocrinology.

[153]  P. Kunapuli,et al.  A combination of ultrahigh throughput PathHunter and cytokine secretion assays to identify glucocorticoid receptor agonists. , 2009, Analytical biochemistry.

[154]  A. Fausto,et al.  Thyroid disruptor 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) prevents internalization of TSH receptor , 2009, Cell and Tissue Research.

[155]  Kevin M. Crofton,et al.  Thyroid-Disrupting Chemicals: Interpreting Upstream Biomarkers of Adverse Outcomes , 2009, Environmental health perspectives.

[156]  Daniel E. Westholm,et al.  Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. , 2009, Endocrinology.

[157]  Irina Gyllenhammar,et al.  Xenopus tropicalis as a Test System for Developmental and Reproductive Toxicity , 2009, Journal of toxicology and environmental health. Part A.

[158]  T. Scanlan,et al.  Iodothyronamines are Oxidatively Deaminated to Iodothyroacetic Acids in vivo , 2009, Chembiochem : a European journal of chemical biology.

[159]  R. Judson,et al.  The Toxicity Data Landscape for Environmental Chemicals , 2008, Environmental health perspectives.

[160]  A. Ondo-Méndez,et al.  Characterization of small-molecule inhibitors of the sodium iodide symporter. , 2008, The Journal of endocrinology.

[161]  M. S. Wagner,et al.  The role of thyroid hormone in testicular development and function. , 2008, The Journal of endocrinology.

[162]  E. Tate,et al.  Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. , 2008, Endocrinology.

[163]  J. Köhrle,et al.  Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates. , 2008, Rapid communications in mass spectrometry : RCM.

[164]  Mineyuki Mizuguchi,et al.  Biosensor discovery of thyroxine transport disrupting chemicals. , 2008, Toxicology and applied pharmacology.

[165]  T. Glenn,et al.  The Thyroid‐Brain Interaction in Thyroid Disorders and Mood Disorders , 2008, Journal of neuroendocrinology.

[166]  E. McLean,et al.  Iodine Deficiency in 2007: Global Progress since 2003 , 2008, Food and nutrition bulletin.

[167]  C. Leblanc,et al.  A colorimetric assay for steady-state analyses of iodo- and bromoperoxidase activities. , 2008, Analytical biochemistry.

[168]  C. Brayne,et al.  Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study , 2008, Psychoneuroendocrinology.

[169]  B. Lerer,et al.  Efficacy and safety of triiodothyronine supplementation in patients with major depressive disorder treated with specific serotonin reuptake inhibitors. , 2008, The international journal of neuropsychopharmacology.

[170]  B. Raaka,et al.  A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. , 2008, Endocrinology.

[171]  R. Birla,et al.  Effect of thyroid hormone on the contractility of self-organized heart muscle , 2008, In Vitro Cellular & Developmental Biology - Animal.

[172]  J. Kaye,et al.  An aberrant protein complex in CSF as a biomarker of Alzheimer disease , 2008, Neurology.

[173]  T. Visser,et al.  Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10. , 2008, Molecular endocrinology.

[174]  J. Fandrey,et al.  Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor. , 2008, Endocrinology.

[175]  Demetrio Raldúa,et al.  Clofibrate and gemfibrozil induce an embryonic malabsorption syndrome in zebrafish. , 2008, Toxicology and applied pharmacology.

[176]  Goulven Merer,et al.  Small‐Molecule Inhibitors of Sodium Iodide Symporter Function , 2008, Chembiochem : a European journal of chemical biology.

[177]  R. Dietz,et al.  Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus). , 2008, Environmental pollution.

[178]  Kevin M Crofton,et al.  Thyroid disrupting chemicals: mechanisms and mixtures. , 2008, International journal of andrology.

[179]  J. Köhrle Environment and endocrinology: the case of thyroidology. , 2008, Annales d'endocrinologie.

[180]  T. Visser,et al.  Thyroid hormone transport in and out of cells , 2008, Trends in Endocrinology & Metabolism.

[181]  Dolly Sarma,et al.  Demonstration of LanthaScreen™ TR-FRET-based nuclear receptor coactivator recruitment assay using PHERAstar, a multi-detection HTS microplate reader , 2008, Indian journal of pharmacology.

[182]  Robert J Kavlock,et al.  Understanding mechanisms of toxicity: insights from drug discovery research. , 2008, Toxicology and applied pharmacology.

[183]  M. Ribeiro Effects of thyroid hormone analogs on lipid metabolism and thermogenesis. , 2008, Thyroid : official journal of the American Thyroid Association.

[184]  Jian Li,et al.  A two-hybrid yeast assay to quantify the effects of xenobiotics on retinoid X receptor-mediated gene expression. , 2008, Toxicology letters.

[185]  M. Obregon Thyroid hormone and adipocyte differentiation. , 2008, Thyroid : official journal of the American Thyroid Association.

[186]  R. Dietz,et al.  Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. , 2008, Environmental science & technology.

[187]  T. Visser,et al.  Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47). , 2008, Molecular nutrition & food research.

[188]  Noel Southall,et al.  Quantitative High-Throughput Screening Using a Live-Cell cAMP Assay Identifies Small-Molecule Agonists of the TSH Receptor , 2008, Journal of biomolecular screening.

[189]  A. Bianco,et al.  Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. , 2008, Endocrine reviews.

[190]  S. Yamada,et al.  Hepatic UDP-Glucuronosyltransferases Responsible for Glucuronidation of Thyroxine in Humans , 2008, Drug Metabolism and Disposition.

[191]  A. Golan,et al.  In Vitro Models Using the Human Placenta to Study Fetal Exposure to Drugs , 2008 .

[192]  O. Mcconnell,et al.  In Vitro Glucuronidation of Thyroxine and Triiodothyronine by Liver Microsomes and Recombinant Human UDP-Glucuronosyltransferases , 2007, Drug Metabolism and Disposition.

[193]  Lynn L. Bergeson,et al.  Building the endocrine disruptor screening program: EPA makes progress , 2007 .

[194]  J. Davey,et al.  Arsenic as an Endocrine Disruptor: Arsenic Disrupts Retinoic Acid Receptor–and Thyroid Hormone Receptor–Mediated Gene Regulation and Thyroid Hormone–Mediated Amphibian Tail Metamorphosis , 2007, Environmental health perspectives.

[195]  R. Zoeller,et al.  Environmental chemicals impacting the thyroid: targets and consequences. , 2007, Thyroid : official journal of the American Thyroid Association.

[196]  I. Klein,et al.  Thyroid disease and the heart. , 2007, Circulation.

[197]  V. Detours,et al.  Roles of hydrogen peroxide in thyroid physiology and disease. , 2007, The Journal of clinical endocrinology and metabolism.

[198]  J. Petrick,et al.  Importance of Hepatic Induction of Constitutive Androstane Receptor and Other Transcription Factors That Regulate Xenobiotic Metabolism and Transport , 2007, Drug Metabolism and Disposition.

[199]  J. Köhrle,et al.  Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats. , 2007, Toxicology.

[200]  Goulven Merer,et al.  A 96-well automated radioiodide uptake assay for sodium/iodide symporter inhibitors. , 2007, Assay and drug development technologies.

[201]  Y. Lévi,et al.  A new bioluminescent cellular assay to measure the transcriptional effects of chemicals that modulate the alpha-1 thyroid hormone receptor. , 2007, Toxicology in vitro : an international journal published in association with BIBRA.

[202]  David S. Sharlin,et al.  Polychlorinated Biphenyls 105 and 118 Form Thyroid Hormone Receptor Agonists after Cytochrome P4501A1 Activation in Rat Pituitary GH3 Cells , 2007, Environmental health perspectives.

[203]  Csaba Fekete,et al.  Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: Role of neuronal afferents and type 2 deiodinase , 2007, Frontiers in Neuroendocrinology.

[204]  G. Grover,et al.  Pharmacological Profile of the Thyroid Hormone Receptor Antagonist NH3 in Rats , 2007, Journal of Pharmacology and Experimental Therapeutics.

[205]  A. Grüters,et al.  Endocrine Disruptors and the Thyroid Gland—A Combined in Vitro and in Vivo Analysis of Potential New Biomarkers , 2007, Environmental health perspectives.

[206]  A. Grüters,et al.  The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase. , 2007, Endocrinology.

[207]  B. Hagenbuch Cellular entry of thyroid hormones by organic anion transporting polypeptides. , 2007, Best practice & research. Clinical endocrinology & metabolism.

[208]  P. Yen,et al.  New insights into thyroid hormone action. , 2007, Best practice & research. Clinical endocrinology & metabolism.

[209]  J. Ritchie,et al.  Tissue uptake of thyroid hormone by amino acid transporters. , 2007, Best practice & research. Clinical endocrinology & metabolism.

[210]  J. Köhrle Thyroid hormone transporters in health and disease: advances in thyroid hormone deiodination. , 2007, Best practice & research. Clinical endocrinology & metabolism.

[211]  Anna Forsby,et al.  Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity , 2007, Human & experimental toxicology.

[212]  J. Bernal Thyroid hormone receptors in brain development and function , 2007, Nature Clinical Practice Endocrinology &Metabolism.

[213]  M. Negishi,et al.  CAR and PXR: The xenobiotic-sensing receptors , 2007, Steroids.

[214]  S. Cianchetta,et al.  Cell-based imaging of sodium iodide symporter activity with the yellow fluorescent protein variant YFP-H148Q/I152L. , 2007, American journal of physiology. Cell physiology.

[215]  Julie Meeks Gardner,et al.  Child development: risk factors for adverse outcomes in developing countries , 2007, The Lancet.

[216]  Maria Teresa Dell'Anno,et al.  The Thyroid Disruptor 1,1,1-Trichloro-2,2-Bis(p-Chlorophenyl)-Ethane Appears to Be an Uncompetitive Inverse Agonist for the Thyrotropin Receptor , 2007, Journal of Pharmacology and Experimental Therapeutics.

[217]  T. Visser,et al.  Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. , 2006, Molecular endocrinology.

[218]  Kathleen L. Caldwell,et al.  Urinary Perchlorate and Thyroid Hormone Levels in Adolescent and Adult Men and Women Living in the United States , 2006, Environmental health perspectives.

[219]  Olivier Fardel,et al.  Differential Regulation of Sinusoidal and Canalicular Hepatic Drug Transporter Expression by Xenobiotics Activating Drug-Sensing Receptors in Primary Human Hepatocytes , 2006, Drug Metabolism and Disposition.

[220]  R. Zoeller,et al.  4-Hydroxy-PCB106 acts as a direct thyroid hormone receptor agonist in rat GH3 cells , 2006, Molecular and Cellular Endocrinology.

[221]  T. Visser,et al.  Mechanisms of Disease: psychomotor retardation and high T3 levels caused by mutations in monocarboxylate transporter 8 , 2006, Nature Clinical Practice Endocrinology &Metabolism.

[222]  Johannes J M van de Sandt,et al.  Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling. , 2006, Toxicology letters.

[223]  K. Yamauchi,et al.  In vitro and in vivo analysis of the thyroid system-disrupting activities of brominated phenolic and phenol compounds in Xenopus laevis. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[224]  A. Murk,et al.  Selected Titles , 2006 .

[225]  V. Darras,et al.  Perchlorate versus other environmental sodium/iodide symporter inhibitors: potential thyroid-related health effects. , 2006, European journal of endocrinology.

[226]  E. Fliers,et al.  Functional neuroanatomy of thyroid hormone feedback in the human hypothalamus and pituitary gland , 2006, Molecular and Cellular Endocrinology.

[227]  A. Murk,et al.  T-screen to quantify functional potentiating, antagonistic and thyroid hormone-like activities of poly halogenated aromatic hydrocarbons (PHAHs). , 2006, Toxicology in vitro : an international journal published in association with BIBRA.

[228]  Bruce Blumberg,et al.  Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. , 2006, Endocrinology.

[229]  J. Köhrle,et al.  Genistein and other soya isoflavones are potent ligands for transthyretin in serum and cerebrospinal fluid. , 2006, The British journal of nutrition.

[230]  A. Pinchera,et al.  Treatment with drugs able to reduce iodine efflux significantly increases the intracellular retention time in thyroid cancer cells stably transfected with sodium iodide symporter complementary deoxyribonucleic acid. , 2006, The Journal of clinical endocrinology and metabolism.

[231]  A. D. Rodrigues,et al.  Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions. , 2006, Current drug metabolism.

[232]  N. Skakkebaek,et al.  Environmental chemicals and thyroid function. , 2006, European journal of endocrinology.

[233]  G. Marsh,et al.  Identification of hydroxylated metabolites in 2,2',4,4'-tetrabromodiphenyl ether exposed rats. , 2006, Chemosphere.

[234]  P. Chambon,et al.  Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis. , 2006, Endocrinology.

[235]  P. Courtoy,et al.  The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland. , 2006, Endocrinology.

[236]  J. García-Estañ,et al.  Vascular and renal function in experimental thyroid disorders. , 2006, European journal of endocrinology.

[237]  H. Ahr,et al.  Studies on the goitrogenic mechanism of action of N,N,N',N'-tetramethylthiourea. , 2006, Toxicology.

[238]  Mineyuki Mizuguchi,et al.  Biosensor recognition of thyroid-disrupting chemicals using transport proteins. , 2006, Analytical chemistry.

[239]  L. Moeller,et al.  Cytosolic action of thyroid hormone leads to induction of hypoxia-inducible factor-1alpha and glycolytic genes. , 2005, Molecular endocrinology.

[240]  N. Shimada,et al.  Detection of thyroid system-disrupting chemicals using in vitro and in vivo screening assays in Xenopus laevis. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[241]  K. Yamauchi,et al.  Characteristics of a thyroid hormone responsive reporter gene transduced into a Xenopus laevis cell line using lentivirus vector. , 2005, General and comparative endocrinology.

[242]  M. Benedetti,et al.  Alteration of thyroid hormone homeostasis by antiepileptic drugs in humans: involvement of glucuronosyltransferase induction , 2005, European Journal of Clinical Pharmacology.

[243]  M. Hays,et al.  Alternate pathways of thyroid hormone metabolism. , 2005, Thyroid : official journal of the American Thyroid Association.

[244]  W. S. Baldwin,et al.  CAR and PXR: xenosensors of endocrine disrupters? , 2005, Chemico-biological interactions.

[245]  D. Cooper,et al.  Amiodarone and the thyroid. , 2005, The American journal of medicine.

[246]  M. Coughtrie,et al.  Human Cytosolic Sulfotransferases , 2005 .

[247]  T. Visser,et al.  Sulfation of Thyroid Hormones , 2005 .

[248]  Richard N Hill,et al.  Risk Assessment For Benefits Analysis: Framework for Analysis of A Thyroid-Disrupting Chemical , 2005, Journal of toxicology and environmental health. Part A.

[249]  Harvey Wong,et al.  Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[250]  M. Tom,et al.  Thyroid hormone export from cells: contribution of P-glycoprotein. , 2005, The Journal of endocrinology.

[251]  Hiromitsu Watanabe,et al.  Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[252]  H. Takigami,et al.  Structural requirements for the interaction of 91 hydroxylated polychlorinated biphenyls with estrogen and thyroid hormone receptors. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[253]  D. Moore,et al.  Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism. , 2005, Endocrinology.

[254]  Hwan-Goo Kang,et al.  Effects of butylated hydroxyanisole on the development and functions of reproductive system in rats. , 2005, Toxicology.

[255]  M. Iida,et al.  Anti-thyroid hormonal activity of tetrabromobisphenol A, a flame retardant, and related compounds: Affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis. , 2005, Life sciences.

[256]  Arno C Gutleb,et al.  T-Screen as a tool to identify thyroid hormone receptor active compounds. , 2005, Environmental toxicology and pharmacology.

[257]  E. Friesema,et al.  Thyroid hormone transporters. , 2005, Biochemical Society transactions.

[258]  Kevin M Crofton,et al.  Mode of Action: Neurotoxicity Induced by Thyroid Hormone Disruption During Development—Hearing Loss Resulting From Exposure to PHAHs , 2005, Critical reviews in toxicology.

[259]  A. Pinchera,et al.  Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter. , 2004, Thyroid : official journal of the American Thyroid Association.

[260]  N. Shimada,et al.  Characteristics of 3,5,3'-triiodothyronine (T3)-uptake system of tadpole red blood cells: effect of endocrine-disrupting chemicals on cellular T3 response. , 2004, Journal of Endocrinology.

[261]  Julia Fentem,et al.  The Feasibility of Replacing Animal Testing for Assessing Consumer Safety: A Suggested Future Direction , 2004, Alternatives to laboratory animals : ATLA.

[262]  H. Jarry,et al.  Multi-organic endocrine disrupting activity of the UV screen benzophenone 2 (BP2) in ovariectomized adult rats after 5 days treatment. , 2004, Toxicology.

[263]  R. Evans,et al.  The Constitutive Androstane Receptor and Pregnane X Receptor Function Coordinately to Prevent Bile Acid-induced Hepatotoxicity* , 2004, Journal of Biological Chemistry.

[264]  R. Zoeller,et al.  Timing of Thyroid Hormone Action in the Developing Brain: Clinical Observations and Experimental Findings , 2004, Journal of neuroendocrinology.

[265]  T. Scanlan,et al.  Induction of Larval Tissue Resorption in Xenopus laevis Tadpoles by the Thyroid Hormone Receptor Agonist GC-1* , 2004, Journal of Biological Chemistry.

[266]  R. Zoeller,et al.  Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors. , 2004, Environmental health perspectives.

[267]  A. Aranda,et al.  A Permissive Retinoid X Receptor/Thyroid Hormone Receptor Heterodimer Allows Stimulation of Prolactin Gene Transcription by Thyroid Hormone and 9-cis-Retinoic Acid , 2004, Molecular and Cellular Biology.

[268]  R. Clewell,et al.  Evidence for Competitive Inhibition of Iodide Uptake by Perchlorate and Translocation of Perchlorate into the Thyroid , 2004, International journal of toxicology.

[269]  C. Mason,et al.  Thyroid Hormone Induces Cerebellar Purkinje Cell Dendritic Development via the Thyroid Hormone Receptor α1 , 2003, The Journal of Neuroscience.

[270]  A. Pinchera,et al.  In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity , 2003, Journal of endocrinological investigation.

[271]  J. Nishikawa,et al.  Basis of a high-throughput method for nuclear receptor ligands. , 2003, Journal of biochemistry.

[272]  J. Deussing,et al.  Thyroid functions of mouse cathepsins B, K, and L. , 2003, The Journal of clinical investigation.

[273]  Ruben Abagyan,et al.  Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[274]  Jie Liu,et al.  Induction of T(4) UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers. , 2003, Toxicology and applied pharmacology.

[275]  K. Yamauchi,et al.  Competitive interactions of chlorinated phenol compounds with 3,3',5-triiodothyronine binding to transthyretin: detection of possible thyroid-disrupting chemicals in environmental waste water. , 2003, Toxicology and applied pharmacology.

[276]  C. Ginter,et al.  The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. , 2003, Endocrine reviews.

[277]  Y. Kuroda,et al.  Polychlorinated biphenyls suppress thyroid hormone-induced transactivation. , 2002, Biochemical and biophysical research communications.

[278]  V. M. Neto,et al.  Thyroid Hormone Actions on Neural Cells , 2002, Cellular and Molecular Neurobiology.

[279]  S. Kitajima,et al.  Effects of kojic acid on thyroidal functions in rats by single-dose administration and in cultured rat thyroid cells (FRTL-5 cells). , 2002, The Journal of toxicological sciences.

[280]  Thomas S. Scanlan,et al.  Design of thyroid hormone receptor antagonists from first principles , 2002, The Journal of Steroid Biochemistry and Molecular Biology.

[281]  K. Nakao,et al.  Thyroid hormone action is disrupted by bisphenol A as an antagonist. , 2002, The Journal of clinical endocrinology and metabolism.

[282]  S. Filetti,et al.  Stimulation of iodide uptake by human chorionic gonadotropin in FRTL-5 cells: effects on sodium/iodide symporter gene and protein expression. , 2002, European journal of endocrinology.

[283]  G. Schreiber,et al.  The evolutionary and integrative roles of transthyretin in thyroid hormone homeostasis. , 2002, The Journal of endocrinology.

[284]  M. Carta,et al.  Association between panic disorder, major depressive disorder and celiac disease: a possible role of thyroid autoimmunity. , 2002, Journal of psychosomatic research.

[285]  P. Darnerud,et al.  Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects. , 2002, Toxicology.

[286]  Abraham Brouwer,et al.  Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[287]  J. Baxter,et al.  Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. , 2002, Journal of medicinal chemistry.

[288]  D. Sheehan,et al.  Goitrogenic and estrogenic activity of soy isoflavones. , 2002, Environmental health perspectives.

[289]  S. Kitamura,et al.  Thyroid hormonal activity of the flame retardants tetrabromobisphenol A and tetrachlorobisphenol A. , 2002, Biochemical and biophysical research communications.

[290]  K. Howdeshell A model of the development of the brain as a construct of the thyroid system. , 2002, Environmental health perspectives.

[291]  Richard C Trembath,et al.  Mutations of the PDS gene, encoding pendrin, are associated with protein mislocalization and loss of iodide efflux: implications for thyroid dysfunction in Pendred syndrome. , 2002, The Journal of clinical endocrinology and metabolism.

[292]  D. Tibboel,et al.  Characterization of iodothyronine sulfatase activities in human and rat liver and placenta. , 2002, Endocrinology.

[293]  U. Feldt-Rasmussen,et al.  The influence of alpha1-acid glycoprotein (orosomucoid) and its glycoforms on the function of human thyrocytes and CHO cells transfected with the human TSH receptor , 2002, Molecular and Cellular Endocrinology.

[294]  M Balls,et al.  Methods of in vitro toxicology. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[295]  C. Klaassen,et al.  Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[296]  M. Privalsky,et al.  Arsenic Trioxide Is a Potent Inhibitor of the Interaction of SMRT Corepressor with Its Transcription Factor Partners, Including the PML-Retinoic Acid Receptor α Oncoprotein Found in Human Acute Promyelocytic Leukemia , 2001, Molecular and Cellular Biology.

[297]  Y. Liu,et al.  Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. , 2001, Drug metabolism and disposition: the biological fate of chemicals.

[298]  T. Visser,et al.  Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. , 2001, Endocrine reviews.

[299]  P. Yen,et al.  Physiological and molecular basis of thyroid hormone action. , 2001, Physiological reviews.

[300]  P. Darnerud,et al.  Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice , 2001, Archives of Toxicology.

[301]  K M Crofton,et al.  Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. , 2001, Toxicological sciences : an official journal of the Society of Toxicology.

[302]  A. D. Dunn,et al.  Update on intrathyroidal iodine metabolism. , 2001, Thyroid : official journal of the American Thyroid Association.

[303]  G. Hager,et al.  Nuclear Cytoplasmic Shuttling by Thyroid Hormone Receptors , 2001, The Journal of Biological Chemistry.

[304]  V. Herzog,et al.  Cysteine Proteinases Mediate Extracellular Prohormone Processing in the Thyroid , 2001, Biological chemistry.

[305]  R. Mortimer,et al.  Different transporters for tri-iodothyronine (T(3)) and thyroxine (T(4)) in the human choriocarcinoma cell line, JAR. , 2000, The Journal of endocrinology.

[306]  L. Hagmar,et al.  Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men , 2000 .

[307]  L. Johnson,et al.  Structure of human transthyretin complexed with bromophenols: a new mode of binding. , 2000, Acta crystallographica. Section D, Biological crystallography.

[308]  C. Pirola,et al.  Expression of TRH and TRH-like peptides in a human glioblastoma-astrocytoma cell line (U-373-MG). , 2000, The Journal of endocrinology.

[309]  D. Medina,et al.  Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems. , 2000, European journal of endocrinology.

[310]  A. De la Vieja,et al.  Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology. , 2000, Physiological reviews.

[311]  I. Meerts,et al.  Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[312]  C. Klaassen,et al.  Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[313]  Wendy E. Wagner,et al.  The Precautionary Principle and Chemical Regulation in the U.S. , 2000 .

[314]  C. Klaassen,et al.  Effects of microsomal enzyme inducers on outer-ring deiodinase activity toward thyroid hormones in various rat tissues. , 2000, Toxicology and applied pharmacology.

[315]  G. Schussler,et al.  Thyroxine-binding proteins. , 2000, Thyroid : official journal of the American Thyroid Association.

[316]  L. A. Simeoni,et al.  Thyroid Hormone Export in Rat FRTL-5 Thyroid Cells and Mouse NIH-3T3 Cells Is Carrier-Mediated, Verapamil-Sensitive, and Stereospecific1. , 1999, Endocrinology.

[317]  M. Sogorb,et al.  Enzyme concentration as an important factor in the in vitro testing of the stereospecificity of the enzymatic hydrolysis of organophosphorus compounds. , 1999, Toxicology in vitro : an international journal published in association with BIBRA.

[318]  H. Glatt,et al.  Sulfation of thyroid hormone by estrogen sulfotransferase. , 1999, The Journal of clinical endocrinology and metabolism.

[319]  T. Visser,et al.  Effects of pentachlorophenol and hydroxylated polychlorinated biphenyls on thyroid hormone conjugation in a rat and a human hepatoma cell line. , 1999, Toxicology in vitro : an international journal published in association with BIBRA.

[320]  F. Greenspan,et al.  The Effect of Thyroid Hormone on Skeletal Integrity , 1999, Annals of Internal Medicine.

[321]  K. Crofton,et al.  Screening methods for thyroid hormone disruptors. , 1999, Environmental health perspectives.

[322]  S. Refetoff,et al.  Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. , 1999, Biochimie.

[323]  J. McLachlan,et al.  Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. , 1999, Environmental health perspectives.

[324]  W. Wiersinga,et al.  Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy , 1999, Clinical endocrinology.

[325]  C. Capen Correlation of mechanistic data and histopathology in the evaluation of selected toxic endpoints of the endocrine system. , 1998, Toxicology letters.

[326]  P. Langer,et al.  Minireview: Polychlorinated Biphenyls and the Thyroid Gland. , 1998, Endocrine regulations.

[327]  M. DeVito,et al.  Dose-response relationships for disposition and hepatic sequestration of polyhalogenated dibenzo-p-dioxins, dibenzofurans, and biphenyls following subchronic treatment in mice. , 1998, Toxicological sciences : an official journal of the Society of Toxicology.

[328]  L. Persani,et al.  Hypothalamic thyrotropin-releasing hormone and thyrotropin biological activity. , 1998, Thyroid : official journal of the American Thyroid Association.

[329]  T. Visser,et al.  In vitro inhibition of thyroid hormone sulfation by polychlorobiphenylols: isozyme specificity and inhibition kinetics. , 1998, Toxicological sciences : an official journal of the Society of Toxicology.

[330]  P. Langer,et al.  Increased thyroid volume and prevalence of thyroid disorders in an area heavily polluted by polychlorinated biphenyls. , 1998, European journal of endocrinology.

[331]  F. Brucker-Davis Effects of environmental synthetic chemicals on thyroid function. , 1998, Thyroid : official journal of the American Thyroid Association.

[332]  F. Legger,et al.  In vitro inhibition of thyroid hormone sulfation by hydroxylated metabolites of halogenated aromatic hydrocarbons. , 1998, Chemical research in toxicology.

[333]  J. Baxter,et al.  A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. , 1998, Chemistry & biology.

[334]  S. Misiti,et al.  Expression and Hormonal Regulation of Coactivator and Corepressor Genes. , 1998, Endocrinology.

[335]  J. Wolff Perchlorate and the thyroid gland. , 1998, Pharmacological reviews.

[336]  T. Visser,et al.  Inhibition of thyroid hormone sulfation by hydroxylated metabolites of polychlorinated biphenyls. , 1998, Chemico-biological interactions.

[337]  T. Visser,et al.  Interactions of Persistent Environmental Organohalogens With the Thyroid Hormone System: Mechanisms and Possible Consequences for Animal and Human Health , 1998, Toxicology and industrial health.

[338]  D. Doerge,et al.  Anti-thyroid isoflavones from soybean: isolation, characterization, and mechanisms of action. , 1997, Biochemical pharmacology.

[339]  I. Klein,et al.  Thyroid hormone and the cardiovascular system , 1997, The Medical clinics of North America.

[340]  S. Ball,et al.  3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro. , 1997, Journal of molecular endocrinology.

[341]  C. Capen,et al.  Mechanistic Data and Risk Assessment of Selected Toxic End Points of the Thyroid Gland , 1997, Toxicologic pathology.

[342]  M. L’Abbé,et al.  A method for the determination of type I iodothyronine deiodinase activity in liver and kidney using 125I-labelled reverse triiodothyronine as a substrate. , 1996, Clinical biochemistry.

[343]  C. Klaassen,et al.  Regulation of hepatic sulfotransferases by steroidal chemicals in rats. , 1996, Drug metabolism and disposition: the biological fate of chemicals.

[344]  J H Koeman,et al.  Alterations in rat brain thyroid hormone status following pre- and postnatal exposure to polychlorinated biphenyls (Aroclor 1254). , 1996, Toxicology and applied pharmacology.

[345]  B. Stuart,et al.  Evidence of chemical stimulation of hepatic metabolism by an experimental acetanilide (FOE 5043) indirectly mediating reductions in circulating thyroid hormone levels in the male rat. , 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[346]  M. Surks,et al.  Drugs and thyroid function. , 1995, The New England journal of medicine.

[347]  A. J. Arduengo,et al.  Subchronic Toxicity Study in Rats with 1-Methyl-3-propylimidazole-2-thione (PTI): Effects on the Thyroid , 1995 .

[348]  B. Stuart,et al.  Extrathyroidally mediated changes in circulating thyroid hormone concentrations in the male rat following administration of an experimental oxyacetamide (FOE 5043). , 1995, Toxicology and applied pharmacology.

[349]  A. Brouwer,et al.  Fetal, neonatal, and long-term alterations in hepatic retinoid levels following maternal polychlorinated biphenyl exposure in rats. , 1995, Toxicology and applied pharmacology.

[350]  D. Doerge,et al.  Mechanism-based inactivation of lactoperoxidase and thyroid peroxidase by resorcinol derivatives. , 1994, Biochemistry.

[351]  Abraham Brouwer,et al.  Effects of Dioxins and Polychlorinated Biphenyls on Thyroid Hormone Status of Pregnant Women and Their Infants , 1994, Pediatric Research.

[352]  A. Bergman,et al.  Selective retention of hydroxylated PCB metabolites in blood. , 1994, Environmental health perspectives.

[353]  J. Koeman,et al.  Different competition of thyroxine binding to transthyretin and thyroxine-binding globulin by hydroxy-PCBs, PCDDs and PCDFs. , 1994, European journal of pharmacology.

[354]  T. Visser,et al.  Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats. , 1993, Toxicology and applied pharmacology.

[355]  S. Safe,et al.  Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans with human transthyretin. , 1993, Chemico-biological interactions.

[356]  T. Visser,et al.  Glucuronidation of thyroid hormone by human bilirubin and phenol UDP‐glucuronyltransferase isoenzymes , 1993, FEBS letters.

[357]  D. Craik,et al.  Thyroid hormone uptake by hepatocytes: structure-activity relationships of phenylanthranilic acids with inhibitory activity. , 1993, Journal of medicinal chemistry.

[358]  J. Parma,et al.  The thyrotropin receptor and the regulation of thyrocyte function and growth. , 1992, Endocrine reviews.

[359]  L. Braverman,et al.  Flavonoid administration immediately displaces thyroxine (T4) from serum transthyretin, increases serum free T4, and decreases serum thyrotropin in the rat. , 1990, Endocrinology.

[360]  R. Vranckx,et al.  Thyroxine-binding globulin and thyroxine-binding prealbumin in hypothyroid and hyperthyroid developing rats. , 1989, Biochimica et biophysica acta.

[361]  R. Vranckx,et al.  A thyroxine binding globulin (TBG)-like protein in the sera of developing and adult rats. , 1987, Biochemical and biophysical research communications.

[362]  P. Keng,et al.  Characterization of radiation resistant hypoxic cell subpopulations in KHT sarcomas. (I). Centrifugal elutriation. , 1987, British Journal of Cancer.

[363]  A. Brouwer,et al.  Binding of a metabolite of 3,4,3',4'-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin. , 1986, Toxicology and applied pharmacology.

[364]  V. Cody,et al.  Rat liver iodothyronine monodeiodinase. Evaluation of the iodothyronine ligand-binding site. , 1986, The Journal of biological chemistry.

[365]  S. Amir,et al.  The active principles of plant extracts with antithyrotropic activity: oxidation products of derivatives of 3,4-dihydroxycinnamic acid. , 1985, Endocrinology.

[366]  P. Larsen,et al.  Evidence for two pathways of iodothyronine 5'-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. , 1983, The Journal of clinical investigation.

[367]  R. Cavalieri,et al.  The effects of drugs on the distribution and metabolism of thyroid hormones. , 1981, Pharmacological reviews.

[368]  J. L. Leonard,et al.  Iodothyronine 5'-deiodinase from rat kidney: substrate specificity and the 5'-deiodination of reverse triiodothyronine. , 1980, Endocrinology.

[369]  T. Visser,et al.  Inhibition of iodothyronine 5′‐deiodinase by thioureylenes; Structure‐activity relationship , 1979, FEBS letters.

[370]  S J Oatley,et al.  Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A. , 1977, Journal of molecular biology.

[371]  J. Mauchamp,et al.  [Development of peroxidase activity and organification of iodide in the thyroid gland of Xenopus laevis (Daudin) during metamorphosis]. , 1973, Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles.

[372]  A. Taurog,et al.  Thyroid peroxidase-catalyzed iodination of thyroglobulin; inhibition by excess iodide. , 1970, Archives of biochemistry and biophysics.

[373]  W. Alexander,et al.  Thyroidal Iodide Transport. VIII. Relation Between Transport, Goitrogenic and Antigoitrogenic Properties of Certain Anions , 1966 .

[374]  J. Köhrle,et al.  Tyrosine kinase inhibitors noncompetitively inhibit MCT8-mediated iodothyronine transport. , 2012, The Journal of clinical endocrinology and metabolism.

[375]  Robert J Kavlock,et al.  Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[376]  S. Amiel,et al.  Comprar Oxford Textbook of Endocrinology and Diabetes 2Ed | Melanie C. Davies | 9780199235292 | Oxford University Press , 2011 .

[377]  J. Fisher,et al.  Determination of six thyroid hormones in the brain and thyroid gland using isotope-dilution liquid chromatography/tandem mass spectrometry. , 2011, Analytical chemistry.

[378]  J. E. Silva,et al.  Physiological importance and control of non-shivering facultative thermogenesis. , 2011, Frontiers in bioscience.

[379]  T. Visser,et al.  Molecular aspects of thyroid hormone transporters, including MCT8, MCT10, and OATPs, and the effects of genetic variation in these transporters. , 2010, Journal of molecular endocrinology.

[380]  Y. Ambroise,et al.  A nonradioactive iodide uptake assay for sodium iodide symporter function. , 2010, Analytical biochemistry.

[381]  R. Vasan,et al.  Thyroid function and Alzheimer's disease. , 2009, Journal of Alzheimer's disease : JAD.

[382]  W. Schoonen,et al.  High-throughput screening for analysis of in vitro toxicity. , 2009, EXS.

[383]  P. Calderon,et al.  Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content. , 2008, Endocrinology.

[384]  Y. Kanai,et al.  Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters. , 2008, Journal of pharmacological sciences.

[385]  D. Dix,et al.  The ToxCast program for prioritizing toxicity testing of environmental chemicals. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.

[386]  C. Glass,et al.  Sensors and Signals: a Coactivator/ Corepressor/epigenetic Code for Integrating Signal-dependent Programs of Transcriptional Response , 2006 .

[387]  R. Zoeller,et al.  At the Cutting Edge Environmental chemicals as thyroid hormone analogues : New studies indicate that thyroid hormone receptors are targets of industrial chemicals ? , 2005 .

[388]  J. Smit,et al.  Dietary flavonoids and iodine metabolism. , 2003, BioFactors.

[389]  J. Dumont,et al.  Anion selectivity by the sodium iodide symporter. , 2003, Endocrinology.

[390]  S. Choudhuri,et al.  Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways. , 2002, The Journal of pharmacology and experimental therapeutics.

[391]  J. Köhrle Iodothyronine deiodinases. , 2002, Methods in enzymology.

[392]  H. Rokos,et al.  Different tissue distribution, elimination, and kinetics of thyroxine and its conformational analog, the synthetic flavonoid EMD 49209 in the rat. , 1997, Endocrinology.

[393]  T. Visser,et al.  Pathways of thyroid hormone metabolism. , 1996, Acta medica Austriaca.

[394]  Capen Cc Mechanisms of chemical injury of thyroid gland. , 1994 .

[395]  F. Delange,et al.  The disorders induced by iodine deficiency. , 1994, Thyroid : official journal of the American Thyroid Association.

[396]  M. Gershengorn Thyrotropin-releasing hormone receptor: cloning and regulation of its expression. , 1993, Recent progress in hormone research.

[397]  C. Atterwill,et al.  A comparison of cultured rat FRTL-5 and porcine thyroid cells for predicting the thyroid toxicity of xenobiotics. , 1990, Toxicology in vitro : an international journal published in association with BIBRA.

[398]  W. Traag,et al.  Competitive inhibition of thyroxin binding to transihyretin by monohy-droxy metabolites of 3,4,3',4'-tetrachlorobiphenyl , 1990 .

[399]  K. J. Berg Interaction of chlorinated phenols with thyroxine binding sites of human transthyretin, albumin and thyroid binding globulin. , 1990 .

[400]  J. Himms-Hagen,et al.  Brown adipose tissue thermogenesis and obesity. , 1989, Progress in lipid research.

[401]  D. Mebs,et al.  Toxicity Testing. Strategies to Determine Needs and Priorities: U.S. National Toxicology Program. 382 pp. Washington, DC: National Academy Press (1984) , 1987 .

[402]  Integrin (cid:1) V (cid:2) 3 Contains a Cell Surface Receptor Site for Thyroid Hormone that Is Linked to Activation of Mitogen-Activated Protein Kinase and Induction of Angiogenesis , 2022 .