Characterization of the Phosphorylation Site of GRTH/DDX25 and Protein Kinase A Binding Interface Provides Structural Basis for the Design of a Non-Hormonal Male Contraceptive

[1]  M. Dufau,et al.  Targeted Knock-In Mice with a Human Mutation in GRTH/DDX25 Reveals the Essential Role of Phosphorylated GRTH in Spermatid Development during Spermatogenesis. , 2019, Human molecular genetics.

[2]  H. C. Pant,et al.  Computational study of the inhibitory mechanism of the kinase CDK5 hyperactivity by peptide p5 and derivation of a pharmacophore , 2016, Journal of Computer-Aided Molecular Design.

[3]  D. Frishman,et al.  Sequence- and Structure-Based Analysis of Tissue-Specific Phosphorylation Sites , 2016, PloS one.

[4]  M. Dufau,et al.  Germ Cell Nuclear Factor (GCNF/RTR) Regulates Transcription of Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in Testicular Germ Cells--The Androgen Connection. , 2015, Molecular endocrinology.

[5]  C. Tsai-Morris,et al.  Role of Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) on Polysomal Associated mRNAs in Mouse Testis , 2012, PloS one.

[6]  C. Tsai-Morris,et al.  Androgen-Induced Activation of Gonadotropin-Regulated Testicular RNA Helicase (GRTH/Ddx25) Transcription: Essential Role of a Nonclassical Androgen Response Element Half-Site , 2012, Molecular and Cellular Biology.

[7]  C. Tsai-Morris,et al.  Testis-specific miRNA-469 Up-regulated in Gonadotropin-regulated Testicular RNA Helicase (GRTH/DDX25)-null Mice Silences Transition Protein 2 and Protamine 2 Messages at Sites within Coding Region , 2011, The Journal of Biological Chemistry.

[8]  C. Tsai-Morris,et al.  Gonadotropin-regulated Testicular RNA Helicase (GRTH/DDX25), a Negative Regulator of Luteinizing/Chorionic Gonadotropin Hormone-induced Steroidogenesis in Leydig Cells , 2011, The Journal of Biological Chemistry.

[9]  C. Tsai-Morris,et al.  Relevance of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) in the structural integrity of the chromatoid body during spermatogenesis. , 2010, Biochimica et biophysica acta.

[10]  G. Wessel,et al.  DEAD-box helicases: posttranslational regulation and function. , 2010, Biochemical and biophysical research communications.

[11]  Jianpeng Ma,et al.  CHARMM: The biomolecular simulation program , 2009, J. Comput. Chem..

[12]  J. Weigelt,et al.  The DEXD/H-box RNA Helicase DDX19 Is Regulated by an α-Helical Switch*S⃞ , 2009, Journal of Biological Chemistry.

[13]  C. Basquin,et al.  The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner , 2009, Nature Structural &Molecular Biology.

[14]  C. Tsai-Morris,et al.  Gonadotropin-regulated Testicular Helicase (DDX25), an Essential Regulator of Spermatogenesis, Prevents Testicular Germ Cell Apoptosis* , 2008, Journal of Biological Chemistry.

[15]  Y. Sheng,et al.  Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: a missense mutation associated with loss of GRTH phosphorylation. , 2007, Molecular human reproduction.

[16]  C. Tsai-Morris,et al.  Gonadotropin-regulated testicular helicase (GRTH/DDX25): an essential regulator of spermatogenesis , 2007, Trends in Endocrinology & Metabolism.

[17]  Y. Sheng,et al.  Gonadotropin-regulated Testicular RNA Helicase (GRTH/Ddx25) Is a Transport Protein Involved in Gene-specific mRNA Export and Protein Translation during Spermatogenesis* , 2006, Journal of Biological Chemistry.

[18]  P. Linder.  Dead-box proteins: a family affair—active and passive players in RNP-remodeling , 2006, Nucleic acids research.

[19]  N. Tanner,et al.  The DEAD-box protein family of RNA helicases. , 2006, Gene.

[20]  S. Hassan.  Amino acid side chain interactions in the presence of salts. , 2005, The journal of physical chemistry. B.

[21]  Y. Sheng,et al.  Genomic organization and transcriptional analysis of gonadotropin-regulated testicular RNA helicase--GRTH/DDX25 gene. , 2004, Gene.

[22]  Y. Sheng,et al.  Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is essential for spermatid development and completion of spermatogenesis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Y. Sheng,et al.  Cell-specific and Hormone-regulated Expression of Gonadotropin-regulated Testicular RNA Helicase Gene (GRTH/Ddx25) Resulting from Alternative Utilization of Translation Initiation Codons in the Rat Testis* , 2003, Journal of Biological Chemistry.

[24]  Susan S. Taylor,et al.  Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase , 2002, Nature Structural Biology.

[25]  J. Shabb.  Physiological substrates of cAMP-dependent protein kinase. , 2001, Chemical reviews.

[26]  C. Tsai-Morris,et al.  A Novel Gonadotropin-regulated Testicular RNA Helicase , 1999, The Journal of Biological Chemistry.

[27]  P Linder,et al.  D‐E‐A‐D protein family of putative RNA helicases , 1992, Molecular microbiology.