Gain and Loss of T Cell Subsets in Old Age—Age-Related Reshaping of the T Cell Repertoire
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B. Grubeck‐Loebenstein | J. Wolf | C. R. Arnold | Stefan Brunner | D. Herndler‐Brandstetter | D. Herndler-Brandstetter
[1] B. Grubeck‐Loebenstein,et al. Persistent viral infections and immune aging , 2011, Ageing Research Reviews.
[2] Yan Zhang,et al. Human cytomegalovirus‐specific CD8+ T‐cell expansions contain long‐lived cells that retain functional capacity in both young and elderly subjects , 2011, Immunology.
[3] D. Klionsky,et al. Eaten alive: a history of macroautophagy , 2010, Nature Cell Biology.
[4] G. Holländer,et al. Emerging strategies to boost thymic function. , 2010, Current opinion in pharmacology.
[5] M. Mildner,et al. miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging , 2010, Aging cell.
[6] Kathryn G. Foster,et al. Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony* , 2010, The Journal of Biological Chemistry.
[7] E. Bjørgo,et al. Novel mechanism of signaling by CD28. , 2010, Immunology letters.
[8] Andreas Radbruch,et al. Organization of immunological memory by bone marrow stroma , 2010, Nature Reviews Immunology.
[9] L. Partridge,et al. Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster , 2010, Cell metabolism.
[10] N. Shen,et al. Evidence for microRNA-mediated regulation in rheumatic diseases , 2009, Annals of the rheumatic diseases.
[11] G. Pawelec,et al. Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation. , 2010, Free radical biology & medicine.
[12] Y. Dobashi,et al. Polyamine-rich food decreases age-associated pathology and mortality in aged mice , 2009, Experimental Gerontology.
[13] Frank Sinner,et al. Induction of autophagy by spermidine promotes longevity , 2009, Nature Cell Biology.
[14] T. Brümmendorf,et al. Accelerated Telomere Shortening in Leukocyte Subpopulations of Patients With Coronary Heart Disease: Role of Cytomegalovirus Seropositivity , 2009, Circulation.
[15] P. Debré,et al. Evidence of premature immune aging in patients thymectomized during early childhood. , 2009, The Journal of clinical investigation.
[16] M. V. D. van den Brink,et al. Rejuvenation of the aging T cell compartment. , 2009, Current opinion in immunology.
[17] M. Lindsay,et al. microRNAs and the immune response. , 2008, Trends in immunology.
[18] N. Weng,et al. CD28(-) T cells: their role in the age-associated decline of immune function. , 2009, Trends in immunology.
[19] Beatrix Grubeck-Loebenstein,et al. Vaccination in the elderly: an immunological perspective. , 2009, Trends in immunology.
[20] L. Haynes,et al. Effects of aging on T cell function , 2009, Current Opinion in Immunology.
[21] A. Tee,et al. Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms. , 2009, Cellular signalling.
[22] Scott N. Mueller,et al. High antigen levels are the cause of T cell exhaustion during chronic viral infection , 2009, Proceedings of the National Academy of Sciences.
[23] R. Ahmed,et al. mTOR regulates memory CD8 T cell differentiation , 2009, Nature.
[24] C. Crumpacker,et al. Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure , 2009, PLoS pathogens.
[25] P. Vigne,et al. Strong Dietary Restrictions Protect Drosophila against Anoxia/Reoxygenation Injuries , 2009, PloS one.
[26] R. Würzner,et al. Thymectomy in early childhood: significant alterations of the CD4(+)CD45RA(+)CD62L(+) T cell compartment in later life. , 2009, Clinical immunology.
[27] A. Thiel,et al. Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets. , 2009, Blood.
[28] M. Blackman,et al. Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice1 , 2009, The Journal of Immunology.
[29] Lutfan Lazuardi,et al. Microarray analysis reveals similarity between CD8+CD28− T cells from young and elderly persons, but not of CD8+CD28+ T cells , 2009, Biogerontology.
[30] W. Savino,et al. Can the Immune System Still Be Efficient in the Elderly? An Immunological and Immunoendocrine Therapeutic Perspective , 2008, Neuroimmunomodulation.
[31] A. Ho,et al. Aging of hematopoietic stem cells is regulated by the stem cell niche , 2008, Experimental Gerontology.
[32] G. Shellam,et al. Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells. , 2008, Immunity.
[33] O. Majdic,et al. The capacity of the TNF family members 4‐1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells , 2008, European journal of immunology.
[34] Janko Nikolich- Zcaron,et al. Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections. , 2008 .
[35] R. Kilpatrick,et al. Response to Comment on “Homeostasis of the Naive CD4+ T Cell Compartment during Aging” , 2008, The Journal of Immunology.
[36] W. Parson,et al. Non-regulatory CD8+CD45RO+CD25+ T-lymphocytes may compensate for the loss of antigen-inexperienced CD8+CD45RA+ T-cells in old age , 2008, Biological chemistry.
[37] G. L. Bentz,et al. Human CMV infection of endothelial cells induces an angiogenic response through viral binding to EGF receptor and β1 and β3 integrins , 2008, Proceedings of the National Academy of Sciences.
[38] Sudhir Gupta,et al. CD95-mediated apoptosis in naïve, central and effector memory subsets of CD4+ and CD8+ T cells in aged humans , 2008, Experimental Gerontology.
[39] D. Weiskopf,et al. Biology of immune responses to vaccines in elderly persons. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[40] J. Phair,et al. Homeostasis of the Naive CD4+ T Cell Compartment during Aging1 , 2008, The Journal of Immunology.
[41] J. Nikolich-Žugich. Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections , 2008, Nature Reviews Immunology.
[42] L. Picker,et al. Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates , 2007, Proceedings of the National Academy of Sciences.
[43] Sudhir Gupta,et al. Susceptibility of naïve and subsets of memory T cells to apoptosis via multiple signaling pathways. , 2007, Autoimmunity reviews.
[44] T. Hibi,et al. Exclusive increase of CX3CR1+CD28−CD4+ T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes , 2007, Inflammatory bowel diseases.
[45] A. Lawson,et al. The Loss of Telomerase Activity in Highly Differentiated CD8+CD28−CD27− T Cells Is Associated with Decreased Akt (Ser473) Phosphorylation1 , 2007, The Journal of Immunology.
[46] Irving L. Weissman,et al. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age , 2007, Nature.
[47] Stefano Caserta,et al. Memories are made of this: synergy of T cell receptor and cytokine signals in CD4(+) central memory cell survival. , 2007, Trends in immunology.
[48] A. Trumpp,et al. Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment , 2007, Nature Medicine.
[49] C. Weyand,et al. Aging and T-cell diversity , 2007, Experimental Gerontology.
[50] Matt Kaeberlein,et al. Recent Developments in Yeast Aging , 2007, PLoS genetics.
[51] R. Jacobson,et al. Immunosenescence: role and measurement in influenza vaccine response among the elderly. , 2007, Vaccine.
[52] John T. Chang,et al. Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses , 2007, Science.
[53] L. Herzenberg,et al. Importance of culturing primary lymphocytes at physiological oxygen levels , 2007, Proceedings of the National Academy of Sciences.
[54] Lutfan Lazuardi,et al. Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly. , 2007, Human immunology.
[55] N. Weng,et al. Generation and Growth of CD28nullCD8+ Memory T Cells Mediated by IL-15 and Its Induced Cytokines1 , 2006, The Journal of Immunology.
[56] S. Jameson,et al. The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells , 2006, Nature Immunology.
[57] Myriam Labalette,et al. Accumulation of memory T cells from childhood to old age: Central and effector memory cells in CD4+ versus effector memory and terminally differentiated memory cells in CD8+ compartment , 2006, Mechanisms of Ageing and Development.
[58] Sudhir Gupta,et al. TNF-α-induced apoptosis in human naïve and memory CD8+ T cells in aged humans , 2006, Experimental Gerontology.
[59] Sudhir Gupta,et al. TNF-alpha-induced apoptosis in human naïve and memory CD8+ T cells in aged humans. , 2006, Experimental gerontology.
[60] Arne N. Akbar,et al. Cytomegalovirus-Specific CD4+ T Cells in Healthy Carriers Are Continuously Driven to Replicative Exhaustion1 , 2005, The Journal of Immunology.
[61] I. Messaoudi,et al. Mice and flies and monkeys too: Caloric restriction rejuvenates the aging immune system of non-human primates , 2005, Experimental Gerontology.
[62] Michael Keller,et al. Age-related differences in phenotype and function of CD4+ T cells are due to a phenotypic shift from naive to memory effector CD4+ T cells. , 2005, International immunology.
[63] S. Swain,et al. Homeostasis and the age-associated defect of CD4 T cells. , 2005, Seminars in immunology.
[64] Louis J. Picker,et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects , 2005, The Journal of experimental medicine.
[65] Sudhir Gupta,et al. Life and death of lymphocytes: a role in immunesenescence , 2005, Immunity & Ageing.
[66] Ana Maria Cuervo,et al. Autophagy and Aging: The Importance of Maintaining "Clean" Cells , 2005, Autophagy.
[67] W. Wood,et al. Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T‐cell aging , 2005, Immunological reviews.
[68] M. Pierer,et al. Post‐thymic in vivo proliferation of naive CD4+ T cells constrains the TCR repertoire in healthy human adults , 2005, European journal of immunology.
[69] L. Haynes,et al. The effect of age on the cognate function of CD4+ T cells , 2005, Immunological reviews.
[70] A. Vallejo,et al. The Influence of Age on T Cell Generation and TCR Diversity1 , 2005, The Journal of Immunology.
[71] T. Randall,et al. Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen , 2005, The Journal of experimental medicine.
[72] R. Würzner,et al. Long-Term Cytomegalovirus Infection Leads to Significant Changes in the Composition of the CD8+ T-Cell Repertoire, Which May Be the Basis for an Imbalance in the Cytokine Production Profile in Elderly Persons , 2005, Journal of Virology.
[73] A. Tzankov,et al. Age‐related loss of naïve T cells and dysregulation of T‐cell/B‐cell interactions in human lymph nodes , 2005, Immunology.
[74] Kim L Kusser,et al. Age-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses , 2004, The Journal of experimental medicine.
[75] G. Pawelec,et al. Is immunosenescence infectious? , 2004, Trends in immunology.
[76] S. Benzer,et al. Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway , 2004, Current Biology.
[77] J. Magaud,et al. Autolysosomes accumulate during in vitro CD8+ T-lymphocyte aging and may participate in induced death sensitization of senescent cells , 2004, Experimental Gerontology.
[78] G. Pawelec,et al. Dysfunctional CMV-specific CD8+ T cells accumulate in the elderly , 2004, Experimental Gerontology.
[79] Antonio Lanzavecchia,et al. Central memory and effector memory T cell subsets: function, generation, and maintenance. , 2004, Annual review of immunology.
[80] P. Linton,et al. Age-related changes in lymphocyte development and function , 2004, Nature Immunology.
[81] S. Rowland-Jones,et al. Functional Discrepancies in HIV-Specific CD8+ T-Lymphocyte Populations Are Related to Plasma Virus Load , 2002, Journal of Clinical Immunology.
[82] R. Aspinall,et al. Thymic Involution in Aging , 2000, Journal of Clinical Immunology.
[83] Richard A. Miller,et al. Age‐related defects in CD4+ T cell activation reversed by glycoprotein endopeptidase , 2003, European journal of immunology.
[84] T. Randall,et al. CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[85] P. Klenerman,et al. Memory Inflation: Continous Accumulation of Antiviral CD8+ T Cells Over Time , 2003, The Journal of Immunology.
[86] R. V. van Lier,et al. IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro. , 2003, Blood.
[87] R. Ahmed,et al. Similarities and differences in CD4+ and CD8+ effector and memory T cell generation , 2003, Nature Immunology.
[88] G. Ridgway,et al. Human Cytomegalovirus Seropositivity Is Associated With Impaired Vascular Function , 2003, Circulation.
[89] F. Sallusto,et al. Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines. , 2003, Blood.
[90] P. Klenerman,et al. Regulation of the Class II MHC Pathway in Primary Human Monocytes by Granulocyte-Macrophage Colony-Stimulating Factor 1 , 2003, The Journal of Immunology.
[91] A. Wolf,et al. IL-4-Producing CD8+ T Cells with a CD62L++(bright) Phenotype Accumulate in a Subgroup of Older Adults and Are Associated with the Maintenance of Intact Humoral Immunity in Old Age1 , 2003, The Journal of Immunology.
[92] R. Effros,et al. CD8 T cells and aging. , 2003, Critical reviews in immunology.
[93] Richard A. Miller,et al. Age-Dependent Defects in TCR-Triggered Cytoskeletal Rearrangement in CD4+ T Cells1 , 2002, The Journal of Immunology.
[94] Walther Parson,et al. Lack of Antibody Production Following Immunization in Old Age: Association with CD8+CD28− T Cell Clonal Expansions and an Imbalance in the Production of Th1 and Th2 Cytokines1 , 2002, The Journal of Immunology.
[95] Jianzhu Chen,et al. Naïve to memory T-cell differentiation during homeostasis-driven proliferation. , 2002, Microbes and infection.
[96] D. Richman,et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections , 2002, Nature Medicine.
[97] S. Kostense,et al. Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-gamma+ HIV-specific T cells during progression to AIDS. , 2002, Blood.
[98] K. Pfeiffer,et al. Circulating cytotoxic CD8+ CD28- T cells in ankylosing spondylitis , 2001, Arthritis research.
[99] J. Sprent,et al. Regulation of naïve and memory T-cell homeostasis. , 2002, Microbes and infection.
[100] M. Sitkovsky,et al. Differential Effects of Physiologically Relevant Hypoxic Conditions on T Lymphocyte Development and Effector Functions , 2001, The Journal of Immunology.
[101] Richard Murray,et al. IL-7 is critical for homeostatic proliferation and survival of naïve T cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[102] S. Blankenberg,et al. Cytomegalovirus Infection With Interleukin-6 Response Predicts Cardiac Mortality in Patients With Coronary Artery Disease , 2001, Circulation.
[103] B. Walker,et al. Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus , 2001, Journal of Virology.
[104] S. Jameson,et al. Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo , 2000, Nature Immunology.
[105] J. Lieberman,et al. Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection. , 2000, Blood.
[106] M. Salmon,et al. Loss of CD28 expression on CD8(+) T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis. , 2000, International immunology.
[107] A. Oxenius,et al. Cytotoxic T Lymphocyte Responses to Human Immunodeficiency Virus: Control and Escape , 2000, Stem cells.
[108] C. Franceschi,et al. Inflamm‐aging: An Evolutionary Perspective on Immunosenescence , 2000 .
[109] C. Franceschi,et al. Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging. , 2000, Blood.
[110] R. Miller,et al. Age-related decline in activation of JNK by TCR- and CD28-mediated signals in murine T-lymphocytes. , 1999, Cellular immunology.
[111] S. Swain,et al. Interleukin 2, but Not Other Common γ Chain–Binding Cytokines, Can Reverse the Defect in Generation of Cd4 Effector T Cells from Naive T Cells of Aged Mice , 1999, The Journal of experimental medicine.
[112] K. Bottomly,et al. Survival of naive CD4 T cells: roles of restricting versus selecting MHC class II and cytokine milieu. , 1999, Journal of immunology.
[113] Louis J. Picker,et al. Changes in thymic function with age and during the treatment of HIV infection , 1998, Nature.
[114] R. Miller,et al. Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: effect of age. , 1998, Cellular immunology.
[115] B. Grubeck‐Loebenstein,et al. No immunity for the elderly , 1998, Nature Medicine.
[116] S. Stenglein,et al. Human Cytomegalovirus Persistently Infects Aortic Endothelial Cells , 1998, Journal of Virology.
[117] Y. Barnett,et al. DNA damage and mutation: contributors to the age-related alterations in T cell-mediated immune responses? , 1998, Mechanisms of Ageing and Development.
[118] A. Vallejo,et al. Aging-related Deficiency of CD28 Expression in CD4+ T Cells Is Associated with the Loss of Gene-specific Nuclear Factor Binding Activity* , 1998, The Journal of Biological Chemistry.
[119] C. Kirk,et al. Early activation defects in T lymphocytes from aged mice , 1997, Immunological reviews.
[120] M. Daucher,et al. Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[121] S. Swain,et al. Antigen-independent changes in naive CD4 T cells with aging , 1996, The Journal of experimental medicine.
[122] C. Franceschi,et al. Expansion of cytotoxic CD8+ CD28− T cells in healthy ageing people, including centenarians , 1996, Immunology.
[123] M. Ritter,et al. Thymic involution with ageing: obsolescence or good housekeeping? , 1996, Immunology today.
[124] H. Ostrer,et al. Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. , 1996, Journal of immunology.
[125] C. Weyand,et al. CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. , 1996, The Journal of clinical investigation.
[126] T. Stulnig,et al. Altered switch in lipid composition during T-cell blast transformation in the healthy elderly. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.
[127] Qingbo Xu,et al. Correlation of lymphocyte lipid composition membrane microviscosity and mitogen response in the aged , 1991, European journal of immunology.
[128] G. Steinmann. Changes in the human thymus during aging. , 1986, Current topics in pathology. Ergebnisse der Pathologie.