Primary cutaneous aspergillosis in neonates: case report and review.

A premature neonate (gestational age, 26 weeks) with multiple prematurity-related problems developed primary cutaneous aspergillosis due to Aspergillus fumigatus on the 30th day of life. The infection developed in an area that had been macerated by adhesive tape. During the infection, renovation of the hospital was in progress near the neonatal intensive care unit. The infection was cured with a short course of therapy with amphotericin B. Five cases of primary cutaneous aspergillosis in neonates have been previously reported in the English-language literature. We review these cases and discuss the risk factors and favorable outcome of the disease when treatment with amphotericin B is instituted.

[1]  R. Schneider,et al.  Invasive Aspergillus infections in a pediatric hospital: a ten‐year review , 1993, The Pediatric infectious disease journal.

[2]  C. Beck-Sague,et al.  Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. National Nosocomial Infections Surveillance System. , 1993, The Journal of infectious diseases.

[3]  M. Edwards,et al.  Invasive aspergillosis in neonates: report of five cases and literature review , 1992, The Pediatric Infectious Disease Journal.

[4]  R. Faix.  Invasive neonatal candidiasis: comparison of albicans and parapsilosis infection. , 1992, The Pediatric infectious disease journal.

[5]  D. Denning,et al.  Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases. , 1990, Reviews of infectious diseases.

[6]  T. Walsh,et al.  Invasive pulmonary aspergillosis in patients with neoplastic diseases. , 1990, Seminars in respiratory infections.

[7]  M. Cairo.  Neonatal neutrophil host defense. Prospects for immunologic enhancement during neonatal sepsis. , 1989, American journal of diseases of children.

[8]  D. Schwartz,et al.  Disseminated neonatal aspergillosis: report of a fatal case and analysis of risk factors , 1988, The Pediatric infectious disease journal.

[9]  J. Miller,et al.  Primary cutaneous aspergillosis associated with Hickman intravenous catheters. , 1987, The New England journal of medicine.

[10]  H. Hill,et al.  Defective oxidative metabolic responses of neutrophils from stressed neonates. , 1981, The Journal of pediatrics.

[11]  A. Sober,et al.  Primary cutaneous aspergillosis in a premature neonate , 1980, The British journal of dermatology.

[12]  D. Anderson,et al.  Leukocyte function in normal and infected neonates. , 1974, The Journal of pediatrics.