The relationship between CD5-expressing B lymphocytes and serologic abnormalities in rheumatoid arthritis patients and their relatives.

The influence of genetic factors on the expression of CD5+ B lymphocytes and their relationship to a broad spectrum of autoantibodies was investigated in a study of 12 patients with rheumatoid arthritis (RA) and 52 of their healthy first-degree relatives. The proportion of CD5+ B cells was significantly higher in RA patients (mean +/- SEM 23.9 +/- 2.7%) compared with that in their relatives (18.3 +/- 1.1%, P less than 0.05) and compared with that in a group of healthy control subjects (16.1 +/- 1.8%; P less than 0.05). Much more striking, however, were the high levels of CD5+ B cells found in the patients and their relatives in 5 of the families studied. Increases in total immunoglobulin levels and autoantibody levels were frequently observed in RA patients (approximately 20-40%) and their relatives (approximately 10-20%). Furthermore, a statistically significant correlation (P less than 0.01) between IgM rheumatoid factor and the percentage of B lymphocytes expressing CD5 was observed.

[1]  D. Isenberg,et al.  Serological abnormalities, including common idiotype PR4, in families with rheumatoid arthritis. , 1989, Annals of the rheumatic diseases.

[2]  S. Muller,et al.  Reactivity of autoantibodies in systemic lupus erythematosus with synthetic core histone peptides. , 1989, International archives of allergy and applied immunology.

[3]  P. Casali,et al.  Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis , 1988, The Journal of experimental medicine.

[4]  P. Lydyard,et al.  Chronic lymphocytic leukemic (CLL) cells secrete multispecific autoantibodies. , 1988, Journal of autoimmunity.

[5]  S. Muller,et al.  The double reactivity of a human monoclonal rheumatoid factor to IgG and histones is related to distinct binding sites , 1988, European journal of immunology.

[6]  N. Talal,et al.  B cells expressing CD5 are increased in Sjögren's syndrome. , 1988, Arthritis and rheumatism.

[7]  P. Lydyard,et al.  CD5-expressing B lymphocytes in the blood and salivary glands of patients with primary Sjögren's syndrome. , 1988, Journal of autoimmunity.

[8]  M. Liang,et al.  The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. , 1988, Arthritis and rheumatism.

[9]  K. Okumura,et al.  Leu-1(CD5) B cell subpopulation in patients with various liver diseases--special reference to hepatitis B virus carrier and to changes caused by prednisolone therapy. , 1988, International archives of allergy and applied immunology.

[10]  L. Mackenzie,et al.  The importance of CD5-positive B cells in nonorgan-specific autoimmune diseases. , 1988, Scandinavian journal of rheumatology. Supplement.

[11]  S. Muller,et al.  Human antinuclear autoantibodies crossreacting with the plasma membrane and the N-terminal region of histone H2B. , 1987, Immunological investigations.

[12]  T. Kipps,et al.  Genetic influence on the levels of circulating CD5 B lymphocytes. , 1987, Journal of immunology.

[13]  R. Maini,et al.  Autoimmunity in rheumatoid arthritis. An approach via a study of B lymphocytes. , 1987, Rheumatic diseases clinics of North America.

[14]  D. Grennan,et al.  Immunoglobulin lambda light chain genes in rheumatoid arthritis. , 1987, Annals of the rheumatic diseases.

[15]  K. Merétey,et al.  Study of autoantibodies, natural antibodies and IgE level in four families with rheumatoid arthritis. , 1987, Zeitschrift fur Rheumatologie.

[16]  R. Hardy,et al.  Rheumatoid factor secretion from human Leu-1+ B cells. , 1987, Science.

[17]  G. Inghirami,et al.  Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset. , 1987, Science.

[18]  P. Youinou,et al.  CD5 positive B cells in patients with rheumatoid arthritis: phorbol ester mediated enhancement of detection. , 1987, Annals of the rheumatic diseases.

[19]  A. Cooke,et al.  CD5-positive B cells in rheumatoid arthritis and chronic lymphocytic leukemia. , 1987, Immunology today.

[20]  R. Hardy,et al.  Development and Physiology of LY‐1 B and its Human Homolog, LEU‐1 B , 1986, Immunological reviews.

[21]  A. Silman,et al.  HLA and rheumatoid arthritis: a combined analysis of 440 British patients. , 1986, Annals of the rheumatic diseases.

[22]  S. Muller,et al.  Comparison of different methods for localizing antigenic regions in histone H2A. , 1986, Molecular immunology.

[23]  R. Hardy,et al.  Peritoneal Ly‐1 B cells: Genetic control, autoantibody production, increased lambda light chain expression , 1986, European journal of immunology.

[24]  G. Janossy,et al.  A rheumatoid arthritis B cell subset expresses a phenotype similar to that in chronic lymphocytic leukemia. , 1985, Arthritis and rheumatism.

[25]  P. Sautière,et al.  Antigenic structure of histone H2B. , 1985, Biochimica et biophysica acta.

[26]  R. Hardy,et al.  Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[27]  M. Dorf,et al.  An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants , 1984, The Journal of experimental medicine.

[28]  J. Braun Spontaneous in vitro occurrence and long-term culture of murine B lymphoblast cell lines. , 1983, Journal of immunology.

[29]  P. Youinou,et al.  Relationship between rheumatoid arthritis and monoclonal gammopathy. , 1983, The Journal of rheumatology.

[30]  R. Hardy,et al.  The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice , 1983, The Journal of experimental medicine.

[31]  K. Hayakawa,et al.  Cell-to-cell interaction controlled by immunoglobulin genes. Role of Thy-1-, Lyt-1+, Ig+ (B') cell in allotype-restricted antibody production , 1982, The Journal of experimental medicine.

[32]  R. Schwartz,et al.  Production of autoantibodies by human-human hybridomas. , 1982, The Journal of clinical investigation.

[33]  A. Chiarandini,et al.  Immunofixation: application to the identification of "difficult" monoclonal components. , 1982, Clinical chemistry.

[34]  D. Wilson,et al.  Incidence of gamma-globulin banding in a healthy population by high-resolution electrophoresis. , 1982, Clinical chemistry.

[35]  M. Gobbi,et al.  Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia , 1982, The Journal of experimental medicine.

[36]  E. Tan,et al.  Evidence for a subset of rheumatoid factors that cross-react with DNA- histone and have a distinct cross-idiotype , 1980, The Journal of experimental medicine.

[37]  J. Ott,et al.  Familial rheumatoid arthritis: linkage of HLA to disease susceptibility locus in four families where proband presented with juvenile rheumatoid arthritis. , 1980, The Journal of clinical investigation.

[38]  P. Stastny Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. , 1978, The New England journal of medicine.

[39]  Y. Kan,et al.  Diagnosis of Homozygous α-Thalassemia in Cultured Amniotic-Fluid Fibroblasts , 1978 .

[40]  D. Carson,et al.  Radioimmunoassay of IgG and IgM rheumatoid factors reacting with human IgG. , 1977, Journal of immunology.

[41]  H. Mcdevitt,et al.  Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis. , 1977, Arthritis and rheumatism.