Insulin's microvascular vasodilatory effects are inversely related to peripheral vascular resistance in overweight, but insulin‐sensitive subjects

The mechanisms underlying obesity‐related hypertension are incompletely understood. Microvascular dysfunction might play a role by increasing peripheral vascular resistance (PVR). Metabolic and microvascular effects of insulin are impaired in obesity, but how these impairments contribute to disturbed blood pressure homeostasis is unclear. Specifically, it is unknown whether local microvascular vasoactive effects of insulin play a role in determining systemic vascular resistance. The aim of this study was to investigate the association between PVR and local microvascular effects of insulin.

[1]  K. Flegal,et al.  Prevalence and trends in obesity among US adults, 1999-2008. , 2010, JAMA.

[2]  Eric Vicaut,et al.  Impaired Tissue Perfusion: A Pathology Common to Hypertension, Obesity, and Diabetes Mellitus , 2008, Circulation.

[3]  C. Stehouwer,et al.  Impaired local microvascular vasodilatory effects of insulin and reduced skin microvascular vasomotion in obese women. , 2008, Microvascular research.

[4]  N. Westerhof,et al.  Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (fa/fa) rats. , 2007, American journal of physiology. Endocrinology and metabolism.

[5]  C. Stehouwer,et al.  Microvascular dysfunction in obesity: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension. , 2007, Physiology.

[6]  C. Stehouwer,et al.  Microvascular dysfunction: a potential pathophysiological role in the metabolic syndrome. , 2007, Hypertension.

[7]  E. Barrett,et al.  Obesity Blunts Insulin-Mediated Microvascular Recruitment in Human Forearm Muscle , 2006, Diabetes.

[8]  M. Quon,et al.  Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: Molecular and Pathophysiological Mechanisms , 2006, Circulation.

[9]  Y. Smulders,et al.  Cardiac Output Measurement by Pulse Dye Densitometry: Comparison with Pulmonary Artery Thermodilution in Post-Cardiac Surgery Patients , 2005, Journal of Clinical Monitoring and Computing.

[10]  Jacob Seidell1.  Epidemiology of Obesity , 2005, Seminars in vascular medicine.

[11]  C. Stehouwer,et al.  Impaired Microvascular Function in Obesity: Implications for Obesity-Associated Microangiopathy, Hypertension, and Insulin Resistance , 2004, Circulation.

[12]  J. Panza,et al.  Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients. , 2003, Hypertension.

[13]  N. Westerhof,et al.  Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles. , 2002, Cardiovascular research.

[14]  J. Panza,et al.  Increased Activity of Endogenous Endothelin in Patients With Type II Diabetes Mellitus , 2002, Circulation.

[15]  Ralph B D'Agostino,et al.  Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. , 2002, Archives of internal medicine.

[16]  Daniel W. Jones,et al.  Mechanisms of obesity-associated cardiovascular and renal disease. , 2002, The American journal of the medical sciences.

[17]  J. Montani,et al.  Pathways from obesity to hypertension: from the perspective of a vicious triangle , 2002, International Journal of Obesity.

[18]  W. Haynes,et al.  Impaired skeletal muscle and skin microcirculatory function in human obesity , 2002, Journal of hypertension.

[19]  Reinder Evertz,et al.  Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia. , 2002, Diabetes.

[20]  A. Pries,et al.  Microcirculation in Hypertension: A New Target for Treatment? , 2001, Circulation.

[21]  M. Quon,et al.  Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. , 2000, Circulation.

[22]  M. Quon,et al.  Insulin stimulates both endothelin and nitric oxide activity in the human forearm. , 1999, Circulation.

[23]  D. Seals,et al.  Neural mechanisms in human obesity-related hypertension. , 1999, Journal of hypertension.

[24]  J. T. ter Maaten,et al.  Microvascular function relates to insulin sensitivity and blood pressure in normal subjects. , 1999, Circulation.

[25]  D. Webb,et al.  Studies with iontophoretic administration of drugs to human dermal vessels in vivo: cholinergic vasodilatation is mediated by dilator prostanoids rather than nitric oxide. , 1998, British journal of clinical pharmacology.

[26]  J J Belch,et al.  Cutaneous Vascular Responses to Acetylcholine are Mediated by a Prostanoid-Dependent Mechanism in Man , 1997, Vascular medicine.

[27]  A C Shore,et al.  Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure. , 1997, The Journal of clinical investigation.

[28]  Masayoshi Fuse,et al.  Cardiac output and circulating blood volume analysis by pulse dye-densitometry , 1997, Journal of Clinical Monitoring.

[29]  A C Shore,et al.  Skin blood flow responses to the iontophoresis of acetylcholine and sodium nitroprusside in man: possible mechanisms. , 1996, The Journal of physiology.

[30]  M. Elam,et al.  Insulin increases forearm vascular resistance in obese, insulin‐resistant hypertensives , 1996, Journal of hypertension.

[31]  B. Trimarco,et al.  Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats. , 1995, Hypertension.

[32]  J. Hall,et al.  Hemodynamic and renal responses to chronic hyperinsulinemia in obese, insulin-resistant dogs. , 1995, Hypertension.

[33]  A. Baron,et al.  Hemodynamic actions of insulin. , 1994, The American journal of physiology.

[34]  P. Vollenweider,et al.  Effects of adrenergic and cholinergic blockade on insulin-induced stimulation of calf blood flow in humans. , 1994, The American journal of physiology.

[35]  A. Baron,et al.  Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure. , 1993, Hypertension.

[36]  J. Hall,et al.  The hemodynamic response to chronic hyperinsulinemia in conscious dogs. , 1991, American journal of hypertension.

[37]  E A Anderson,et al.  Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. , 1991, The Journal of clinical investigation.

[38]  A C Guyton,et al.  The relationship of cardiac output and arterial pressure control. , 1981, Circulation.

[39]  J. T. ter Maaten,et al.  Capillary recruitment is impaired in essential hypertension and relates to insulin's metabolic and vascular actions. , 2001, Cardiovascular research.

[40]  G. Schmid-Schönbein,et al.  Penetration of the systemic blood pressure into the microvasculature of rat skeletal muscle. , 1991, Microvascular research.