Polyp Morphology: An Interobserver Evaluation for the Paris Classification Among International Experts

OBJECTIVES:The Paris classification is an international classification system for describing polyp morphology. Thus far, the validity and reproducibility of this classification have not been assessed. We aimed to determine the interobserver agreement for the Paris classification among seven Western expert endoscopists.METHODS:A total of 85 short endoscopic video clips depicting polyps were created and assessed by seven expert endoscopists according to the Paris classification. After a digital training module, the same 85 polyps were assessed again. We calculated the interobserver agreement with a Fleiss kappa and as the proportion of pairwise agreement.RESULTS:The interobserver agreement of the Paris classification among seven experts was moderate with a Fleiss kappa of 0.42 and a mean pairwise agreement of 67%. The proportion of lesions assessed as “flat” by the experts ranged between 13 and 40% (P<0.001). After the digital training, the interobserver agreement did not change (kappa 0.38, pairwise agreement 60%).CONCLUSIONS:Our study is the first to validate the Paris classification for polyp morphology. We demonstrated only a moderate interobserver agreement among international Western experts for this classification system. Our data suggest that, in its current version, the use of this classification system in daily practice is questionable and it is unsuitable for comparative endoscopic research. We therefore suggest introduction of a simplification of the classification system.

[1]  D. Altman,et al.  Reliability and initial validation of the ulcerative colitis endoscopic index of severity. , 2013, Gastroenterology.

[2]  E. Kuipers,et al.  Adenoma detection with cap-assisted colonoscopy versus regular colonoscopy: a randomised controlled trial , 2011, Gut.

[3]  Aeilko H. Zwinderman,et al.  Polyp measurement based on CT colonography and colonoscopy: variability and systematic differences , 2009, European Radiology.

[4]  L. Boenicke,et al.  The concurrence of histologically positive resection margins and sessile morphology is an important risk factor for lymph node metastasis after complete endoscopic removal of malignant colorectal polyps , 2010, International Journal of Colorectal Disease.

[5]  Paul Fockens,et al.  Participation and yield of colonoscopy versus non-cathartic CT colonography in population-based screening for colorectal cancer: a randomised controlled trial. , 2012, The Lancet. Oncology.

[6]  Y. Nakanishi,et al.  Predictive Histopathologic Factors for Lymph Node Metastasis in Patients With Nonpedunculated Submucosal Invasive Colorectal Carcinoma , 2005, Diseases of the colon and rectum.

[7]  L. Rabeneck,et al.  Association of Colonoscopy and Death From Colorectal Cancer , 2009, Annals of Internal Medicine.

[8]  Harminder Singh,et al.  Risk of developing colorectal cancer following a negative colonoscopy examination: evidence for a 10-year interval between colonoscopies. , 2006, JAMA.

[9]  A. Zauber,et al.  Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. , 2012, The New England journal of medicine.

[10]  Charles J. Lightdale,et al.  Update on the Paris Classification of Superficial Neoplastic Lesions in the Digestive Tract , 2005, Endoscopy.

[11]  Charles J. Lightdale,et al.  The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002. , 2003, Gastrointestinal endoscopy.

[12]  Sarah K. McGill,et al.  Proficiency in the Diagnosis of Nonpolypoid Colorectal Neoplasm Yields High Adenoma Detection Rates , 2012, Digestive Diseases and Sciences.

[13]  Paul Fockens,et al.  Accuracy for optical diagnosis of small colorectal polyps in nonacademic settings. , 2012, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[14]  T. Gotoda,et al.  Endoscopic indications for endoscopic mucosal resection of laterally spreading tumours in the colorectum , 2006, Gut.

[15]  Steven Brown,et al.  A prospective clinicopathological and endoscopic evaluation of flat and depressed colorectal lesions in the United Kingdom , 2003, American Journal of Gastroenterology.

[16]  J. R. Landis,et al.  The measurement of observer agreement for categorical data. , 1977, Biometrics.

[17]  E. Kuipers,et al.  protocolStudy protocol : population screening for colorectal cancer by colonoscopy or CT colonography : a randomized controlled trial , 2010 .

[18]  B. Veress,et al.  Flat and depressed colorectal tumours in a southern Swedish population: a prospective chromoendoscopic and histopathological study , 2002, Gut.

[19]  Shinji Tanaka,et al.  Nonpolypoid (flat and depressed) colorectal neoplasms. , 2006, Gastroenterology.

[20]  Silvia Sanduleanu,et al.  Development of expertise in the detection and classification of non-polypoid colorectal neoplasia: Experience-based data at an academic GI unit. , 2010, Gastrointestinal endoscopy clinics of North America.

[21]  Bjorn Winkens,et al.  Postcolonoscopy colorectal cancers are preventable: a population-based study , 2013, Gut.

[22]  S. Nivatvongs Surgical management of malignant colorectal polyps. , 2002, The Surgical clinics of North America.

[23]  E. Kuipers,et al.  Features of adenoma and colonoscopy associated with recurrent colorectal neoplasia based on a large community-based study. , 2013, Gastroenterology.

[24]  H. Brenner,et al.  Interval cancers after negative colonoscopy: population-based case-control study , 2011, Gut.

[25]  P. Rutgeerts,et al.  The role of centralized reading of endoscopy in a randomized controlled trial of mesalamine for ulcerative colitis. , 2013, Gastroenterology.

[26]  T. Fujii,et al.  Flat and depressed colonic neoplasms: a prospective study of 1000 colonoscopies in the UK , 2000, The Lancet.

[27]  R. Soetikno,et al.  Endoscopic appearance of proximal colorectal neoplasms and potential implications for colonoscopy in cancer prevention. , 2012, Gastrointestinal endoscopy.

[28]  R. Haggitt,et al.  Prognostic factors in colorectal carcinomas arising in adenomas: implications for lesions removed by endoscopic polypectomy. , 1985, Gastroenterology.

[29]  Noriko Suzuki,et al.  Optical diagnosis of small colorectal polyps at routine colonoscopy (Detect InSpect ChAracterise Resect and Discard; DISCARD trial): a prospective cohort study. , 2009, The Lancet. Oncology.

[30]  S. Cross,et al.  A prospective clinicopathological and endoscopic evaluation of flat and depressed colorectal lesions in the United Kingdom. , 2003 .

[31]  D. Altman,et al.  Translational Gastroenterology , 2011 .

[32]  K. Togashi,et al.  Predictive factors for lymph node metastasis in t1 stage colorectal Carcinomas , 2003, Diseases of the colon and rectum.

[33]  Shinji Tanaka,et al.  Endoscopic prediction of deep submucosal invasive carcinoma: validation of the narrow-band imaging international colorectal endoscopic (NICE) classification. , 2013, Gastrointestinal endoscopy.

[34]  Linda Rabeneck,et al.  Rates of new or missed colorectal cancers after colonoscopy and their risk factors: a population-based analysis. , 2007, Gastroenterology.

[35]  H. Pohl,et al.  Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study. , 2013, Gastroenterology.

[36]  A. Rastogi,et al.  Prevalence of advanced histological features in diminutive and small colon polyps. , 2012, Gastrointestinal endoscopy.

[37]  Walter Park,et al.  Prevalence of nonpolypoid (flat and depressed) colorectal neoplasms in asymptomatic and symptomatic adults. , 2008, JAMA.