In Vitro Effects of Spectinomycin and Ceftriaxone Alone or in Combination with Other Antibiotics against Chlamydia trachomatis

ABSTRACT The in vitro effects of spectinomycin and ceftriaxone, alone or in combination with erythromycin, ofloxacin, and doxycycline, against Chlamydia trachomatis were investigated by the checkerboard method and compared by Ridit (reference identical unit) analysis. A combination of spectinomycin with erythromycin or doxycycline was found to be more effective than that of ceftriaxone.

[1]  K. Workowski,et al.  Sexually transmitted diseases treatment guidelines, 2015. , 2015, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[2]  A. Stucki,et al.  Ceftriaxone acts synergistically with levofloxacin in experimental meningitis and reduces levofloxacin-induced resistance in penicillin-resistant pneumococci. , 2004, The Journal of antimicrobial chemotherapy.

[3]  Thomas Gift,et al.  A Cost-Effectiveness Evaluation of Testing and Treatment of Chlamydia trachomatis Infection Among Asymptomatic Women Infected With Neisseria gonorrhoeae , 2002, Sexually transmitted diseases.

[4]  P. Allan,et al.  A retrospective study of the clinical effectiveness of the treatment of genital co-infection with N. gonorrhoeae and C. trachomatis in Coventry , 2002, International journal of STD & AIDS.

[5]  J. Meis,et al.  Comparison of Fractional Inhibitory Concentration Index with Response Surface Modeling for Characterization of In Vitro Interaction of Antifungals against Itraconazole-Susceptible and -Resistant Aspergillus fumigatus Isolates , 2002, Antimicrobial Agents and Chemotherapy.

[6]  A. Eley,et al.  Antimicrobial Susceptibility Testing ofChlamydia trachomatis Using a Reverse Transcriptase PCR-Based Method , 1999, Antimicrobial Agents and Chemotherapy.

[7]  A. Nagayama,et al.  Minimum Inhibitory and Minimal Lethal Concentration against Chlamydia trachomatis Dependent on the Time of Addition and the Duration of the Presence of Antibiotics , 1999, Chemotherapy.

[8]  E. Nagy,et al.  Investigation of the synergic effects of aminoglycoside-fluoroquinolone and third-generation cephalosporin combinations against clinical isolates of Pseudomonas spp. , 1999, The Journal of antimicrobial chemotherapy.

[9]  D. Levy,et al.  Surveillance for waterborne-disease outbreaks--United States, 1995-1996. , 1998, MMWR. CDC surveillance summaries : Morbidity and mortality weekly report. CDC surveillance summaries.

[10]  W. Sermeus,et al.  Ridit Analysis on Ordinal Data , 1996, Western journal of nursing research.

[11]  A K Highsmith,et al.  Surveillance for waterborne disease outbreaks--United States, 1991-1992. , 1993, MMWR. CDC surveillance summaries : Morbidity and mortality weekly report. CDC surveillance summaries.

[12]  E. Frost,et al.  Typing Chlamydia trachomatis by detection of restriction fragment length polymorphism in the gene encoding the major outer membrane protein. , 1991, The Journal of infectious diseases.

[13]  J. Covino,et al.  Comparison of ofloxacin and ceftriaxone in the treatment of uncomplicated gonorrhea caused by penicillinase-producing and non-penicillinase-producing strains , 1990, Antimicrobial Agents and Chemotherapy.

[14]  B. Romanowski,et al.  In vitro activities of lomefloxacin, tetracycline, penicillin, spectinomycin, and ceftriaxone against Neisseria gonorrhoeae and Chlamydia trachomatis , 1989, Antimicrobial Agents and Chemotherapy.

[15]  G. Burrows,et al.  In Vitro Assessment of the Efficacy of Erythromycin in Combination with Oxytetracycline or Spectinomycin against Pasteurella Haemolytica , 1989, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

[16]  A. Barry Standardization of antimicrobial susceptibility testing. , 1989, Clinics in laboratory medicine.

[17]  F. Judson,et al.  Susceptibility testing of Chlamydia trachomatis: from eggs to monoclonal antibodies , 1988, Antimicrobial Agents and Chemotherapy.

[18]  H. Handsfield,et al.  Comparative study of ceftriaxone and spectinomycin in the treatment of uncomplicated gonorrhea in women. , 1984, The American journal of medicine.

[19]  M. Hammerschlag,et al.  In Vitro Activity of a Group of Broad-Spectrum Cephalosporins and Other β-Lactam Antibiotics Against Chlamydia trachomatis , 1983, Antimicrobial Agents and Chemotherapy.

[20]  M. Hammerschlag,et al.  In vitro activity of a group of broad-spectrum cephalosporins and other beta-lactam antibiotics against Chlamydia trachomatis , 1983, Antimicrobial Agents and Chemotherapy.

[21]  V. Lorian Antibiotics in laboratory medicine , 2005 .

[22]  N. Shishkov,et al.  [Possible synergic action of some drug combinations against Mycoplasma gallisepticum]. , 1975, Veterinarno-meditsinski nauki.

[23]  J. Ruiloba [Antimicrobial combinations]. , 1972, Gaceta medica de Mexico.