Fiber optic probes for biomedical optical spectroscopy.

Fiber optic probes are a key element for biomedical spectroscopic sensing. We review the use of fiber optic probes for optical spectroscopy, focusing on applications in turbid media, such as tissue. The design of probes for reflectance, polarized reflectance, fluorescence, and Raman spectroscopy is illustrated. We cover universal design principles as well as technologies for beam deflecting and reshaping.

[1]  M. Nichols,et al.  Design and testing of a white-light, steady-state diffuse reflectance spectrometer for determination of optical properties of highly scattering systems. , 1997, Applied optics.

[2]  N. Nishioka,et al.  Colonic polyp differentiation using time-resolved autofluorescence spectroscopy. , 1998, Gastrointestinal endoscopy.

[3]  I J Bigio,et al.  Measuring absorption coefficients in small volumes of highly scattering media: source-detector separations for which path lengths do not depend on scattering properties. , 1997, Applied optics.

[4]  R. Rava,et al.  SPECTROSCOPIC DIAGNOSIS OF COLONIC DYSPLASIA , 1991, Photochemistry and photobiology.

[5]  R. Alfano,et al.  Laser induced fluorescence spectroscopy from native cancerous and normal tissue , 1984 .

[6]  I Itzkan,et al.  Mathematical model of fluorescence endoscopic image formation. , 1998, Applied optics.

[7]  M Motamedi,et al.  Evaluation of spectral correction techniques for fluorescence measurements on pigmented lesions in vivo. , 1996, Journal of photochemistry and photobiology. B, Biology.

[8]  Shuming Nie,et al.  Rapid noninvasive optical characterization of the human lens , 1994 .

[9]  A H Kaye,et al.  Photodynamic therapy of brain tumours. , 1993, Annals of the Academy of Medicine, Singapore.

[10]  Linda T. Nieman,et al.  Fiber optic probe for polarized reflectance spectroscopy in vivo: design and performance. , 2002, Journal of biomedical optics.

[11]  Y. Yazdi,et al.  Monte Carlo fluorescence verification of experimental results for the combined ultrasonic and spectroscopic imaging of coronary artery disease. , 1993, Biomedical sciences instrumentation.

[12]  B. Wilson,et al.  Monte Carlo modeling of light propagation in highly scattering tissues. I. Model predictions and comparison with diffusion theory , 1989, IEEE Transactions on Biomedical Engineering.

[13]  W Lohmann,et al.  Significance of autofluorescence for the optical demarcation of field cancerisation in the upper aerodigestive tract. , 1997, Acta oto-laryngologica.

[14]  J. Haringsma,et al.  The Value of Fluorescence Techniques in Gastrointestinal Endoscopy: Better than the Endoscopist's Eye? I: The European Experience , 1998, Endoscopy.

[15]  T. Mang,et al.  Photodynamic therapy for the treatment of nonmelanomatous cutaneous malignancies. , 1998, Seminars in cutaneous medicine and surgery.

[16]  M L Myrick,et al.  Comparison of some fiber optic configurations for measurement of luminescence and Raman scattering. , 1990, Applied optics.

[17]  Wilson Sibbett,et al.  AN ENDOSCOPIC SYSTEM FOR THE EARLY DETECTION OF CANCERS OF THE GASTROINTESTINAL TRACT , 1998 .

[18]  N Kollias,et al.  Spectroscopic measurement of diffuse reflectance for enhanced detection of bladder carcinoma. , 1998, Urology.

[19]  Michael S. Feld,et al.  A model for extraction of diagnostic information from laser induced fluorescence spectra of human artery wall , 1989 .

[20]  J. M. Nauta,et al.  Photodynamic therapy of oral cancer. A review of basic mechanisms and clinical applications. , 1996, European journal of oral sciences.

[21]  M. Feld,et al.  Raman Spectroscopy and Fluorescence Photon Migration for Breast Cancer Diagnosis and Imaging , 1998, Photochemistry and photobiology.

[22]  B. M. Bernheim IV. Organoscopy: Cystoscopy of the Abdominal Cavity. , 1911, Annals of surgery.

[23]  C. MacAulay,et al.  Development of a fluorescence video endoscopy imaging system for the early detection of cancer in the gastrointestinal tract , 1997, Photonics West - Biomedical Optics.

[24]  Yukihiro Ozaki,et al.  Near-infrared FT-Raman spectra of the rat brain tissues , 1992, Neuroscience Letters.

[25]  Y Wang,et al.  Rapid, noninvasive concentration measurements of aqueous biological analytes by near-infrared Raman spectroscopy. , 1996, Applied optics.

[26]  Ramasamy Manoharan,et al.  Histochemical analysis of biological tissues using Raman spectroscopy , 1996 .

[27]  R M Cothren,et al.  Gastrointestinal tissue diagnosis by laser-induced fluorescence spectroscopy at endoscopy. , 1990, Gastrointestinal endoscopy.

[28]  Christopher J. Frank,et al.  Raman spectroscopy of normal and diseased human breast tissues. , 1995, Analytical chemistry.

[29]  CLAUDE C. FRAZIER,et al.  PHOTODYNAMIC THERAPY IN DERMATOLOGY , 1996, International journal of dermatology.

[30]  S Andersson-Engels,et al.  Changes in spectral shape of tissue optical properties in conjunction with laser-induced thermotherapy. , 1998, Applied optics.

[31]  David E. Battey,et al.  New spectroscopic instrument based on volume holographic optical elements , 1995, Electronic Imaging.

[32]  Angela A. Eick,et al.  Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics. , 1998, Applied optics.

[33]  R Richards-Kortum,et al.  Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology. , 1999, Optics express.

[34]  W. Zijlstra,et al.  Definition, significance and measurement of quantities pertaining to the oxygen carrying properties of human blood. , 1996, Scandinavian journal of clinical and laboratory investigation. Supplementum.

[35]  Rebecca R. Richards-Kortum,et al.  Dual imaging of arterial walls: intravascular ultrasound and fluorescence spectroscopy , 1993, Photonics West - Lasers and Applications in Science and Engineering.

[36]  R. Dasari,et al.  Prospects for in vivo Raman spectroscopy , 2000 .

[37]  G. Jarry,et al.  Coherence and polarization of light propagating through scattering media and biological tissues. , 1998, Applied optics.

[38]  R. Rava,et al.  Quantitative histochemical analysis of human artery using Raman spectroscopy. , 1992, Journal of photochemistry and photobiology. B, Biology.

[39]  Michael L. Wach,et al.  In vivo determination of the molecular composition of artery wall by intravascular Raman spectroscopy. , 2000, Analytical chemistry.

[40]  M. Biel Photodynamic therapy and the treatment of head and neck cancers. , 1996, Journal of clinical laser medicine & surgery.

[41]  Calum MacAulay,et al.  Laser-induced fluorescence spectroscopy at endoscopy: tissue optics, Monte Carlo modeling, and in vivo measurements , 1995 .

[42]  B. Wilson,et al.  Monte Carlo modeling of light propagation in highly scattering tissues. II. Comparison with measurements in phantoms , 1989, IEEE Transactions on Biomedical Engineering.

[43]  Michael S. Feld,et al.  Imaging human epithelial properties with polarized light-scattering spectroscopy , 2001, Nature Medicine.

[44]  M. Zellweger,et al.  An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy. , 1997, Physics in medicine and biology.

[45]  T. Joshua Pfefer,et al.  Effect of fiber optic probe design on fluorescent light propagation in tissue , 2001, SPIE BiOS.

[46]  B Miedema,et al.  Emission spectra of colonic tissue and endogenous fluorophores. , 1998, The American journal of the medical sciences.

[47]  S. Thomsen,et al.  Physiological and Pathological Factors of Human Breast Disease That Can Influence Optical Diagnosis a , 1998, Annals of the New York Academy of Sciences.

[48]  N Ramanujam,et al.  In vivo diagnosis of cervical intraepithelial neoplasia using 337-nm-excited laser-induced fluorescence. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[49]  Lihong V. Wang,et al.  Monte Carlo Modeling of Light Transport in Multi-layered Tissues in Standard C , 1992 .

[50]  Steven L. Jacques,et al.  Polarized light transmission through skin using video reflectometry: toward optical tomography of superficial tissue layers , 1996, Photonics West.

[51]  H. V. Hulst Light Scattering by Small Particles , 1957 .

[52]  L Wang,et al.  Propagation of polarized light in turbid media: simulated animation sequences. , 2000, Optics express.

[53]  T. Gansler,et al.  Characterization of human breast biopsy specimens with near-IR Raman spectroscopy. , 1994, Analytical chemistry.

[54]  D W Rattner,et al.  Reflectance spectroscopy of pancreatic microcirculation. , 1996, Journal of applied physiology.

[55]  Paul R. Carey,et al.  Biochemical Applications of Raman and Resonance Raman Spectroscopies , 1982 .

[56]  C J de Lima,et al.  Development of catheters with low fiber background signals for Raman spectroscopic diagnosis applications. , 2000, Artificial organs.

[57]  K.M. O'Brien,et al.  Development and evaluation of spectral classification algorithms for fluorescence guided laser angioplasty , 1989, IEEE Transactions on Biomedical Engineering.

[58]  N. Nishioka,et al.  Identification of Colonic Dysplasia and Neoplasia by Diffuse Reflectance Spectroscopy and Pattern Recognition Techniques , 1998 .

[59]  Michael B. Wallace,et al.  Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution , 1998 .

[60]  J. S. Dam,et al.  Determination of tissue optical properties from diffuse reflectance profiles by multivariate calibration. , 1998, Applied optics.

[61]  A H Kaye,et al.  Photodynamic therapy of brain tumors. , 1996, Seminars in surgical oncology.

[62]  R M Cothren,et al.  Laser-induced fluorescence microscopy of normal colon and dysplasia in colonic adenomas: implications for spectroscopic diagnosis. , 1995, The American journal of gastroenterology.

[63]  M. Patterson,et al.  Improved solutions of the steady-state and the time-resolved diffusion equations for reflectance from a semi-infinite turbid medium. , 1997, Journal of the Optical Society of America. A, Optics, image science, and vision.

[64]  American Conference Of Governmental Industrial Hygienists 1998 Ventilation A O , 2019 .

[65]  R Marchesini,et al.  Light-induced fluorescence spectroscopy of adenomas, adenocarcinomas and non-neoplastic mucosa in human colon. I. In vitro measurements. , 1992, Journal of photochemistry and photobiology. B, Biology.

[66]  Calum MacAulay,et al.  Light scattering from normal and neoplastic cells: FDTD modeling based on quantitative cytology , 2000 .

[67]  J. Mourant,et al.  Ultraviolet and visible spectroscopies for tissue diagnostics: fluorescence spectroscopy and elastic-scattering spectroscopy. , 1997, Physics in medicine and biology.

[68]  E. Sinofsky High power diffusing tip fibers for photocoagulation , 1996, Conference Proceedings LEOS'96 9th Annual Meeting IEEE Lasers and Electro-Optics Society.

[69]  R. Steiner,et al.  Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue. , 1996, Applied optics.

[70]  M. Feld,et al.  Feasibility of measuring blood glucose concentration by near-infrared Raman spectroscopy. , 1997, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[71]  Michael S. Feld,et al.  Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ , 1999 .

[72]  T. Flotte,et al.  Laser-induced fluorescence detection of dysplasia in rat urinary bladder , 1994 .

[73]  Paul F. Buckley,et al.  Spectroscopic diagnosis of esophageal cancer: new classification model, improved measurement system. , 1995, Gastrointestinal endoscopy.

[74]  I Itzkan,et al.  Rapid multiexcitation fluorescence spectroscopy system for in vivo tissue diagnosis. , 1996, Applied optics.

[75]  Jan Vydra,et al.  Improved all-silica fibers for deep-UV applications , 1999, Photonics West - Biomedical Optics.

[76]  G.R. Gindi,et al.  Neural network and conventional classifiers for fluorescence-guided laser angioplasty , 1991, IEEE Transactions on Biomedical Engineering.

[77]  Pascal O. Rol,et al.  High-Power Laser Transmission through Optical Fibers Applications to Ophthalmology , 1991 .

[78]  S. Majumder,et al.  Breast cancer diagnosis using N2 laser excited autofluorescence spectroscopy , 1997, Lasers in surgery and medicine.

[79]  C. Depeursinge,et al.  Monte Carlo study of diffuse reflectance at source–detector separations close to one transport mean free path , 1999 .

[80]  H. Ward New laser techniques for diagnosis and treatment of deep-seated brain lesions , 1997 .

[81]  R. Richards-Kortum,et al.  Raman spectroscopy for cancer detection: a review , 1997, Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136).

[82]  A E Profio,et al.  Imaging fluorescence bronchoscopy for localizing early bronchial cancer and carcinoma in situ. , 1984, Progress in clinical and biological research.

[83]  Michael L. Myrick,et al.  Elimination of Background in Fiber-Optic Raman Measurements , 1990 .

[84]  B. Wilson,et al.  The value of fluorescence techniques in gastrointestinal endoscopy--better than the endoscopist's eye? II: The North American experience. , 1998, Endoscopy.

[85]  Robert R. Alfano,et al.  Optical spectroscopy of benign and malignant breast tissues , 1996, Photonics West.

[86]  B. Wilson,et al.  Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. , 1989, Applied optics.

[87]  Brian C. Wilson,et al.  In vivo Near-infrared Raman Spectroscopy: Demonstration of Feasibility During Clinical Gastrointestinal Endoscopy¶ , 2000, Photochemistry and photobiology.

[88]  S. Chow,et al.  Light-induced fluorescence spectroscopy: a potential diagnostic tool for oral neoplasia. , 1996, Proceedings of the National Science Council, Republic of China. Part B, Life sciences.

[89]  Yang Wang,et al.  Near-Infrared Raman Spectrometer Systems for Human Tissue Studies , 1997 .

[90]  S. Naylor,et al.  Report of the Fourth International Workshop on Human Chromosome 2 Mapping 1996 , 1992 .

[91]  Y. Yazdi,et al.  Combined ultrasound and fluorescence spectroscopy for physico-chemical imaging of atherosclerosis , 1995, IEEE Transactions on Biomedical Engineering.

[92]  Peter Niederer,et al.  Fiber beam shaping and ophthalmic applications , 1995, Other Conferences.

[93]  B. Wilson,et al.  A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo. , 1992, Medical physics.

[94]  L. Wang,et al.  White light oblique incidence reflectometer formeasuring absorption and reduced scatteringspectra of tissue-like turbid media. , 1997, Optics express.

[95]  H. Wulf,et al.  Diagnosis of Basal Cell Carcinoma by Raman Spectroscopy , 1997 .

[96]  Photodynamic therapy in lung cancer , 2012 .

[97]  R. Richards-Kortum,et al.  Cost‐Effectiveness Analysis of Diagnosis and Management of Cervical Squamous Intraepithelial Lesions , 1998, Obstetrics and gynecology.

[98]  M. Biel Photodynamic therapy and the treatment of head and neck neoplasia , 1998, The Laryngoscope.

[99]  R. Doornbos,et al.  The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy. , 1999, Physics in medicine and biology.

[100]  D. Ferris,et al.  Multimodal Hyperspectral Imaging for the Noninvasive Diagnosis of Cervical Neoplasia , 2001, Journal of lower genital tract disease.

[101]  V. G. Artjushenko,et al.  Mechanism of UV laser-induced absorption in fused silica fibers , 1991 .

[102]  Patrick E. O'Rourke,et al.  Sampling probes enhance remote chemical analyses , 1995 .

[103]  L. Deckelbaum,et al.  Laser-induced fluorescence spectroscopy of human colonic mucosa. Detection of adenomatous transformation. , 1990, Gastroenterology.

[104]  Y. Sinichkin,et al.  LASER FLUORESCENCE SPECTROSCOPY OF HUMAN SKIN IN VIVO : THE EFFECT OF ERYTHEMA , 1994 .

[105]  J. S. Dam,et al.  Fiber-optic probe for noninvasive real-time determination of tissue optical properties at multiple wavelengths. , 2001, Applied optics.

[106]  Bruce J. Tromberg,et al.  In-vivo local determination of tissue optical properties , 1999, European Conference on Biomedical Optics.

[107]  R Richards-Kortum,et al.  Fluorescence spectroscopy of the cervix: Influence of acetic acid, cervical mucus, and vaginal medications , 1999, Lasers in surgery and medicine.

[108]  H Messmann,et al.  Endoscopic fluorescence detection of dysplasia in patients with Barrett's esophagus, ulcerative colitis, or adenomatous polyps after 5-aminolevulinic acid-induced protoporphyrin IX sensitization. , 1999, Gastrointestinal endoscopy.

[109]  W. Zijlstra,et al.  Absorption spectra of human fetal and adult oxyhemoglobin, de-oxyhemoglobin, carboxyhemoglobin, and methemoglobin. , 1991, Clinical chemistry.

[110]  Andres F. Zuluaga,et al.  Fluorescence Excitation Emission Matrices of Human Tissue: A System for in vivo Measurement and Method of Data Analysis , 1999 .

[111]  R. Richards-Kortum,et al.  Safety Analysis: Relative Risks of Ultraviolet Exposure from Fluorescence Spectroscopy and Colposcopy Are Comparable* , 1997, Photochemistry and Photobiology.

[112]  M Fitzmaurice,et al.  Endoscopic detection of dysplasia in patients with Barrett's esophagus using light-scattering spectroscopy. , 2000, Gastroenterology.

[113]  A. Nicia,et al.  Lens coupling in fiber-optic devices: efficiency limits. , 1981, Applied optics.

[114]  N Ramanujam,et al.  Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia (CIN). , 1994, Gynecologic oncology.

[115]  E. Sevick-Muraca,et al.  Quantitative optical spectroscopy for tissue diagnosis. , 1996, Annual review of physical chemistry.

[116]  Michael S. Feld,et al.  Near infrared fourier transform Raman spectroscopy of human artery , 1991 .

[117]  G. Zonios,et al.  Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo. , 1999, Applied optics.

[118]  N. Oleinick,et al.  The photobiology of photodynamic therapy: cellular targets and mechanisms. , 1998, Radiation research.

[119]  S. Svanberg,et al.  Medical diagnostic system based on simultaneous multispectral fluorescence imaging. , 1994, Applied optics.

[120]  G. Zonios,et al.  Morphological model of human colon tissue fluorescence , 1996, IEEE Transactions on Biomedical Engineering.

[121]  N. Ramanujam,et al.  Development of a Fiber Optic Probe to Measure NIR Raman Spectra of Cervical Tissue In Vivo , 1998, Photochemistry and photobiology.

[122]  G. Puppels,et al.  Raman spectroscopy for quantifying cholesterol in intact coronary artery wall. , 1998, Atherosclerosis.

[123]  T. Papazoglou,et al.  Malignancies and atherosclerotic plaque diagnosis--is laser induced fluorescence spectroscopy the ultimate solution? , 1995, Journal of photochemistry and photobiology. B, Biology.

[124]  L. Baert,et al.  In vivo fluorescence detection of human bladder carcinoma without sensitizing agents. , 1994, The Journal of the American Paraplegia Society.

[125]  S L Jacques,et al.  Fluorescence spectroscopy of turbid media: Autofluorescence of the human aorta. , 1989, Applied optics.

[126]  W S Grundfest,et al.  Control of excimer laser aided tissue ablation via laser-induced fluorescence monitoring. , 1990, Applied optics.

[127]  B. Palcic,et al.  Autofluorescence of normal and malignant bronchial tissue , 1991, Lasers in surgery and medicine.

[128]  Ashleyj . Welch,et al.  Optical-Thermal Response of Laser-Irradiated Tissue , 1995 .

[129]  Grant Lu,et al.  Optical fiber for UV-IR broadband spectroscopy , 1998, Astronomical Telescopes and Instrumentation.

[130]  Pascal O. Rol,et al.  Optics for transscleral laser applications , 1991 .

[131]  Brian C. Wilson,et al.  Study of Fiber-Optic Probes for in vivo Medical Raman Spectroscopy , 1999 .

[132]  H van den Bergh,et al.  On the Evolution of Some Endoscopic Light Delivery Systems for Photodynamic Therapy , 1998, Endoscopy.

[133]  M Fitzmaurice,et al.  Histopathology of human coronary atherosclerosis by quantifying its chemical composition with Raman spectroscopy. , 1998, Circulation.

[134]  H Stepp,et al.  Fluorescence Endoscopy of Gastrointestinal Diseases: Basic Principles, Techniques, and Clinical Experience , 1998, Endoscopy.

[135]  R. Richards-Kortum,et al.  Study of the fluorescence properties of normal and neoplastic human cervical tissue , 1993, Lasers in surgery and medicine.

[136]  P. Monnier,et al.  Clinical determination of tissue optical properties by endoscopic spatially resolved reflectometry. , 1996, Applied optics.

[137]  D. R. Sandison,et al.  Method to Determine Tissue Fluorescence Efficiency in vivo and Predict Signal-to-Noise Ratio for Spectrometers , 1998 .

[138]  M. Hartmann,et al.  Light scattering by small particles. Von H. C. VANDE HULST. New York: Dover Publications, Inc. 1981. Paperback, 470 S., 103 Abb. und 46 Tab., US $ 7.50 , 1984 .

[139]  M F Mitchell,et al.  Statistical techniques for diagnosing CIN using fluorescence spectroscopy: SVD and CART , 1995, Journal of cellular biochemistry. Supplement.

[140]  S L Jacques,et al.  Use of a laser beam with an oblique angle of incidence to measure the reduced scattering coefficient of a turbid medium. , 1995, Applied optics.

[141]  R. Richards-Kortum,et al.  Fibre Optic Probes in Optical Spectroscopy, Clinical Applications , 1999 .

[142]  Kagan Tumer,et al.  Ensembles of radial basis function networks for spectroscopic detection of cervical precancer , 1998, IEEE Transactions on Biomedical Engineering.

[143]  M S Patterson,et al.  The use of a neural network to determine tissue optical properties from spatially resolved diffuse reflectance measurements. , 1992, Physics in medicine and biology.

[144]  H. G. Schulze,et al.  Fiber-optic Probes with Improved Excitation and Collection Efficiency for Deep-uv Raman and Resonance Raman Spectroscopy Probes with Improved Excitation and Collection Efficiency for Deep-uv Raman and Resonance , 1998 .

[145]  Vitali I. Konov,et al.  Mechanisms of optical losses in polycrystalline fibers , 1992, Other Conferences.

[146]  M. Feld,et al.  Diagnosis of fibrous arterial atherosclerosis using fluorescence. , 1985, Applied optics.

[147]  K. Schomacker,et al.  Autofluorescence guided biopsy for the early diagnosis of bladder carcinoma. , 1998, The Journal of urology.

[148]  A J Welch,et al.  Sources of contrast in confocal reflectance imaging. , 1996, Applied optics.

[149]  S. Lakhani,et al.  Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results. , 2000, Journal of biomedical optics.

[150]  J Moan,et al.  The Biophysical Foundations of Photodynamic Therapy , 1998, Endoscopy.

[151]  D. Choy,et al.  Fluorescence spectra from cancerous and normal human breast and lung tissues , 1987, Annual Meeting Optical Society of America.

[152]  R. Alfano,et al.  Optical spectroscopic diagnosis of cancer and normal breast tissues , 1989 .

[153]  Georges Wagnières,et al.  AN ENDOSCOPIC FLUORESCENCE IMAGING SYSTEM FOR SIMULTANEOUS VISUAL EXAMINATION AND PHOTODETECTION OF CANCERS , 1997 .

[154]  New laser techniques for diagnosis and treatment of deep-seated brain lesions. , 1998, Journal of laser applications.

[155]  N Kollias,et al.  Fluorescence photography in the evaluation of hyperpigmentation in photodamaged skin. , 1997, Journal of the American Academy of Dermatology.

[156]  R. Rava,et al.  In situ optical histochemistry of human artery using near infrared Fourier transform Raman spectroscopy. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[157]  Benjamin A. Rockwell,et al.  A procedure for multiple-pulse maximum permissible exposure determination under the Z136.1-2000 American National Standard for Safe Use of Lasers , 2001 .

[158]  S. Jacques,et al.  Hybrid model of Monte Carlo simulation and diffusion theory for light reflectance by turbid media. , 1993, Journal of the Optical Society of America. A, Optics, image science, and vision.

[159]  R. Rava,et al.  A one-layer model of laser-induced fluorescence for diagnosis of disease in human tissue: applications to atherosclerosis , 1989, IEEE Transactions on Biomedical Engineering.

[160]  H Ward Molding of laser energy by shaped optic fiber tips , 1987, Lasers in surgery and medicine.

[161]  G. Jarry,et al.  Coherent components of forward light propagation through scattering mediaComposantes cohrentes de l , 1997 .

[162]  K. Messmer,et al.  Orthogonal polarization spectral imaging: A new method for study of the microcirculation , 1999, Nature Medicine.

[163]  J. Dowson,et al.  Quantitative studies of the autofluorescence derived from neuronal lipofuscin , 1981, Journal of microscopy.

[164]  Arthur F. Gmitro,et al.  In-Vivo Fluorescence Spectroscopy Of Normal And Atherosclerotic Arteries , 1988, Photonics West - Lasers and Applications in Science and Engineering.

[165]  R. Richards-Kortum,et al.  Raman spectroscopy for the detection of cancers and precancers. , 1996, Journal of biomedical optics.

[166]  K. Svanberg,et al.  Laser‐Based Spectroscopic Methods in Tissue Characterization , 1998, Annals of the New York Academy of Sciences.

[167]  R. Richards-Kortum,et al.  Noninvasive diagnosis of oral neoplasia based on fluorescence spectroscopy and native tissue autofluorescence. , 1998, Archives of otolaryngology--head & neck surgery.

[168]  B. Wilson,et al.  In Vivo Fluorescence Spectroscopy and Imaging for Oncological Applications , 1998, Photochemistry and photobiology.

[169]  R Richards-Kortum,et al.  Reflectance spectroscopy for in vivo characterization of ovarian tissue , 2001, Lasers in surgery and medicine.

[170]  N Kollias,et al.  Endogenous skin fluorescence includes bands that may serve as quantitative markers of aging and photoaging. , 1998, The Journal of investigative dermatology.

[171]  I Itzkan,et al.  Autofluorescence characteristics of oral mucosa , 1997, Head & neck.

[172]  R R Alfano,et al.  Pulsed and cw laser fluorescence spectra from cancerous, normal, and chemically treated normal human breast and lung tissues. , 1989, Applied optics.

[173]  A H Kaye,et al.  Photodynamic therapy of brain tumors. , 1995, Journal of clinical laser medicine & surgery.

[174]  K. Svanberg,et al.  Investigation of possible fluorophores in human atherosclerotic plaques , 1992 .

[175]  R. Richards-Kortum,et al.  Combined fluorescence and reflectance spectroscopy: in vivo assessment of oral cavity epithelial neoplasia , 1998, Technical Digest. Summaries of Papers Presented at the Conference on Lasers and Electro-Optics. Conference Edition. 1998 Technical Digest Series, Vol.6 (IEEE Cat. No.98CH36178).

[176]  B F Overholt,et al.  Endoscopic fluorescence detection of high-grade dysplasia in Barrett's esophagus. , 1996, Gastroenterology.

[177]  Leonid N. Butvina,et al.  Mechanisms of optical losses in polycrystalline KRS-5 fibers , 1986 .

[178]  Thomas C. Wright,et al.  Preliminary experimental results from multi-center clinical trials for detection of cervical precancerous lesions using the Cerviscan/spl trade/ system: a novel full-field evoked tissue fluorescence based imaging instrument , 2001, 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[179]  I J Bigio,et al.  Spectroscopic diagnosis of bladder cancer with elastic light scattering , 1995, Lasers in surgery and medicine.

[180]  H. Kato,et al.  Photodynamic therapy for lung cancer--a review of 19 years' experience. , 1998, Journal of photochemistry and photobiology. B, Biology.

[181]  Yurii P. Sinichkin,et al.  In vivo fluorescence spectroscopy of the human skin: experiments and models. , 1998, Journal of biomedical optics.

[182]  H. Bergh,et al.  Photodynamic therapy of early squamous cell carcinomas of the esophagus: a review of 31 cases. , 1998, Endoscopy.

[183]  O. Cussenot,et al.  The Role of Laser‐Induced Autofluorescence Spectroscopy in Bladder Tumor Detection: Dependence on the Excitation Wavelength , 1998, Annals of the New York Academy of Sciences.

[184]  Anthony J. Durkin Quantitative fluorescence spectroscopy of turbid samples , 1995 .

[185]  S L Jacques,et al.  Gestational age correlates with skin reflectance in newborn infants of 24-42 weeks gestation. , 1993, Biology of the neonate.

[186]  Massoud Motamedi,et al.  Spectroscopic detection of oral and skin tissue transformation in a model for squamous cell carcinoma: autofluorescence versus systemic aminolevulinic acid-induced fluorescence , 1996 .

[187]  Michael S. Patterson,et al.  Hybrid Monte Carlo - Diffusion Theory Modelling Of Light Distributions In Tissue. , 1988, Photonics West - Lasers and Applications in Science and Engineering.

[188]  N. Nishioka Laser-induced fluorescence spectroscopy. , 1994, Gastrointestinal endoscopy clinics of North America.

[189]  K Svanberg,et al.  In vivo fluorescence imaging for tissue diagnostics. , 1997, Physics in medicine and biology.

[190]  L Burke,et al.  Identification of cervical intraepithelial neoplasia (CIN) using UV‐excited fluorescence and diffuse‐reflectance tissue spectroscopy , 2001, Lasers in surgery and medicine.

[191]  Wei Chen,et al.  Multivariate discriminating algorithm for analyzing laser-induced fluorescence spectra of human gastrointestinal cancer , 1998, Other Conferences.

[192]  Autofluorescence in normal and malignant human oral tissues and in DMBA-induced hamster buccal pouch carcinogenesis. , 2007, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[193]  F J McGovern,et al.  Fluorescence detection of bladder carcinoma. , 1997, Urology.

[194]  I Itzkan,et al.  Early diagnosis of upper aerodigestive tract cancer by autofluorescence. , 1996, Archives of otolaryngology--head & neck surgery.

[195]  R. Dasari,et al.  Compound parabolic concentrator probe for efficient light collection in spectroscopy of biological tissue. , 1996, Applied optics.

[196]  J. Mourant,et al.  Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms. , 1997, Applied optics.

[197]  P. Carey CHAPTER 2 – Principles of Raman Spectroscopy , 1982 .

[198]  S L Jacques,et al.  Measurement of tissue optical properties by the use of oblique-incidence optical fiber reflectometry. , 1997, Applied optics.

[199]  H E Savage,et al.  Native cellular fluorescence of neoplastic upper aerodigestive mucosa. , 1995, Archives of otolaryngology--head & neck surgery.

[200]  Gregg Staerkel,et al.  Cervical Precancer Detection Using a Multivariate Statistical Algorithm Based on Laser‐Induced Fluorescence Spectra at Multiple Excitation Wavelengths , 1996, Photochemistry and photobiology.

[201]  D. Hochman,et al.  Intrinsic optical changes in neuronal tissue. Basic mechanisms. , 1997, Neurosurgery clinics of North America.

[202]  Ramasamy Manoharan,et al.  Detection and identification of a single DNA base molecule using surface-enhanced Raman scattering (SERS) , 1998 .

[203]  S. Avrillier,et al.  Influence of the emission-reception geometry in laser-induced fluorescence spectra from turbid media. , 1998, Applied optics.

[204]  N Ramanujam,et al.  In vivo fluorescence spectroscopy: potential for non-invasive, automated diagnosis of cervical intraepithelial neoplasia and use as a surrogate endpoint biomarker. , 1994, Journal of cellular biochemistry. Supplement.

[205]  E.V. Trujillo,et al.  Development of a cost-effective optical system for detection of cervical pre-cancer , 1996, Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[206]  A. Mahadevan-Jansen,et al.  Near‐Infrared Raman Spectroscopy for In Vitro Detection of Cervical Precancers , 1998 .

[207]  Haishan Zeng,et al.  Real‐time endoscopic fluorescence imaging for early cancer detection in the gastrointestinal tract , 1998 .

[208]  Stanley M. Angel,et al.  Comparative Study of Some Fiber-Optic Remote Raman Probe Designs. Part II: Tests of Single-Fiber, Lensed, and Flat- and Bevel-Tip Multi-Fiber Probes , 1996 .

[209]  O. Cussenot,et al.  Laser induced autofluorescence diagnosis of bladder tumors: dependence on the excitation wavelength. , 1996, The Journal of urology.

[210]  Frank K. Tittel,et al.  Autofluorescence maps of atherosclerotic human arteries--A new technique in medical imaging , 1987 .

[211]  R Richards-Kortum,et al.  Fluorescence spectroscopy: A technique with potential to improve the early detection of aerodigestive tract neoplasia , 1998, Head & neck.

[212]  Rebecca Richards-Kortum,et al.  Fluorescence Spectroscopy of Turbid Media , 1995 .

[213]  Otmar Koehn,et al.  Radiation resistance of optical fibers: correlation between UV attenuation and radiation-induced loss , 1993, Other Conferences.

[214]  O. Hess,et al.  Excimer laser spectroscopy: influence of tissue ablation on vessel wall fluorescence. , 1998, Journal of laser applications.

[215]  R J Ott,et al.  Classification of reflectance spectra from pigmented skin lesions, a comparison of multivariate discriminant analysis and artificial neural networks , 2000, Physics in medicine and biology.

[216]  A H Hielscher,et al.  Monte Carlo simulations of the diffuse backscattering mueller matrix for highly scattering media. , 2000, Applied optics.

[217]  Britton Chance,et al.  Fast and noninvasive fluorescence imaging of biological tissues in vivo using a flying-spot scanner , 2001, IEEE Transactions on Biomedical Engineering.

[218]  J. Mourant,et al.  Polarized wavelength-dependent measurements of turbid media. , 1999, Optics express.

[219]  R. Marchesini,et al.  Natural fluorescence of normal and neoplastic human colon: A comprehensive “ex vivo” study , 1995, Lasers in surgery and medicine.

[220]  F. Khachik,et al.  Non-invasive raman spectroscopic detection of carotenoids in human skin. , 2000, The Journal of investigative dermatology.

[221]  Lihong V. Wang,et al.  White light oblique incidence reflectometer for measuring absorption and reduced scattering spectra of tissue-like turbid media , 1998 .

[222]  A. Bohorfoush Tissue Spectroscopy for Gastrointestinal Diseases , 1996, Endoscopy.

[223]  K. Dorschel,et al.  Transmission Of Short Pulsed High Power UV Laser Radiation Through Fibres Depending On Pulse Length, Intensity And Long Term Behaviour , 1988, Photonics West - Lasers and Applications in Science and Engineering.

[224]  H Lui,et al.  Current status of photodynamic therapy in dermatology. , 1997, Dermatologic clinics.

[225]  S. Lam Bronchoscopic, photodynamic, and laser diagnosis and therapy of lung neoplasms. , 1996, Current opinion in pulmonary medicine.

[226]  S. Angel,et al.  Comparative Study of Some Fiber-Optic Remote Raman Probe Designs. Part I: Model for Liquids and Transparent Solids , 1996 .