Serum-mediated recognition of liposomes by phagocytic cells of the reticuloendothelial system - The concept of tissue specificity.

The mechanisms responsible for the clearance and recognition of intravenously injected liposomes by phagocytic cells of the reticuloendothelial system are presently not well understood. Here, we address a multiplicity of physicochemical and physiopathological factors which influence the clearance kinetics and tissue distribution of liposomes administered into the circulation. Emphasis is particularly drawn towards the concept of liposome-blood protein interaction and its role in liposome recognition by various phagocytes of the reticuloendothelial system.

[1]  A. Gabizon,et al.  Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[2]  S. Lee,et al.  Macrophage plasma membrane and secretory properties in murine malaria. Effects of Plasmodium yoelii blood-stage infection on macrophages in liver, spleen, and blood , 1986, The Journal of experimental medicine.

[3]  H M Patel,et al.  Serum opsonins and phagocytosis of saturated and unsaturated phospholipid liposomes. , 1989, Biochimica et biophysica acta.

[4]  M. Poznansky,et al.  Biological approaches to the controlled delivery of drugs: a critical review. , 1984, Pharmacological reviews.

[5]  K. Wake,et al.  Modes of endocytosis of latex particles in sinusoidal endothelial and Kupffer cells of normal and perfused rat liver. , 1985, Experimental cell research.

[6]  S. Moghimi.  Mechanisms of splenic clearance of blood cells and particles : towards development of new splenotropic agents , 1995 .

[7]  D. Absolom.  [13] Opsonins and dysopsonins: An overview , 1986 .

[8]  H. Morselt,et al.  Intrahepatic Distribution of Long-Circulating Liposomes Containing Polyethylene Glycol) Distearoyl Phosphatidylethanolamine , 1994 .

[9]  Dexi Liu,et al.  Serum independent liposome uptake by mouse liver. , 1996, Biochimica et biophysica acta.

[10]  J. Baldeschwieler,et al.  Effect of cholesterol on the uptake and intracellular degradation of liposomes by liver and spleen; a combined biochemical and gamma-ray perturbed angular correlation study. , 1989, Biochimica et biophysica acta.

[11]  H. Gewurz,et al.  Interactions of C-reactive protein and complement with liposomes. II. Influence of membrane composition. , 1979, Journal of immunology.

[12]  C. Alving,et al.  Naturally occurring autoantibodies to cholesterol in humans. , 1989, Biochemical Society transactions.

[13]  C. Alving.  Natural antibodies against phospholipids and liposomes in humans. , 1984, Biochemical Society transactions.

[14]  Hamid Laga,et al.  The role of an alpha2-macroglobulin of rat serum in the phagocytosis of colloidal particles. , 1977, Biochimica et biophysica acta.

[15]  P. Cullis,et al.  Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes. , 1992, The Journal of biological chemistry.

[16]  M. Woodle,et al.  Sterically stabilized liposomes. , 1992, Biochimica et biophysica acta.

[17]  A. Tall.  Studies on the transfer of phosphatidylcholine from unilamellar vesicles into plasma high density lipoproteins in the rat. , 1980, Journal of lipid research.

[18]  S. Moghimi,et al.  Opsonophagocytosis of liposomes by peritoneal macrophages and bone marrow reticuloendothelial cells. , 1992, Biochimica et biophysica acta.

[19]  R S McCuskey,et al.  Phagocytosis, an unrecognized property of murine endothelial liver cells , 1986, Hepatology.

[20]  N. Hogg,et al.  Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3. , 1988, The Journal of clinical investigation.

[21]  S. Moghimi,et al.  Tissue specific opsonins for phagocytic cells and their different affinity for cholesterol‐rich liposomes , 1988, FEBS letters.

[22]  M. N. Jones,et al.  The effect of blood on the uptake of liposomal lipid by perfused rat liver. , 1991, Biochimica et biophysica acta.

[23]  S. Davis,et al.  Organ-Specific Targeting of Synthetic and Natural Drug Carriers , 1994 .

[24]  C. Alving,et al.  Complement-Dependent Phagocytosis of Liposomes: Suppression by “Stealth” Lipids , 1992 .

[25]  R. Juliano.  Factors affecting the clearance kinetics and tissue distribution of liposomes, microspheres and emulsions , 1988 .

[26]  C. Mold,et al.  Effect of gangliosides on activation of the alternative pathway of human complement. , 1988, Journal of immunology.

[27]  Moghimi Sm,et al.  Serum factors that regulate phagocytosis of liposomes by Kupffer cells , 1993 .

[28]  B. Wallace,et al.  Binding of fibronectin to phospholipid vesicles. , 1983, The Journal of biological chemistry.

[29]  J. Parks,et al.  Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteins. , 1978, Biochimica et biophysica acta.

[30]  F. Bonte,et al.  Interactions of liposomes with serum proteins. , 1986, Chemistry and physics of lipids.

[31]  F. Bonte,et al.  Interactions of polymerizable phosphatidylcholine vesicles with blood components: relevance to biocompatibility. , 1987, Biochimica et biophysica acta.

[32]  M. Bally,et al.  The Binding of Phosphatidylglycerol Liposomes to Rat Platelets Is Mediated by Complement , 1990, Thrombosis and Haemostasis.

[33]  D. Mason,et al.  Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3. , 1986, Immunology.

[34]  G. Scherphof,et al.  Targeting of lactosylceramide-containing liposomes to hepatocytes in vivo. , 1983, Biochimica et biophysica acta.

[35]  M. Bally,et al.  Interactions of Liposomes and Platelets , 1988, Thrombosis and Haemostasis.

[36]  S. Wright,et al.  Transient adhesion of neutrophils to endothelium , 1989, The Journal of experimental medicine.

[37]  A. Tall,et al.  [37] Lipoprotein-liposome interactions , 1986 .

[38]  S. Moghimi,et al.  Exploiting bone marrow microvascular structure for drug delivery and future therapies , 1995 .

[39]  C. Alving,et al.  Suppression of phagocytic function and phospholipid metabolism in macrophages by phosphatidylinositol liposomes. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[40]  R. Mahley,et al.  Chylomicron metabolism. Chylomicron uptake by bone marrow in different animal species. , 1989, The Journal of biological chemistry.

[41]  V. Kolb-Bachofen,et al.  Coating particles with a block co-polymer (poloxamine-908) suppresses opsonization but permits the activity of dysopsonins in the serum. , 1993, Biochimica et biophysica acta.

[42]  P. Cullis,et al.  Influence of dose on liposome clearance: critical role of blood proteins. , 1996, Biochimica et biophysica acta.

[43]  T. Saba,et al.  Humoral mediated macrophage response during tumour growth. , 1975, British Journal of Cancer.

[44]  T. Yasuda,et al.  Regulation of glycophorin of complement activation via the alternative pathway. , 1982, Biochemical and biophysical research communications.

[45]  G. Gregoriadis,et al.  Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection. , 1985, Biochimica et biophysica acta.

[46]  D. Liu,et al.  Co-existence of serum-dependent and serum-independent mechanisms for liposome clearance and involvement of non-Kupffer cells in liposome uptake by mouse liver. , 1996, Biochimica et biophysica acta.

[47]  J H Senior,et al.  Fate and behavior of liposomes in vivo: a review of controlling factors. , 1987, Critical reviews in therapeutic drug carrier systems.

[48]  P. Cullis,et al.  β2-Glycoprotein I Is a Major Protein Associated with Very Rapidly Cleared Liposomes in Vivo, Suggesting a Significant Role in the Immune Clearance of "Non-self" Particles (*) , 1995, The Journal of Biological Chemistry.

[49]  Dexi Liu,et al.  Recognition and clearance of liposomes containing phosphatidylserine are mediated by serum opsonin. , 1995, Biochimica et biophysica acta.

[50]  D. Knook,et al.  Relation between localization and function of rat liver Kupffer cells. , 1982, Laboratory investigation; a journal of technical methods and pathology.

[51]  K. Williams,et al.  Effects of apolipoproteins A-IV and A-I on the uptake of phospholipid liposomes by hepatocytes. , 1989, The Journal of biological chemistry.

[52]  C. Alving,et al.  Effects of negatively charged lipids on phagocytosis of liposomes opsonized by complement. , 1983, Biochimica et biophysica acta.

[53]  L. Huang,et al.  Effect of chemically modified GM1 and neoglycolipid analogs of GM1 on liposome circulation time: evidence supporting the dysopsonin hypothesis. , 1993, Biochimica et biophysica acta.

[54]  G. Matyas,et al.  Complement-dependent phagocytosis of liposomes by macrophages: suppressive effects of "stealth" lipids. , 1991, Biochemical and biophysical research communications.

[55]  Y. Kawai,et al.  Is control of distribution of liposomes between tumors and bone marrow possible? , 1996, Biochimica et biophysica acta.

[56]  H. Patel,et al.  Differentiation in hepatic and splenic phagocytic activity during reticuloendothelial blockade with cholesterol-free and cholesterol-rich liposomes. , 1986, Biochimica et biophysica acta.

[57]  K Fujikawa,et al.  Binding and activation properties of human factor XII, prekallikrein, and derived peptides with acidic lipid vesicles. , 1985, Biochemistry.

[58]  C. Alving,et al.  Anaphylactoid reactions mediated by autoantibodies to cholesterol in miniature pigs. , 1989, Journal of immunology.

[59]  D. Tyrrell,et al.  The effect of serum protein fractions on liposome-cell interactions in cultured cells and the perfused rat liver. , 1977, Biochimica et biophysica acta.

[60]  D. Devine,et al.  The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes. , 1991, Journal of immunology.

[61]  Alving Cr,et al.  Antibodies to cholesterol, cholesterol conjugates and liposomes: implications for atherosclerosis and autoimmunity. , 1991 .

[62]  H M Patel,et al.  Serum opsonins and liposomes: their interaction and opsonophagocytosis. , 1992, Critical reviews in therapeutic drug carrier systems.

[63]  P. Cullis,et al.  Separation of large unilamellar liposomes from blood components by a spin column procedure: towards identifying plasma proteins which mediate liposome clearance in vivo. , 1991, Biochimica et biophysica acta.

[64]  J. M. Yoffey,et al.  RETICULO-ENDOTHELIAL CELLS IN THE BONE MARROW OF THE GUINEA-PIG. , 1963, Journal of anatomy.

[65]  R. Steinman,et al.  Liver macrophages in murine listeriosis. Cell-mediated immunity is correlated with an influx of macrophages capable of generating reactive oxygen intermediates , 1985, The Journal of experimental medicine.

[66]  N. Narula,et al.  Anti-KCA-3, a monoclonal antibody reactive with a rat complement C3 receptor, distinguishes Kupffer cells from other macrophages. , 1993, Journal of immunology.

[67]  M. Hostetter,et al.  The biochemistry of opsonization: central role of the reactive thiolester of the third component of complement. , 1984, The Journal of infectious diseases.

[68]  S. Moghimi,et al.  Altered tissue-specific opsonic activities and opsono-recognition of liposomes in tumour-bearing rats. , 1996, Biochimica et biophysica acta.

[69]  V. Devita,et al.  Hypercalcemia in chronic granulocytic leukemia , 1971, Cancer.

[70]  D. Devine,et al.  Liposome-complement interactions in rat serum: implications for liposome survival studies. , 1994, Biochimica et biophysica acta.

[71]  K. Funato,et al.  Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma. , 1992, Biochimica et biophysica acta.

[72]  T. Stossel.  Quantitative studies of phagocytosis. Kinetic effects of cations and heat-labile opsonin. , 1973 .

[73]  B. E. Ryman,et al.  Inhibitory effect of cholesterol on the uptake of liposomes by liver and spleen. , 1983, Biochimica et biophysica acta.

[74]  D. Birmingham,et al.  Primate erythrocyte-immune complex-clearing mechanism. , 1983, The Journal of clinical investigation.

[75]  S. Moghimi,et al.  Differential properties of organ-specific serum opsonins for liver and spleen macrophages. , 1989, Biochimica et biophysica acta.

[76]  G. Gregoriadis,et al.  Interaction of liposomes with blood plasma proteins. , 1976, Biochemical Society transactions.

[77]  P. Arese,et al.  Enhanced IgG‐ and complement‐independent phagocytosis of sulfatide‐enriched human erythrocytes by human monocytes , 1992, FEBS letters.

[78]  S. Wright,et al.  Tumor-promoting phorbol esters stimulate C3b and C3b' receptor-mediated phagocytosis in cultured human monocytes , 1982, The Journal of experimental medicine.

[79]  H. Wurm.  beta 2-Glycoprotein-I (apolipoprotein H) interactions with phospholipid vesicles. , 1984, The International journal of biochemistry.

[80]  M. Luostarinen,et al.  Clinical Significance of Lung Uptake in Liver Scanning , 1986, Nuklearmedizin.

[81]  G Gregoriadis,et al.  Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles. , 1991, Biochimica et biophysica acta.

[82]  P. Cullis,et al.  Influence of cholesterol on the association of plasma proteins with liposomes. , 1996, Biochemistry.

[83]  S. Wright,et al.  Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes. , 1986, Journal of immunology.

[84]  G. Strejan,et al.  Naturally occurring antibodies to liposomes. II. Specificity and electrophoretic pattern of rabbit antibodies reacting with sphingomyelin-containing liposomes. , 1981, Journal of immunology.

[85]  M. Tavassoli.  Intravascular Phagocytosis in the Rabbit Bone Marrow: A Possible Fate of Normal Senescent Red Cells , 1977, British journal of haematology.

[86]  D. Fearon,et al.  Membrane sialic acid on target particles modulates their phagocytosis by a trypsin-sensitive mechanism on human monocytes. , 1978, Proceedings of the National Academy of Sciences of the United States of America.