Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.

[1]  William P. Katt,et al.  Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer , 2019, Cell reports.

[2]  Paul J. Hoffman,et al.  Comprehensive Integration of Single-Cell Data , 2018, Cell.

[3]  Ryan M. O’Connell,et al.  MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancers. , 2019, JCI insight.

[4]  Dou Liu,et al.  Metabolic regulation of T cell development by Sin1–mTORC2 is mediated by pyruvate kinase M2 , 2018, Journal of molecular cell biology.

[5]  D. Spaner,et al.  Peroxisome Proliferator-Activated Receptor–δ Supports the Metabolic Requirements of Cell Growth in TCRβ-Selected Thymocytes and Peripheral CD4+ T Cells , 2018, The Journal of Immunology.

[6]  H. Chi,et al.  Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells , 2018, Science Immunology.

[7]  Nicole M. Chapman,et al.  mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis , 2018, Nature Communications.

[8]  Qing Yang,et al.  Zinc improves mitochondrial respiratory function and prevents mitochondrial ROS generation at reperfusion by phosphorylating STAT3 at Ser727. , 2018, Journal of molecular and cellular cardiology.

[9]  P. Romero,et al.  Mitochondria‐Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells , 2018, Immunity.

[10]  H. Young,et al.  Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions , 2018, Cell reports.

[11]  T. Cameron Waller,et al.  Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism , 2017, Nature Cell Biology.

[12]  Ryan M. O’Connell,et al.  miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response. , 2017, Blood.

[13]  S. Dimauro,et al.  Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate Decisions During T Cell Activation and Differentiation. , 2017, Cell metabolism.

[14]  C. Leslie,et al.  Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism , 2016, Science.

[15]  T. Sparwasser,et al.  Metabolic pathways in T cell activation and lineage differentiation. , 2016, Seminars in immunology.

[16]  Amy M Becker,et al.  Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells. , 2016, Immunity.

[17]  Ryan M. O’Connell,et al.  Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth , 2016, PloS one.

[18]  Liang Chen,et al.  Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53 , 2016, The Journal of Immunology.

[19]  B. Croker,et al.  Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus , 2016, The Journal of Immunology.

[20]  Yingming Zhao,et al.  The rate of glycolysis quantitatively mediates specific histone acetylation sites , 2015, Cancer & Metabolism.

[21]  M. Buck,et al.  T cell metabolism drives immunity , 2015, The Journal of experimental medicine.

[22]  D. Wallace,et al.  Essential role of mitochondrial energy metabolism in Foxp3+ T‐regulatory cell function and allograft survival , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  J. Locasale,et al.  Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. , 2015, The Journal of clinical investigation.

[24]  A. Goldrath,et al.  The TCR’s sensitivity to self-peptide–MHC dictates the ability of naïve CD8+ T cells to respond to foreign antigens , 2014, Nature Immunology.

[25]  Margaret Alexander,et al.  miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation. , 2014, Immunity.

[26]  J. Rathmell,et al.  The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. , 2014, Cell metabolism.

[27]  Neville E. Sanjana,et al.  Improved vectors and genome-wide libraries for CRISPR screening , 2014, Nature Methods.

[28]  P. Allen,et al.  Intrinsic CD4+ T cell sensitivity and response to pathogen are set and sustained by avidity for thymic and peripheral self-pMHC , 2014, Nature Immunology.

[29]  E. Taylor,et al.  Regulation of pyruvate metabolism and human disease , 2013, Cellular and Molecular Life Sciences.

[30]  Ronald N Germain,et al.  T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens. , 2013, Immunity.

[31]  J. Licht,et al.  Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. , 2013, Immunity.

[32]  J. Veuthey,et al.  Identification and Functional Expression of the Mitochondrial Pyruvate Carrier , 2012, Science.

[33]  Claire Redin,et al.  A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans , 2012, Science.

[34]  T. Möröy,et al.  Miz-1 Is Required To Coordinate the Expression of TCRβ and p53 Effector Genes at the Pre-TCR “β-Selection” Checkpoint , 2011, The Journal of Immunology.

[35]  Ryan M. O’Connell,et al.  MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. , 2010, Immunity.

[36]  Shimon Sakaguchi,et al.  Regulation of Zap70 Expression During Thymocyte Development Enables Temporal Separation of CD4 and CD8 Repertoire Selection at Different Signaling Thresholds , 2010, Science Signaling.

[37]  David K. Finlay,et al.  LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells , 2009, European journal of immunology.

[38]  E. Ho,et al.  Zinc supplementation increases zinc status and thymopoiesis in aged mice. , 2009, The Journal of nutrition.

[39]  M. Komatsu,et al.  Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes1 , 2009, The Journal of Immunology.

[40]  J. Lafaille,et al.  Swift Entry of Myelin-Specific T Lymphocytes into the Central Nervous System in Spontaneous Autoimmune Encephalomyelitis1 , 2008, The Journal of Immunology.

[41]  D. Wraith,et al.  Cutting Edge: Th1 Cells Facilitate the Entry of Th17 Cells to the Central Nervous System during Experimental Autoimmune Encephalomyelitis1 , 2008, The Journal of Immunology.

[42]  D. Ayer,et al.  Glucose sensing by MondoA:Mlx complexes: A role for hexokinases and direct regulation of thioredoxin-interacting protein expression , 2008, Proceedings of the National Academy of Sciences.

[43]  Ellen V. Rothenberg,et al.  Launching the T-cell-lineage developmental programme , 2008, Nature Reviews Immunology.

[44]  M. Birnbaum,et al.  Akt1 and Akt2 are required for αβ thymocyte survival and differentiation , 2007, Proceedings of the National Academy of Sciences.

[45]  David K. Finlay,et al.  Notch-induced T cell development requires phosphoinositide-dependent kinase 1 , 2007, The EMBO journal.

[46]  S. Shinton,et al.  Ablation of Ribosomal Protein L22 Selectively Impairs αβ T Cell Development by Activation of a p53-Dependent Checkpoint , 2007 .

[47]  S. Shinton,et al.  Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint. , 2007, Immunity.

[48]  B. Blom,et al.  Stimulated plasmacytoid dendritic cells impair human T-cell development. , 2006, Blood.

[49]  A. Krueger,et al.  Articles on similar topics can be found in the following Blood collections Cell Cycle (231 articles) , 2006 .

[50]  W. Swat,et al.  Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival. , 2006, Blood.

[51]  M. Ciofani,et al.  Notch promotes survival of pre–T cells at the β-selection checkpoint by regulating cellular metabolism , 2005, Nature Immunology.

[52]  K. Song,et al.  VDUP1 is required for the development of natural killer cells. , 2005, Immunity.

[53]  T. Mcclanahan,et al.  IL-23 drives a pathogenic T cell population that induces autoimmune inflammation , 2005, The Journal of experimental medicine.

[54]  J. Laurent,et al.  New insights into the proliferation and differentiation of early mouse thymocytes. , 2004, International immunology.

[55]  William C Hahn,et al.  Lentivirus-delivered stable gene silencing by RNAi in primary cells. , 2003, RNA.

[56]  P. Fraker,et al.  Apoptosis plays a distinct role in the loss of precursor lymphocytes during zinc deficiency in mice. , 2002, The Journal of nutrition.

[57]  B. Ames,et al.  Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[58]  Alex E. Lash,et al.  Gene Expression Omnibus: NCBI gene expression and hybridization array data repository , 2002, Nucleic Acids Res..

[59]  L. Leiva,et al.  Reduced thymocyte proliferation but not increased apoptosis as a possible cause of thymus atrophy in iron-deficient mice , 2001, British Journal of Nutrition.

[60]  G. Weiss,et al.  Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation. , 1999, Biochimica et biophysica acta.

[61]  A. Grinberg,et al.  CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity , 1998, The Journal of experimental medicine.

[62]  M. Cooper,et al.  Impairment of  T and B Cell Development by Treatment with a Type I Interferon , 1998, The Journal of experimental medicine.

[63]  I. Stamenkovic,et al.  Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes , 1996, The Journal of experimental medicine.

[64]  P. Leenen,et al.  Inhibition of proliferation and differentiation during early T cell development by anti‐transferrin receptor antibody , 1994, European journal of immunology.

[65]  J. Trent,et al.  WAF1, a potential mediator of p53 tumor suppression , 1993, Cell.

[66]  T. Nakayama,et al.  CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection. , 1993, International immunology.

[67]  W. Swat,et al.  CD 69 expression during selection and maturation of CD4+8+ thymocytes , 1993, European journal of immunology.

[68]  P. Chappuis,et al.  Restoration of the thymus in aging mice by in vivo zinc supplementation. , 1993, Clinical immunology and immunopathology.

[69]  Yamaguchi Masayoshi,et al.  Role of zinc as an activator of mitochondrial function in rat liver , 1982 .