Frequency and partial characterization of adenylate cyclase‐stimulating activity in tumors associated with humoral hypercalcemia of malignancy

Parathyroid hormone‐like adenylate cyclase‐stimulating activity (ACSA) has previously been identified in small numbers of tumors or tumor‐conditioned tissue culture medium derived from patients or animals with humoral hypercalcemia of malignancy (HHM). We examined the frequency with which this ACSA occurred in a large group of tumor extracts derived from patients with HHM (n = 20), and compared this to three control groups: normocalcemia‐associated tumors (n = 20), hypercalcemic control tumors (n = 7), and normal, nonmalignant tissue samples (n = 10). Eighteen of 20 HHM‐associated tumor extracts displayed ACSA whereas only 4 of 37 controls contained detectable ACSA.

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