PEGylated Polymeric Nanoparticles Loaded with 2-Methoxyestradiol for the Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model.

[1]  A. Zemella,et al.  One to one comparison of cell-free synthesized erythropoietin conjugates modified with linear polyglycerol and polyethylene glycol , 2023, Scientific reports.

[2]  M. Motamedi,et al.  Simvastatin-loaded liposome nanoparticles treatment for uterine leiomyoma in a patient-derived xenograft mouse model: a pilot study , 2022, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.

[3]  Qiwei Yang,et al.  Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation. , 2021, Pharmacological research.

[4]  Yan Wang,et al.  FDA’s Poly (Lactic-Co-Glycolic Acid) Research Program and Regulatory Outcomes , 2021, The AAPS Journal.

[5]  S. Łukasiewicz,et al.  Polycaprolactone Nanoparticles as Promising Candidates for Nanocarriers in Novel Nanomedicines , 2021, Pharmaceutics.

[6]  M. Motamedi,et al.  Liposomal 2-Methoxyestradiol Nanoparticles for Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model , 2020, Reproductive Sciences.

[7]  S. Hua Synthesis and in vitro characterization of oxytocin receptor targeted PEGylated immunoliposomes for drug delivery to the uterus , 2019, Journal of liposome research.

[8]  Mostafa A Borahay,et al.  New and Emerging Therapies for Uterine Fibroids , 2017, Seminars in Reproductive Medicine.

[9]  A. Al-Hendy,et al.  Estrogen Receptors and Signaling in Fibroids: Role in Pathobiology and Therapeutic Implications , 2017, Reproductive Sciences.

[10]  D. Friend Drug delivery for the treatment of endometriosis and uterine fibroids , 2017, Drug Delivery and Translational Research.

[11]  E. Jeung,et al.  Effect of 2-methoxyestradiol on SK-LMS-1 uterine leiomyosarcoma cells , 2017, Oncology letters.

[12]  E. Rytting,et al.  Cytotoxicity of Endocytosis and Efflux Inhibitors in the BeWo Cell Line , 2017, Journal of pharmaceutical research international.

[13]  E. Rytting,et al.  Transport of digoxin-loaded polymeric nanoparticles across BeWo cells, an in vitro model of human placental trophoblast. , 2015, Therapeutic delivery.

[14]  A. Al-Hendy,et al.  Signaling Pathways in Leiomyoma: Understanding Pathobiology and Implications for Therapy , 2015, Molecular medicine.

[15]  N. Chabbert-Buffet,et al.  Fibroid growth and medical options for treatment. , 2014, Fertility and sterility.

[16]  J. Reineke,et al.  Quantitative detection of PLGA nanoparticle degradation in tissues following intravenous administration. , 2013, Molecular pharmaceutics.

[17]  M. Motamedi,et al.  Nanomedicine for uterine leiomyoma therapy. , 2013, Therapeutic delivery.

[18]  Concepcion R. Diaz-Arrastia,et al.  2-Methoxyestradiol causes functional repression of transforming growth factor β3 signaling by ameliorating Smad and non-Smad signaling pathways in immortalized uterine fibroid cells. , 2012, Fertility and sterility.

[19]  A. Oberhauser,et al.  Tracking UNC-45 chaperone-myosin interaction with a titin mechanical reporter. , 2012, Biophysical journal.

[20]  S. Verenich,et al.  Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges. , 2010, Molecular pharmaceutics.

[21]  H. Swai,et al.  In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles. , 2010, Toxicology and applied pharmacology.

[22]  A. Al-Hendy,et al.  Antiproliferative and proapoptotic effects of epigallocatechin gallate on human leiomyoma cells. , 2010, Fertility and sterility.

[23]  A. Mueck,et al.  2-Methoxyestradiol—Biology and mechanism of action , 2010, Steroids.

[24]  Liangfang Zhang,et al.  Nanoparticle-assisted combination therapies for effective cancer treatment. , 2010, Therapeutic delivery.

[25]  S. Bulun,et al.  Progesterone is essential for maintenance and growth of uterine leiomyoma. , 2010, Endocrinology.

[26]  Concepcion R. Diaz-Arrastia,et al.  Catechol-O-Methyltransferase Expression and 2-Methoxyestradiol Affect Microtubule Dynamics and Modify Steroid Receptor Signaling in Leiomyoma Cells , 2009, PloS one.

[27]  M. Lottering,et al.  In vitro effects of 2‐methoxyestradiol on cell numbers, morphology, cell cycle progression, and apoptosis induction in oesophageal carcinoma cells , 2009, Cell biochemistry and function.

[28]  Juliane Nguyen,et al.  Biodegradable polymeric nanocarriers for pulmonary drug delivery , 2008 .

[29]  A. Al-Hendy,et al.  Estrogen Metabolite 2-Methoxyestradiol Induces Apoptosis and Inhibits Cell Proliferation and Collagen Production in Rat and Human Leiomyoma Cells: A Potential Medicinal Treatment for Uterine Fibroids , 2006, The Journal of the Society for Gynecologic Investigation: JSGI.

[30]  Andres F Oberhauser,et al.  The mechanical properties of E. coli type 1 pili measured by atomic force microscopy techniques. , 2006, Biophysical journal.

[31]  G. Sledge,et al.  Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer , 2006, Investigational New Drugs.

[32]  A. Sparreboom,et al.  Plasma protein binding of the investigational anticancer agent 2-methoxyestradiol , 2006, Anti-cancer drugs.

[33]  C. Yiannoutsos,et al.  A Phase II Multicenter, Randomized, Double-Blind, Safety Trial Assessing the Pharmacokinetics, Pharmacodynamics, and Efficacy of Oral 2-Methoxyestradiol Capsules in Hormone-Refractory Prostate Cancer , 2005, Clinical Cancer Research.

[34]  U. Ulmsten,et al.  Antiproliferative activity and toxicity of 2-methoxyestradiol in cervical cancer xenograft mice , 2004, International Journal of Gynecologic Cancer.

[35]  K. Avgoustakis,et al.  Effect of copolymer composition on the physicochemical characteristics, in vitro stability, and biodistribution of PLGA-mPEG nanoparticles. , 2003, International journal of pharmaceutics.

[36]  J. Haseman,et al.  Immortalization of Human Uterine Leiomyoma and Myometrial Cell Lines After Induction of Telomerase Activity: Molecular and Phenotypic Characteristics , 2002, Laboratory Investigation.

[37]  Mariano Carrion-Vazquez,et al.  The mechanical hierarchies of fibronectin observed with single-molecule AFM. , 2002, Journal of molecular biology.

[38]  J. Clarke,et al.  Mechanical and chemical unfolding of a single protein: a comparison. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[39]  Andres F. Oberhauser,et al.  The molecular elasticity of the extracellular matrix protein tenascin , 1998, Nature.

[40]  W. Catherino,et al.  Uterine fibroids , 2016, Nature Reviews Disease Primers.

[41]  L. Ding,et al.  Underlying mechanism of 2-methoxyestradiol-induced apoptosis and growth arrest in SKOV3 human ovarian cancer cells. , 2015, European review for medical and pharmacological sciences.

[42]  J. Segars,et al.  Proceedings from theNational Institute of Child Health and Human Development conference on the Uterine Fibroid Research Update Workshop. , 2011, Fertility and sterility.

[43]  R. Langer,et al.  Polymeric nanoparticles for drug delivery. , 2010, Methods in molecular biology.

[44]  David B Dunson,et al.  High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. , 2003, American journal of obstetrics and gynecology.