PEGylated Polymeric Nanoparticles Loaded with 2-Methoxyestradiol for the Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model.
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A. Oberhauser | M. Motamedi | E. Rytting | G. Kilic | Mostafa A Borahay | J. Saada | K. Vincent | Mansi Shah | Paul J. Bujalowski | Gregory W. Kirschen | Salama A. Salama | Jinping Yang | Sanaalarab Al Enazy
[1] A. Zemella,et al. One to one comparison of cell-free synthesized erythropoietin conjugates modified with linear polyglycerol and polyethylene glycol , 2023, Scientific reports.
[2] M. Motamedi,et al. Simvastatin-loaded liposome nanoparticles treatment for uterine leiomyoma in a patient-derived xenograft mouse model: a pilot study , 2022, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.
[3] Qiwei Yang,et al. Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation. , 2021, Pharmacological research.
[4] Yan Wang,et al. FDA’s Poly (Lactic-Co-Glycolic Acid) Research Program and Regulatory Outcomes , 2021, The AAPS Journal.
[5] S. Łukasiewicz,et al. Polycaprolactone Nanoparticles as Promising Candidates for Nanocarriers in Novel Nanomedicines , 2021, Pharmaceutics.
[6] M. Motamedi,et al. Liposomal 2-Methoxyestradiol Nanoparticles for Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model , 2020, Reproductive Sciences.
[7] S. Hua. Synthesis and in vitro characterization of oxytocin receptor targeted PEGylated immunoliposomes for drug delivery to the uterus , 2019, Journal of liposome research.
[8] Mostafa A Borahay,et al. New and Emerging Therapies for Uterine Fibroids , 2017, Seminars in Reproductive Medicine.
[9] A. Al-Hendy,et al. Estrogen Receptors and Signaling in Fibroids: Role in Pathobiology and Therapeutic Implications , 2017, Reproductive Sciences.
[10] D. Friend. Drug delivery for the treatment of endometriosis and uterine fibroids , 2017, Drug Delivery and Translational Research.
[11] E. Jeung,et al. Effect of 2-methoxyestradiol on SK-LMS-1 uterine leiomyosarcoma cells , 2017, Oncology letters.
[12] E. Rytting,et al. Cytotoxicity of Endocytosis and Efflux Inhibitors in the BeWo Cell Line , 2017, Journal of pharmaceutical research international.
[13] E. Rytting,et al. Transport of digoxin-loaded polymeric nanoparticles across BeWo cells, an in vitro model of human placental trophoblast. , 2015, Therapeutic delivery.
[14] A. Al-Hendy,et al. Signaling Pathways in Leiomyoma: Understanding Pathobiology and Implications for Therapy , 2015, Molecular medicine.
[15] N. Chabbert-Buffet,et al. Fibroid growth and medical options for treatment. , 2014, Fertility and sterility.
[16] J. Reineke,et al. Quantitative detection of PLGA nanoparticle degradation in tissues following intravenous administration. , 2013, Molecular pharmaceutics.
[17] M. Motamedi,et al. Nanomedicine for uterine leiomyoma therapy. , 2013, Therapeutic delivery.
[18] Concepcion R. Diaz-Arrastia,et al. 2-Methoxyestradiol causes functional repression of transforming growth factor β3 signaling by ameliorating Smad and non-Smad signaling pathways in immortalized uterine fibroid cells. , 2012, Fertility and sterility.
[19] A. Oberhauser,et al. Tracking UNC-45 chaperone-myosin interaction with a titin mechanical reporter. , 2012, Biophysical journal.
[20] S. Verenich,et al. Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges. , 2010, Molecular pharmaceutics.
[21] H. Swai,et al. In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles. , 2010, Toxicology and applied pharmacology.
[22] A. Al-Hendy,et al. Antiproliferative and proapoptotic effects of epigallocatechin gallate on human leiomyoma cells. , 2010, Fertility and sterility.
[23] A. Mueck,et al. 2-Methoxyestradiol—Biology and mechanism of action , 2010, Steroids.
[24] Liangfang Zhang,et al. Nanoparticle-assisted combination therapies for effective cancer treatment. , 2010, Therapeutic delivery.
[25] S. Bulun,et al. Progesterone is essential for maintenance and growth of uterine leiomyoma. , 2010, Endocrinology.
[26] Concepcion R. Diaz-Arrastia,et al. Catechol-O-Methyltransferase Expression and 2-Methoxyestradiol Affect Microtubule Dynamics and Modify Steroid Receptor Signaling in Leiomyoma Cells , 2009, PloS one.
[27] M. Lottering,et al. In vitro effects of 2‐methoxyestradiol on cell numbers, morphology, cell cycle progression, and apoptosis induction in oesophageal carcinoma cells , 2009, Cell biochemistry and function.
[28] Juliane Nguyen,et al. Biodegradable polymeric nanocarriers for pulmonary drug delivery , 2008 .
[29] A. Al-Hendy,et al. Estrogen Metabolite 2-Methoxyestradiol Induces Apoptosis and Inhibits Cell Proliferation and Collagen Production in Rat and Human Leiomyoma Cells: A Potential Medicinal Treatment for Uterine Fibroids , 2006, The Journal of the Society for Gynecologic Investigation: JSGI.
[30] Andres F Oberhauser,et al. The mechanical properties of E. coli type 1 pili measured by atomic force microscopy techniques. , 2006, Biophysical journal.
[31] G. Sledge,et al. Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer , 2006, Investigational New Drugs.
[32] A. Sparreboom,et al. Plasma protein binding of the investigational anticancer agent 2-methoxyestradiol , 2006, Anti-cancer drugs.
[33] C. Yiannoutsos,et al. A Phase II Multicenter, Randomized, Double-Blind, Safety Trial Assessing the Pharmacokinetics, Pharmacodynamics, and Efficacy of Oral 2-Methoxyestradiol Capsules in Hormone-Refractory Prostate Cancer , 2005, Clinical Cancer Research.
[34] U. Ulmsten,et al. Antiproliferative activity and toxicity of 2-methoxyestradiol in cervical cancer xenograft mice , 2004, International Journal of Gynecologic Cancer.
[35] K. Avgoustakis,et al. Effect of copolymer composition on the physicochemical characteristics, in vitro stability, and biodistribution of PLGA-mPEG nanoparticles. , 2003, International journal of pharmaceutics.
[36] J. Haseman,et al. Immortalization of Human Uterine Leiomyoma and Myometrial Cell Lines After Induction of Telomerase Activity: Molecular and Phenotypic Characteristics , 2002, Laboratory Investigation.
[37] Mariano Carrion-Vazquez,et al. The mechanical hierarchies of fibronectin observed with single-molecule AFM. , 2002, Journal of molecular biology.
[38] J. Clarke,et al. Mechanical and chemical unfolding of a single protein: a comparison. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[39] Andres F. Oberhauser,et al. The molecular elasticity of the extracellular matrix protein tenascin , 1998, Nature.
[40] W. Catherino,et al. Uterine fibroids , 2016, Nature Reviews Disease Primers.
[41] L. Ding,et al. Underlying mechanism of 2-methoxyestradiol-induced apoptosis and growth arrest in SKOV3 human ovarian cancer cells. , 2015, European review for medical and pharmacological sciences.
[42] J. Segars,et al. Proceedings from theNational Institute of Child Health and Human Development conference on the Uterine Fibroid Research Update Workshop. , 2011, Fertility and sterility.
[43] R. Langer,et al. Polymeric nanoparticles for drug delivery. , 2010, Methods in molecular biology.
[44] David B Dunson,et al. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. , 2003, American journal of obstetrics and gynecology.