ICRP Publication 120: Radiological Protection in Cardiology

Cardiac nuclear medicine, cardiac computed tomography (CT), interventional cardiology procedures, and electrophysiology procedures are increasing in number and account for an important share of patient radiation exposure in medicine. Complex percutaneous coronary interventions and cardiac electrophysiology procedures are associated with high radiation doses. These procedures can result in patient skin doses that are high enough to cause radiation injury and an increased risk of cancer. Treatment of congenital heart disease in children is of particular concern. Additionally, staff(1) in cardiac catheterisation laboratories may receive high doses of radiation if radiological protection tools are not used properly. The Commission provided recommendations for radiological protection during fluoroscopically guided interventions in Publication 85, for radiological protection in CT in Publications 87 and 102, and for training in radiological protection in Publication 113 (ICRP, 2000b,c, 2007a, 2009). This report is focused specifically on cardiology, and brings together information relevant to cardiology from the Commission's published documents. There is emphasis on those imaging procedures and interventions specific to cardiology. The material and recommendations in the current document have been updated to reflect the most recent recommendations of the Commission. This report provides guidance to assist the cardiologist with justification procedures and optimisation of protection in cardiac CT studies, cardiac nuclear medicine studies, and fluoroscopically guided cardiac interventions. It includes discussions of the biological effects of radiation, principles of radiological protection, protection of staff during fluoroscopically guided interventions, radiological protection training, and establishment of a quality assurance programme for cardiac imaging and intervention. As tissue injury, principally skin injury, is a risk for fluoroscopically guided interventions, particular attention is devoted to clinical examples of radiation-related skin injuries from cardiac interventions, methods to reduce patient radiation dose, training recommendations, and quality assurance programmes for interventional fluoroscopy.

[1]  A. Einstein,et al.  Estimating risk of cancer associated with radiation exposure from 64-slice computed tomography coronary angiography. , 2007, JAMA.

[2]  Thea M Lundberg,et al.  Measuring and minimizing the radiation dose to nuclear medicine technologists. , 2002, Journal of nuclear medicine technology.

[3]  R. Shore,et al.  Cataracts among Chernobyl Clean-up Workers: Implications Regarding Permissible Eye Exposures , 2007, Radiation research.

[4]  M. Walsh,et al.  Radiation safety in the practice of cardiology , 1998 .

[5]  LK Wagner,et al.  Radiation injury is a potentially serious complication to fluoroscopically-guided complex interventions , 2007, Biomedical imaging and intervention journal.

[6]  E Vano,et al.  Patient doses from fluoroscopically guided cardiac procedures in pediatrics , 2007, Physics in medicine and biology.

[7]  Xiaokui Li,et al.  New Technology and Methodologies for Intraoperative, Perioperative, and Intraprocedural Monitoring of Surgical and Catheter Interventions for Congenital Heart Disease , 2002, Echocardiography.

[8]  E. Vañó,et al.  Lens injuries induced by occupational exposure in non-optimized interventional radiology laboratories. , 1998, The British journal of radiology.

[9]  Eugenio Picano,et al.  Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease. , 2006, European heart journal.

[10]  E. Topol,et al.  Use of radiographic devices by cardiologists , 1995 .

[11]  J. Spertus,et al.  ACCF/SCAI/STS/AATS/AHA/ASNC 2009 Appropriateness Criteria for Coronary Revascularization: a report by the American College of Cardiology Foundation Appropriateness Criteria Task Force, Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, American Association for Th , 2009, Journal of the American College of Cardiology.

[12]  Donald L. Miller Overview of contemporary interventional fluoroscopy procedures. , 2008, Health physics.

[13]  Teresa Wu,et al.  Automatic Monitoring of Localized Skin Dose with Fluoroscopic and Interventional Procedures , 2011, Journal of Digital Imaging.

[14]  L. Wann,et al.  ACCF/ASE/ACEP/AHA/ASNC/SCAI/SCCT/SCMR 2008 appropriateness criteria for stress echocardiography: a report of the American College of Cardiology Foundation Appropriateness Criteria Task Force, American Society of Echocardiography, American College of Emergency Physicians, American Heart Association, , 2008, Journal of the American College of Cardiology.

[15]  Andrew E Arai,et al.  Radiation Dose from Single-Heartbeat Coronary CT Angiography Performed with a 320 – Detector Row Volume Scanner 1 , 2010 .

[16]  X. Castells,et al.  Revisión sistemática de estudios poblacionales de prevalencia de catarata , 2006 .

[17]  R. Gibbons,et al.  ACCF/ASNC appropriateness criteria for single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI): a report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group and the American Society of Nuclear Card , 2005, Journal of the American College of Cardiology.

[18]  Donald L. Miller,et al.  Occupational health hazards in the interventional laboratory: time for a safer environment. , 2009, Heart rhythm.

[19]  D. L. Preston,et al.  Solid Cancer Incidence in Atomic Bomb Survivors: 1958–1998 , 2007, Radiation research.

[20]  S. Darby,et al.  Commentary: A dose-response relationship for radiation-induced heart disease--current issues and future prospects. , 2008, International journal of epidemiology.

[21]  Thomas Flohr,et al.  Multislice helical CT of the heart with retrospective ECG gating: reduction of radiation exposure by ECG-controlled tube current modulation , 2002, European Radiology.

[22]  M. Roizen,et al.  Ionizing Radiation in Cardiac Imaging: A Science Advisory From the American Heart Association Committee on Cardiac Imaging of the Council on Clinical Cardiology and Committee on Cardiovascular Imaging and Intervention of the Council on Cardiovascular Radiology and Intervention , 2010 .

[23]  J. Knuuti,et al.  EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology , 2005, European Journal of Nuclear Medicine and Molecular Imaging.

[24]  Stephen Balter,et al.  ACCF/AHA/HRS/SCAI clinical competence statement on physician knowledge to optimize patient safety and image quality in fluoroscopically guided invasive cardiovascular procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task , 2005, Circulation.

[25]  Michael G Stabin,et al.  Radiopharmaceuticals for Nuclear Cardiology: Radiation Dosimetry, Uncertainties, and Risk , 2008, Journal of Nuclear Medicine.

[26]  Jeroen J. Bax,et al.  Cardiac computed tomography: indications, applications, limitations, and training requirements: report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT of the European Society of Cardiology and the European Council of Nuclear Cardiology. , 2008, European heart journal.

[27]  T. Shope,et al.  Radiation-induced skin injuries from fluoroscopy. , 1996, Radiographics : a review publication of the Radiological Society of North America, Inc.

[28]  E. Vañó,et al.  Approaches to establishing reference levels in interventional radiology. , 2001, Radiation protection dosimetry.

[29]  W. Moore,et al.  Physical factors determining the utility of radiation safety glasses. , 1980, Medical physics.

[30]  Michael G Stabin,et al.  Uncertainties in Internal Dose Calculations for Radiopharmaceuticals , 2008, Journal of Nuclear Medicine.

[31]  S. Achenbach,et al.  Coronary computed tomography angiography with a consistent dose below 1 mSv using prospectively electrocardiogram-triggered high-pitch spiral acquisition. , 2010, European heart journal.

[32]  Stephen Balter,et al.  Radiation safety program for the cardiac catheterization laboratory , 2011, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[33]  L. Dauer,et al.  TI-201 stress tests and homeland security , 2007, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[34]  B. Archer,et al.  Management of patient skin dose in fluoroscopically guided interventional procedures. , 2000, Journal of vascular and interventional radiology : JVIR.

[35]  R. Shack,et al.  Radiation dermatitis. , 1987, Clinics in plastic surgery.

[36]  H. Thierens,et al.  Patient-Specific Dose and Radiation Risk Estimation in Pediatric Cardiac Catheterization , 2005, Circulation.

[37]  W. O’Neill,et al.  Reducing radiation dose in the cardiac catheterization laboratory by design alterations and staff education. , 2002, The American journal of cardiology.

[38]  B. Li,et al.  CANCER INCIDENCE AND RISK ESTIMATION AMONG MEDICAL X-RAY WORKERS IN CHINA, 1950–1995 , 2002, Health physics.

[39]  Madan M Rehani,et al.  Radiation Cataract Risk in Interventional Cardiology Personnel , 2010, Radiation research.

[40]  H. Weghaupt,et al.  Contrast acuity in cataracts of different morphology and association to self-reported visual function. , 2006, Investigative ophthalmology & visual science.

[41]  D. Preston,et al.  Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure. , 2002, Journal of the National Cancer Institute.

[42]  L. Wagner,et al.  Radiation-attenuating surgical gloves: effects of scatter and secondary electron production. , 1996, Radiology.

[43]  Stephen Balter,et al.  Comparison of four techniques to estimate radiation dose to skin during angiographic and interventional radiology procedures. , 2002, Journal of vascular and interventional radiology : JVIR.

[44]  E. Depuey,et al.  Introduction to the Guidelines , 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[45]  Javier Sanz,et al.  Radiation dose and cancer risk estimates in 16-slice computed tomography coronary angiography , 2008, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[46]  M. Comas,et al.  [Systematic review of population-based studies of the prevalence of cataracts]. , 2006, Archivos de la Sociedad Espanola de Oftalmologia.

[47]  Peter Ammann,et al.  Impact of a lead glass screen on scatter radiation to eyes and hands in interventional cardiologists , 2006, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[48]  R. Morin,et al.  Effect of Acquisition Technique on Radiation Dose and Image Quality in Multidetector Row Computed Tomography Coronary Angiography With Submillimeter Collimation , 2005, Investigative radiology.

[49]  S. Solomon,et al.  Unprotected operator eye lens doses in oncologic interventional radiology are clinically significant: estimation from patient kerma-area-product data. , 2010, Journal of vascular and interventional radiology : JVIR.

[50]  Stephen Balter,et al.  Occupational hazards of interventional cardiologists: Prevalence of orthopedic health problems in contemporary practice , 2004, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[51]  Frederick A. Masoudi,et al.  ACCF/SCAI/STS/MTS/AHA/ASNC 2009 Appropriateness Criteria for Coronary Revascularization. Commentary , 2009 .

[52]  Alexander Norbash,et al.  Occupational health hazards in the interventional laboratory: time for a safer environment. , 2009, Journal of vascular and interventional radiology : JVIR.

[53]  P C Brennan,et al.  Potential Irish dose reference levels for cardiac interventional examinations. , 2009, The British journal of radiology.

[54]  K. Dimopoulos,et al.  Cardiac resynchronisation may reduce all-cause mortality: meta-analysis of preliminary COMPANION data with CONTAK-CD, InSync ICD, MIRACLE and MUSTIC. , 2004, International journal of cardiology.

[55]  F. Mettler,et al.  Radiation burns as a severe complication of fluoroscopically guided cardiological interventions. , 2004, Journal of interventional cardiology.

[56]  C. Fife,et al.  Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. , 2006, Journal of the American Academy of Dermatology.

[57]  Martin A Lodge,et al.  Human Biodistribution and Radiation Dosimetry of 82Rb , 2010, The Journal of Nuclear Medicine.

[58]  J. Paul,et al.  MDCT of the coronary arteries: feasibility of low-dose CT with ECG-pulsed tube current modulation to reduce radiation dose. , 2006, AJR. American journal of roentgenology.

[59]  International project on individual monitoring and radiation exposure levels in interventional cardiology. , 2011, Radiation protection dosimetry.

[60]  Zhonghua Sun,et al.  Prospective versus retrospective ECG-gated multislice CT coronary angiography: a systematic review of radiation dose and diagnostic accuracy. , 2012, European journal of radiology.

[61]  T. Wenzl Increased brain cancer risk in physicians with high radiation exposure. , 2005, Radiology.

[62]  Maria Grazia Andreassi,et al.  Radiation risk from pediatric cardiac catheterization: friendly fire on children with congenital heart disease. , 2009, Circulation.

[63]  K. Strauss,et al.  Image gently, step lightly: increasing radiation dose awareness in pediatric interventions through an international social marketing campaign. , 2009, Journal of vascular and interventional radiology : JVIR.

[64]  Andrew J. Einstein,et al.  Medical imaging: the radiation issue , 2009, Nature Reviews Cardiology.

[65]  E. Vañó,et al.  Eye lens exposure to radiation in interventional suites: caution is warranted. , 2008, Radiology.

[66]  C. Tracy,et al.  ACCF/AHA/HRS/SCAI FLUOROSCOPY CLINICAL COMPETENCE STATEMENT ACCF/AHA/HRS/SCAI Clinical Competence Statement on Physician Knowledge to Optimize Patient Safety and Image Quality in Fluoroscopically Guided Invasive Cardiovascular Procedures , 2004 .

[67]  A. Hanlon,et al.  Diabetes mellitus: a predictor for late radiation morbidity. , 1999, International journal of radiation oncology, biology, physics.

[68]  C. J. Kotre,et al.  Reference levels in PTCA as a function of procedure complexity. , 2005, Radiation protection dosimetry.

[69]  S. Kimmel,et al.  Contemporary trends in coronary intervention: A report from the registry of the Society for Cardiac Angiography and Interventions , 2000, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[70]  M. Finkelstein Is brain cancer an occupational disease of cardiologists? , 1998, The Canadian journal of cardiology.

[71]  E Vañó,et al.  Radiation exposure to medical staff in interventional and cardiac radiology. , 1998, The British journal of radiology.

[72]  D. Salat,et al.  Reference levels at European level for cardiac interventional procedures. , 2008, Radiation protection dosimetry.

[73]  Masayuki Zuguchi,et al.  Radiation dose to the pediatric cardiac catheterization and intervention patient. , 2010, AJR. American journal of roentgenology.

[74]  R. Nowotny,et al.  A pilot study exploring the possibility of establishing guidance levels in x-ray directed interventional procedures. , 2008, Medical physics.

[75]  M. Stabin PROPOSED REVISION TO THE RADIATION DOSIMETRY OF 82RB , 2010, Health physics.

[76]  T. Komppa,et al.  Occupational dose constraints in interventional cardiology procedures: the DIMOND approach. , 2004, Physics in medicine and biology.

[77]  Gabriel Bartal,et al.  Guidelines for patient radiation dose management. , 2009, Journal of vascular and interventional radiology : JVIR.

[78]  H. Justino The ALARA concept in pediatric cardiac catheterization: techniques and tactics for managing radiation dose , 2006, Pediatric Radiology.

[79]  S. Balter Stray radiation in the cardiac catheterisation laboratory. , 2001, Radiation protection dosimetry.

[80]  L. Wagner,et al.  Endovascular and interventional procedures in obese patients: a review of procedural technique modifications and radiation management. , 2006, Journal of vascular and interventional radiology : JVIR.

[81]  R. Padovani,et al.  Patient doses and dosimetric evaluations in interventional cardiology. , 2009, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[82]  Donald L. Miller,et al.  OCCUPATIONAL RADIATION DOSES TO OPERATORS PERFORMING CARDIAC CATHETERIZATION PROCEDURES , 2008, Health physics.

[83]  G. Matanoski,et al.  The current mortality rates of radiologists and other physician specialists: specific causes of death. , 1975, American journal of epidemiology.

[84]  R. Gibbons,et al.  Evaluation of coronary CTA Appropriateness Criteria in an academic medical center. , 2010, Journal of the American College of Radiology : JACR.

[85]  D. Stram,et al.  Review and evaluation of updated research on the health effects associated with low-dose ionising radiation. , 2010, Radiation protection dosimetry.

[86]  S. McFadden,et al.  X-ray dose and associated risks from radiofrequency catheter ablation procedures. , 2002, The British journal of radiology.

[87]  C. Sistrom,et al.  In support of the ACR Appropriateness Criteria. , 2008, Journal of the American College of Radiology : JACR.

[88]  J. Malone,et al.  Quality criteria for cardiac images in diagnostic and interventional cardiology. , 2001, The British journal of radiology.

[89]  K. H. Mild,et al.  Ionizing radiation, cellular telephones and the risk for brain tumours , 2001, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[90]  E Vano,et al.  Radiation exposure to cardiologists: how it could be reduced , 2003, Heart.

[91]  P. Wust,et al.  Radiation Exposure to Patient and Staff in Hepatic Chemoembolization: Risk Estimation of Cancer and Deterministic Effects , 2006, CardioVascular and Interventional Radiology.

[92]  D. Preston,et al.  Clinical and epidemiologic characteristics of first primary tumors of the central nervous system and related organs among atomic bomb survivors in Hiroshima and Nagasaki, 1958–1995 , 2004, Cancer.

[93]  Donald L. Miller,et al.  Clinical radiation management for fluoroscopically guided interventional procedures. , 2010, Radiology.

[94]  I. Turesson,et al.  The predictive value of skin telangiectasia for late radiation effects in different normal tissues. , 1986, International journal of radiation oncology, biology, physics.

[95]  Gabriel Bartal,et al.  Occupational radiation protection in interventional radiology: a joint guideline of the Cardiovascular and Interventional Radiology Society of Europe and the Society of Interventional Radiology. , 2010, Journal of vascular and interventional radiology : JVIR.

[96]  H. D. Roedler,et al.  Accuracy of internal dose calculations with special consideration of radiopharmaceutical biokinetics , 1981 .

[97]  K. P. Kim,et al.  Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer. , 2009, Archives of internal medicine.

[98]  Keith Binks,et al.  The non-cancer mortality experience of male workers at British Nuclear Fuels plc, 1946–2005 , 2008, International journal of epidemiology.

[99]  E. Vano,et al.  Preliminary reference levels in interventional cardiology , 2003, European Radiology.

[100]  A. Sigurdson,et al.  Can low-dose radiation increase risk of cardiovascular disease? , 2008, The Lancet.

[101]  Cynthia H McCollough,et al.  Standardized medical terminology for cardiac computed tomography: a report of the Society of Cardiovascular Computed Tomography. , 2011, Journal of cardiovascular computed tomography.

[102]  L. Wagner,et al.  The effect of fellows' training in invasive cardiology on radiological exposure of patients. , 2007, Radiation protection dosimetry.

[103]  Tsung O Cheng,et al.  The current state of cardiology in China , 2004, International Journal of Cardiology.

[104]  E. Vañó,et al.  Dosimetric and radiation protection considerations based on some cases of patient skin injuries in interventional cardiology. , 1998, The British journal of radiology.

[105]  K. Faulkner,et al.  Analysis of the frequency of interventional cardiology in various European countries. , 2008, Radiation protection dosimetry.

[106]  L. Renaud A 5-y follow-up of the radiation exposure to in-room personnel during cardiac catheterization. , 1992, Health physics.

[107]  Madan M Rehani,et al.  Risk for radiation‐induced cataract for staff in interventional cardiology: Is there reason for concern? , 2010, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[108]  C. Morillo,et al.  The World Survey of Cardiac Pacing and Cardioverter Defibrillators: Calendar Year 2001 , 2004, Pacing and clinical electrophysiology : PACE.

[109]  J. Moore,et al.  Future of interventional cardiology in pediatrics , 2003, Current opinion in cardiology.

[110]  R. Padovani,et al.  Staff dosimetry in interventional cardiology. , 2001, Radiation protection dosimetry.

[111]  Jörg Hausleiter,et al.  Estimated radiation dose associated with cardiac CT angiography. , 2009, JAMA.

[112]  Stephen Balter,et al.  Fluoroscopically guided interventional procedures: a review of radiation effects on patients' skin and hair. , 2010, Radiology.

[113]  W. Howard,et al.  Optimal Medical Therapy with or without PCI for Stable Coronary Disease , 2008 .

[114]  Haraldur Bjarnason,et al.  An investigation of operator exposure in interventional radiology. , 2006, Radiographics : a review publication of the Radiological Society of North America, Inc.

[115]  R S Nickerson,et al.  The Framingham Eye Study. I. Outline and major prevalence findings. , 1977, American journal of epidemiology.

[116]  P. Khong,et al.  Radiation dose and cancer risk in retrospectively and prospectively ECG-gated coronary angiography using 64-slice multidetector CT. , 2010, The British journal of radiology.

[117]  G. Bernardi,et al.  Retrospective evaluation of occurrence of skin injuries in interventional cardiac procedures. , 2005, Radiation protection dosimetry.

[118]  F. Verdun,et al.  Radiation exposure and radiation protection in interventional cardiology , 2005 .

[119]  H Thierens,et al.  A large-scale multicentre study in Belgium of dose area product values and effective doses in interventional cardiology using contemporary X-ray equipment. , 2007, Radiation protection dosimetry.

[120]  Donald L. Miller,et al.  Radiation management for interventions using fluoroscopic or computed tomographic guidance during pregnancy: a joint guideline of the Society of Interventional Radiology and the Cardiovascular and Interventional Radiological Society of Europe with Endorsement by the Canadian Interventional Radiology , 2012, Journal of vascular and interventional radiology : JVIR.

[121]  E L Siegel,et al.  Severe skin reactions from interventional fluoroscopy: case report and review of the literature. , 1999, Radiology.

[122]  F. Mettler,et al.  Skin injuries from fluoroscopically guided procedures: part 1, characteristics of radiation injury. , 2001, AJR. American journal of roentgenology.

[123]  J. Dahm,et al.  Radiation exposure benefit of a lead cap in invasive cardiology , 2003, Heart.

[124]  J. Earls,et al.  Prospectively gated low-dose CCTA: 24 months experience in more than 2,000 clinical cases , 2009, The International Journal of Cardiovascular Imaging.

[125]  Donald L. Miller,et al.  Minimising radiation exposure to physicians performing fluoroscopically guided cardiac catheterisation procedures: a review. , 2009, Radiation protection dosimetry.

[126]  H. Calkins,et al.  Predictors of fluoroscopy time and estimated radiation exposure during radiofrequency catheter ablation procedures. , 1998, The American journal of cardiology.

[127]  J. Min,et al.  ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American , 2010, Journal of cardiovascular computed tomography.

[128]  William S Weintraub,et al.  A contemporary overview of percutaneous coronary interventions. The American College of Cardiology-National Cardiovascular Data Registry (ACC-NCDR). , 2002, Journal of the American College of Cardiology.

[129]  Madan M. Rehani,et al.  Training of interventional cardiologists in radiation protection--the IAEA's initiatives. , 2007, International journal of cardiology.

[130]  S. Solomon,et al.  Comparing strategies for operator eye protection in the interventional radiology suite. , 2010, Journal of vascular and interventional radiology : JVIR.

[131]  M. Vidovich,et al.  Radiation safety among cardiology fellows. , 2010, The American journal of cardiology.

[132]  John S. Daniel The X-Rays , 1896 .

[133]  J. Dahm,et al.  Significant reduction of radiation exposure to operator and staff during cardiac interventions by analysis of radiation leakage and improved lead shielding. , 2002, The American journal of cardiology.

[134]  S. Furui,et al.  Patients' skin dose during percutaneous coronary intervention for chronic total occlusion , 2008, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[135]  D A Savitz,et al.  Occupation and adult gliomas. , 2000, American journal of epidemiology.

[136]  Dong Zhao,et al.  Future Cardiovascular Disease in China: Markov Model and Risk Factor Scenario Projections From the Coronary Heart Disease Policy Model–China , 2010, Circulation. Cardiovascular quality and outcomes.

[137]  E. Vañó,et al.  Training in radiological protection for interventionalists. Initial Spanish experience. , 2003, The British journal of radiology.

[138]  J I Ten,et al.  Skin radiation injuries in patients following repeated coronary angioplasty procedures. , 2001, The British journal of radiology.

[139]  Cynthia H McCollough,et al.  CT dose: how to measure, how to reduce. , 2008, Health physics.

[140]  P. Dendy Radiation risks in interventional radiology. , 2008, British Journal of Radiology.

[141]  M. Rehani,et al.  Radiation effects in fluoroscopically guided cardiac interventions--keeping them under control. , 2006, International journal of cardiology.

[142]  R. Shore,et al.  Epidemiological Studies of Cataract Risk at Low to Moderate Radiation Doses: (Not) Seeing is Believing , 2010, Radiation research.

[143]  Stephen Balter,et al.  Minimizing radiation-induced skin injury in interventional radiology procedures. , 2002, Radiology.

[144]  M. Blettner,et al.  Medical exposure to ionising radiation and the risk of brain tumours: Interphone study group, Germany. , 2007, European journal of cancer.

[145]  Natalie N. Braun,et al.  Radiation exposure and pregnancy: when should we be concerned? , 2007, Radiographics : a review publication of the Radiological Society of North America, Inc.

[146]  Michael G. Stabin,et al.  Radiation Dose to Patients from Radiopharmaceuticals , 2009 .

[147]  J. Valentin,et al.  Managing patient dose in multi-detector computed tomography(MDCT). ICRP Publication 102. , 2007, Annals of the ICRP.

[148]  Randall C. Thompson,et al.  Radiation Dose to Patients From Cardiac Diagnostic Imaging , 2007, Circulation.

[149]  Jeroen J. Bax,et al.  IMAGING GUIDELINES FOR NUCLEAR CARDIOLOGY PROCEDURES A Report of The American Society of Nuclear Cardiology Quality Assurance Committee , 2006 .

[150]  R. Morin,et al.  Radiation dose in computed tomography of the heart. , 2003, Circulation.

[151]  Stephen Balter A preliminary investigation of ambient light in the interventional fluoroscopy laboratory , 2005, SPIE Medical Imaging.

[152]  B. Wall,et al.  The historical development of reference doses in diagnostic radiology , 1998 .

[153]  J. Mahmarian Stress only myocardial perfusion imaging: Is it time for a change? , 2010, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[154]  Jack Valentin,et al.  Managing patient dose in computed tomography , 2000 .

[155]  Thomas F. Budinger,et al.  MIRD primer for absorbed dose calculations , 1988 .

[156]  C J Martin,et al.  A review of radiology staff doses and dose monitoring requirements. , 2009, Radiation protection dosimetry.

[157]  Donald L. Miller,et al.  Cancer risks associated with external radiation from diagnostic imaging procedures , 2012, CA: a cancer journal for clinicians.

[158]  Keith J Strauss,et al.  Pause and pulse: ten steps that help manage radiation dose during pediatric fluoroscopy. , 2011, AJR. American journal of roentgenology.

[159]  A. Pasciak,et al.  Does "spreading" skin dose by rotating the C-arm during an intervention work? , 2011, Journal of vascular and interventional radiology : JVIR.

[160]  Gabriel Bartal,et al.  Quality improvement guidelines for recording patient radiation dose in the medical record for fluoroscopically guided procedures. , 2012, Journal of vascular and interventional radiology : JVIR.

[161]  Bernhard Bischoff,et al.  Image quality and radiation exposure with a low tube voltage protocol for coronary CT angiography results of the PROTECTION II Trial. , 2010, JACC. Cardiovascular imaging.

[162]  L. Johnson,et al.  Low event rate for stress-only perfusion imaging in patients evaluated for chest pain. , 2002, Journal of the American College of Cardiology.

[163]  K Faulkner,et al.  An estimate of the collective dose to the European population from cardiac X-ray procedures. , 2008, The British journal of radiology.

[164]  T. Olgar,et al.  Effects of radiologists' skill and experience on patient doses in interventional examinations. , 2008, Radiation protection dosimetry.

[165]  Virginia Tsapaki,et al.  Radiation exposure to patients during interventional procedures in 20 countries: initial IAEA project results. , 2009, AJR. American journal of roentgenology.

[166]  E. Vañó,et al.  Clinical and technical determinants of the complexity of percutaneous transluminal coronary angioplasty procedures: Analysis in relation to radiation exposure parameters , 2000, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[167]  J. Callen,et al.  Fluoroscopy-induced chronic radiation skin injury: a disease perhaps often overlooked. , 2007, Archives of dermatology.

[168]  J. Allan GENETIC SUSCEPTIBILITY TO RADIOGENIC CANCER IN HUMANS , 2008, Health physics.

[169]  K. Empen,et al.  Identification of less-irradiating tube angulations in invasive cardiology. , 2004, Journal of the American College of Cardiology.

[170]  B. Pasternack,et al.  Skin Cancer after X-Ray Treatment for Scalp Ringworm , 2002, Radiation research.

[171]  K. P. Kim,et al.  Coronary artery calcification screening: estimated radiation dose and cancer risk. , 2009, Archives of internal medicine.

[172]  Masayuki Zuguchi,et al.  Relationship between fluoroscopic time, dose-area product, body weight, and maximum radiation skin dose in cardiac interventional procedures. , 2006, AJR. American journal of roentgenology.

[173]  R. Smart Task-specific monitoring of nuclear medicine technologists' radiation exposure. , 2004, Radiation protection dosimetry.

[174]  W. Hoffmann,et al.  Cardiac Catheterization: Impact of Face and Neck Shielding on New Estimates of Effective Dose , 2009, Health physics.

[175]  E. Efstathopoulos,et al.  Medical personnel and patient dosimetry during coronary angiography and intervention. , 2003, Physics in medicine and biology.

[176]  Cynthia H McCollough,et al.  Estimating effective dose for CT using dose-length product compared with using organ doses: consequences of adopting International Commission on Radiological Protection publication 103 or dual-energy scanning. , 2010, AJR. American journal of roentgenology.

[177]  Steen Z Abildstrom,et al.  64-multislice detector computed tomography coronary angiography as potential alternative to conventional coronary angiography: a systematic review and meta-analysis. , 2007, European heart journal.

[178]  H Thierens,et al.  A large-scale multicentre study of patient skin doses in interventional cardiology: dose-area product action levels and dose reference levels. , 2009, The British journal of radiology.

[179]  J Vassileva,et al.  Patient dose in interventional radiology: a European survey. , 2008, Radiation protection dosimetry.

[180]  F. Mettler,et al.  Skin injuries from fluoroscopically guided procedures: part 2, review of 73 cases and recommendations for minimizing dose delivered to patient. , 2001, AJR. American journal of roentgenology.

[181]  W. Laskey,et al.  Changes in the practice of percutaneous coronary intervention: a comparison of enrollment waves in the National Heart, Lung, and Blood Institute (NHLBI) Dynamic Registry. , 2001, The American journal of cardiology.

[182]  M. Togni,et al.  Percutaneous coronary interventions in Europe 1992-2003. , 2004, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.

[183]  E. Ritman,et al.  CORONARY ANGIOGRAPHIC EXAMINATION WITH THE DYNAMIC SPATIAL RECONSTRUCTOR , 1984, Circulation.

[184]  Patient dosimetry in interventional radiology using slow films. , 1997, The British journal of radiology.

[185]  Bernhard Bischoff,et al.  Impact of a reduced tube voltage on CT angiography and radiation dose: results of the PROTECTION I study. , 2009, JACC. Cardiovascular imaging.

[186]  H. Alkadhi,et al.  Meta-analysis: Diagnostic Performance of Low-Radiation-Dose Coronary Computed Tomography Angiography , 2011, Annals of Internal Medicine.

[187]  K. Bowen,et al.  Iatrogenic deep musculocutaneous radiation injury following percutaneous coronary intervention. , 2003, The Journal of invasive cardiology.

[188]  R. deKemp,et al.  New effective dose estimates for Rubidium-82 based on dynamic PET/CT imaging in humans , 2010 .

[189]  H. Sugiyama,et al.  Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003 , 2010, BMJ : British Medical Journal.

[190]  E Vano,et al.  Influence of patient thickness and operation modes on occupational and patient radiation doses in interventional cardiology. , 2006, Radiation protection dosimetry.

[191]  E. Vañó,et al.  Accreditation in radiation protection for cardiologists and interventionalists. , 2005, Radiation protection dosimetry.

[192]  Radiological protection and safety in medicine , 1996 .

[193]  D. Berman,et al.  ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 Appropriate Use Criteria for Cardiac Radionuclide Imaging: A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the American Society of Nuclear Cardiology, the American College of Radiology, the American Heart Associa , 2009, Journal of the American College of Cardiology.

[194]  C J Martin,et al.  A study of the distribution of dose across the hands of interventional radiologists and cardiologists. , 2005, The British journal of radiology.

[195]  G. Giles,et al.  Occupational exposure to ionizing and non-ionizing radiation and risk of glioma. , 2007, Occupational medicine.

[196]  D. Berman,et al.  Recent technologic advances in nuclear cardiology , 2007, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[197]  C. Kelsey,et al.  Using a sterile disposable protective surgical drape for reduction of radiation exposure to interventionalists. , 2002, AJR. American journal of roentgenology.

[198]  Younes Boudjemline,et al.  Percutaneous insertion of the pulmonary valve. , 2002, Journal of the American College of Cardiology.

[199]  Pamela S Douglas,et al.  Developing an action plan for patient radiation safety in adult cardiovascular medicine: proceedings from the Duke University Clinical Research Institute/American College of Cardiology Foundation/American Heart Association think tank held on February 28, 2011. , 2012, Circulation. Cardiovascular imaging.

[200]  K. Chinnaiyan,et al.  Radiation dose from cardiac computed tomography before and after implementation of radiation dose-reduction techniques. , 2009, JAMA.

[201]  R. Gibbons,et al.  Application of appropriateness criteria to stress single-photon emission computed tomography sestamibi studies and stress echocardiograms in an academic medical center. , 2008, Journal of the American College of Cardiology.

[202]  Javier Sanz,et al.  The Importance of End-Systole for Optimal Reconstruction Protocol of Coronary Angiography With 16-Slice Multidetector Computed Tomography , 2005, Investigative radiology.

[203]  Heavy metal pad shielding during fluoroscopic interventions. , 2006, Journal of vascular and interventional radiology : JVIR.

[204]  K. Eagle,et al.  President's page: the appropriate cardiologist: responsible stewardship in a golden era of cardiology. , 2004, Journal of the American College of Cardiology.

[205]  E. Hall ALARA CONCEPT IN PEDIATRIC IMAGING : ONCOLOGY Radiation biology for pediatric radiologists , 2008 .

[206]  Occupational radiation exposure from fluoroscopically guided percutaneous transhepatic biliary procedures. , 2006, Journal of vascular and interventional radiology : JVIR.

[207]  E Vaño,et al.  Occupational radiation doses in interventional cardiology: a 15-year follow-up. , 2006, The British journal of radiology.

[208]  M. Stabin,et al.  Nuclear medicine dosimetry , 2006, Physics in medicine and biology.

[209]  Wojciech Zareba,et al.  Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. , 2002, The New England journal of medicine.

[210]  R. Hendel,et al.  A multicenter assessment of the use of single-photon emission computed tomography myocardial perfusion imaging with appropriateness criteria. , 2010, Journal of the American College of Cardiology.