[Cushing's disease treatment with transsphenoidal surgery during pregnancy].

We report a 26 year old female with Cushing's disease who became pregnant during the course of her disease. She was treated by transsphenoidal surgery during the second trimester of pregnancy, achieving resolution of hypercortisolism. She had a normal delivery at term, her offspring was healthy, and she had a normal lactation. Currently, five years after surgery, she is asymptomatic. According to our literature review, this patient is the fifth reported case of pituitary adenomectomy during gestation.

[1]  J. R. Sneyd,et al.  Cushing's disease treated by trans-sphenoidal selective adenomectomy in mid-pregnancy. , 1998, British journal of anaesthesia.

[2]  R. Ross,et al.  Diagnosis and selective cure of Cushing's disease during pregnancy by transsphenoidal surgery. , 1995, European journal of endocrinology.

[3]  J. Malley,et al.  A comparison of the standard high dose dexamethasone suppression test and the overnight 8-mg dexamethasone suppression test for the differential diagnosis of adrenocorticotropin-dependent Cushing's syndrome. , 1994, The Journal of clinical endocrinology and metabolism.

[4]  M. McCarthy,et al.  Predicting relapse after transsphenoidal surgery for Cushing's disease. , 1993, The Journal of clinical endocrinology and metabolism.

[5]  D. Lowe,et al.  Transsphenoidal resection in Cushing's disease: undetectable serum cortisol as the definition of successfuI treatment , 1993, Clinical endocrinology.

[6]  E. Adashi,et al.  Cushing syndrome in pregnancy. , 1992, Obstetrics and gynecology.

[7]  J. Monchik,et al.  Management of Cushing's syndrome secondary to adrenal adenoma during pregnancy. , 1990, Surgery.

[8]  B. Scheithauer,et al.  The pituitary gland in pregnancy: a clinicopathologic and immunohistochemical study of 69 cases. , 1990, Mayo Clinic proceedings.

[9]  F. Hofeldt,et al.  Cushing's syndrome in pregnancy. , 1990, Obstetrical & gynecological survey.

[10]  G. Elizondo,et al.  Pituitary gland growth during normal pregnancy: an in vivo study using magnetic resonance imaging. , 1988, The American journal of medicine.

[11]  T. Okagaki,et al.  Pregnancy-induced changes in prolactinomas as assessed with computed tomography. , 1988, The Journal of reproductive medicine.

[12]  J. C. Davis,et al.  SUCCESSFUL MANAGEMENT OF CUSHING'S DISEASE DURING PREGNANCY BY TRANSSPHENOIDAL ADENECTOMY , 1987, Clinical endocrinology.

[13]  A. von zur Mühlen,et al.  [Cushing syndrome and pregnancy]. , 1984, Geburtshilfe und Frauenheilkunde.

[14]  J. Donoso,et al.  [Cushing's syndrome and pregnancy with spontaneous remission after delivery]. , 1982, Revista medica de Chile.