Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles

In this work, a nanoscale reduced graphene oxide-iron oxide nanoparticle (RGO-IONP) complex is noncovalently functionalized with polyethylene glycol (PEG), obtaining a RGO-IONP-PEG nanocomposite with excellent physiological stability, strong NIR optical absorbance, and superparamagnetic properties. Using this theranostic nanoprobe, in-vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging are carried out, uncovering high passive tumor targeting, which is further used for effective photothermal ablation of tumors in mice.

[1]  Hua Zhang,et al.  Graphene-based composites. , 2012, Chemical Society reviews.

[2]  Kai Yang,et al.  In vivo pharmacokinetics, long-term biodistribution, and toxicology of PEGylated graphene in mice. , 2011, ACS nano.

[3]  G. Eda,et al.  Graphene oxide as a chemically tunable platform for optical applications. , 2010, Nature chemistry.

[4]  Peng Chen,et al.  Centimeter-long and large-scale micropatterns of reduced graphene oxide films: fabrication and sensing applications. , 2010, ACS nano.

[5]  C. Fan,et al.  Protein corona-mediated mitigation of cytotoxicity of graphene oxide. , 2011, ACS nano.

[6]  Ming-Jium Shieh,et al.  Multimodal image-guided photothermal therapy mediated by 188Re-labeled micelles containing a cyanine-type photosensitizer. , 2011, ACS nano.

[7]  Xin Wang,et al.  Fabrication of flexible metal-nanoparticle films using graphene oxide sheets as substrates. , 2009, Small.

[8]  Xiaohua Huang,et al.  Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. , 2006, Journal of the American Chemical Society.

[9]  Mark C Hersam,et al.  Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung. , 2011, Nano letters.

[10]  Yuehe Lin,et al.  Graphene/TiO2 nanocomposites: synthesis, characterization and application in hydrogen evolution from water photocatalytic splitting , 2010 .

[11]  Zhuang Liu,et al.  Graphene based gene transfection. , 2011, Nanoscale.

[12]  Kai Yang,et al.  Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors. , 2011, Biomaterials.

[13]  Zhuang Liu,et al.  Carbon nanotubes as photoacoustic molecular imaging agents in living mice. , 2008, Nature nanotechnology.

[14]  Michael J Sailor,et al.  Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. , 2009, Cancer research.

[15]  Younan Xia,et al.  Near-infrared gold nanocages as a new class of tracers for photoacoustic sentinel lymph node mapping on a rat model. , 2009, Nano letters.

[16]  Lehui Lu,et al.  Magnetite/reduced graphene oxide nanocomposites: One step solvothermal synthesis and use as a novel platform for removal of dye pollutants , 2011 .

[17]  Y. Jeong,et al.  Image-guided prostate cancer therapy using aptamer-functionalized thermally cross-linked superparamagnetic iron oxide nanoparticles. , 2011, Small.

[18]  Feng Gao,et al.  In vivo molecular photoacoustic tomography of melanomas targeted by bioconjugated gold nanocages. , 2010, ACS nano.

[19]  Chunhai Fan,et al.  A Graphene Nanoprobe for Rapid, Sensitive, and Multicolor Fluorescent DNA Analysis , 2010 .

[20]  Zhijun Zhang,et al.  Composites of aminodextran-coated Fe3O4 nanoparticles and graphene oxide for cellular magnetic resonance imaging. , 2011, ACS applied materials & interfaces.

[21]  Jing Kong,et al.  Can graphene be used as a substrate for Raman enhancement? , 2010, Nano letters.

[22]  Kai Yang,et al.  Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy. , 2012, Biomaterials.

[23]  Dong Chen,et al.  Multifunctional gold nanoshells on silica nanorattles: a platform for the combination of photothermal therapy and chemotherapy with low systemic toxicity. , 2011, Angewandte Chemie.

[24]  Zhuoxuan Lu,et al.  Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI-grafted graphene oxide. , 2011, Small.

[25]  Z. Marković,et al.  In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes. , 2011, Biomaterials.

[26]  Kai Yang,et al.  The influence of surface chemistry and size of nanoscale graphene oxide on photothermal therapy of cancer using ultra-low laser power. , 2012, Biomaterials.

[27]  Zhuang Liu,et al.  Nano-graphene oxide for cellular imaging and drug delivery , 2008, Nano research.

[28]  Qiyuan He,et al.  Graphene-based materials: synthesis, characterization, properties, and applications. , 2011, Small.

[29]  Zhuo. Sun,et al.  Capacitive behavior of graphene–ZnO composite film for supercapacitors , 2009 .

[30]  Hua Zhang,et al.  Preparation of novel 3D graphene networks for supercapacitor applications. , 2011, Small.

[31]  Xin Huang,et al.  Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity , 2011 .

[32]  H. Choi,et al.  In vivo near-infrared mediated tumor destruction by photothermal effect of carbon nanotubes. , 2009, ACS Nano.

[33]  Claudia Calcagno,et al.  Multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer. , 2011, ACS nano.

[34]  Hui Zhang,et al.  Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells. , 2007, Nano letters.

[35]  Younan Xia,et al.  Gold nanocages covered by smart polymers for controlled release with near-infrared light , 2009, Nature materials.

[36]  Hailiang Wang,et al.  Nanocrystal growth on graphene with various degrees of oxidation. , 2010, Journal of the American Chemical Society.

[37]  Kian Ping Loh,et al.  Graphene-based SELDI probe with ultrahigh extraction and sensitivity for DNA oligomer. , 2010, Journal of the American Chemical Society.

[38]  Zhuang Liu,et al.  Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy. , 2011, Biomaterials.

[39]  Zhuang Liu,et al.  PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. , 2008, Journal of the American Chemical Society.

[40]  G. Dai,et al.  Image-guided breast tumor therapy using a small interfering RNA nanodrug. , 2010, Cancer research.

[41]  Yongsheng Chen,et al.  Superparamagnetic graphene oxide–Fe3O4nanoparticles hybrid for controlled targeted drug carriers , 2009 .

[42]  Kai Yang,et al.  Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. , 2010, Nano letters.

[43]  Weibo Cai,et al.  Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy , 2008, Proceedings of the National Academy of Sciences.

[44]  Shixin Wu,et al.  Synthesis of gold square-like plates from ultrathin gold square sheets: the evolution of structure phase and shape. , 2011, Angewandte Chemie.

[45]  H. Dai,et al.  High performance in vivo near-IR (>1 μm) imaging and photothermal cancer therapy with carbon nanotubes , 2010, Nano research.

[46]  Zhijun Zhang,et al.  Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs. , 2010, Small.