Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding

[1]  R. Ramirez-Solis,et al.  Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach , 2015, Transgenic Research.

[2]  M. Poutanen,et al.  Imbalanced lipid homeostasis in the conditional Dicer1 knockout mouse epididymis causes instability of the sperm membrane , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  Yun Sun,et al.  Androgenic regulation of beta-defensins in the mouse epididymis , 2014, Reproductive Biology and Endocrinology.

[4]  E. Kremmer,et al.  CRIS—A Novel cAMP-Binding Protein Controlling Spermiogenesis and the Development of Flagellar Bending , 2013, PLoS genetics.

[5]  Koichiro Tamura,et al.  MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. , 2013, Molecular biology and evolution.

[6]  P. Barran,et al.  Partial Deletion of Chromosome 8 β-defensin Cluster Confers Sperm Dysfunction and Infertility in Male Mice , 2013, PLoS genetics.

[7]  D. Lin,et al.  The Novel Human β-Defensin 114 Regulates Lipopolysaccharide (LPS)-mediated Inflammation and Protects Sperm from Motility Loss* , 2013, The Journal of Biological Chemistry.

[8]  J. Kirkman-Brown,et al.  Ca2+ Signals Generated by CatSper and Ca2+ Stores Regulate Different Behaviors in Human Sperm* , 2013, The Journal of Biological Chemistry.

[9]  M. Poutanen,et al.  Dicer1 Ablation in the Mouse Epididymis Causes Dedifferentiation of the Epithelium and Imbalance in Sex Steroid Signaling , 2012, PloS one.

[10]  Z. Wang,et al.  mBin1b transgenic mice show enhanced resistance to epididymal infection by bacteria challenge , 2012, Genes and Immunity.

[11]  J. Dorin,et al.  β-Defensins: Multifunctional Modulators of Infection, Inflammation and More? , 2012, Journal of Innate Immunity.

[12]  M. Poutanen,et al.  Loss of Cysteine-Rich Secretory Protein 4 (Crisp4) Leads to Deficiency in Sperm-Zona Pellucida Interaction in Mice1 , 2012, Biology of reproduction.

[13]  T. Nishigaki,et al.  Calcium channels in the development, maturation, and function of spermatozoa. , 2011, Physiological reviews.

[14]  A. I. Yudin,et al.  A Common Mutation in the Defensin DEFB126 Causes Impaired Sperm Function and Subfertility , 2011, Science Translational Medicine.

[15]  M. Okabe,et al.  Most fertilizing mouse spermatozoa begin their acrosome reaction before contact with the zona pellucida during in vitro fertilization , 2011, Proceedings of the National Academy of Sciences.

[16]  Shuanggang Hu,et al.  The epididymis-specific antimicrobial peptide β-defensin 15 is required for sperm motility and male fertility in the rat (Rattus norvegicus) , 2011, Cellular and Molecular Life Sciences.

[17]  Joachim W. Deitmer,et al.  Role of Carbonic Anhydrase IV in the Bicarbonate-Mediated Activation of Murine and Human Sperm , 2010, PloS one.

[18]  L. Altucci,et al.  A Gradient of 2-Arachidonoylglycerol Regulates Mouse Epididymal Sperm Cell Start-Up1 , 2010, Biology of reproduction.

[19]  D. Hunt,et al.  Use of differential isotopic labeling and mass spectrometry to analyze capacitation-associated changes in the phosphorylation status of mouse sperm proteins. , 2009, Journal of proteome research.

[20]  G. Cornwall New insights into epididymal biology and function. , 2008, Human reproduction update.

[21]  A. Salicioni,et al.  Chloride Is Essential for Capacitation and for the Capacitation-associated Increase in Tyrosine Phosphorylation* , 2008, Journal of Biological Chemistry.

[22]  A. I. Yudin,et al.  Beta-defensin 22 is a major component of the mouse sperm glycocalyx. , 2008, Reproduction.

[23]  A. I. Yudin,et al.  Macaque sperm coating protein DEFB126 facilitates sperm penetration of cervical mucus. , 2008, Human reproduction.

[24]  J. Liu,et al.  Cloning and identification of a novel sperm binding protein, HEL-75, with antibacterial activity and expressed in the human epididymis. , 2008, Human reproduction.

[25]  Wei Yan,et al.  Catsper3 and Catsper4 Are Essential for Sperm Hyperactivated Motility and Male Fertility in the Mouse1 , 2007, Biology of reproduction.

[26]  S. Yenugu,et al.  Characterization and functions of beta defensins in the epididymis. , 2007, Asian journal of andrology.

[27]  S. Suarez,et al.  Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: Release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm. , 2007, Developmental biology.

[28]  D. Clapham,et al.  All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility , 2007, Proceedings of the National Academy of Sciences.

[29]  Theresa L. Chang,et al.  Defensins in innate antiviral immunity , 2006, Nature Reviews Immunology.

[30]  Enno Klüver,et al.  Synthesis and structure–activity relationship of β‐defensins, multi‐functional peptides of the immune system , 2006, Journal of peptide science : an official publication of the European Peptide Society.

[31]  D. Clapham,et al.  Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel , 2006, Nature.

[32]  F. Blecha,et al.  Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. , 2005, Physiological genomics.

[33]  M. Poutanen,et al.  Discovery and characterization of new epididymis-specific beta-defensins in mice. , 2005, Biochimica et biophysica acta.

[34]  M. Selsted,et al.  Mammalian defensins in the antimicrobial immune response , 2005, Nature Immunology.

[35]  A. I. Yudin,et al.  Macaque sperm release ESP13.2 and PSP94 during capacitation: The absence of ESP13.2 is linked to sperm‐zona recognition and binding , 2004, Molecular reproduction and development.

[36]  M. Ensslin,et al.  Mammalian fertilization , 2004, Current Biology.

[37]  H. Chan,et al.  An epididymis-specific β-defensin is important for the initiation of sperm maturation , 2004, Nature Cell Biology.

[38]  S. Yenugu,et al.  The Androgen-Regulated Epididymal Sperm-Binding Protein, Human β-Defensin 118 (DEFB118) (Formerly ESC42), Is an Antimicrobial β-Defensin , 2004 .

[39]  B. Jaiswal,et al.  Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[40]  P. Carmeliet,et al.  A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[41]  S. Yenugu,et al.  The androgen-regulated epididymal sperm-binding protein, human beta-defensin 118 (DEFB118) (formerly ESC42), is an antimicrobial beta-defensin. , 2004, Endocrinology.

[42]  R. Hammer,et al.  Hyperactivated sperm motility driven by CatSper2 is required for fertilization , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[43]  A. I. Yudin,et al.  ESP13.2, a Member of the β-Defensin Family, Is a Macaque Sperm Surface-Coating Protein Involved in the Capacitation Process1 , 2003, Biology of reproduction.

[44]  C. Semple,et al.  Signal sequence conservation and mature peptide divergence within subgroups of the murine beta-defensin gene family. , 2003, Molecular biology and evolution.

[45]  M. Palladino,et al.  Messenger RNA (mRNA) Expression for the Antimicrobial Peptides β-Defensin-1 and β-Defensin-2 in the Male Rat Reproductive Tract: β-Defensin-1 mRNA in Initial Segment and Caput Epididymidis Is Regulated by Androgens and Not Bacterial Lipopolysaccharides1 , 2003, Biology of reproduction.

[46]  L. Levin,et al.  Compartmentalization of bicarbonate‐sensitive adenylyl cyclase in distinct signaling microdomains , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[47]  James M. Wilson,et al.  β-Defensin 1 Contributes to Pulmonary Innate Immunity in Mice , 2002, Infection and Immunity.

[48]  D. Davidson,et al.  Characterization of the Mouse Beta Defensin 1, Defb1, Mutant Mouse Model , 2002, Infection and Immunity.

[49]  Jesse D. Walters,et al.  Discovery of five conserved β-defensin gene clusters using a computational search strategy , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[50]  P. Seeburg,et al.  Codon‐improved Cre recombinase (iCre) expression in the mouse , 2002, Genesis.

[51]  J. Jarow A sperm ion channel required for sperm motility and male fertility. , 2002, The Journal of urology.

[52]  K. Hamil,et al.  Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and human. , 2001, Endocrinology.

[53]  O. Fröhlich,et al.  Epididymal Specificity and Androgen Regulation of Rat EP21 , 2001, Biology of reproduction.

[54]  R. Aitken,et al.  Impact of Epididymal Maturation on the Tyrosine Phosphorylation Patterns Exhibited by Rat Spermatozoa1 , 2001, Biology of reproduction.

[55]  D. Higgins,et al.  T-Coffee: A novel method for fast and accurate multiple sequence alignment. , 2000, Journal of molecular biology.

[56]  L. Yogev,et al.  Zona pellucida binding improvement effect of different sperm preparation techniques is not related to changes in sperm motility characterizations. , 2000, Fertility and sterility.

[57]  G. Doncel,et al.  Baboon spermatozoa-zona pellucida binding assay. , 2000, Contraception.

[58]  K. Hamil,et al.  HE2β and HE2γ, New Members of an Epididymis-Specific Family of Androgen-Regulated Proteins in the Human. , 2000, Endocrinology.

[59]  B. Robaire,et al.  The Coming of Age of the Epididymis , 2000 .

[60]  N. Daigle,et al.  Simplified generation of targeting constructs using ET recombination. , 1999, Nucleic acids research.

[61]  J. Miyazaki,et al.  A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission. , 1997, Biochemical and biophysical research communications.

[62]  D. Schoevaert-Brossault,et al.  Changes in flagellar movement of rat spermatozoa along the length of the epididymis: manual and computer-aided image analysis. , 1996, Cell motility and the cytoskeleton.

[63]  G. Kopf,et al.  Capacitation of mouse spermatozoa. I. Correlation between the capacitation state and protein tyrosine phosphorylation. , 1995, Development.

[64]  E. Nieschlag,et al.  Changes in movement characteristics of human spermatozoa along the length of the epididymis. , 1993, Biology of reproduction.

[65]  T. Cooper,et al.  Characterization of the motility of maturing rat spermatozoa by computer-aided objective measurement. , 1992, Journal of reproduction and fertility.

[66]  R. Demott,et al.  Movement characteristics of boar sperm obtained from the oviduct or hyperactivated in vitro. , 1992, Journal of andrology.

[67]  D. Katz,et al.  Evidence for the function of hyperactivated motility in sperm. , 1991, Biology of reproduction.

[68]  J. D. Neill,et al.  The Physiology of reproduction , 1988 .

[69]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.