Synthesis of Polyethylenimine-Based Nanocarriers for Systemic Tumor Targeting of Nucleic Acids.

[1]  M. Ogris,et al.  Up-Scaled Synthesis and Characterization of Nonviral Gene Delivery Particles for Transient In Vitro and In Vivo Transgene Expression. , 2016, Human gene therapy methods.

[2]  M. Ogris,et al.  Gene therapy and imaging in preclinical and clinical oncology: recent developments in therapy and theranostics. , 2014, Therapeutic delivery.

[3]  M. Ogris,et al.  Nucleic acid carrier systems based on polyethylenimine conjugates for the treatment of metastatic tumors. , 2013, Current medicinal chemistry.

[4]  Hasan Uludağ,et al.  Specific effects of PEGylation on gene delivery efficacy of polyethylenimine: interplay between PEG substitution and N/P ratio. , 2012, Acta biomaterialia.

[5]  F. Szoka,et al.  Nucleic acid delivery: the missing pieces of the puzzle? , 2012, Accounts of chemical research.

[6]  M. Ogris,et al.  Synthesis of linear polyethylenimine and use in transfection. , 2012, Cold Spring Harbor protocols.

[7]  M. Ogris,et al.  Sustained, high transgene expression in liver with plasmid vectors using optimized promoter‐enhancer combinations , 2011, The journal of gene medicine.

[8]  D. Schaffert,et al.  Disconnecting the yin and yang relation of epidermal growth factor receptor (EGFR)-mediated delivery: a fully synthetic, EGFR-targeted gene transfer system avoiding receptor activation. , 2011, Human gene therapy.

[9]  S. Hart,et al.  Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery. , 2011, Nanomedicine : nanotechnology, biology, and medicine.

[10]  R. Senekowitsch-Schmidtke,et al.  Epidermal Growth Factor Receptor-targeted 131I-therapy of Liver Cancer Following Systemic Delivery of the Sodium Iodide Symporter Gene. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

[11]  Andrey L Rogach,et al.  Drug nanocarriers labeled with near-infrared-emitting quantum dots (quantoplexes): imaging fast dynamics of distribution in living animals. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

[12]  D. Lamm,et al.  Phase I/II marker lesion study of intravesical BC-819 DNA plasmid in H19 over expressing superficial bladder cancer refractory to bacillus Calmette-Guerin. , 2008, The Journal of urology.

[13]  C. Bräuchle,et al.  Dynamics of photoinduced endosomal release of polyplexes. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[14]  M. Ogris,et al.  Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding. , 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[15]  Daniel W. Pack,et al.  Design and development of polymers for gene delivery , 2005, Nature Reviews Drug Discovery.

[16]  Qing Ge,et al.  Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Jaroslav Pelisek,et al.  Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[18]  C. Culmsee,et al.  Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer , 2004, The journal of gene medicine.

[19]  J. Behr,et al.  A model for non‐viral gene delivery: through syndecan adhesion molecules and powered by actin , 2004, The journal of gene medicine.

[20]  M. Schleef,et al.  Animal‐free production of ccc‐supercoiled plasmids for research and clinical applications , 2004, The journal of gene medicine.

[21]  A. El-Aneed,et al.  An overview of current delivery systems in cancer gene therapy. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[22]  Yuichi Yamasaki,et al.  In situ single cell observation by fluorescence resonance energy transfer reveals fast intra‐cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine , 2004, The journal of gene medicine.

[23]  F. Szoka,et al.  Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes* , 2003, Journal of Biological Chemistry.

[24]  Ernst Wagner,et al.  Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[25]  M. Ogris,et al.  Tissue-dependent factors affect gene delivery to tumors in vivo , 2003, Gene Therapy.

[26]  G. De Rosa,et al.  Spectrophotometric determination of polyethylenimine in the presence of an oligonucleotide for the characterization of controlled release formulations. , 2003, Journal of pharmaceutical and biomedical analysis.

[27]  Franz Worek,et al.  Molar absorption coefficients for the reduced Ellman reagent: reassessment. , 2003, Analytical biochemistry.

[28]  E. Wagner,et al.  Design and gene delivery activity of modified polyethylenimines. , 2001, Advanced drug delivery reviews.

[29]  S. Carotta,et al.  DNA/polyethylenimine transfection particles: Influence of ligands, polymer size, and PEGylation on internalization and gene expression , 2001, AAPS PharmSci.

[30]  S. Carotta,et al.  Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo , 2001, The journal of gene medicine.

[31]  Haeshin Lee,et al.  DNA transfection using linear poly(ethylenimine) prepared by controlled acid hydrolysis of poly(2-ethyl-2-oxazoline). , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[32]  G. Levi,et al.  Rapid crossing of the pulmonary endothelial barrier by polyethylenimine/DNA complexes , 2000, Gene Therapy.

[33]  M. Ogris,et al.  PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery , 1999, Gene Therapy.

[34]  K Mechtler,et al.  The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells , 1998, Gene Therapy.

[35]  G. Merlo,et al.  Polyethylenimine-based intravenous delivery of transgenes to mouse lung , 1998, Gene Therapy.

[36]  S. Ferrari,et al.  ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo , 1997, Gene Therapy.

[37]  F. Szoka,et al.  The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes , 1997, Gene Therapy.

[38]  D. Scherman,et al.  A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[39]  D. Schaffert,et al.  The establishment of an up-scaled micro-mixer method allows the standardized and reproducible preparation of well-defined plasmid/LPEI polyplexes. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[40]  Ernst Wagner,et al.  Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer. , 2003, Bioconjugate chemistry.

[41]  J. Coll,et al.  Side‐effects of a systemic injection of linear polyethylenimine–DNA complexes , 2002, The journal of gene medicine.

[42]  E. Wagner,et al.  Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application , 2001, Gene Therapy.