HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche
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L. Cope | L. Resar | A. Ewald | Yu-Ting Chang | L. Xian | D. Huso | A. Fasano | Amy M. Belton | D. Georgess | S. Senger | Q. Gu | T. Huso | Wenyong Kuang | Xiaoyan Zhang | Stefania Senger | Tait H Huso
[1] K. Ross,et al. SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b , 2016, Cell.
[2] L. Cope,et al. The High Mobility Group A1 (HMGA1) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 (MMP-2) in a subset of tumors. , 2016, Gynecologic oncology.
[3] H. Clevers,et al. Visualization of a short-range Wnt gradient in the intestinal stem-cell niche , 2016, Nature.
[4] James E. Verdone,et al. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters , 2016, Proceedings of the National Academy of Sciences.
[5] H. Akiyama,et al. SOX9 maintains reserve stem cells and preserves radioresistance in mouse small intestine. , 2015, Gastroenterology.
[6] A. van Oudenaarden,et al. Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. , 2015, Cell stem cell.
[7] Fengchao Wang,et al. A high throughput platform for stem cell-niche co-cultures and downstream gene expression analysis , 2015, Nature Cell Biology.
[8] J. Mendell,et al. Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis , 2014, Genes & development.
[9] B. Koo,et al. A Video Protocol of Retroviral Infection in Primary Intestinal Organoid Culture , 2014, Journal of visualized experiments : JoVE.
[10] H. Clevers,et al. Stem cells marked by the R-spondin receptor LGR5. , 2014, Gastroenterology.
[11] J. Rossant,et al. Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts , 2014, Development.
[12] R. Huebner,et al. Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells , 2014, Development.
[13] Zhongsheng Sun,et al. RSPO2–LGR5 signaling has tumour-suppressive activity in colorectal cancer , 2014, Nature Communications.
[14] H. Clevers,et al. Retroviral gene expression control in primary organoid cultures. , 2013, Current protocols in stem cell biology.
[15] J. Hurley,et al. The molecular genetics of colorectal cancer , 2013, Frontline Gastroenterology.
[16] Kathleen R. Cho,et al. Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation. , 2013, The American journal of pathology.
[17] H. Clevers. The Intestinal Crypt, A Prototype Stem Cell Compartment , 2013, Cell.
[18] Y. Okada,et al. HMGA2 is a driver of tumor metastasis. , 2013, Cancer research.
[19] Douglas Strathdee,et al. TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis , 2013, Developmental cell.
[20] H. Clevers,et al. Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications , 2013, Science.
[21] Leslie Cope,et al. HMGA1: A Master Regulator of Tumor Progression in Triple-Negative Breast Cancer Cells , 2013, PloS one.
[22] Ashton T. Brock,et al. The Wnt/β‐catenin/T‐cell factor 4 pathway up‐regulates high‐mobility group A1 expression in colon cancer , 2013, Cell biochemistry and function.
[23] Ashton T. Brock,et al. The Wnt/β‐catenin/TCF‐4 pathway upregulates HMGA1 expression in colon cancer , 2013 .
[24] K. Kinzler,et al. Cancer Genome Landscapes , 2013, Science.
[25] J. Kowalski,et al. HMGA1 overexpression correlates with relapse in childhood B-lineage acute lymphoblastic leukemia , 2013, Leukemia & lymphoma.
[26] R. Russell,et al. Intestinal label-retaining cells are secretory precursors expressing Lgr5 , 2013, Nature.
[27] J. Ringe,et al. Transdifferentiation of mesenchymal stem cells-derived adipogenic-differentiated cells into osteogenic- or chondrogenic-differentiated cells proceeds via dedifferentiation and have a correlation with cell cycle arresting and driving genes. , 2013, Differentiation; research in biological diversity.
[28] A. Ewald. Practical considerations for long-term time-lapse imaging of epithelial morphogenesis in three-dimensional organotypic cultures. , 2013, Cold Spring Harbor protocols.
[29] K. Jensen,et al. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. , 2012, Cancer cell.
[30] Elias T. Zambidis,et al. HMGA1 Reprograms Somatic Cells into Pluripotent Stem Cells by Inducing Stem Cell Transcriptional Networks , 2012, PloS one.
[31] Hans Clevers,et al. Wnt/β-Catenin Signaling and Disease , 2012, Cell.
[32] L. Resar,et al. High mobility group A1 and cancer: potential biomarker and therapeutic target. , 2012, Histology and histopathology.
[33] C. Iacobuzio-Donahue,et al. HMGA1 Induces Intestinal Polyposis in Transgenic Mice and Drives Tumor Progression and Stem Cell Properties in Colon Cancer Cells , 2012, PloS one.
[34] H. Clevers,et al. Controlled gene expression in primary Lgr5 organoid cultures , 2011, Nature Methods.
[35] J. Kowalski,et al. HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis , 2011, BMC Genomics.
[36] P. Mali,et al. Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures , 2011, Cell Research.
[37] Bassem A. Hassan,et al. Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors , 2010, Nature communications.
[38] R. Nusse,et al. Lentiviral Vectors to Probe and Manipulate the Wnt Signaling Pathway , 2010, PloS one.
[39] L. Resar. The high mobility group A1 gene: transforming inflammatory signals into cancer? , 2010, Cancer research.
[40] L. Cope,et al. HMGA1 Correlates with Advanced Tumor Grade and Decreased Survival in Pancreatic Ductal Adenocarcinoma , 2009, Modern Pathology.
[41] M. Nakao,et al. HMGA1 is induced by Wnt/beta-catenin pathway and maintains cell proliferation in gastric cancer. , 2009, The American journal of pathology.
[42] D. K. Lorance,et al. Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium. , 2009, American journal of physiology. Gastrointestinal and liver physiology.
[43] Jeanne Kowalski,et al. The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies? , 2008, Cancer research.
[44] A. Regev,et al. An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors , 2008, Nature Genetics.
[45] L. Resar,et al. HMGA2 Participates in Transformation in Human Lung Cancer , 2008, Molecular Cancer Research.
[46] A. Fusco,et al. Roles of HMGA proteins in cancer , 2007, Nature Reviews Cancer.
[47] H. Clevers,et al. Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.
[48] Philippe Blache,et al. Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium , 2007, The Journal of cell biology.
[49] L. Resar,et al. The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. , 2007, Cancer research.
[50] Hans Clevers,et al. SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. , 2006, Gastroenterology.
[51] Thomas Werner,et al. MatInspector and beyond: promoter analysis based on transcription factor binding sites , 2005, Bioinform..
[52] K. Boyd,et al. Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny , 2005, Genesis.
[53] L. Resar,et al. The HMG-I Oncogene Causes Highly Penetrant, Aggressive Lymphoid Malignancy in Transgenic Mice and Is Overexpressed in Human Leukemia , 2004, Cancer Research.
[54] David Baltimore,et al. Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors , 2002, Science.
[55] J. Rowley,et al. The pattern of gene expression in human CD34+ stem/progenitor cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[56] L. Resar,et al. Sequence and analysis of the murine Hmgiy (Hmga1) gene locus. , 2001, Gene.
[57] R. Reeves,et al. Architectural Transcription Factor HMGI(Y) Promotes Tumor Progression and Mesenchymal Transition of Human Epithelial Cells , 2001, Molecular and Cellular Biology.
[58] L. Resar,et al. HMG-I/Y, a New c-Myc Target Gene and Potential Oncogene , 2000, Molecular and Cellular Biology.
[59] Jeffrey R. Huth,et al. The solution structure of an HMG-I(Y)–DNA complex defines a new architectural minor groove binding motif , 1997, Nature Structural Biology.
[60] A. Simeone,et al. High level expression of the HMGI (Y) gene during embryonic development. , 1996, Oncogene.
[61] Dimitris Thanos,et al. Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y) , 1995, Cell.
[62] T. Maniatis,et al. Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome , 1995, Cell.
[63] H. Zoghbi,et al. Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. , 1993, Nucleic acids research.
[64] R. Reeves,et al. Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). , 1988, The Journal of biological chemistry.
[65] L. Resar,et al. High mobility group A1 and cancer: potential biomarker and therapeutic target. , 2012, Histology and histopathology.
[66] Kevin J. Cheung,et al. 3D culture assays of murine mammary branching morphogenesis and epithelial invasion. , 2015, Methods in molecular biology.
[67] Hans Clevers,et al. Primary mouse small intestinal epithelial cell cultures. , 2013, Methods in molecular biology.
[68] L. Cope,et al. HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma , 2009, Modern Pathology.
[69] R. Simon,et al. Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas. , 2007, Cancer research.