HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

[1]  K. Ross,et al.  SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b , 2016, Cell.

[2]  L. Cope,et al.  The High Mobility Group A1 (HMGA1) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 (MMP-2) in a subset of tumors. , 2016, Gynecologic oncology.

[3]  H. Clevers,et al.  Visualization of a short-range Wnt gradient in the intestinal stem-cell niche , 2016, Nature.

[4]  James E. Verdone,et al.  Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters , 2016, Proceedings of the National Academy of Sciences.

[5]  H. Akiyama,et al.  SOX9 maintains reserve stem cells and preserves radioresistance in mouse small intestine. , 2015, Gastroenterology.

[6]  A. van Oudenaarden,et al.  Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. , 2015, Cell stem cell.

[7]  Fengchao Wang,et al.  A high throughput platform for stem cell-niche co-cultures and downstream gene expression analysis , 2015, Nature Cell Biology.

[8]  J. Mendell,et al.  Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis , 2014, Genes & development.

[9]  B. Koo,et al.  A Video Protocol of Retroviral Infection in Primary Intestinal Organoid Culture , 2014, Journal of visualized experiments : JoVE.

[10]  H. Clevers,et al.  Stem cells marked by the R-spondin receptor LGR5. , 2014, Gastroenterology.

[11]  J. Rossant,et al.  Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts , 2014, Development.

[12]  R. Huebner,et al.  Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells , 2014, Development.

[13]  Zhongsheng Sun,et al.  RSPO2–LGR5 signaling has tumour-suppressive activity in colorectal cancer , 2014, Nature Communications.

[14]  H. Clevers,et al.  Retroviral gene expression control in primary organoid cultures. , 2013, Current protocols in stem cell biology.

[15]  J. Hurley,et al.  The molecular genetics of colorectal cancer , 2013, Frontline Gastroenterology.

[16]  Kathleen R. Cho,et al.  Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation. , 2013, The American journal of pathology.

[17]  H. Clevers.  The Intestinal Crypt, A Prototype Stem Cell Compartment , 2013, Cell.

[18]  Y. Okada,et al.  HMGA2 is a driver of tumor metastasis. , 2013, Cancer research.

[19]  Douglas Strathdee,et al.  TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis , 2013, Developmental cell.

[20]  H. Clevers,et al.  Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications , 2013, Science.

[21]  Leslie Cope,et al.  HMGA1: A Master Regulator of Tumor Progression in Triple-Negative Breast Cancer Cells , 2013, PloS one.

[22]  Ashton T. Brock,et al.  The Wnt/β‐catenin/T‐cell factor 4 pathway up‐regulates high‐mobility group A1 expression in colon cancer , 2013, Cell biochemistry and function.

[23]  Ashton T. Brock,et al.  The Wnt/β‐catenin/TCF‐4 pathway upregulates HMGA1 expression in colon cancer , 2013 .

[24]  K. Kinzler,et al.  Cancer Genome Landscapes , 2013, Science.

[25]  J. Kowalski,et al.  HMGA1 overexpression correlates with relapse in childhood B-lineage acute lymphoblastic leukemia , 2013, Leukemia & lymphoma.

[26]  R. Russell,et al.  Intestinal label-retaining cells are secretory precursors expressing Lgr5 , 2013, Nature.

[27]  J. Ringe,et al.  Transdifferentiation of mesenchymal stem cells-derived adipogenic-differentiated cells into osteogenic- or chondrogenic-differentiated cells proceeds via dedifferentiation and have a correlation with cell cycle arresting and driving genes. , 2013, Differentiation; research in biological diversity.

[28]  A. Ewald.  Practical considerations for long-term time-lapse imaging of epithelial morphogenesis in three-dimensional organotypic cultures. , 2013, Cold Spring Harbor protocols.

[29]  K. Jensen,et al.  Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. , 2012, Cancer cell.

[30]  L. Cope,et al.  HMGA1 Reprograms Somatic Cells into Pluripotent Stem Cells by Inducing Stem Cell Transcriptional Networks , 2012, PloS one.

[31]  Hans Clevers,et al.  Wnt/β-Catenin Signaling and Disease , 2012, Cell.

[32]  L. Resar,et al.  High mobility group A1 and cancer: potential biomarker and therapeutic target. , 2012, Histology and histopathology.

[33]  C. Iacobuzio-Donahue,et al.  HMGA1 Induces Intestinal Polyposis in Transgenic Mice and Drives Tumor Progression and Stem Cell Properties in Colon Cancer Cells , 2012, PloS one.

[34]  H. Clevers,et al.  Controlled gene expression in primary Lgr5 organoid cultures , 2011, Nature Methods.

[35]  J. Kowalski,et al.  HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis , 2011, BMC Genomics.

[36]  P. Mali,et al.  Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures , 2011, Cell Research.

[37]  Bassem A. Hassan,et al.  Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors , 2010, Nature communications.

[38]  R. Nusse,et al.  Lentiviral Vectors to Probe and Manipulate the Wnt Signaling Pathway , 2010, PloS one.

[39]  L. Resar.  The high mobility group A1 gene: transforming inflammatory signals into cancer? , 2010, Cancer research.

[40]  L. Cope,et al.  HMGA1 Correlates with Advanced Tumor Grade and Decreased Survival in Pancreatic Ductal Adenocarcinoma , 2009, Modern Pathology.

[41]  M. Nakao,et al.  HMGA1 is induced by Wnt/beta-catenin pathway and maintains cell proliferation in gastric cancer. , 2009, The American journal of pathology.

[42]  D. K. Lorance,et al.  Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[43]  Jeanne Kowalski,et al.  The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies? , 2008, Cancer research.

[44]  A. Regev,et al.  An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors , 2008, Nature Genetics.

[45]  L. Resar,et al.  HMGA2 Participates in Transformation in Human Lung Cancer , 2008, Molecular Cancer Research.

[46]  A. Fusco,et al.  Roles of HMGA proteins in cancer , 2007, Nature Reviews Cancer.

[47]  H. Clevers,et al.  Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.

[48]  Philippe Blache,et al.  Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium , 2007, The Journal of cell biology.

[49]  L. Resar,et al.  The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. , 2007, Cancer research.

[50]  Hans Clevers,et al.  SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. , 2006, Gastroenterology.

[51]  Thomas Werner,et al.  MatInspector and beyond: promoter analysis based on transcription factor binding sites , 2005, Bioinform..

[52]  K. Boyd,et al.  Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny , 2005, Genesis.

[53]  L. Resar,et al.  The HMG-I Oncogene Causes Highly Penetrant, Aggressive Lymphoid Malignancy in Transgenic Mice and Is Overexpressed in Human Leukemia , 2004, Cancer Research.

[54]  David Baltimore,et al.  Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors , 2002, Science.

[55]  J. Rowley,et al.  The pattern of gene expression in human CD34+ stem/progenitor cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[56]  R. Reeves,et al.  Sequence and analysis of the murine Hmgiy (Hmga1) gene locus. , 2001, Gene.

[57]  R. Reeves,et al.  Architectural Transcription Factor HMGI(Y) Promotes Tumor Progression and Mesenchymal Transition of Human Epithelial Cells , 2001, Molecular and Cellular Biology.

[58]  L. Resar,et al.  HMG-I/Y, a New c-Myc Target Gene and Potential Oncogene , 2000, Molecular and Cellular Biology.

[59]  Jeffrey R. Huth,et al.  The solution structure of an HMG-I(Y)–DNA complex defines a new architectural minor groove binding motif , 1997, Nature Structural Biology.

[60]  A. Simeone,et al.  High level expression of the HMGI (Y) gene during embryonic development. , 1996, Oncogene.

[61]  Dimitris Thanos,et al.  Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y) , 1995, Cell.

[62]  T. Maniatis,et al.  Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome , 1995, Cell.

[63]  H. Zoghbi,et al.  Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. , 1993, Nucleic acids research.

[64]  R. Reeves,et al.  Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). , 1988, The Journal of biological chemistry.

[65]  L. Resar,et al.  High mobility group A1 and cancer: potential biomarker and therapeutic target. , 2012, Histology and histopathology.

[66]  Kevin J. Cheung,et al.  3D culture assays of murine mammary branching morphogenesis and epithelial invasion. , 2015, Methods in molecular biology.

[67]  Hans Clevers,et al.  Primary mouse small intestinal epithelial cell cultures. , 2013, Methods in molecular biology.

[68]  L. Cope,et al.  HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma , 2009, Modern Pathology.

[69]  R. Simon,et al.  Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas. , 2007, Cancer research.