The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer’s Disease

[1]  Y. Bao,et al.  Leisure Activities and the Risk of Dementia , 2022, Neurology.

[2]  Ch Lai,et al.  Social isolation reinforces aging-related behavioral inflexibility by promoting neuronal necroptosis in basolateral amygdala , 2022, Molecular Psychiatry.

[3]  E. Rolls,et al.  Associations of Social Isolation and Loneliness With Later Dementia , 2022, Neurology.

[4]  T. Nagasaka,et al.  Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease , 2022, GeroScience.

[5]  C. DeCarli,et al.  Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline , 2022, Neurology.

[6]  Natalie M. Golaszewski,et al.  Evaluation of Social Isolation, Loneliness, and Cardiovascular Disease Among Older Women in the US , 2022, JAMA network open.

[7]  M. Pirinen,et al.  Association of social isolation, loneliness and genetic risk with incidence of dementia: UK Biobank Cohort Study , 2020, BMJ Open.

[8]  L. Fratiglioni,et al.  Loneliness, Not Social Support, Is Associated with Cognitive Decline and Dementia Across Two Longitudinal Population-Based Cohorts , 2021, Journal of Alzheimer's disease : JAD.

[9]  M. Maroun,et al.  Acute social isolation and regrouping cause short- and long-term molecular changes in the rat medial amygdala , 2021, Molecular Psychiatry.

[10]  T. Spires-Jones,et al.  Potential neurobiological links between social isolation and Alzheimer's disease risk , 2021, The European journal of neuroscience.

[11]  K. Tye,et al.  The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation , 2021, Cell.

[12]  J. Holt-Lunstad,et al.  Loneliness and Social Isolation as Risk Factors: The Power of Social Connection in Prevention , 2021, American journal of lifestyle medicine.

[13]  M. Pomper,et al.  Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease , 2021, Acta neuropathologica communications.

[14]  Ryan J. Piers,et al.  Associations of loneliness with risk of Alzheimer's disease dementia in the Framingham Heart Study , 2021, Alzheimer's & dementia : the journal of the Alzheimer's Association.

[15]  K. Tye,et al.  The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation , 2021, Cell.

[16]  A. Koyanagi,et al.  Is loneliness associated with mild cognitive impairment in low‐ and middle‐income countries? , 2021, International journal of geriatric psychiatry.

[17]  M. Inzitari,et al.  Is loneliness a predictor of the modern geriatric giants? Analysis from the survey of health, ageing, and retirement in Europe. , 2021, Maturitas.

[18]  C. Chapman,et al.  Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease , 2021, Biology Open.

[19]  R. Hen,et al.  Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression , 2020, Psychoneuroendocrinology.

[20]  Perceived Social Isolation , 2021, Encyclopedia of Gerontology and Population Aging.

[21]  M. Sekeres,et al.  Social isolation induces hyperactivity and exploration in aged female mice. , 2021, PloS one.

[22]  Martyn Shuttleworth,et al.  Ecological Validity , 2021, Encyclopedia of Evolutionary Psychological Science.

[23]  C. Son,et al.  A Comparison of Isolation Stress and Unpredictable Chronic Mild Stress for the Establishment of Mouse Models of Depressive Disorder , 2021, Frontiers in Behavioral Neuroscience.

[24]  N. Inestrosa,et al.  Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus , 2020, Scientific Reports.

[25]  S. Kim,et al.  Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice , 2020, bioRxiv.

[26]  C. Pariante,et al.  The type of stress matters: repeated injection and permanent social isolation stress in male mice have a differential effect on anxiety- and depressive-like behaviours, and associated biological alterations , 2020, Translational Psychiatry.

[27]  M. Calamia,et al.  Social factors that predict cognitive decline in older African American adults , 2020, International journal of geriatric psychiatry.

[28]  K. Kullander,et al.  A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice , 2020, Nature Neuroscience.

[29]  A. Steptoe,et al.  Social isolation, rather than loneliness, is associated with cognitive decline in older adults: the China Health and Retirement Longitudinal Study , 2020, Psychological Medicine.

[30]  A. Terracciano,et al.  Loneliness is associated with risk of cognitive impairment in the Survey of Health, Ageing and Retirement in Europe , 2020, International journal of geriatric psychiatry.

[31]  Milo R. Smith,et al.  Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior , 2020, Nature Communications.

[32]  N. Alrasheed,et al.  Analysis of the molecular and behavioral effects of acute social isolation on rats , 2020, Behavioural Brain Research.

[33]  M. Chumley,et al.  Prolonged isolation stress accelerates the onset of Alzheimer’s disease-related pathology in 5xFAD mice despite running wheels and environmental enrichment , 2019, Behavioural Brain Research.

[34]  C. Brayne,et al.  Longitudinal analysis of the impact of loneliness on cognitive function over a 20-year follow-up , 2020, Aging & mental health.

[35]  N. Smidt,et al.  A longitudinal study of the impact of social network size and loneliness on cognitive performance in depressed older adults , 2020, Aging & mental health.

[36]  F. F. Caballero,et al.  Are loneliness and social isolation associated with cognitive decline? , 2019, International journal of geriatric psychiatry.

[37]  Keith A. Johnson,et al.  Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults. , 2019, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[38]  Kinzo Matsumoto,et al.  Post-weaning social isolation of mice: A putative animal model of developmental disorders. , 2019, Journal of pharmacological sciences.

[39]  A. Sundström,et al.  Loneliness Increases the Risk of All-Cause Dementia and Alzheimer’s Disease , 2019, The journals of gerontology. Series B, Psychological sciences and social sciences.

[40]  S. Gourley,et al.  Social Isolation in Adolescence Disrupts Cortical Development and Goal-Dependent Decision-Making in Adulthood, Despite Social Reintegration , 2019, eNeuro.

[41]  A. Salvador,et al.  The relationship between loneliness and cognition in healthy older men and women: The role of cortisol , 2019, Psychoneuroendocrinology.

[42]  C. Epperson,et al.  Sex Differences in Vulnerability and Resilience to Stress Across the Life Span , 2019, Biological Psychiatry.

[43]  P. Greengard,et al.  Mapping the physiological and molecular markers of stress and SSRI antidepressant treatment in S100a10 corticostriatal neurons , 2019, Molecular Psychiatry.

[44]  P. Tariot,et al.  Behavior Rating Scale for Dementia , 2019 .

[45]  Yang Zhang,et al.  Social housing promotes cognitive function through enhancing synaptic plasticity in APP/PS1 mice , 2019, Behavioural Brain Research.

[46]  G. Livingston,et al.  Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study , 2019, PLoS medicine.

[47]  A. Steptoe,et al.  Social engagement before and after dementia diagnosis in the English Longitudinal Study of Ageing , 2019, PloS one.

[48]  A. Steptoe,et al.  Exploring the bidirectional associations between loneliness and cognitive functioning over 10 years: the English longitudinal study of ageing , 2019, International journal of epidemiology.

[49]  N. Tabet,et al.  Social networks and loneliness in people with Alzheimer's dementia , 2019, International journal of geriatric psychiatry.

[50]  E. Nestler,et al.  Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females , 2019, Front. Behav. Neurosci..

[51]  J. Popp,et al.  High Cortisol and the Risk of Dementia and Alzheimer’s Disease: A Review of the Literature , 2019, Front. Aging Neurosci..

[52]  R. Woods,et al.  Living alone and cognitive function in later life. , 2019, Archives of gerontology and geriatrics.

[53]  B. Harvey,et al.  Social isolation rearing-induced anxiety and response to agomelatine in male and female rats: Role of corticosterone, oxytocin, and vasopressin , 2019, Journal of psychopharmacology.

[54]  W. Ray,et al.  The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease , 2019, Front. Aging Neurosci..

[55]  K. Kondrakiewicz,et al.  Ecological validity of social interaction tests in rats and mice , 2018, Genes, brain, and behavior.

[56]  H. Brodaty,et al.  The Association between Social Engagement, Loneliness, and Risk of Dementia: A Systematic Review and Meta-Analysis. , 2018, Journal of Alzheimer's disease : JAD.

[57]  Keith A. Johnson,et al.  Regional tau pathology and loneliness in cognitively normal older adults , 2018, Translational Psychiatry.

[58]  A. Terracciano,et al.  Loneliness and Risk of Dementia. , 2018, The journals of gerontology. Series B, Psychological sciences and social sciences.

[59]  B. Rybarczyk,et al.  Isolation, Not Loneliness or Cynical Hostility, Predicts Cognitive Decline in Older Americans , 2018, Journal of aging and health.

[60]  M. Irwin,et al.  Associations of objective versus subjective social isolation with sleep disturbance, depression, and fatigue in community-dwelling older adults , 2018, Aging & mental health.

[61]  Y. Zhong,et al.  Social Isolation Induces Rac1-Dependent Forgetting of Social Memory. , 2018, Cell reports.

[62]  E. Newcombe,et al.  Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease , 2018, Journal of Neuroinflammation.

[63]  D. Llewellyn,et al.  LIVING ALONE AND COGNITIVE FUNCTION IN LATER LIFE , 2018, Alzheimer's & Dementia.

[64]  A. Villringer,et al.  Social network types in old age and incident dementia , 2018, Das Gesundheitswesen.

[65]  W. Paulus,et al.  Decreased cerebral Irp‐1B limits impact of social isolation in wild type and Alzheimer's disease modeled in Drosophila melanogaster , 2018, Genes, brain, and behavior.

[66]  David J. Anderson,et al.  The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress , 2018, Cell.

[67]  U. Hochgeschwender,et al.  Altered Behavior in Mice Socially Isolated During Adolescence Corresponds With Immature Dendritic Spine Morphology and Impaired Plasticity in the Prefrontal Cortex , 2018, Front. Behav. Neurosci..

[68]  C. Mariani,et al.  Living Alone and Dementia Incidence: A Clinical-Based Study in People With Mild Cognitive Impairment , 2018, Journal of geriatric psychiatry and neurology.

[69]  H. Arakawa.  Ethological approach to social isolation effects in behavioral studies of laboratory rodents , 2018, Behavioural Brain Research.

[70]  Y. Fang,et al.  Loneliness and the risk of dementia among older Chinese adults: gender differences , 2018, Aging & mental health.

[71]  G. Hu,et al.  Enriched physical environment reverses spatial cognitive impairment of socially isolated APPswe/PS1dE9 transgenic mice before amyloidosis onset , 2018, CNS neuroscience & therapeutics.

[72]  R. Taylor,et al.  Social Isolation, Depression, and Psychological Distress Among Older Adults , 2018, Journal of aging and health.

[73]  B. Harvey,et al.  Studies into the anxiolytic actions of agomelatine in social isolation reared rats: Role of corticosterone and sex , 2018, Journal of psychopharmacology.

[74]  Hongyu Zhao,et al.  Loneliness 5 years ante-mortem is associated with disease-related differential gene expression in postmortem dorsolateral prefrontal cortex , 2018, Translational Psychiatry.

[75]  M. Rapp,et al.  Testing the stress-buffering hypothesis of social support in couples coping with early-stage dementia , 2016, PloS one.

[76]  M. Mielke.  Sex and Gender Differences in Alzheimer's Disease Dementia. , 2018, The Psychiatric times.

[77]  J. Roberts,et al.  Social Connectedness, Perceived Isolation, and Dementia: Does the Social Environment Moderate the Relationship Between Genetic Risk and Cognitive Well-Being? , 2017, The Gerontologist.

[78]  W. Caan,et al.  An overview of systematic reviews on the public health consequences of social isolation and loneliness. , 2017, Public health.

[79]  M. Orrell,et al.  Loneliness, Social Integration, and Incident Dementia Over 6 Years: Prospective Findings From the English Longitudinal Study of Ageing , 2017, The journals of gerontology. Series B, Psychological sciences and social sciences.

[80]  A. Ali,et al.  Study on Social Isolation as a Risk Factor in Development of AlzheimerâÂÂs Disease in Rats , 2017 .

[81]  M. Glymour,et al.  Loneliness, depression and cognitive function in older U.S. adults , 2017, International journal of geriatric psychiatry.

[82]  M. Orrell,et al.  Positive and Negative Experiences of Social Support and Risk of Dementia in Later Life: An Investigation Using the English Longitudinal Study of Ageing , 2017, Journal of Alzheimer's disease : JAD.

[83]  L. Berkman,et al.  Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia , 2017, Alzheimer's & dementia.

[84]  Eva M. Klein,et al.  Loneliness in the general population: prevalence, determinants and relations to mental health , 2017, BMC Psychiatry.

[85]  J. Herman,et al.  Behavioral and physiological consequences of enrichment loss in rats , 2017, Psychoneuroendocrinology.

[86]  L. Ferrucci,et al.  Long-term cortisol measures predict Alzheimer disease risk , 2017, Neurology.

[87]  I. Gaisler-Salomon,et al.  Differential effects of social isolation in adolescent and adult mice on behavior and cortical gene expression , 2017, Behavioural Brain Research.

[88]  A. Haq,et al.  The Pathophysiology of Perceived Social Isolation: Effects on Health and Mortality , 2017, Cureus.

[89]  Tih-Shih Lee,et al.  Psychosocial Risk and Protective Factors and Incident Mild Cognitive Impairment and Dementia in Community Dwelling Elderly: Findings from the Singapore Longitudinal Ageing Study. , 2017, Journal of Alzheimer's disease : JAD.

[90]  Keith A. Johnson,et al.  Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults. , 2016, JAMA psychiatry.

[91]  E. Lambe,et al.  Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels , 2016, eLife.

[92]  B. Harvey,et al.  The α2C-adrenoceptor antagonist, ORM-10921, has antipsychotic-like effects in social isolation reared rats and bolsters the response to haloperidol , 2016, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[93]  A. Bush,et al.  Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia. , 2016, The Journal of toxicological sciences.

[94]  Hong Zhou,et al.  Citalopram Ameliorates Synaptic Plasticity Deficits in Different Cognition-Associated Brain Regions Induced by Social Isolation in Middle-Aged Rats , 2016, Molecular Neurobiology.

[95]  Steven L. Neuberg,et al.  PERSONALITY PROCESSES AND INDIVIDUAL DIFFERENCES Individual Differences in Fundamental Social Motives , 2016 .

[96]  Andre Fischer,et al.  Environmental enrichment as a method to improve cognitive function. What can we learn from animal models? , 2016, NeuroImage.

[97]  F. Biggio,et al.  Sex differences in the outcome of juvenile social isolation on HPA axis function in rats , 2016, Neuroscience.

[98]  M. M. Holmes.  Social regulation of adult neurogenesis: A comparative approach , 2016, Frontiers in Neuroendocrinology.

[99]  B. Hanratty,et al.  Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies , 2016, Heart.

[100]  T. Tilburg,et al.  Social Isolation and Loneliness , 2016 .

[101]  Y. Conwell,et al.  Loneliness and Cognitive Function in Older Adults: Findings From the Chinese Longitudinal Healthy Longevity Survey , 2016, The journals of gerontology. Series B, Psychological sciences and social sciences.

[102]  R. Marioni,et al.  Social activity, cognitive decline and dementia risk: a 20-year prospective cohort study , 2015, BMC Public Health.

[103]  H. van Marwijk,et al.  Loneliness is associated with poor prognosis in late-life depression: Longitudinal analysis of the Netherlands study of depression in older persons. , 2015, Journal of affective disorders.

[104]  M. Gunnar,et al.  The social buffering of the hypothalamic–pituitary–adrenocortical axis in humans: Developmental and experiential determinants , 2015, Social neuroscience.

[105]  I-Min Lee,et al.  Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship. , 2015, JAMA internal medicine.

[106]  Burkhard Becher,et al.  Immune attack: the role of inflammation in Alzheimer disease , 2015, Nature Reviews Neuroscience.

[107]  J. Haro,et al.  The association between social relationships and depression: a systematic review. , 2015, Journal of affective disorders.

[108]  L. Nilsson,et al.  Social relationships and risk of dementia: a population-based study , 2015, International Psychogeriatrics.

[109]  Timothy B. Smith,et al.  Loneliness and Social Isolation as Risk Factors for Mortality , 2015, Perspectives on psychological science : a journal of the Association for Psychological Science.

[110]  G. Hu,et al.  Isolation Housing Exacerbates Alzheimer’s Disease-Like Pathophysiology in Aged APP/PS1 Mice , 2015, The international journal of neuropsychopharmacology.

[111]  D. Kang,et al.  Loneliness and cognitive function in the older adult: a systematic review , 2015, International Psychogeriatrics.

[112]  Zhi-jun Zhang,et al.  Citalopram Attenuates Tau Hyperphosphorylation and Spatial Memory Deficit Induced by Social Isolation Rearing in Middle-Aged Rats , 2015, Journal of Molecular Neuroscience.

[113]  W. Maier,et al.  Associations between Dementia Outcomes and Depressive Symptoms, Leisure Activities, and Social Support , 2014, Dementia and Geriatric Cognitive Disorders Extra.

[114]  P. Gean,et al.  Social Interaction Rescues Memory Deficit in an Animal Model of Alzheimer's Disease by Increasing BDNF-Dependent Hippocampal Neurogenesis , 2014, The Journal of Neuroscience.

[115]  J. Cacioppo,et al.  Toward a neurology of loneliness. , 2014, Psychological bulletin.

[116]  D. Praticò,et al.  Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease. , 2014, Human molecular genetics.

[117]  Paolo Parigi,et al.  Social Isolation in America , 2014 .

[118]  L. Tan,et al.  Behavioral and Psychological Symptoms in Alzheimer's Disease , 2014, BioMed research international.

[119]  Tim P Morris,et al.  The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies , 2014, Trials.

[120]  A. Döring,et al.  How much does it hurt to be lonely? Mental and physical differences between older men and women in the KORA‐Age Study , 2014, International journal of geriatric psychiatry.

[121]  Jens F. Binder,et al.  Relationships and the Social Brain , 2014 .

[122]  L. Nilsson,et al.  The relationship between marital and parental status and the risk of dementia , 2014, International Psychogeriatrics.

[123]  J. Weiner,et al.  The impact of social isolation on HPA axis function, anxiety-like behaviors, and ethanol drinking , 2014, Front. Integr. Neurosci..

[124]  R. Mayeux,et al.  Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease , 2013, Nature Neuroscience.

[125]  Alejandro F Frangi,et al.  Modifiable lifestyle factors in dementia: a systematic review of longitudinal observational cohort studies. , 2014, Journal of Alzheimer's disease : JAD.

[126]  Mhs Carla M. Perissinotto MD,et al.  Living Alone, Socially Isolated or Lonely—What are We Measuring? , 2014, Journal of General Internal Medicine.

[127]  C. Venero,et al.  Long-term social isolation in the adulthood results in CA1 shrinkage and cognitive impairment , 2013, Neurobiology of Learning and Memory.

[128]  S. Wagner,et al.  Rapid and Reversible Impairments of Short- and Long-Term Social Recognition Memory Are Caused by Acute Isolation of Adult Rats via Distinct Mechanisms , 2013, PloS one.

[129]  A. Teo,et al.  The role of social isolation in social anxiety disorder: a systematic review and meta-analysis. , 2013, Journal of anxiety disorders.

[130]  J. Wardle,et al.  Social isolation, loneliness, and all-cause mortality in older men and women , 2013, Proceedings of the National Academy of Sciences.

[131]  A. Steptoe,et al.  Social isolation and loneliness , 2012 .

[132]  Robert A Schoevers,et al.  Feelings of loneliness, but not social isolation, predict dementia onset: results from the Amsterdam Study of the Elderly (AMSTEL) , 2012, Journal of Neurology, Neurosurgery & Psychiatry.

[133]  Elizabeth Dugan,et al.  Social Isolation, Loneliness and Health Among Older Adults , 2012, Journal of aging and health.

[134]  Zuoxin Wang,et al.  The Social Environment and Neurogenesis in the Adult Mammalian Brain , 2012, Front. Hum. Neurosci..

[135]  Jens F. Binder,et al.  Relationships and the social brain: integrating psychological and evolutionary perspectives. , 2012, British journal of psychology.

[136]  H. O’connell,et al.  Loneliness and cognition in older people: The Dublin Healthy Ageing study , 2012, Aging & mental health.

[137]  P. Gean,et al.  Amelioration of social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model , 2012, Neurobiology of Disease.

[138]  C. J. McGrath,et al.  The Effect , 2012 .

[139]  J L Andersson,et al.  Social Network Size Affects Neural Circuits in Macaques , 2011, Science.

[140]  A. Beekman,et al.  Increased risk of mortality associated with social isolation in older men: only when feeling lonely? Results from the Amsterdam Study of the Elderly (AMSTEL) , 2011, Psychological Medicine.

[141]  P. Gean,et al.  The Involvement of Cdk5 Activator p35 in Social Isolation-Triggered Onset of Early Alzheimer’s Disease-Related Cognitive Deficit in the Transgenic Mice , 2011, Neuropsychopharmacology.

[142]  L. Hawkley,et al.  Social isolation , 2011, Annals of the New York Academy of Sciences.

[143]  Andrew Steptoe,et al.  Loneliness, social isolation, and behavioral and biological health indicators in older adults. , 2011, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[144]  T. Nabeshima,et al.  Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders. , 2011, The international journal of neuropsychopharmacology.

[145]  Yen-Yu Chang,et al.  Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice , 2011, Brain Research.

[146]  M. Ohno,et al.  Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease , 2010, Molecular Brain.

[147]  H. Amièva,et al.  What Aspects of Social Network Are Protective for Dementia? Not the Quantity But the Quality of Social Interactions Is Protective Up to 15 Years Later , 2010, Psychosomatic medicine.

[148]  J. Kiecolt-Glaser,et al.  Close relationships, inflammation, and health , 2010, Neuroscience & Biobehavioral Reviews.

[149]  L. Hawkley,et al.  Loneliness Matters: A Theoretical and Empirical Review of Consequences and Mechanisms , 2010, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[150]  Louise C Hawkley,et al.  Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study. , 2010, Psychology and aging.

[151]  Kristopher J Preacher,et al.  Loneliness impairs daytime functioning but not sleep duration. , 2010, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[152]  L. Flicker.  Modifiable lifestyle risk factors for Alzheimer's disease. , 2010, Journal of Alzheimer's disease : JAD.

[153]  H. Bimonte-Nelson,et al.  Impact of the hypothalamic-pituitary-adrenal/gonadal axes on trajectory of age-related cognitive decline. , 2010, Progress in brain research.

[154]  R. Castellani,et al.  Alzheimer disease. , 2010, Disease-a-month : DM.

[155]  L. Hawkley,et al.  Perceived social isolation and cognition , 2009, Trends in Cognitive Sciences.

[156]  C R Jack,et al.  Imaging and Biomarkers in Early Alzheimer's Disease and Mild Cognitive Impairment , 2009, Clinical pharmacology and therapeutics.

[157]  B. Winblad,et al.  Leisure Activities in Late Life in Relation to Dementia Risk: Principal Component Analysis , 2009, Dementia and Geriatric Cognitive Disorders.

[158]  C. Lowry,et al.  Consequences of Post-Weaning Social Isolation on Anxiety Behavior and Related Neural Circuits in Rodents , 2009, Front. Behav. Neurosci..

[159]  J. Feldon,et al.  Limited impact of social isolation on Alzheimer-like symptoms in a triple transgenic mouse model. , 2009, Behavioral neuroscience.

[160]  G. Forster,et al.  Adult rats exposed to early-life social isolation exhibit increased anxiety and conditioned fear behavior, and altered hormonal stress responses , 2009, Hormones and Behavior.

[161]  Joe Verghese,et al.  Social networks and their role in preventing dementia , 2009, Indian journal of psychiatry.

[162]  A. Lobo,et al.  Non-cognitive psychopathological symptoms associated with incident mild cognitive impairment and dementia, alzheimer’s type , 2008, Neurotoxicity Research.

[163]  E. Cornwell,et al.  Measuring social isolation among older adults using multiple indicators from the NSHAP study. , 2009, The journals of gerontology. Series B, Psychological sciences and social sciences.

[164]  K. Fone,et al.  Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders , 2008, Neuroscience & Biobehavioral Reviews.

[165]  J. Csernansky,et al.  Corticosterone and related receptor expression are associated with increased β-amyloid plaques in isolated Tg2576 mice , 2008, Neuroscience.

[166]  Diana B Petitti,et al.  Social network, cognitive function, and dementia incidence among elderly women. , 2008, American journal of public health.

[167]  Simon Lovestone,et al.  The GSK3 hypothesis of Alzheimer's disease , 2008, Journal of neurochemistry.

[168]  A. Kolanowski,et al.  Prescribing activities that engage passive residents. An innovative method. , 2008, Journal of gerontological nursing.

[169]  G. Hawthorne.  Perceived social isolation in a community sample: its prevalence and correlates with aspects of peoples’ lives , 2008, Social Psychiatry and Psychiatric Epidemiology.

[170]  Yikyung Park,et al.  Physical activity recommendations and decreased risk of mortality. , 2007, Archives of internal medicine.

[171]  J. D. McGaugh,et al.  Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice , 2007, Neurobiology of Disease.

[172]  D. Holtzman,et al.  Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity , 2007, Proceedings of the National Academy of Sciences.

[173]  J. Schneider,et al.  Loneliness and risk of Alzheimer disease. , 2007, Archives of general psychiatry.

[174]  N. Zilka,et al.  Risk and protective factors for sporadic Alzheimer's disease. , 2007, Acta virologica.

[175]  G. Miller,et al.  If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. , 2007, Psychological bulletin.

[176]  R. D'Agostino,et al.  Social networks and inflammatory markers in the Framingham Heart Study. , 2006, Journal of biosocial science.

[177]  Maria Petersson,et al.  Antistress, Well‐Being, Empathy and Social Support , 2006 .

[178]  Matthew E. Brashears,et al.  Social Isolation in America: Changes in Core Discussion Networks over Two Decades , 2006 .

[179]  J. Schneider,et al.  The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study , 2006, The Lancet Neurology.

[180]  L. Berkman,et al.  Relation of social integration to inflammatory marker concentrations in men and women 70 to 79 years. , 2006, The American journal of cardiology.

[181]  L. Hawkley,et al.  Loneliness as a specific risk factor for depressive symptoms: cross-sectional and longitudinal analyses. , 2006, Psychology and aging.

[182]  L. Berkman,et al.  Social integration and concentrations of C-reactive protein among US adults. , 2006, Annals of epidemiology.

[183]  Laura Fratiglioni,et al.  Mental, Physical and Social Components in Leisure Activities Equally Contribute to Decrease Dementia Risk , 2006, Dementia and Geriatric Cognitive Disorders.

[184]  Antonio Lobo,et al.  The ZARADEMP Project on the incidence, prevalence and risk factors of dementia (and depression) in the elderly community: II. Methods and first results , 2005 .

[185]  A. Lobo,et al.  The ZARADEMP Project on the incidence, prevalence and risk factors of dementia (and depression) in the elderly community: I. The context and the objectives , 2005 .

[186]  J. Csernansky,et al.  Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress , 2004, Neuroscience.

[187]  R. Petersen.  Mild cognitive impairment as a diagnostic entity , 2004, Journal of internal medicine.

[188]  Chadi Touma,et al.  Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer’s disease , 2004, Neurobiology of Aging.

[189]  Simon Lovestone,et al.  Is MCI really just early dementia? A systematic review of conversion studies , 2004, International Psychogeriatrics.

[190]  E. Alleva,et al.  Long-term effects of the periadolescent environment on exploratory activity and aggressive behaviour in mice: social versus physical enrichment , 2004, Physiology & Behavior.

[191]  D. Hay,et al.  Peer relations in childhood. , 2004, Journal of child psychology and psychiatry, and allied disciplines.

[192]  Peng Xia,et al.  Modification of hippocampal neurogenesis and neuroplasticity by social environments , 2003, Experimental Neurology.

[193]  R. Westendorp,et al.  Leisure activities and the risk of dementia. , 2003, The New England journal of medicine.

[194]  H. Buschke,et al.  Leisure activities and the risk of dementia in the elderly. , 2003, The New England journal of medicine.

[195]  L. Tsai,et al.  A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains , 2002, FEBS letters.

[196]  Laura Fratiglioni,et al.  Late-life engagement in social and leisure activities is associated with a decreased risk of dementia: a longitudinal study from the Kungsholmen project. , 2002, American journal of epidemiology.

[197]  F. Lang,et al.  Regulation of social relationships in later adulthood. , 2001, The journals of gerontology. Series B, Psychological sciences and social sciences.

[198]  B. Winblad,et al.  Influence of social network on occurrence of dementia: a community-based longitudinal study , 2000, The Lancet.

[199]  R. Sapolsky,et al.  Glucocorticoids, stress, and their adverse neurological effects: relevance to aging , 1999, Experimental Gerontology.

[200]  J. Kaprio,et al.  Relationship of leisure-time physical activity and mortality: the Finnish twin cohort. , 1998, JAMA.

[201]  M F Weiner,et al.  The Behavior Rating Scale for Dementia of the Consortium to Establish a Registry for Alzheimer's Disease. The Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease. , 1995, The American journal of psychiatry.

[202]  R. Baumeister,et al.  The need to belong: desire for interpersonal attachments as a fundamental human motivation. , 1995, Psychological bulletin.

[203]  S. Mirra,et al.  Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists. , 1993, Archives of pathology & laboratory medicine.

[204]  S. Fisher.  Stress, health and disease. , 1993, British journal of hospital medicine.

[205]  G. Drewes,et al.  Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau , 1992, FEBS letters.

[206]  J. Woodgett,et al.  Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase , 1992, Neuroscience Letters.

[207]  C. Stevens,et al.  Aquaporin 4 and glymphatic flow have central roles in brain fluid homeostasis , 2021, Nature Reviews Neuroscience.

[208]  D. Sommers,et al.  A longitudinal analysis , 1992 .

[209]  F. Ames.  Sex and the brain. , 1991, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[210]  H. Wiśniewski,et al.  Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[211]  W. E. Berg,et al.  Loneliness among the elderly: a causal approach. , 1985, Journal of gerontology.

[212]  G. Glenner,et al.  Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein , 1984 .

[213]  G. Glenner,et al.  Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. , 1984, Biochemical and biophysical research communications.

[214]  R. Wolff.  A behavior rating scale. , 1961, The American journal of occupational therapy : official publication of the American Occupational Therapy Association.

[215]  H. V. VON WITZLEBEN.  On loneliness. , 1958, Psychiatry.

[216]  A. Anastasi.  Individual differences. , 2020, Annual review of psychology.