Influence of metal ion solutions on rabbit osteoclast activities in vitro.

The purpose of the present study was to compare the effects of various metal ions (aluminium, chromium, cobalt, gold, iron, strontium, titanium and vanadium) on rabbit osteoclast activities, with respect to their number, size, resorptive capacity and their capacity to release proteinases. Marked heterogeneous osteoclastic behaviour was observed early in culture with metal ions (24 h) in term of resorption parameters. In contrast, protease activities (cysteine-proteinase and metalloproteinase activities) were not modulated in our culture conditions. Aluminium, iron, gold and titanium reduced the number of osteoclasts significantly. Aluminium and gold had no effect on osteoclast-mediated resorption on dentin-slices, although aluminium induced a greater number of very small lacunae. Titanium reduced only the mean surface area per lacunae, cobalt reduced the mean surface area of lacunae and increased their number, and iron reduced both parameters. Strontium had no effect on osteoclast formation and on total dentin slice surface resorbed. However, strontium increased the number of small lacunae formed on dentin-slices by osteoclasts. Chromium had no effect on osteoclast activities. These findings indicate that metal ions induce very early effects on osteoclasts, which can contribute to periprosthetic pathologies via different cellular mechanisms.

[1]  M. Yamaguchi,et al.  Zinc compounds inhibit osteoclast-like cell formation at the earlier stage of rat marrow culture but not osteoclast function , 1996, Molecular and Cellular Biochemistry.

[2]  C. Brigati,et al.  Tissue inhibitors of metalloproteases: Regulation and biological activities , 2004, Clinical & Experimental Metastasis.

[3]  D. Heymann,et al.  Osteoclastic acidification pathways during bone resorption. , 2002, Bone.

[4]  D. Heymann,et al.  Osteoprotegerin: a new therapeutic agent for the treatment of bone disease. , 2001, Drug discovery today.

[5]  M. Padrines,et al.  Potential synergies between matrix proteins and soluble factors on resorption and proteinase activities of rabbit bone cells. , 2001, Histology and histopathology.

[6]  T. Kojo,et al.  Preferential degradation of osteoclasts by titanium tetrachloride. , 2001, Journal of biomedical materials research.

[7]  V. Goldberg,et al.  Titanium Particles Stimulate Bone Resorption by Inducing Differentiation of Murine Osteoclasts , 2001, The Journal of bone and joint surgery. American volume.

[8]  D. Heymann,et al.  Ultrastructural evidence in vitro of osteoclast-induced degradation of calcium phosphate ceramic by simultaneous resorption and phagocytosis mechanisms. , 2001, Histology and histopathology.

[9]  T. Chambers.  Regulation of the differentiation and function of osteoclasts , 2000, The Journal of pathology.

[10]  D. Howie,et al.  The effect of particle phagocytosis and metallic wear particles on osteoclast formation and bone resorption in vitro. , 2000, The Journal of arthroplasty.

[11]  P. Marc,et al.  Human growth hormone stimulates proteinase activities of rabbit bone cells via IGF-I. , 2000, Biochemical and biophysical research communications.

[12]  M. Karsdal,et al.  Proteinases in bone resorption: obvious and less obvious roles. , 2000, Clinica chimica acta; international journal of clinical chemistry.

[13]  N. Fujii,et al.  Tissue response to titanium implants in the rat maxilla: ultrastructural and histochemical observations of the bone-titanium interface. , 2000, Journal of periodontology.

[14]  C. Dunstan.  Osteoprotegerin and Osteoprotegerin Ligand Mediate the Local Regulation of Bone Resorption , 2000 .

[15]  D. Chappard,et al.  The early remodeling phases around titanium implants: a histomorphometric assessment of bone quality in a 3- and 6-month study in sheep. , 1999, The International journal of oral & maxillofacial implants.

[16]  H. Dimai,et al.  Effects of Zinc on Human Skeletal Alkaline Phosphatase Activity In Vitro , 1999, Calcified Tissue International.

[17]  G. Daculsi,et al.  Cytokines, growth factors and osteoclasts. , 1998, Cytokine.

[18]  N. Athanasou,et al.  Osteoclastic differentiation by mononuclear phagocytes containing biomaterial particles , 1998, Archives of Orthopaedic and Trauma Surgery.

[19]  K. Suzuki,et al.  Effects of surface roughness of titanium implants on bone remodeling activity of femur in rabbits. , 1997, Bone.

[20]  G. Daculsi,et al.  Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite/beta-tricalcium phosphate ratios. , 1997, Biomaterials.

[21]  D. Puleo,et al.  Effect of metal ions on the formation and function of osteoclastic cells in vitro. , 1997, Journal of biomedical materials research.

[22]  D. Howie,et al.  In vitro human monocyte response to wear particles of titanium alloy containing vanadium or niobium. , 1997, The Journal of bone and joint surgery. British volume.

[23]  鈴木 和彦.  Effect of surface roughness of titanium implants on bone remodeling activity of femur in rabbits , 1997 .

[24]  D. Murray,et al.  Radio-opaque Agents In Bone Cement Increase Bone Resorption , 1997 .

[25]  G. Gronowicz,et al.  Response of human osteoblasts to implant materials: Integrin‐mediated adhesion , 1996, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[26]  A. K. Wilson,et al.  Effects of cadmium on osteoclast formation and activity in vitro. , 1996, Toxicology and applied pharmacology.

[27]  D. Puleo,et al.  Ti-6Al-4V ion solution inhibition of osteogenic cell phenotype as a function of differentiation timecourse in vitro. , 1996, Biomaterials.

[28]  J. Gonzales,et al.  In Vitro Studies on the Role of Titanium in Aseptic Loosening , 1996, Clinical orthopaedics and related research.

[29]  G. Roodman,et al.  Advances in bone biology: the osteoclast. , 1996, Endocrine reviews.

[30]  P. Ducheyne,et al.  Local accumulation of titanium released from a titanium implant in the absence of wear. , 1996, Journal of biomedical materials research.

[31]  W J Maloney,et al.  Periprosthetic osteolysis in total hip arthroplasty: the role of particulate wear debris. , 1995, Instructional course lectures.

[32]  B. Riggs,et al.  Zeolite a inhibits osteoclast‐mediated bone resorption in vitro , 1995, Journal of cellular biochemistry.

[33]  H. Hildebrand,et al.  Titanium-induced enzyme activation on murine peritoneal macrophages in primary culture. , 1995, Biomaterials.

[34]  J. Galante,et al.  Mechanisms of bone loss associated with total hip replacement. , 1993, The Orthopedic clinics of North America.

[35]  K. Schaller,et al.  Nickel-, chrom- and cobalt-concentrations in human tissue and body fluids of hip prosthesis patients. , 1992, Journal of trace elements and electrolytes in health and disease.

[36]  P. Nijweide,et al.  Identification of osteopontin in isolated rabbit osteoclasts. , 1992, Biochemical and biophysical research communications.

[37]  T. Wright,et al.  Cobalt-alloy metal debris in periarticular tissues from total hip revision arthroplasties. Metal contents and associated histologic findings. , 1992, Clinical orthopaedics and related research.

[38]  L. Dorr,et al.  Histologic, biochemical, and ion analysis of tissue and fluids retrieved during total hip arthroplasty. , 1990, Clinical orthopaedics and related research.

[39]  F. Llach,et al.  Aluminum administration in the Rat separately affects the osteoblast and Bone mineralization , 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[40]  M. Lieberherr,et al.  Aluminum action on mouse bone cell metabolism and response to PTH and 1,25(OH)2D3. , 1987, Kidney international.

[41]  P. Marie,et al.  Short-term effects of fluoride and strontium on bone formation and resorption in the mouse. , 1986, Metabolism: clinical and experimental.

[42]  H. Tschesche.  Proteinases in Inflammation and Tumor Invasion , 1986 .

[43]  D. Modrowski,et al.  Effects of Iron Overload on Bone Remodelling in Pigs , 1985 .

[44]  M. de Vernejoul,et al.  Effects of iron overload on bone remodeling in pigs. , 1984, The American journal of pathology.

[45]  A. Tashjian,et al.  Inhibition of stimulated bone resorption by vanadate. , 1983, Endocrinology.