Response to Comment on Yang et al. Association of Statin Use and Reduced Risk of Lower-Extremity Amputation Among Patients With Diabetes: A Nationwide Population-Based Cohort Observation. Diabetes Care 2016;39:e54–e55

We thank Fox et al. (1) for their noteworthy comments concerning the need for clinical trials regarding the role of statins in preserving the lower extremities of patients with diabetes mellitus (DM). Complications of the extremities, comprising peripheral artery disease, peripheral neuropathy, foot ulcer, critical limb ischemia, and ultimately limb loss, constitute a huge health burden for patients with DM. Our recent study (2) showed the beneficial effect of statins in patients with type 2 diabetes leading to a 52% reduction in …