A new high spatial resolution micro-angiographic camera will enable routine viewing within a region of interest of detailed vascular structure unable to be seen with current full field of view (FOV) angiographic detectors. Such details include perforator vessels, vessel contractility or compliance, and condition and location of 50 micron or smaller stent wires. Although the basic CsI(Tl) phosphor-optical taper-CCD design of the new ROI micro-angiographic camera is essentially the same as that of the pre-clinical prototype, many of the physical parameters are much improved. The FOV is 5 cm X 5 cm vs. the previous 1 cm X 1 cm; the phosphor thickness is 350 - 400 micron vs. the previous 100 micron; the taper ratio is now 1.8 rather than 3.0 (2.8X improvement in light collection). The pixel size is either 25 or 50 micron. Additionally, detector noise may now be carefully considered in the camera design as may mechanical supporting mechanisms, methods to synchronize image acquisition with exposure and the effects of other physical factors such as exposure parameters, tube loading, focal spot size and geometric unsharpness. It is expected that this new capability should allow improved treatments and further development of smaller interventional devices and catheter delivery systems.
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