The ECAT HRRT: performance and first clinical application of the new high resolution research tomograph

The ECAT HRRT is a three-dimensional (3-D) only dedicated brain tomograph employing the new scintillator lutetium-oxy-orthosilicate (LSO) and using depth of interaction (DOI) information to achieve uniform isotropic resolution across a 20-cm diameter volume. With its unique technological innovations it represents the prototype of a new generation of high-resolution brain tomographs. The physical performance with respect to count rate, live time, scatter, sensitivity, and resolution was evaluated with phantom studies and measurements with a point source. The HRRTs imaging performance was tested with phantoms and fluorodeoxyglucose (FDG) scans performed in animal and human brains. We find that due to the significantly improved resolution and the large solid angle covered by the panel detectors, several issues that have been adequately solved for older generation scanners demand new attention for the HRRT, like acquiring and handling large amounts of data effectively, strategies for optimal reconstruction, shielding, and correction of random coincidences.

[1]  C. Knoss,et al.  BeeHive: cluster reconstruction of 3-D PET data in a Windows NT network using FORE , 2000, 2000 IEEE Nuclear Science Symposium. Conference Record (Cat. No.00CH37149).

[2]  R M Lewitt,et al.  Performance of the Fourier rebinning algorithm for PET with large acceptance angles. , 1998, Physics in medicine and biology.

[3]  Claude Comtat,et al.  Weighted schemes applied to 3D-OSEM reconstruction in PET , 1999, 1999 IEEE Nuclear Science Symposium. Conference Record. 1999 Nuclear Science Symposium and Medical Imaging Conference (Cat. No.99CH37019).

[4]  D. Townsend,et al.  The Theory and Practice of 3D PET , 1998, Developments in Nuclear Medicine.

[5]  Michel Defrise,et al.  Exact and approximate rebinning algorithms for 3-D PET data , 1997, IEEE Transactions on Medical Imaging.

[6]  K Wienhard,et al.  The ECAT EXACT HR: Performance of a New High Resolution Positron Scanner , 1994, Journal of computer assisted tomography.

[7]  Michael E. Casey,et al.  Random correction for positron emission tomography using singles count rates , 2000, 2000 IEEE Nuclear Science Symposium. Conference Record (Cat. No.00CH37149).

[8]  Klaus Wienhard,et al.  Advantages using pulse shape discrimination to assign the depth of interaction information (DOI) from a multi-layer phoswich detector , 1998 .

[9]  Klaus Wienhard,et al.  Performance results of a new DOI detector block for a high resolution PET-LSO research tomograph HRRT , 1997 .

[10]  M. Zambelli,et al.  A 2-dimensional detector decoding study on BGO arrays with quadrant sharing photomultipliers , 1994 .

[11]  E. Hoffman,et al.  Performance standards in positron emission tomography. , 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[12]  Lars Eriksson,et al.  Performance evaluation of a new LSO high resolution research tomograph-HRRT , 1999, 1999 IEEE Nuclear Science Symposium. Conference Record. 1999 Nuclear Science Symposium and Medical Imaging Conference (Cat. No.99CH37019).

[13]  Wai-Hoi Wong,et al.  A positron camera detector design with cross-coupled scintillators and quadrant sharing photomultipliers , 1992 .

[14]  E. Hoffman,et al.  3-D phantom to simulate cerebral blood flow and metabolic images for PET , 1990 .

[15]  G Muehllehner,et al.  Constrained Fourier space method for compensation of missing data in emission computed tomography. , 1988, IEEE transactions on medical imaging.

[16]  Charles C. Watson,et al.  Reconstruction strategies for the HRRT , 2000, 2000 IEEE Nuclear Science Symposium. Conference Record (Cat. No.00CH37149).