In Silico Biology: From Simulation to Understanding

Mathematical modelling is feasible only if the biological system under consideration meets certain criteria--if they are met, a comprehensive quantitative approach not only yields information about the dynamics of intracellular processes but eventually allows for the prediction of population behaviour from molecular interactions.

[1]  Timothy J. Mitchison,et al.  Determining the position of the cell division plane , 2003, Nature.

[2]  J. Hopfield,et al.  From molecular to modular cell biology , 1999, Nature.

[3]  D. Burgess,et al.  Induction of cytokinesis is independent of precisely regulated microtubule dynamics. , 2005, Molecular biology of the cell.

[4]  I. Macara,et al.  Mammalian Pins Is a Conformational Switch that Links NuMA to Heterotrimeric G Proteins , 2004, Cell.

[5]  Hiroaki Kitano,et al.  Biological robustness , 2008, Nature Reviews Genetics.

[6]  S. van den Heuvel,et al.  A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C elegans. , 2003, Genes & development.

[7]  G. Gundersen,et al.  Interaction between EB1 and p150glued Is Required for Anaphase Astral Microtubule Elongation and Stimulation of Cytokinesis , 2005, Current Biology.

[8]  Victor Sourjik,et al.  Receptor clustering and signal processing in E. coli chemotaxis. , 2004, Trends in microbiology.

[9]  J. Vilar,et al.  From molecular noise to behavioural variability in a single bacterium , 2004, Nature.

[10]  S. Leibler,et al.  An ultrasensitive bacterial motor revealed by monitoring signaling proteins in single cells. , 2000, Science.

[11]  Dennis Bray,et al.  The Chemotactic Behavior of Computer-Based Surrogate Bacteria , 2007, Current Biology.

[12]  T. Duke,et al.  Heightened sensitivity of a lattice of membrane receptors. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[13]  J. Adler A method for measuring chemotaxis and use of the method to determine optimum conditions for chemotaxis by Escherichia coli. , 1973, Journal of general microbiology.

[14]  S. V. Aksenov,et al.  A spatially extended stochastic model of the bacterial chemotaxis signalling pathway. , 2003, Journal of molecular biology.

[15]  Ellen S. Vitetta,et al.  An allosteric model for heterogeneous receptor complexes : Understanding bacterial chemotaxis responses to multiple stimuli , 2006 .

[16]  N Le Novère,et al.  Conformational spread in a ring of proteins: a stochastic approach to allostery. , 2001, Journal of molecular biology.

[17]  J. Timmer,et al.  Design principles of a bacterial signalling network , 2005, Nature.

[18]  H. Berg,et al.  Functional interactions between receptors in bacterial chemotaxis , 2004, Nature.

[19]  D. Bray,et al.  Receptor clustering as a cellular mechanism to control sensitivity , 1998, Nature.