Rare genetic variants explain missing heritability in smoking

[1]  Amanda Lee Hughes,et al.  Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects , 2022, Nature Genetics.

[2]  Andrew D. Johnson,et al.  Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data , 2022, Nature Genetics.

[3]  Christopher D. Brown,et al.  The power of genetic diversity in genome-wide association studies of lipids , 2021, Nature.

[4]  David M. Evans,et al.  Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data , 2021, Nature communications.

[5]  J. Casanova,et al.  Taking population stratification into account by local permutations in rare‐variant association studies on small samples , 2021, Genetic epidemiology.

[6]  M. P. Concas,et al.  Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour , 2021, Nature Human Behaviour.

[7]  A. Abdellaoui,et al.  Dissecting polygenic signals from genome-wide association studies on human behaviour , 2021, Nature Human Behaviour.

[8]  S. Vrieze,et al.  Genetic architecture of four smoking behaviors using partitioned SNP heritability. , 2021, Addiction.

[9]  Fergus R. Cooper,et al.  Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations , 2020, Nature Communications.

[10]  Megan U. Carnes,et al.  Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits , 2020, Nature communications.

[11]  Seunggeun Lee,et al.  Efficient mixed model approach for large-scale genome-wide association studies of ordinal categorical phenotypes , 2020, bioRxiv.

[12]  Alexander E. Lopez,et al.  Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis , 2020, Nature Genetics.

[13]  P. Sullivan,et al.  Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia , 2020, Nature Communications.

[14]  N. Grarup,et al.  Estimating narrow-sense heritability using family data from admixed populations , 2020, Heredity.

[15]  Seunggeun Lee,et al.  Fast and robust ancestry prediction using principal component analysis. , 2020, Bioinformatics.

[16]  Benedetta Bigio,et al.  Controlling for human population stratification in rare variant association studies , 2020, Scientific Reports.

[17]  Swapan Mallick,et al.  Insights into human genetic variation and population history from 929 diverse genomes , 2019, Science.

[18]  Brendan P. Zietsch,et al.  Genetic correlates of social stratification in Great Britain , 2019, Nature Human Behaviour.

[19]  A. Kong,et al.  Deconstructing the sources of genotype-phenotype associations in humans , 2019, Science.

[20]  Alexander I. Young.  Solving the missing heritability problem , 2019, PLoS genetics.

[21]  Noah Zaitlen,et al.  Ultra-rare variants drive substantial cis-heritability of human gene expression , 2019, Nature Genetics.

[22]  Brian E. Cade,et al.  Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program , 2019, Nature.

[23]  Dajiang J. Liu,et al.  Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci , 2019, Molecular Psychiatry.

[24]  Dajiang J. Liu,et al.  Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use , 2018, Nature Genetics.

[25]  Brady T West,et al.  Associations Between Early Onset of E-cigarette Use and Cigarette Smoking and Other Substance Use Among US Adolescents: A National Study , 2018, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[26]  C. Sabatti,et al.  Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates , 2018, bioRxiv.

[27]  Haoyu Zhang,et al.  Power Analysis for Genetic Association Test (PAGEANT) provides insights to challenges for rare variant association studies , 2018, Bioinform..

[28]  P. Visscher,et al.  Imprint of assortative mating on the human genome , 2018, Nature Human Behaviour.

[29]  P. Visscher,et al.  Meta-analysis of genome-wide association studies for height and body mass index in ∼700,000 individuals of European ancestry , 2018, bioRxiv.

[30]  M. Neale,et al.  Response to the Commentary on Maes et al. "A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents." , 2017, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[31]  A. Metspalu,et al.  Hidden heritability due to heterogeneity across seven populations , 2017, Nature Human Behaviour.

[32]  Rasool Tahmasbi,et al.  Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits , 2017, Nature Genetics.

[33]  B. Neale,et al.  Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection , 2016, bioRxiv.

[34]  Loukas Moutsianas,et al.  Exploring the genetic architecture of inflammatory bowel disease , 2016 .

[35]  Stephen C. J. Parker,et al.  The genetic architecture of type 2 diabetes , 2016, Nature.

[36]  Shane A. McCarthy,et al.  Reference-based phasing using the Haplotype Reference Consortium panel , 2016, Nature Genetics.

[37]  Bruce S Weir,et al.  Model-free Estimation of Recent Genetic Relatedness. , 2016, American journal of human genetics.

[38]  P. Visscher,et al.  Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index , 2015, Nature Genetics.

[39]  D. Boomsma,et al.  Spousal resemblance for smoking: Underlying mechanisms and effects of cohort and age. , 2015, Drug and alcohol dependence.

[40]  P. Visscher,et al.  Nature Genetics Advance Online Publication , 2022 .

[41]  Robert M. Maier,et al.  Genetic Basis of Complex Genetic Disease: The Contribution of Disease Heterogeneity to Missing Heritability , 2014, Current Epidemiology Reports.

[42]  C. Spencer,et al.  Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.

[43]  R. West,et al.  How does rate of smoking cessation vary by age, gender and social grade? Findings from a population survey in England. , 2013, Addiction.

[44]  C. Bustamante,et al.  RFMix: a discriminative modeling approach for rapid and robust local-ancestry inference. , 2013, American journal of human genetics.

[45]  N. Patterson,et al.  Using Extended Genealogy to Estimate Components of Heritability for 23 Quantitative and Dichotomous Traits , 2013, PLoS genetics.

[46]  Claudio J. Verzilli,et al.  An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People , 2012, Science.

[47]  A. Clark,et al.  Recent Explosive Human Population Growth Has Resulted in an Excess of Rare Genetic Variants , 2012, Science.

[48]  P M Visscher,et al.  Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses , 2012, Molecular Psychiatry.

[49]  Pablo Cingolani,et al.  © 2012 Landes Bioscience. Do not distribute. , 2022 .

[50]  Greg Gibson,et al.  Rare and common variants: twenty arguments , 2012, Nature Reviews Genetics.

[51]  E. Lander,et al.  The mystery of missing heritability: Genetic interactions create phantom heritability , 2012, Proceedings of the National Academy of Sciences.

[52]  G. McVean,et al.  Differential confounding of rare and common variants in spatially structured populations , 2011, Nature Genetics.

[53]  D. Boomsma,et al.  Interplay between heritability of smoking and environmental conditions? A comparison of two birth cohorts , 2011, BMC public health.

[54]  P. Visscher,et al.  Estimating missing heritability for disease from genome-wide association studies. , 2011, American journal of human genetics.

[55]  P. Visscher,et al.  GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.

[56]  P. Visscher,et al.  Common SNPs explain a large proportion of heritability for human height , 2011 .

[57]  Jason H. Moore,et al.  Missing heritability and strategies for finding the underlying causes of complex disease , 2010, Nature Reviews Genetics.

[58]  J. Boardman,et al.  Trends in the Genetic Influences on Smoking , 2010, Journal of health and social behavior.

[59]  A. Eyre-Walker.  Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies. , 2010, Proceedings of the National Academy of Sciences of the United States of America.

[60]  Judy H. Cho,et al.  Finding the missing heritability of complex diseases , 2009, Nature.

[61]  L. Powell.  APPROXIMATING VARIANCE OF DEMOGRAPHIC PARAMETERS USING THE DELTA METHOD: A REFERENCE FOR AVIAN BIOLOGISTS , 2007 .

[62]  N. Martin,et al.  Assortative Mating for Cigarette Smoking and for Alcohol Consumption in Female Australian Twins and their Spouses , 2006, Behavior genetics.

[63]  Toby Johnson,et al.  Theoretical models of selection and mutation on quantitative traits , 2005, Philosophical Transactions of the Royal Society B: Biological Sciences.

[64]  J. O'Loughlin,et al.  Smoking trajectories of adolescent novice smokers in a longitudinal study of tobacco use. , 2005, Annals of epidemiology.

[65]  W. Iacono,et al.  Childhood externalizing and internalizing psychopathology in the prediction of early substance use. , 2004, Addiction.

[66]  G. Willemsen,et al.  The association of current smoking behavior with the smoking behavior of parents, siblings, friends and spouses. , 2003, Addiction.

[67]  L. Degenhardt,et al.  The relationship between tobacco use, substance-use disorders and mental health: results from the National Survey of Mental Health and Well-being. , 2001, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.