Bloodstream infections exacerbate incidence and severity of symptomatic glucocorticoid‐induced osteonecrosis

Osteonecrosis is a common toxicity associated with glucocorticoid (e.g., dexamethasone and prednisone) treatment of children with acute lymphoblastic leukemia (ALL), but risk factors are incompletely defined. Infections are also a common complication of ALL therapy. Lipopolysaccharide (LPS) is used experimentally to mimic infection‐related systemic effects. To our knowledge, the contribution of systemic infections to the risk of glucocorticoid‐induced osteonecrosis has not been investigated.

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