Biomimetics using nanotechnology/nanoparticles in dental tissue regeneration

Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissues and organ functionality. The regeneration of dental tissues remains a challenge due to the complexity of structures and the current prevalence of dental diseases. However, recent advances in nanotechnology, acting as biomimetic tools, show great potential to overcome these challenges. The purpose of this chapter is to provide the general dental practitioner a background of nanotechnology in tissue engineering, its accomplishments in dentistry and its future applications in dental tissue regeneration.

[1]  Antonios G Mikos,et al.  Biomimetic materials for tissue engineering. , 2003, Biomaterials.

[2]  Syozi Nakashima,et al.  Effect of a test dentifrice containing nano-sized calcium carbonate on remineralization of enamel lesions in vitro. , 2009, Journal of oral science.

[3]  Yan Deng,et al.  Bio‐Inspired Enamel Repair via Glu‐Directed Assembly of Apatite Nanoparticles: an Approach to Biomaterials with Optimal Characteristics , 2011, Advanced materials.

[4]  D. Wise,et al.  Enhanced bioactivity of a poly(propylene fumarate) bone graft substitute by augmentation with nano-hydroxyapatite. , 2003, Bio-medical materials and engineering.

[5]  E. Reynolds,et al.  Retention in Plaque and Remineralization of Enamel Lesions by Various Forms of Calcium in a Mouthrinse or Sugar-free Chewing Gum , 2003, Journal of dental research.

[6]  T. Gotterbarm,et al.  The efficacy of Biobon™ and Ostim™ within metaphyseal defects using the Göttinger Minipig , 2009, Archives of Orthopaedic and Trauma Surgery.

[7]  Elisabetta Foresti,et al.  Synthetic Biomimetic Carbonate-Hydroxyapatite Nanocrystals for Enamel Remineralization , 2008 .

[8]  Moncy V. Jose,et al.  Aligned bioactive multi-component nanofibrous nanocomposite scaffolds for bone tissue engineering. , 2010, Macromolecular bioscience.

[9]  E. Reynolds,et al.  New Approaches to Enhanced Remineralization of Tooth Enamel , 2010, Journal of dental research.

[10]  J. Vacanti,et al.  A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. , 2003, Biomaterials.

[11]  Sven Henning,et al.  Polyvinyl alcohol-collagen-hydroxyapatite biocomposite nanofibrous scaffold: Mimicking the key features of natural bone at the nanoscale level , 2010 .

[12]  E. Reynolds,et al.  Casein Phosphopeptide-Amorphous Calcium Phosphate Incorporated into Sugar Confections Inhibits the Progression of Enamel Subsurface Lesions in situ , 2010, Caries Research.

[13]  K. Chennazhi,et al.  Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration. , 2012, Carbohydrate polymers.

[14]  Robert N Grass,et al.  Remineralization of human dentin using ultrafine bioactive glass particles. , 2007, Acta biomaterialia.

[15]  A. Mata,et al.  Bioactive Nanofibers Instruct Cells to Proliferate and Differentiate During Enamel Regeneration , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[16]  Thomas J Webster,et al.  Using hydroxyapatite nanoparticles and decreased crystallinity to promote osteoblast adhesion similar to functionalizing with RGD. , 2006, Biomaterials.

[17]  P. Martus,et al.  Enamel and dentine remineralization by nano-hydroxyapatite toothpastes. , 2011, Journal of dentistry.

[18]  Cato T Laurencin,et al.  Polyphosphazene/nano-hydroxyapatite composite microsphere scaffolds for bone tissue engineering. , 2008, Biomacromolecules.

[19]  T. Webster,et al.  Nanotechnology and nanomaterials: Promises for improved tissue regeneration , 2009 .

[20]  Jae Hoon Lee,et al.  The Effect of Nano-Sized β-Tricalcium Phosphate on Remineralization in Glass Ionomer Dental Luting Cement , 2007 .

[21]  Li Li,et al.  Repair of enamel by using hydroxyapatite nanoparticles as the building blocks , 2008 .

[22]  M V Swain,et al.  Micromechanical Property Recovery of Human Carious Dentin Achieved with Colloidal Nano-β-tricalcium Phosphate , 2008, Journal of dental research.

[23]  K. Cross,et al.  Effect of Addition of Citric Acid and Casein Phosphopeptide-Amorphous Calcium Phosphate to a Sugar-Free Chewing Gum on Enamel Remineralization in situ , 2007, Caries Research.

[24]  T. Webster,et al.  Specific proteins mediate enhanced osteoblast adhesion on nanophase ceramics. , 2000, Journal of biomedical materials research.

[25]  Masayuki Otsuki,et al.  Materials chemistry: A synthetic enamel for rapid tooth repair , 2005, Nature.

[26]  W. Bonfield,et al.  The response of osteoblasts to nanocrystalline silicon-substituted hydroxyapatite thin films. , 2006, Biomaterials.

[27]  Peter X Ma,et al.  Biomimetic materials for tissue engineering. , 2008, Advanced drug delivery reviews.

[28]  R. W. Siegel,et al.  Mechanical properties of nanophase metals , 1994 .

[29]  H. Kock,et al.  Open Reduction and Palmar Plate-Osteosynthesis in Combination with a Nanocrystalline Hydroxyapatite Spacer in the Treatment of Comminuted Fractures of the Distal Radius , 2006, Journal of hand surgery.

[30]  M. Menger,et al.  Injectable nanocrystalline hydroxyapatite paste for bone substitution: in vivo analysis of biocompatibility and vascularization. , 2007, Journal of biomedical materials research. Part B, Applied biomaterials.

[31]  E. Reynolds,et al.  The Anticariogenic Effect of Sugar-Free Gum Containing CPP-ACP Nanocomplexes on Approximal Caries Determined Using Digital Bitewing Radiography , 2008, Caries Research.

[32]  S. Stupp,et al.  Organoapatites: materials for artificial bone. I. Synthesis and microstructure. , 1992, Journal of biomedical materials research.

[33]  Haiyang Yu,et al.  Combined effects of nano-hydroxyapatite and Galla chinensis on remineralisation of initial enamel lesion in vitro. , 2010, Journal of dentistry.

[34]  S. Shi,et al.  Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. , 2008, Journal of endodontics.

[35]  M Busacca,et al.  A novel nano-composite multi-layered biomaterial for treatment of osteochondral lesions: technique note and an early stability pilot clinical trial. , 2010, Injury.

[36]  Jing Zhang,et al.  A review on endogenous regenerative technology in periodontal regenerative medicine. , 2010, Biomaterials.

[37]  Kai Sun,et al.  Self-assembly of synthetic hydroxyapatite nanorods into an enamel prism-like structure. , 2005, Journal of colloid and interface science.

[38]  Y. Fujishiro,et al.  Coating of Hydroxyapatite on Titanium Plates Using Thermal Dissociation of Calcium-EDTA Chelate Complex in Phosphate Solutions under Hydrothermal Conditions , 1995 .

[39]  Christian Hannig,et al.  Nanomaterials in preventive dentistry. , 2010, Nature nanotechnology.

[40]  S N Jayasinghe,et al.  In vitro assessment of the biological response to nano-sized hydroxyapatite , 2004, Journal of materials science. Materials in medicine.

[41]  S. Shi,et al.  SHED Differentiate into Functional Odontoblasts and Endothelium , 2010, Journal of dental research.

[42]  L. Morbidelli,et al.  Nanostructured HA crystals up-regulate FGF-2 expression and activity in microvascular endothelium promoting angiogenesis. , 2007, Bone.

[43]  Haiyang Yu,et al.  Effect of nano-hydroxyapatite concentration on remineralization of initial enamel lesion in vitro , 2009, Biomedical materials.

[44]  I. Berger,et al.  Void filling of tibia compression fracture zones using a novel resorbable nanocrystalline hydroxyapatite paste in combination with a hydroxyapatite ceramic core: first clinical results , 2006, Archives of Orthopaedic and Trauma Surgery.

[45]  B HEDEGARD,et al.  Further studies on the leakage between resin material and gold alloy in resin-faced gold cups. , 1963, Acta odontologica Scandinavica.

[46]  J. Moradian-Oldak,et al.  The structural biology of the developing dental enamel matrix. , 1999, Journal of structural biology.

[47]  F. Schwarz,et al.  Healing of intrabony peri-implantitis defects following application of a nanocrystalline hydroxyapatite (Ostim) or a bovine-derived xenograft (Bio-Oss) in combination with a collagen membrane (Bio-Gide). A case series. , 2006, Journal of clinical periodontology.

[48]  Limin Sun,et al.  Nanocomposites with Ca and PO4 release: effects of reinforcement, dicalcium phosphate particle size and silanization. , 2007, Dental materials : official publication of the Academy of Dental Materials.

[49]  S. Both,et al.  Development of an electrospun nano-apatite/PCL composite membrane for GTR/GBR application. , 2009, Acta biomaterialia.

[50]  S. Mickenautsch,et al.  Caries preventive effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP): a meta-analysis , 2009, Acta odontologica Scandinavica.

[51]  R. Tuan,et al.  Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. , 2010, Tissue engineering. Part A.

[52]  K. J. Toumba,et al.  Effect of Slow-Release Fluoride Devices and Casein Phosphopeptide/Amorphous Calcium Phosphate Nanocomplexes on Enamel Remineralization in vitro , 2010, Caries Research.

[53]  Elizabeth G Loboa,et al.  Tools and techniques for craniofacial tissue engineering. , 2003, Tissue engineering.

[54]  Xing Yi Li,et al.  Remineralization Effect of the Nano-HA Toothpaste on Artificial Caries , 2007 .

[55]  Jd Bader,et al.  Casein phosphopeptide–amorphous calcium phosphate shows promise for preventing caries , 2010, Evidence-Based Dentistry.

[56]  Thomas J Webster,et al.  Increased osteoblast and decreased Staphylococcus epidermidis functions on nanophase ZnO and TiO2. , 2006, Journal of biomedical materials research. Part A.

[57]  Hong Zhou,et al.  Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine , 2011, International Journal of Oral Science.

[58]  Zhiyong Tang,et al.  Acellular Synthesis of a Human Enamel‐like Microstructure , 2006 .

[59]  A. Sadr,et al.  Effects of CPP-ACP with sodium fluoride on inhibition of bovine enamel demineralization: a quantitative assessment using micro-computed tomography. , 2011, Journal of dentistry.

[60]  I. Stokroos,et al.  The Remineralization of EDTA–Treated Human Dentine , 1999, Caries Research.

[61]  Xurong Xu,et al.  Effect of crystallinity of calcium phosphate nanoparticles on adhesion, proliferation, and differentiation of bone marrow mesenchymal stem cells , 2007 .

[62]  C. Llena,et al.  Anticariogenicity of casein phosphopeptide-amorphous calcium phosphate: a review of the literature. , 2009, The journal of contemporary dental practice.

[63]  C. Sharma,et al.  Nanoceramic Matrices: Biomedical Applications , 2006 .

[64]  M. Kavitha,et al.  Comparison of the remineralization potential of CPP-ACP and CPP-ACP with 900 ppm fluoride on eroded human enamel: An in situ study. , 2010, Archives of oral biology.

[65]  B. N. Cavalcanti,et al.  Tissue engineering: from research to dental clinics. , 2012, Dental materials : official publication of the Academy of Dental Materials.

[66]  E. Reynolds,et al.  Acid Resistance of Enamel Subsurface Lesions Remineralized by a Sugar-Free Chewing Gum Containing Casein Phosphopeptide-Amorphous Calcium Phosphate , 2004, Caries Research.

[67]  K. Onuma,et al.  Nucleation and growth of hydroxyapatite nanocrystals for nondestructive repair of early caries lesions , 2005 .

[68]  V. Rosa,et al.  Regenerative endodontics in light of the stem cell paradigm. , 2011, International dental journal.

[69]  D. Kalyon,et al.  Osteochondral tissue formation through adipose-derived stromal cell differentiation on biomimetic polycaprolactone nanofibrous scaffolds with graded insulin and Beta-glycerophosphate concentrations. , 2011, Tissue engineering. Part A.

[70]  Marisa A. Sambito,et al.  Increased osteoblast functions on undoped and yttrium-doped nanocrystalline hydroxyapatite coatings on titanium. , 2006, Biomaterials.

[71]  G. Michler,et al.  Nanocristalline Hydroxyapatite for Bone Repair , 2007 .

[72]  Y. K. Kim,et al.  Phosphoric acid esters cannot replace polyvinylphosphonic acid as phosphoprotein analogs in biomimetic remineralization of resin-bonded dentin. , 2009, Dental materials : official publication of the Academy of Dental Materials.

[73]  H. Kock,et al.  The use of nanocrystalline hydroxyapatite for the reconstruction of calcaneal fractures: Preliminary results. , 2006, The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons.

[74]  Changwen Hu,et al.  Preparation of ultrahigh-aspect-ratio hydroxyapatite nanofibers in reverse micelles under hydrothermal conditions. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[75]  J. Vacanti,et al.  Tissue engineering : Frontiers in biotechnology , 1993 .

[76]  Hong Zhou,et al.  Biomaterial selection for tooth regeneration. , 2011, Tissue engineering. Part B, Reviews.

[77]  Masahiro Yoshimura,et al.  Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants , 1998 .

[78]  Y. K. Kim,et al.  Mineralisation of reconstituted collagen using polyvinylphosphonic acid/polyacrylic acid templating matrix protein analogues in the presence of calcium, phosphate and hydroxyl ions. , 2010, Biomaterials.

[79]  H. Kwon,et al.  Combined Effects of Nano-Hydroxyapatite and NaF on Remineralization of Early Caries Lesion , 2007 .

[80]  L. Morbidelli,et al.  The effect of hydroxyapatite nanocrystals on microvascular endothelial cell viability and functions. , 2006, Journal of biomedical materials research. Part A.

[81]  T. Webster,et al.  Increased osteoblast functions on theta + delta nanofiber alumina. , 2005, Biomaterials.

[82]  K. Gerlach,et al.  [Treatment of jaw cysts with a new kind of nanoparticular hydroxylapatite]. , 2007, Mund-, Kiefer- und Gesichtschirurgie : MKG.

[83]  E. Reynolds,et al.  Remineralization of Enamel Subsurface Lesions by Casein Phosphopeptide-stabilized Calcium Phosphate Solutions , 1997, Journal of dental research.

[84]  M. Prabhakaran,et al.  Biomimetic hydroxyapatite-containing composite nanofibrous substrates for bone tissue engineering , 2010, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[85]  P. Ma,et al.  Nanofibrous Scaffolds for Dental and Craniofacial Applications , 2012, Journal of dental research.

[86]  Gottfried Schmalz,et al.  Self-assembling peptide amphiphile nanofibers as a scaffold for dental stem cells. , 2008, Tissue engineering. Part A.

[87]  P. Reichart,et al.  Lateral alveolar ridge augmentation using a synthetic nano-crystalline hydroxyapatite bone substitution material (Ostim): preliminary clinical and histological results. , 2007, Clinical oral implants research.

[88]  Seeram Ramakrishna,et al.  Enhanced biomineralization in osteoblasts on a novel electrospun biocomposite nanofibrous substrate of hydroxyapatite/collagen/chitosan. , 2010, Tissue engineering. Part A.

[89]  Claudia L. Bianchi,et al.  Surface enamel remineralization: biomimetic apatite nanocrystals and fluoride ions different effects , 2009 .

[90]  E. Reynolds.  Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: a review. , 1998, Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry.

[91]  T. Webster,et al.  Enhanced osteoclast-like cell functions on nanophase ceramics. , 2001, Biomaterials.

[92]  F. Tay,et al.  Biomimetic Remineralization of Resin-bonded Acid-etched dentin , 2009, Journal of dental research.

[93]  H. Yu,et al.  Remineralization Potential of Nano-Hydroxyapatite on Initial Enamel Lesions: An in vitro Study , 2011, Caries Research.

[94]  J. Wiltfang,et al.  Bone regeneration in osseous defects using a resorbable nanoparticular hydroxyapatite. , 2005, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[95]  T. Gotterbarm,et al.  [Animal study of the bone substitute material Ostim within osseous defects in Göttinger minipigs]. , 2008, Zeitschrift fur Orthopadie und Unfallchirurgie.