Mesangial matrix expansion in a novel mouse model of diabetic kidney disease associated with the metabolic syndrome

1Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium 2University Hospitals Leuven, Department of Nephrology and Renal Transplantation, Leuven, Belgium 3Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium 4Department of Imaging and Pathology, Division of Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium 5Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA 6William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, Minnesota, USA

[1]  M. Lanaspa,et al.  Fructose Production and Metabolism in the Kidney. , 2020, Journal of the American Society of Nephrology : JASN.

[2]  Byron H. Smith,et al.  Using computer‐assisted morphometrics of 5‐year biopsies to identify biomarkers of late renal allograft loss , 2019, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[3]  L. Balmer,et al.  Genetic characterization of early renal changes in a novel mouse model of diabetic kidney disease. , 2019, Kidney international.

[4]  J. Aboumsallem,et al.  Cholesterol-Lowering Gene Therapy Prevents Heart Failure with Preserved Ejection Fraction in Obese Type 2 Diabetic Mice , 2019, International journal of molecular sciences.

[5]  H. Kempen,et al.  Effective Treatment of Diabetic Cardiomyopathy and Heart Failure with Reconstituted HDL (Milano) in Mice , 2019, International journal of molecular sciences.

[6]  Jia-You Fang,et al.  In Vivo Rodent Models of Type 2 Diabetes and Their Usefulness for Evaluating Flavonoid Bioactivity , 2019, Nutrients.

[7]  C. Mathieu,et al.  Occurrence of Diabetic Nephropathy After Renal Transplantation Despite Intensive Glycemic Control: An Observational Cohort Study , 2019, Diabetes Care.

[8]  M. Herman,et al.  Fructose metabolism and metabolic disease , 2018, The Journal of clinical investigation.

[9]  C. Alpers,et al.  A Novel Type 2 Diabetes Mouse Model of Combined Diabetic Kidney Disease and Atherosclerosis. , 2017, The American journal of pathology.

[10]  H. Heerspink,et al.  Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment. , 2017, Journal of the American Society of Nephrology : JASN.

[11]  H. Florez,et al.  How to prevent the microvascular complications of type 2 diabetes beyond glucose control , 2017, British Medical Journal.

[12]  C. Conover,et al.  PAPP-A in normal human mesangial cells: effect of inflammation and factors related to diabetic nephropathy. , 2016, The Journal of endocrinology.

[13]  M. Barac-nieto,et al.  Insulin Prevents Hyperfiltration and Proteinuria but Not Glomerular Hypertrophy and Increases Mesangial Matrix Expansion in Diabetic Rats , 2016, Medical Principles and Practice.

[14]  H. Makino,et al.  Inhibition of SGLT2 alleviates diabetic nephropathy by suppressing high glucose‐induced oxidative stress in type 1 diabetic mice , 2016, Pharmacology research & perspectives.

[15]  Frank B Hu,et al.  Fructose and Cardiometabolic Health: What the Evidence From Sugar-Sweetened Beverages Tells Us. , 2015, Journal of the American College of Cardiology.

[16]  A. Rule,et al.  Nephron hypertrophy and glomerulosclerosis and their association with kidney function and risk factors among living kidney donors. , 2014, Clinical journal of the American Society of Nephrology : CJASN.

[17]  R. Minutolo,et al.  Sodium/glucose cotransporter 2 inhibitors and prevention of diabetic nephropathy: targeting the renal tubule in diabetes. , 2014, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[18]  H. Yamada,et al.  Long-Term Treatment with the Sodium Glucose Cotransporter 2 Inhibitor, Dapagliflozin, Ameliorates Glucose Homeostasis and Diabetic Nephropathy in db/db Mice , 2014, PloS one.

[19]  H. Koepsell,et al.  SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice. , 2014, American journal of physiology. Renal physiology.

[20]  Kuang-Yu Jen,et al.  Reliability of whole slide images as a diagnostic modality for renal allograft biopsies. , 2013, Human pathology.

[21]  M. Empie,et al.  Fructose metabolism in humans – what isotopic tracer studies tell us , 2012, Nutrition & Metabolism.

[22]  Philip F Halloran,et al.  Superiority of virtual microscopy versus light microscopy in transplantation pathology , 2012, Clinical transplantation.

[23]  Josef Coresh,et al.  Chronic kidney disease , 2012, The Lancet.

[24]  H. Gin,et al.  Large kidneys predict poor renal outcome in subjects with diabetes and chronic kidney disease , 2010, BMC nephrology.

[25]  M. Lanaspa,et al.  Dietary fructose causes tubulointerstitial injury in the normal rat kidney. , 2010, American journal of physiology. Renal physiology.

[26]  C. Alpers,et al.  Mouse models of diabetic nephropathy. , 2005, Journal of the American Society of Nephrology : JASN.

[27]  Samy Suissa,et al.  Renal and retinal effects of enalapril and losartan in type 1 diabetes. , 2009, The New England journal of medicine.

[28]  S. Menini,et al.  Advanced lipoxidation end‐products mediate lipid‐induced glomerular injury: role of receptor‐mediated mechanisms , 2009, The Journal of pathology.

[29]  G. Deferrari,et al.  Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy. , 2008, American journal of physiology. Renal physiology.

[30]  A. Luke,et al.  Sugary Soda Consumption and Albuminuria: Results from the National Health and Nutrition Examination Survey, 1999–2004 , 2008, PloS one.

[31]  M. Kramer,et al.  The early natural history of nephropathy in Type 1 Diabetes: III. Predictors of 5-year urinary albumin excretion rate patterns in initially normoalbuminuric patients. , 2005, Diabetes.

[32]  Michael Brownlee,et al.  The pathobiology of diabetic complications: a unifying mechanism. , 2005, Diabetes.

[33]  S. Adler.  Diabetic nephropathy: Linking histology, cell biology, and genetics. , 2004, Kidney international.

[34]  T. Berl,et al.  Pathogenesis of Diabetic Nephropathy , 2004, Reviews in Endocrine and Metabolic Disorders.

[35]  D. Heudes,et al.  Morphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation. , 2003, Kidney international.

[36]  A. Komatsuda,et al.  Complications of IgA nephropathy in a non-insulin-dependent diabetes model, the Akita mouse. , 2002, The Tohoku journal of experimental medicine.

[37]  M. Mauer,et al.  The early natural history of nephropathy in type 1 diabetes: II. Early renal structural changes in type 1 diabetes. , 2002, Diabetes.

[38]  R. Bell,et al.  High-fructose feeding of streptozotocin-diabetic rats is associated with increased cataract formation and increased oxidative stress in the kidney , 2000, British Journal of Nutrition.

[39]  M. Feinglos,et al.  Diet-Induced Type II Diabetes in C57BL/6J Mice , 1988, Diabetes.

[40]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.

[41]  M. Steffes,et al.  Structural-functional relationships in diabetic nephropathy. , 1984, The Journal of clinical investigation.

[42]  C. B. Kahn,et al.  Kidney Size in Diabetes Mellitus , 1974, Diabetes.

[43]  E. Weibel,et al.  A principle for counting tissue structures on random sections. , 1962, Journal of applied physiology.

[44]  Yusuke Suzuki,et al.  High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats. , 2018, The Journal of toxicological sciences.

[45]  T. Nakagawa,et al.  Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. , 2007, American journal of physiology. Renal physiology.

[46]  Ge Wang.  which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fractal MapReduce decomposition of sequence alignment , 2005 .

[47]  R. Lindeman,et al.  The aging kidney. , 1986, Comprehensive therapy.