Microchips in Medicine: Current and Future Applications

With the objective of improving efficacy and morbidity, device manufacturers incorporate chemicals or drugs into medical implants. Using multiple reservoirs of discrete drug doses, microchips represent a new technology capable of on-demand release of various drugs over long periods of time. Herein, we review drug delivery systems, how microchips work, recent investigations, and future applications in various fields of medicine.

[1]  R Langer,et al.  Microchips as Controlled Drug-Delivery Devices. , 2000, Angewandte Chemie.

[2]  Michael J Cima,et al.  Microchip technology in drug delivery , 2000, Annals of medicine.

[3]  K. Shakesheff,et al.  Polymeric systems for controlled drug release. , 1999, Chemical reviews.

[4]  T. Desai,et al.  Microfabricated drug delivery systems: from particles to pores. , 2003, Advanced drug delivery reviews.

[5]  M. Einarson Controlled-release microchip , 1999, Nature Biotechnology.

[6]  Ali Khademhosseini,et al.  Microfabrication technologies for oral drug delivery. , 2012, Advanced drug delivery reviews.

[7]  Peter Woias,et al.  Micropumps—past, progress and future prospects , 2005 .

[8]  N Rajgor,et al.  Implantable drug delivery systems: An overview , 2011 .

[9]  M. Staples,et al.  Dosage Form Development, in Vitro Release Kinetics, and in Vitro–in Vivo Correlation for Leuprolide Released from an Implantable Multi-reservoir Array , 2007, Pharmaceutical Research.

[10]  Robert Langer,et al.  First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip , 2012, Science Translational Medicine.

[11]  K. B. Sutradhar,et al.  Implantable microchip: the futuristic controlled drug delivery system , 2016, Drug delivery.

[12]  Robert Langer,et al.  Multi-pulse drug delivery from a resorbable polymeric microchip device , 2003, Nature materials.

[13]  A. Dash,et al.  Therapeutic applications of implantable drug delivery systems. , 1998, Journal of pharmacological and toxicological methods.

[14]  Jerry Avorn Technology , 1929, Nature.

[15]  R. Langer,et al.  Drug delivery and targeting. , 1998, Nature.

[16]  Teruo Okano,et al.  Pulsatile drug release control using hydrogels. , 2002, Advanced drug delivery reviews.

[17]  John T Santini,et al.  Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device , 2006, Nature Biotechnology.

[18]  Henry Brem,et al.  Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[19]  John T Santini,et al.  Electrothermally activated microchips for implantable drug delivery and biosensing. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[20]  Mauro Ferrari,et al.  Controlled-release microchips , 2006, Expert opinion on drug delivery.

[21]  D. Bikiaris,et al.  Recent advances in oral pulsatile drug delivery. , 2009, Recent patents on drug delivery & formulation.

[22]  Nicholas A Peppas,et al.  Microfabricated drug delivery devices. , 2005, International journal of pharmaceutics.

[23]  William B. Liechty,et al.  Polymers for drug delivery systems. , 2010, Annual review of chemical and biomolecular engineering.

[24]  M. Staples,et al.  Long-term Stability and in vitro Release of hPTH(1–34) from a Multi-reservoir Array , 2008, Pharmaceutical Research.