Alteration of protein glycosylation in liver diseases.

[1]  G. Karvountzis,et al.  Relation of alpha-fetoprotein in acute hepatitis to severity and prognosis. , 1974, Annals of internal medicine.

[2]  H. Schachter The subcellular sites of glycosylation. , 1974, Biochemical Society symposium.

[3]  J. Turner,et al.  DOES T4 TOXICOSIS EXIST ? , 1975, The Lancet.

[4]  J. Kerckaert,et al.  Characterization and isolation of nine rat alpha-fetoprotein variants by gel electrophoresis and lectin affinity chromatography. , 1977, Biochemical and biophysical research communications.

[5]  R. Laine,et al.  Structure of the oligosaccharide chains in human alpha 1-protease inhibitor. , 1979, The Journal of biological chemistry.

[6]  Y. Tashiro,et al.  Hyperasialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma: Asialoglycoprotein receptor in cirrhosis and liver cell carcinoma , 1984 .

[7]  C. Barsigian,et al.  Carbohydrate abnormalities of N-linked plasma glycoproteins in liver disease. , 1987, Laboratory investigation; a journal of technical methods and pathology.

[8]  R. Kerbel,et al.  Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. , 1987, Science.

[9]  Y. Aoyagi,et al.  The reactivity of alpha-1-antitrypsin with Lens culinaris agglutinin and its usefulness in the diagnosis of neoplastic diseases of the liver. , 1987, British Journal of Cancer.

[10]  G. Anderson,et al.  DESIALYLATED TRANSFERRIN AS A SEROLOGICAL MARKER OF CHRONIC EXCESSIVE ALCOHOL INGESTION , 1987, The Lancet.

[11]  Modifications of concanavalin A patterns of alpha 1-acid glycoprotein and alpha 2-HS glycoprotein in alcoholic liver disease. , 1988, Clinica chimica acta; international journal of clinical chemistry.

[12]  S. Rajalakshmi,et al.  Expression of N-acetylglucosaminyltransferase III in hepatic nodules during rat liver carcinogenesis promoted by orotic acid. , 1988, The Journal of biological chemistry.

[13]  J. Féger,et al.  Modifications of Concanavalin A patterns of α1-acid glycoprotein and α2-HS glycoprotein in alcoholic liver disease , 1988 .

[14]  M. Isemura,et al.  The fucosylation index of alpha‐fetoprotein and its usefulness in the early diagnosis of hepatocellular carcinoma , 1988, Cancer.

[15]  A. Kobata,et al.  Altered glycosylation of serum transferrin of patients with hepatocellular carcinoma. , 1989, The Journal of biological chemistry.

[16]  J. Paulson,et al.  Glycosyltransferases. Structure, localization, and control of cell type-specific glycosylation. , 1989, The Journal of biological chemistry.

[17]  C. Koeleman,et al.  N-acetylglucosaminyltransferase III, IV and V activities in Novikoff ascites tumour cells, mouse lymphoma cells and hen oviduct. Application of a sensitive and specific assay by use of high-performance liquid chromatography. , 1989, European journal of biochemistry.

[18]  J. Wieruszeski,et al.  Presence of fucosylated triantennary, tetraantennary and pentaantennary glycans in transferrin synthesized by the human hepatocarcinoma cell line Hep G2. , 1989, European journal of biochemistry.

[19]  S. Fujii,et al.  Determination of N-acetylglucosaminyltransferases III, IV and V in normal and hepatoma tissues of rats. , 1990, Biochimica et biophysica acta.

[20]  J. V. Dijk,et al.  The biology of transferrin. , 1990 .

[21]  K. Taketa,et al.  Lectin-reactive profiles of alpha-fetoprotein characterizing hepatocellular carcinoma and related conditions. , 1990, Gastroenterology.

[22]  J. Neefjes,et al.  Protein glycosylation. , 1990, Current opinion in cell biology.

[23]  Accumulation of glycoprotein in the Golgi apparatus of hepatocytes in alcoholic liver injuries. , 1991, The American journal of gastroenterology.

[24]  Roger Williams,et al.  Differential alpha‐fetoprotein lectin binding in hepatocellular carcinoma. Diagnostic utility at low serum levels , 1991, Cancer.

[25]  T. Hada,et al.  Enzymatic basis of sugar structures of α‐fetoprotein in hepatoma and hepatoblastoma cell lines: Correlation with activities of α1–6 fucosyltransferase and N‐acetylglucosaminyltransferases III and V , 1992, International journal of cancer.

[26]  G. Turner N-glycosylation of serum proteins in disease and its investigation using lectins. , 1992, Clinica chimica acta; international journal of clinical chemistry.

[27]  J. Renau‐Piqueras,et al.  Chronic ethanol consumption induces accumulation of proteins in the liver Golgi apparatus and decreases galactosyltransferase activity. , 1992, Alcoholism, clinical and experimental research.

[28]  W. Brown,et al.  Abnormal surface distribution of the human asialoglycoprotein receptor in cirrhosis , 1992, Hepatology.

[29]  H. Asakura,et al.  Structural analysis on the sugar chains of human alpha 1-antitrypsin: presence of fucosylated biantennary glycan in hepatocellular carcinoma. , 1993, Archives of biochemistry and biophysics.

[30]  D. Harvey Quantitative aspects of the matrix-assisted laser desorption mass spectrometry of complex oligosaccharides. , 1993, Rapid communications in mass spectrometry : RCM.

[31]  H. Asakura,et al.  Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans. , 1993, British Journal of Cancer.

[32]  N. Hayashi,et al.  N-acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis. , 1993, Cancer research.

[33]  A. Varki,et al.  Biological roles of oligosaccharides: all of the theories are correct , 1993, Glycobiology.

[34]  C. Record,et al.  Abnormally fucosylated haptoglobin as a marker for alcoholic liver disease but not excessive alcohol consumption or non-alcoholic liver disease. , 1993, Clinica chimica acta; international journal of clinical chemistry.

[35]  Fucosylation Index of α‐Fetoprotein, a Possible Aid in the Early Recognition of Hepatocellular Carcinoma in Patients with Cirrhosis , 1993, Hepatology.

[36]  N. Sharon,et al.  Protein glycosylation. Structural and functional aspects. , 1993, European journal of biochemistry.

[37]  M. Karas,et al.  Oligosaccharides from human milk as revealed by matrix-assisted laser desorption/ionization mass spectrometry. , 1994, Analytical biochemistry.

[38]  C. Record,et al.  Monosaccharide composition of haptoglobin in liver diseases and alcohol abuse: large changes in glycosylation associated with alcoholic liver disease. , 1994, Clinica chimica acta; international journal of clinical chemistry.

[39]  Y. Maeda,et al.  Alteration of asparagine-linked glycosylation in serum transferrin of patients with hepatocellular carcinoma. , 1994, Clinica chimica acta; international journal of clinical chemistry.

[40]  J. S. Wang,et al.  Microheterogeneity of serum glycoproteins in alcoholics: is desialo-transferrin the marker of chronic alcohol drinking or alcoholic liver injury? , 1994, Alcoholism, clinical and experimental research.

[41]  Selective suppression of N-acetylglucosaminyltransferase III activity in a human hepatoblastoma cell line transfected with hepatitis B virus. , 1994, Cancer research.

[42]  N-AcetylglucosaminyltransferaseIII and V Messenger RNA Levels in LEC Rats during Hepatocarcinogenesis , 1994 .

[43]  R. Dwek Glycobiology: "towards understanding the function of sugars". , 1996, Biochemical Society transactions.

[44]  H. Fusamoto,et al.  Transfection of N-Acetylglucosaminyltransferase III Gene Suppresses Expression of Hepatitis B Virus in a Human Hepatoma Cell Line, HB611 (*) , 1995, The Journal of Biological Chemistry.

[45]  M. Lakshman,et al.  Long-term ethanol exposure impairs glycosylation of both N- and O-glycosylated proteins in rat liver. , 1995, Metabolism: clinical and experimental.

[46]  C. Lieber,et al.  Serum carbohydrate‐deficient transferrin: Mechanism of increase after chronic alcohol intake , 1995 .

[47]  T. Suda,et al.  Microheterogeneity of serum transferrin in the diagnosis of hepatocellular carcinoma , 1996, Journal of gastroenterology and hepatology.

[48]  D. Hochstrasser,et al.  New alterations of serum glycoproteins in alcoholic and cirrhotic patients revealed by high resolution two-dimensional gel electrophoresis. , 1996, Biochemical and biophysical research communications.

[49]  M. Monsigny,et al.  Increased α2,6 Sialylation of N-Glycans in a Transgenic Mouse Model of Hepatocellular Carcinoma , 1997 .

[50]  C. Rogler,et al.  Progression of hepatic neoplasms is severely retarded in mice lacking the bisecting N-acetylglucosamine on N-glycans: evidence for a glycoprotein factor that facilitates hepatic tumor progression. , 1998, Cancer research.

[51]  K. Yamamura,et al.  Ectopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[52]  Naoyuki Taniguchi,et al.  Gene expression of α1‐6 fucosyltransferase in human hepatoma tissues: A possible implication for increased fucosylation of α‐fetoprotein , 1998 .

[53]  E. Damme Handbook of plant lectins : properties and biomedical applications , 1998 .

[54]  S. Kornfeld Diseases of abnormal protein glycosylation: an emerging area. , 1998, The Journal of clinical investigation.

[55]  K. Suzuki,et al.  Gene expression of alpha1-6 fucosyltransferase in human hepatoma tissues: a possible implication for increased fucosylation of alpha-fetoprotein. , 1998, Hepatology.

[56]  M. Yanagi,et al.  Serum N‐acetylglucosaminyltransferase III activities in hepatocellular carcinoma , 1998, Journal of gastroenterology and hepatology.

[57]  Zhao-You Tang,et al.  Elevated activity of N -acetylglucosaminyltransferase V in human hepatocellular carcinoma , 1998, Journal of Cancer Research and Clinical Oncology.

[58]  J. Dennis,et al.  Glycoprotein glycosylation and cancer progression. , 1999, Biochimica et biophysica acta.

[59]  Usefulness of Lens culinaris agglutinin A-reactive fraction of alpha-fetoprotein (AFP-L3) as a marker of distant metastasis from hepatocellular carcinoma. , 1999, Oncology reports.

[60]  D. Lavanchy,et al.  Microheterogeneity of serum glycoproteins in patients with chronic alcohol abuse compared with carbohydrate-deficient glycoprotein syndrome type I. , 1999, Clinical chemistry.

[61]  M. Lakshman,et al.  Chronic ethanol consumption leads to destabilization of rat liver β-galactoside α2,6-sialyltransferase mRNA , 1999 .

[62]  Y. Ikeda,et al.  Implication of N-acetylglucosaminyltransferases III and V in cancer: gene regulation and signaling mechanism. , 1999, Biochimica et biophysica acta.

[63]  M. Aebi,et al.  The dolichol pathway of N-linked glycosylation. , 1999, Biochimica et biophysica acta.

[64]  H. L. Chen,et al.  Opposing changes in N-acetylglucosaminyltransferase-V and -III during the cell cycle and all-trans retinoic acid treatment of hepatocarcinoma cell line. , 2000, Biochimica et biophysica acta.

[65]  C. Rogler,et al.  Diethylnitrosamine-induced Liver Tumors in Mice-acetylglucosaminyltransferase III in the Progression of N New Evidence for an Extra-Hepatic Role of Updated Version , 2000 .

[66]  S. Yamashita,et al.  Ectopic expression of alpha1,6 fucosyltransferase in mice causes steatosis in the liver and kidney accompanied by a modification of lysosomal acid lipase. , 2001, Glycobiology.

[67]  T. Suda,et al.  N‐Acetylglucosaminyltransferase V as a possible aid for the evaluation of tumor invasiveness in patients with hepatocellular carcinoma , 2001, Journal of gastroenterology and hepatology.

[68]  M. Monden,et al.  Elevated expression of UDP‐N‐acetylglucosamine: αmannoside β1,6 N‐acetylglucosaminyltransferase is an early event in hepatocarcinogenesis , 2001 .

[69]  B. Samyn-Petit,et al.  The human sialyltransferase family. , 2001, Biochimie.

[70]  Young-Choon Lee,et al.  Expression of Bisecting N-Acetylglucosaminyltransferase-III in Human Hepatocarcinoma Tissues, Fetal Liver Tissues, and Hepatoma Cell Lines of Hep3B and HepG2 , 2001, Cancer investigation.

[71]  M. Monden,et al.  Elevated expression of UDP-N-acetylglucosamine: alphamannoside beta1,6 N-acetylglucosaminyltransferase is an early event in hepatocarcinogenesis. , 2001, International journal of cancer.

[72]  S. Satomura,et al.  AFP-L3: a new generation of tumor marker for hepatocellular carcinoma. , 2001, Clinica chimica acta; international journal of clinical chemistry.

[73]  Kevin D. Smith,et al.  A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases. , 2002, Biomedical chromatography : BMC.

[74]  Yi Cao,et al.  Differential Expression of β-Galactoside α2,6 Sialyltransferase and Sialoglycans in Normal and Cirrhotic Liver and Hepatocellular Carcinoma , 2002, Laboratory Investigation.

[75]  Influence of chronic ethanol consumption on toxic effects of 1,2-dichloroethane: glycolipoprotein retention and impairment of dolichol concentration in rat liver microsomes and Golgi apparatus. , 2002, Toxicology.

[76]  Yi Cao,et al.  Differential expression of beta-galactoside alpha2,6 sialyltransferase and sialoglycans in normal and cirrhotic liver and hepatocellular carcinoma. , 2002, Laboratory investigation; a journal of technical methods and pathology.

[77]  R. Spiro Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds. , 2002, Glycobiology.

[78]  C. Rogler,et al.  Reduced hepatocyte proliferation is the basis of retarded liver tumor progression and liver regeneration in mice lacking N-acetylglucosaminyltransferase III. , 2003, Cancer research.

[79]  M. Fiorentino,et al.  Expression of β-galactoside α2,6 sialyltransferase and of α2,6-sialylated glycoconjugates in normal human liver, hepatocarcinoma, and cirrhosis , 2003 .

[80]  G. Gores,et al.  Value of determining carbohydrate-deficient transferrin isoforms in the diagnosis of alcoholic liver disease. , 2003, Mayo Clinic proceedings.

[81]  J. Michalski,et al.  The effects of ethanol on the glycosylation of human transferrin. , 2003, Glycobiology.

[82]  Abderrahman Maftah,et al.  The fucosyltransferase gene family: an amazing summary of the underlying mechanisms of gene evolution. , 2003 .

[83]  M. Fiorentino,et al.  Expression of beta-galactoside alpha2,6 sialyltransferase and of alpha2,6-sialylated glycoconjugates in normal human liver, hepatocarcinoma, and cirrhosis. , 2004, Glycobiology.

[84]  Tae-Wook Chung,et al.  The Hepatitis B Virus X Protein Inhibits Secretion of Apolipoprotein B by Enhancing the Expression of N-Acetylglucosaminyltransferase III* , 2004, Journal of Biological Chemistry.

[85]  R. Contreras,et al.  Noninvasive diagnosis of liver cirrhosis using DNA sequencer–based total serum protein glycomics , 2004, Nature Network Boston.

[86]  Young-Choon Lee,et al.  Elevated expression of bisecting N‐acetylglucosaminyltransferase‐III gene in a human fetal hepatocyte cell line by hepatitis B virus , 2004, Journal of gastroenterology and hepatology.

[87]  Tae-Wook Chung,et al.  Hyperexpression of N-acetylglucosaminyltransferase-III in liver tissues of transgenic mice causes fatty body and obesity through severe accumulation of Apo A-I and Apo B. , 2004, Archives of biochemistry and biophysics.

[88]  Determination of serum carbohydrate-deficient transferrin in the diagnosis of alcoholic liver disease. , 2005, Hepatobiliary & pancreatic diseases international : HBPD INT.

[89]  J. Paulson,et al.  Glycomics: an integrated systems approach to structure-function relationships of glycans , 2005, Nature Methods.

[90]  J. Michalski,et al.  Glycomics and mass spectrometry. , 2005, Current pharmaceutical design.

[91]  M. Molinari,et al.  The glycan code of the endoplasmic reticulum: asparagine-linked carbohydrates as protein maturation and quality-control tags. , 2005, Trends in cell biology.

[92]  J. Gu,et al.  Fucosylation of N-Glycans Regulates the Secretion of Hepatic Glycoproteins into Bile Ducts* , 2006, Journal of Biological Chemistry.

[93]  R. Contreras,et al.  Glycome mapping on DNA sequencing equipment , 2006, Nature Protocols.

[94]  Naoyuki Taniguchi,et al.  Decoding sugar functions by identifying target glycoproteins. , 2006, Current opinion in structural biology.

[95]  Suzanne Miyamoto,et al.  Clinical applications of glycomic approaches for the detection of cancer and other diseases. , 2006, Current opinion in molecular therapeutics.

[96]  Ram Sasisekharan,et al.  The sweet side of biomarker discovery , 2006, Nature Biotechnology.

[97]  Alexandre Louvet,et al.  Mass spectrometric approach for screening modifications of total serum N-glycome in human diseases: application to cirrhosis. , 2006, Glycobiology.

[98]  J. Sung,et al.  High-throughput quantitative profiling of serum N-glycome by MALDI-TOF mass spectrometry and N-glycomic fingerprint of liver fibrosis. , 2007, Clinical chemistry.

[99]  M. Szmitkowski,et al.  Serum free sialic acid as a marker of alcohol abuse. , 2007, Alcoholism, clinical and experimental research.

[100]  M. Sherman,et al.  Clinical Utility of AFP-L3% Measurement in North American Patients with HCV-Related Cirrhosis , 2007, The American Journal of Gastroenterology.

[101]  Mary Ann Comunale,et al.  Increased Levels of Galactose-Deficient Anti-Gal Immunoglobulin G in the Sera of Hepatitis C Virus-Infected Individuals with Fibrosis and Cirrhosis , 2007, Journal of Virology.

[102]  R. Field,et al.  Emerging glycomics technologies. , 2007, Nature chemical biology.

[103]  N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma , 2007 .

[104]  M. Lakshman,et al.  Liver Galβ1,4GlcNAc α2,6-sialyltransferase is down-regulated in human alcoholics: possible cause for the appearance of asialoconjugates , 2007 .

[105]  Lara K Mahal,et al.  Deciphering the glycocode: the complexity and analytical challenge of glycomics. , 2007, Current opinion in chemical biology.

[106]  Naoyuki Taniguchi,et al.  Functional roles of N‐glycans in cell signaling and cell adhesion in cancer , 2008, Cancer science.

[107]  Roland Contreras,et al.  [N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus]. , 2008, Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.